Reference on EC 2.4.2.4 - thymidine phosphorylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Barbas, C.F.; Wong, C.H.
Overexpression and substrate specificity studies of phosphodeoxyribomutase and thymidine phosphorylase
Bioorg. Chem.
19
261-269
1991
Escherichia coli
-
Zimmerman, M.; Seidenberg, J.
Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues
J. Biol. Chem.
239
2618-2621
1964
Cavia porcellus, Homo sapiens, Mesocricetus auratus, Rattus norvegicus
Lee, C.S.; Jimenez, B.M.; O'Sullivan, W.J.
Purification and characterization of uridine (thymidine) phosphorylase from Giardia lamblia
Mol. Biochem. Parasitol.
30
271-287
1988
Giardia intestinalis
Sugata, S.; Kono, A.; Hara, Y.; Karube, Y.; Matsushima, Y.
Partial purification of a thymidine phosphorylase from human gastric cancer
Chem. Pharm. Bull.
34
1219-1222
1986
Homo sapiens
Hoffee, P.A.; Blank, J.
Thymidine phosphorylase from Salmonella typhimurium
Methods Enzymol.
51
437-442
1978
Salmonella enterica subsp. enterica serovar Typhimurium
Schwartz, M.
Thymidine phosphorylase from Escherichia coli
Methods Enzymol.
51
442-445
1978
Escherichia coli
Zimmerman, M.
Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases
J. Biol. Chem.
239
2622-2627
1964
Escherichia coli, Homo sapiens, Rattus norvegicus, Escherichia coli B / ATCC 11303
Cook, W.J.; Koszalka, G.W.; Hall, W.W.; Burns, C.L.; Ealick, S.E.
Crystallization and preliminary x-ray investigation of thymidine phosphorylase from Escherichia coli
J. Biol. Chem.
262
3788-3789
1987
Escherichia coli
Walter, M.R.; Cook, W.J.; Cole, L.B.; Short, S.A.; Koszalka, G.W.; Krenitsky, T.A.; Ealick, S.E.
Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution
J. Biol. Chem.
265
14016-14022
1990
Escherichia coli
Iltzsch, M.H.; El Kouni, M.H.; Cha, S.
Kinetic studies of thymidine phosphorylase from mouse liver
Biochemistry
24
6799-6807
1985
Mus musculus
Desgranges, C.; Razaka, G.; Rabaud, M.; Bricaud, H.
Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase
Biochim. Biophys. Acta
654
211-218
1981
Homo sapiens
Blank, J.G.; Hoffee, P.A.
Purification and properties of thymidine phosphorylase from Salmonella typhimurium
Arch. Biochem. Biophys.
168
259-265
1975
Salmonella enterica subsp. enterica serovar Typhimurium
Kubilus, J.; Lee, L.D.; Baden, H.P.
Purification of thymidine phosphorylase from human amniochorion
Biochim. Biophys. Acta
527
221-228
1978
Homo sapiens
Krenitsky, T.A.; Tuttle, J.V.
Correlation of substrate-stabilization patterns with proposed mechanisms for three nucleoside phosphorylases
Biochim. Biophys. Acta
703
247-249
1982
Escherichia coli
Voytek, P.
Purification of thymidine phosphorylase from Escherichia coli and its photoinactivation in the presence of thymine, thymidine, and some halogenated analogs
J. Biol. Chem.
250
3660-3665
1975
Escherichia coli
Avraham, Y.; Grossowicz, N.; Yashphe, J.
Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei
Biochim. Biophys. Acta
1040
287-293
1990
Lacticaseibacillus casei
Avraham, Y.; Yashphe, J.; Grossowicz, N.
Thymidine phosphorylase and uridine phosphorylase of Lactobacillus casei
FEMS Microbiol. Lett.
56
29-34
1988
Lacticaseibacillus casei
-
el Kouni, M.H.; el Kouni, M.M.; Naguib, F.N.
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines
Cancer Res.
53
3687-3693
1993
Homo sapiens, Mus musculus
Pizzorno, G.; Cao, D.; Leffert, J.J.; Russell, R.L.; Zhang, D.; Handschumacher, R.E.
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update
Biochim. Biophys. Acta
1587
133-144
2002
Homo sapiens
Veres, Z.; Neszmelyi, A.; Szabolcs, A.; Denes, G.
Inhibition of uridine phosphorylase by pyrimidine nucleoside analogs and consideration of substrate binding to the enzyme based on solution conformation as seen by NMR spectroscopy
Eur. J. Biochem.
178
173-181
1988
Rattus norvegicus
de Bruin, M.; Smid, K.; Laan, A.C.; Noordhuis, P.; Fukushima, M.; Hoekman, K.; Pinedo, H.M.; Peters, G.J.
Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells
Biochem. Biophys. Res. Commun.
301
675-679
2003
Homo sapiens
Finnis, C.; Dodsworth, N.; Pollitt, C.E.; Carr, G.; Sleep, D.
Thymidine phosphorylase activity of platelet-derived endothelial cell growth factor is responsible for endothelial cell mitogenicity
Eur. J. Biochem.
212
201-210
1993
Escherichia coli, Homo sapiens
Liu, M.; Cao, D.; Russell, R.; Handschumacher, R.E.; Pizzorno, G.
Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors
Cancer Res.
58
5418-5424
1998
Homo sapiens
Miszczak-Zaborska, E.; Wozniak, K.
The activity of thymidine phosphorylase obtained from human uterine leiomyomas and studied in the presence of pyrimidine derivatives
Z. Naturforsch. c
52
670-675
1997
Homo sapiens
Miyadera, K.; Dohmae, N.; Takio, K.; Sumizawa, T.; Haraguchi, M.; Furukawa, T.; Yamada, Y.; Akiyama, S.
Structural characterization of thymidine phosphorylase purified from human placenta
Biochem. Biophys. Res. Commun.
212
1040-1045
1995
Homo sapiens
Miyadera, K.; Sumizawa, T.; Haraguchi, M.; Yoshida, H.; Konstanty, W.; Yamada, Y.; Akiyama, S.
Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase
Cancer Res.
55
1687-1690
1995
Homo sapiens
Rick, S.W.; Abashkin, Y.G.; Hilderbrandt, R.L.; Burt, S.K.
Computational studies of the domain movement and the catalytic mechanism of thymidine phosphorylase
Proteins
37
242-252
1999
Escherichia coli
Sumizawa, T.; Furukawa, T.; Haraguchi, M.; Yoshimura, A.; Takeyasu, A.; Ishizawa, M.; Yamada, Y.; Akiyama, S.
Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor
J. Biochem.
114
9-14
1993
Homo sapiens
Klein, R.S.; Lenzi, M.; Lim, T.H.; Hotchkiss, K.A.; Wilson, P.; Schwartz, E.L.
Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase
Biochem. Pharmacol.
62
1257-1263
2001
Homo sapiens
Focher, F.; Spadari, S.
Thymidine phosphorylase: a two-face janus in anticancer chemotherapy
Curr. Cancer Drug Targets
1
141-153
2001
Escherichia coli, Homo sapiens
Yang, Q.; Yoshimura, G.; Mori, I.; Sakurai, T.; Kakudo, K.
Thymidine phosphorylase and breast carcinoma
Anticancer Res.
22
2355-2360
2002
Homo sapiens
Votruba, I.; Pomeisl, K.; Tloust'ova, E.; Holy, A.; Otova, B.
Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines
Biochem. Pharmacol.
69
1517-1521
2005
Rattus norvegicus
Mendieta, J.; Martin-Santamaria, S.; Priego, E.M.; Balzarini, J.; Camarasa, M.J.; Perez-Perez, M.J.; Gago, F.
Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations
Biochemistry
43
405-414
2004
Escherichia coli (P07650)
McNally, V.A.; Gbaj, A.; Douglas, K.T.; Stratford, I.J.; Jaffar, M.; Freeman, S.; Bryce, R.A.
Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening
Bioorg. Med. Chem. Lett.
13
3705-3709
2003
Escherichia coli, Homo sapiens
Akiyama, S.; Furukawa, T.; Sumizawa, T.; Takebayashi, Y.; Nakajima, Y.; Shimaoka, S.; Haraguchi, M.
The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression
Cancer Sci.
95
851-857
2004
Homo sapiens
De Bruin, M.; Van Capel, T.; Smid, K.; Fukushima, M.; Hoekman, K.; Pinedo, H.M.; Peters, G.J.
The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase
Eur. J. Pharmacol.
491
93-99
2004
Homo sapiens
Miszczak-Zaborska, E.; Wojcik-Krowiranda, K.; Kubiak, R.; Bienkiewicz, A.; Bartkowiak, J.
The activity of thymidine phosphorylase as a new ovarian tumor marker
Gynecol. Oncol.
94
86-92
2004
Homo sapiens
Liekens, S.; Hernandez, A.I.; Ribatti, D.; De Clercq, E.; Camarasa, M.J.; Perez-Perez, M.J.; Balzarini, J.
The nucleoside derivative 5'-O-trityl-inosine (KIN59)suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
J. Biol. Chem.
279
29598-29605
2004
Escherichia coli, Homo sapiens
Reigan, P.; Edwards, P.N.; Gbaj, A.; Cole, C.; Barry, S.T.; Page, K.M.; Ashton, S.E.; Luke, R.W.; Douglas, K.T.; Stratford, I.J.; Jaffar, M.; Bryce, R.A.; Freeman, S.
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs
J. Med. Chem.
48
392-402
2005
Escherichia coli, Homo sapiens (P19971), Homo sapiens
Kobayashi, M.; Okamoto, K.; Akimori, T.; Tochika, N.; Yoshimoto, T.; Okabayashi, T.; Sugimoto, T.; Araki, K.
Localization of thymidine phosphorylase in advanced gastric and colorectal cancer
J. Mol. Histol.
35
69-74
2004
Homo sapiens
Panova, N.G.; Shcheveleva, E.V.; Alexeev, C.S.; Mukhortov, V.G.; Zuev, A.N.; Mikhailov, S.N.; Esipov, R.S.; Chuvikovsky, D.V.; Miroshnikov, A.I.
Use of 4-thiouridine and 4-thiothymidine in studies on pyrimidine nucleoside phosphorylases
Mol. Biol.
38
770-776
2004
Escherichia coli
-
Norman, R.A.; Barry, S.T.; Bate, M.; Breed, J.; Colls, J.G.; Ernill, R.J.; Luke, R.W.; Minshull, C.A.; McAlister, M.S.; McCall, E.J.; McMiken, H.H.; Paterson, D.S.; Timms, D.; Tucker, J.A.; Pauptit, R.A.
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
Structure
12
75-84
2004
Homo sapiens (P19971), Homo sapiens
Ma, T.; Zhu, Z.G.; Ji, Y.B.; Zhang, Y.; Yu, Y.Y.; Liu, B.Y.; Yin, H.R.; Lin, Y.Z.
Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridine
World J. Gastroenterol.
10
172-176
2004
Homo sapiens
Zhang, J.M.; Mizoi, T.; Shiiba, K.; Sasaki, I.; Matsuno, S.
Expression of thymidine phosphorylase by macrophages in colorectal cancer tissues
World J. Gastroenterol.
10
545-549
2004
Homo sapiens
Liakakos, T.; Troupis, T.; Ghiconti, I.; Triantafyllidis, S.; Macheras, A.; Karatzas, G.; Pavlakis, K.
Immunohistochemical localization of thymidine phosphorylase in gastric cancer: is there a role of the differential expression in tumor cells and associated stromal cells?
Anticancer Res.
26
3899-3904
2006
Homo sapiens (P19971), Homo sapiens
El Omari, K.; Bronckaers, A.; Liekens, S.; Perez-Perez, M.J.; Balzarini, J.; Stammers, D.K.
Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design
Biochem. J.
399
199-204
2006
Homo sapiens (P19971), Homo sapiens
Panova, N.G.; Alexeev, C.S.; Kuzmichov, A.S.; Shcheveleva, E.V.; Gavryushov, S.A.; Polyakov, K.M.; Kritzyn, A.M.; Mikhailov, S.N.; Esipov, R.S.; Miroshnikov, A.I.
Substrate specificity of Escherichia coli thymidine phosphorylase
Biochemistry
72
21-28
2007
Escherichia coli, Escherichia coli (P07650)
Jeung, H.C.; Che, X.F.; Haraguchi, M.; Zhao, H.Y.; Furukawa, T.; Gotanda, T.; Zheng, C.L.; Tsuneyoshi, K.; Sumizawa, T.; Roh, J.K.; Akiyama, S.
Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase
FEBS Lett.
580
1294-1302
2006
Homo sapiens (P19971)
Hirano, M.; Lagier-Tourenne, C.; Valentino, M.L.; Marti, R.; Nishigaki, Y.
Thymidine phosphorylase mutations cause instability of mitochondrial DNA
Gene
354
152-156
2005
Homo sapiens (P19971), Homo sapiens
Passantino, L.; Patruno, R.; Valerio, P.; Penna, A.; Mazzone, F.; Zito, A.F.; Catalano, V.; Pellecchia, A.; Jirillo, E.; Ranieri, G.
Thymidine phosphorylase profiles in nonmalignant and malignant pancreatic tissue. Potential therapeutic role of capecitabine on tumoral and endothelial cells and tumor-infiltrating macrophages
Immunopharmacol. Immunotoxicol.
27
95-107
2005
Homo sapiens
Temmink, O.H.; de Bruin, M.; Laan, A.C.; Turksma, A.W.; Cricca, S.; Masterson, A.J.; Noordhuis, P.; Peters, G.J.
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells
Int. J. Biochem. Cell Biol.
38
1759-1765
2006
Homo sapiens (P19971)
Temmink, O.H.; de Bruin, M.; Turksma, A.W.; Cricca, S.; Laan, A.C.; Peters, G.J.
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines
Int. J. Biochem. Cell Biol.
39
565-575
2007
Homo sapiens
Ezaki, T.; Ikegami, T.; Maeda, T.; Yamada, T.; Ishida, T.; Hashizume, M.; Maehara, Y.
Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinoma
Int. J. Clin. Oncol.
10
171-176
2005
Homo sapiens
van Kuilenburg, A.B.; Zoetekouw, L.
Determination of thymidine phosphorylase activity by a non-radiochemical assay using reversed-phase high-performance liquid chromatography
J. Chromatogr. B
820
271-275
2005
Homo sapiens
Meropol, N.J.; Gold, P.J.; Diasio, R.B.; Andria, M.; Dhami, M.; Godfrey, T.; Kovatich, A.J.; Lund, K.A.; Mitchell, E.; Schwarting, R.
Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer
J. Clin. Oncol.
24
4069-4077
2006
Homo sapiens (P19971), Homo sapiens
Edwards, P.N.
A kinetic, modeling and mechanistic re-analysis of thymidine phosphorylase and some related enzymes
J. Enzyme Inhib. Med. Chem.
21
483-499
2006
Homo sapiens (P19971), Homo sapiens
Gbaj, A.; Edwards, P.N.; Reigan, P.; Freeman, S.; Jaffar, M.; Douglas, K.T.
Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants
J. Enzyme Inhib. Med. Chem.
21
69-73
2006
Escherichia coli
Allan, A.L.; Gladstone, P.L.; Price, M.L.; Hopkins, S.A.; Juarez, J.C.; Donate, F.; Ternansky, R.J.; Shaw, D.E.; Ganem, B.; Li, Y.; Wang, W.; Ealick, S.
Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase
J. Med. Chem.
49
7807-7815
2006
Homo sapiens (P19971), Homo sapiens
McNally, V.A.; Rajabi, M.; Gbaj, A.; Stratford, I.J.; Edwards, P.N.; Douglas, K.T.; Bryce, R.A.; Jaffar, M.; Freeman, S.
Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase
J. Pharm. Pharmacol.
59
537-547
2007
Homo sapiens, Homo sapiens (P19971)
Kalman, T.I.; Lai, L.
6-Substituted 5-fluorouracil derivatives as transition state analogue inhibitors of thymidine phosphorylase
Nucleosides Nucleotides Nucleic Acids
24
367-373
2005
Escherichia coli
Liekens, S.; Balzarini, J.; Hernandez, A.I.; De Clercq, E.; Priego, E.M.; Camarasa, M.J.; Perez-Perez, M.J.
Thymidine phosphorylase is noncompetitively inhibited by 5-O-trityl-inosine (KIN59) and related compounds
Nucleosides Nucleotides Nucleic Acids
25
975-980
2006
Escherichia coli, Homo sapiens (P19971), Homo sapiens
Chujo, M.; Miura, T.; Kawano, Y.; Miyawaki, M.; Imakiire, T.; Hayashita, Y.; Kawahara, K.
Thymidine phosphorylase levels and dihydropyrimidine dehydrogenase levels in non-small cell lung cancer tissues
Oncol. Rep.
16
777-780
2006
Homo sapiens (P19971), Homo sapiens
Oberemm, A.; Meckert, C.; Brandenburger, L.; Herzig, A.; Lindner, Y.; Kalenberg, K.; Krause, E.; Ittrich, C.; Kopp-Schneider, A.; Stahlmann, R.; Richter-Reichhelm, H.; Gundert-Remy, U.
Differential signatures of protein expression in marmoset liver and thymus induced by single-dose TCDD treatment
Toxicology
206
33-48
2005
Homo sapiens (P19971)
Ogiuchi, Y.; Maruoka, Y.; Ando, T.; Kobayashi, M.; Ogiuchi, H.
Thymidylate synthase, thymidine phosphorylase and orotate phosphoribosyl transferase levels as predictive factors of chemotherapy in oral squamous cell carcinoma
Acta Histochem. Cytochem.
41
39-46
2008
Homo sapiens
Jensen, S.A.; Vainer, B.; Witton, C.J.; Jorgensen, J.T.; Sorensen, J.B.
Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer
Acta Oncol.
47
1054-1061
2008
Homo sapiens
Ijuin, T.; Nibu, K.; Doi, K.; Inoue, H.; Saitoh, M.; Ohtsuki, N.; Makino, K.; Amatsu, M.
Thymidine phosphorylase mRNA level predicts survival of patients with advanced oropharyngeal cancer
Acta Otolaryngol.
127
305-311
2007
Homo sapiens
Puglisi, F.; Cardellino, G.G.; Crivellari, D.; Di Loreto, C.; Magri, M.D.; Minisini, A.M.; Mansutti, M.; Andreetta, C.; Russo, S.; Lombardi, D.; Perin, T.; Damante, G.; Veronesi, A.
Thymidine phosphorylase expression is associated with time to progression in patients receiving low-dose, docetaxel-modulated capecitabine for metastatic breast cancer
Ann. Oncol.
19
1541-1546
2008
Homo sapiens
Soong, R.; Shah, N.; Salto-Tellez, M.; Tai, B.C.; Soo, R.A.; Han, H.C.; Ng, S.S.; Tan, W.L.; Zeps, N.; Joseph, D.; Diasio, R.B.; Iacopetta, B.
Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
Ann. Oncol.
19
915-919
2008
Homo sapiens
Andreetta, C.; Puppin, C.; Minisini, A.; Valent, F.; Pegolo, E.; Damante, G.; Di Loreto, C.; Pizzolitto, S.; Pandolfi, M.; Fasola, G.; Piga, A.; Puglisi, F.
Thymidine phosphorylase expression and benefit from capecitabine in patients with advanced breast cancer
Ann. Oncol.
20
265-271
2008
Homo sapiens
Puglisi, F.; Andreetta, C.; Valent, F.; Minisini, A.M.; Rijavec, E.; Russo, S.; Mansutti, M.; Cardellino, G.; Pizzolitto, S.; Di Loreto, C.
Anthracyclines and taxanes induce the upregulation of thymidine phosphorylase in breast cancer cells
Anticancer Drugs
18
883-888
2007
Homo sapiens (P19971), Homo sapiens
Koizumi, W.; Okayasu, I.; Hyodo, I.; Sakamoto, J.; Kojima, H.; Kojima, H.
Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenase
Anticancer Drugs
19
819-824
2008
Homo sapiens
Ogata, Y.; Sasatomi, T.; Mori, S.; Matono, K.; Ishibashi, N.; Akagi, Y.; Fukushima, T.; Murakami, H.; Ushijima, M.; Shirouzu, K.
Significance of thymidine phosphorylase in metronomic chemotherapy using CPT-11 and doxifluridine for advanced colorectal carcinoma
Anticancer Res.
27
2605-2611
2007
Homo sapiens
Sakurai, Y.; Yoshida, I.; Kamoshida, S.; Inaba, K.; Isogaki, J.; Komori, Y.; Uyama, I.; Tsutsumi, Y.
Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts
Anticancer Res.
28
1593-1602
2008
Homo sapiens, Mus musculus (Q99N42), Mus musculus
Ikeda, R.; Tajitsu, Y.; Iwashita, K.; Che, X.F.; Yoshida, K.; Ushiyama, M.; Furukawa, T.; Komatsu, M.; Yamaguchi, T.; Shibayama, Y.; Yamamoto, M.; Zhao, H.Y.; Arima, J.; Takeda, Y.; Akiyama, S.; Yamada, K.
Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3
Biochem. Biophys. Res. Commun.
370
220-224
2008
Homo sapiens
Liekens, S.; Bronckaers, A.; Perez-Perez, M.J.; Balzarini, J.
Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy
Biochem. Pharmacol.
74
1555-1567
2007
Homo sapiens
Hatano, A.; Harano, A.; Takigawa, Y.; Naramoto, Y.; Toda, K.; Nakagomi, Y.; Yamada, H.
Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase
Bioorg. Med. Chem.
16
3866-3870
2008
Escherichia coli
Pomeisl, K.; Holy, A.; Votruba, I.; Pohl, R.
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase
Bioorg. Med. Chem. Lett.
18
1364-1367
2008
Escherichia coli, Homo sapiens
Bartsch, R.; Steger, G.G.; Forstner, B.; Wenzel, C.; Pluschnig, U.; Rizovski, B.; Altorjai, G.; Zielinski, C.C.; Mader, R.M.
Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel
BMC Clin. Pharmacol.
7
7-7
2007
Homo sapiens
Graham-Cole, C.L.; Thomas, H.D.; Taylor, G.A.; Newell, D.R.; Melton, R.G.; Hesp, R.; Boddy, A.V.
An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed
Cancer Chemother. Pharmacol.
59
197-206
2007
Homo sapiens
Guarcello, V.; Blanquicett, C.; Naguib, F.N.; El Kouni, M.H.
Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity
Cancer Chemother. Pharmacol.
62
85-96
2008
Homo sapiens
Saif, M.W.; Black, G.; Roy, S.; Bell, D.; Russo, S.; Eloubeidi, M.A.; Steg, A.; Johnson, M.R.; Zelterman, D.; Diasio, R.B.
Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylase
Cancer J.
13
247-256
2007
Homo sapiens
Layman, R.M.; Thomas, D.G.; Griffith, K.A.; Smerage, J.B.; Helvie, M.A.; Roubidoux, M.A.; Diehl, K.M.; Newman, L.A.; Sabel, M.S.; Hayman, J.A.; Pierce, L.J.; Hayes, D.F.; Schott, A.F.
Neoadjuvant docetaxel and capecitabine and the use of thymidine phosphorylase as a predictive biomarker in breast cancer
Clin. Cancer Res.
13
4092-4097
2007
Homo sapiens
Chen, L.C.; Hsueh, C.; Tsang, N.M.; Liang, Y.; Chang, K.P.; Hao, S.P.; Yu, J.S.; Chang, Y.S.
Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma
Clin. Cancer Res.
14
3807-3813
2008
Homo sapiens
Reigan, P.; Gbaj, A.; Stratford, I.J.; Bryce, R.A.; Freeman, S.
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors
Eur. J. Med. Chem.
43
1248-1260
2008
Escherichia coli, Homo sapiens (P19971), Homo sapiens
Stoebner, P.E.; Le Gallic, L.; Berthe, M.L.; Boulle, N.; Lallemant, B.; Marque, M.; Gaspard, C.; Delfour, C.; Lavabre-Bertrand, T.; Martinez, J.; Meunier, L.
Decreased expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in basal cell carcinomas
Exp. Dermatol.
17
908-915
2008
Homo sapiens
Jinfeng, M.; Kimura, W.; Sakurai, F.; Moriya, T.; Mizutani, M.; Hirai, I.
Prognostic role of angiogenesis and its correlations with thymidine phosphorylase and p53 expression in ductal adenocarcinoma of the pancreas
Hepatogastroenterology
54
1635-1640
2007
Homo sapiens
Hayashi, T.; Kawahara, H.; Kobayashi, S.; Kashiwagi, H.; Hirai, K.; Yanaga, K.
Importance of thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase expression at the invasive front of T3 rectal cancer as prognostic factors
Hepatogastroenterology
55
403-406
2008
Homo sapiens
Haraguchi, M.; Komuta, K.; Ueda, T.; Akashi, A.; Minami, S.; Furui, J.; Kanematsu, T.
Prognostic significance of the serum thymidine phosphorylase levels in venous blood drainage specimens in patients with colorectal cancer
Hepatogastroenterology
55
418-421
2008
Homo sapiens
Kobayashi, Y.; Wada, Y.; Ohara, T.; Okuda, Y.; Suzuki, N.; Hasegawa, K.; Kiguchi, K.; Ishizuka, B.
Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues
Hum. Cell
20
107-110
2007
Homo sapiens
Miyake, K.; Imura, S.; Yoshizumi, T.; Ikemoto, T.; Morine, Y.; Shimada, M.
Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer
Int. J. Clin. Oncol.
12
111-119
2007
Homo sapiens
Ranieri, G.; Grammatica, L.; Patruno, R.; Zito, A.F.; Valerio, P.; Iacobellis, S.; Gadaleta, C.; Gasparini, G.; Ribatti, D.
A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients
J. Cell. Mol. Med.
11
362-368
2007
Homo sapiens
Jang, J.S.; Lee, W.S.; Lee, J.S.; Kim, H.W.; Ko, G.H.; Ha, W.S.
The expression of thymidine phosphorylase in cancer-infiltrating inflammatory cells in stomach cancer
J. Korean Med. Sci.
22
S109-S114
2007
Homo sapiens
Nencka, R.; Votruba, I.; Hrebabecky, H.; Jansa, P.; Tloustova, E.; Horska, K.; Masojidkova, M.; Holy, A.
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase
J. Med. Chem.
50
6016-6023
2007
Homo sapiens
Honda, J.; Sasa, M.; Moriya, T.; Bando, Y.; Hirose, T.; Takahashi, M.; Nagao, T.; Tangoku, A.
Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results
J. Med. Invest.
55
54-60
2008
Homo sapiens
Gunningham, S.P.; Currie, M.J.; Morrin, H.R.; Tan, E.Y.; Turley, H.; Dachs, G.U.; Watson, A.I.; Frampton, C.; Robinson, B.A.; Fox, S.B.
The angiogenic factor thymidine phosphorylase up-regulates the cell adhesion molecule P-selectin in human vascular endothelial cells and is associated with P-selectin expression in breast cancers
J. Pathol.
212
335-344
2007
Homo sapiens
Kocakova, I.; Svoboda, M.; Kubosova, K.; Chrenko, V.; Roubalova, E.; Krejci, E.; Sefr, R.; Slampa, P.; Frgala, T.; Zaloudik, J.
Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma
Neoplasma
54
447-453
2007
Homo sapiens
Mazurek, A.; Kuc, P.; Mazurek-Wadolkowska, E.; Laudanski, T.
A role of thymidine phosphorylase and P53 tissue protein expression in biology of endometrial cancer
Neoplasma
55
261-265
2008
Homo sapiens
Grierson, J.R.; Brockenbrough, J.S.; Rasey, J.S.; Wiens, L.W.; Schwartz, J.L.; Jordan, R.; Vesselle, H.
Evaluation of 5-deoxy-5-[F-18]fluorothymidine as a tracer of intracellular thymidine phosphorylase activity
Nucl. Med. Biol.
34
471-478
2007
Homo sapiens
Pomeisl, K.; Holy, A.; Votruba, I.
Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase
Nucleic Acids Symp. Ser.
52
657-658
2008
Homo sapiens
Panova, N.; Kosiova, I.; Petrova, M.; Vanek, V.; Liboska, R.; Kovackova, S.; Kocalka, P.; Kralikova, S.; Tocik, Z.; Pav, O.; Paces, O.; Rejman, D.; Rosenberg, I.
Nucleoside phosphonic acids in thymidine phosphorylase inhibition: structure-activity relationship
Nucleic Acids Symp. Ser.
52
665-666
2008
Homo sapiens
Pomeisl, K.; Votruba, I.; Holy, A.; Pohl, R.
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
Nucleosides Nucleotides Nucleic Acids
26
1025-1028
2007
Escherichia coli, Homo sapiens
Bijnsdorp, I.V.; de Bruin, M.; Laan, A.C.; Fukushima, M.; Peters, G.J.
The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior
Nucleosides Nucleotides Nucleic Acids
27
681-691
2008
Homo sapiens
Han, H.S.; Hwang, T.S.
Angiogenesis in gastric cancer: importance of the thymidine phosphorylase expression of cancer cells as an angiogenic factor
Oncol. Rep.
17
61-65
2007
Homo sapiens
Tanikawa, T.; Waguri-Nagaya, Y.; Kusabe, T.; Aoyama, M.; Asai, K.; Otsuka, T.
Gliostatin/thymidine phosphorylase-regulated vascular endothelial growth-factor production in human fibroblast-like synoviocytes
Rheumatol. Int.
27
553-559
2007
Homo sapiens
Saif, M.W.; Juneja, V.; Black, G.; Thronton, J.; Johnson, M.R.; Diasio, R.B.
Palmar-plantar erythrodysesthesia in patients receiving capecitabine and intratumor thymidine phosphorylase and dihydropyrimidine dehydrogenase: is there a pharmacologic explanation?
Support. Cancer Ther.
4
211-218
2007
Homo sapiens
Hua, D.; Huang, Z.H.; Mao, Y.; Deng, J.Z.
Thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouracil-based adjuvant chemotherapy for gastric cancer
World J. Gastroenterol.
13
5030-5034
2007
Homo sapiens
Fujimoto, K.; Matsumura, Y.; Tani, Y.; Ozono, S.; Hirao, Y.; Okajima, E.
Tissue levels of pyrimidine nucleoside phosphorylase activity in human and rodent bladder cancer and normal bladder tissue
Int. J. Urol.
14
754-759
2007
Homo sapiens (P19971), Homo sapiens
Nakajima, Y.; Madhyastha, R.; Maruyama, M.
2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progression
Anticancer Agents Med. Chem.
9
239-245
2009
Homo sapiens
Loo, W.T.; Chow, L.W.; Suzuki, T.; Ono, K.; Ishida, T.; Hirakawa, H.; Ohuchi, N.; Sasano, H.
Expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in human breast carcinoma cells and tissues
Anticancer Res.
29
2525-2530
2009
Homo sapiens
Mitsiki, E.; Papageorgiou, A.C.; Iyer, S.; Thiyagarajan, N.; Prior, S.H.; Sleep, D.; Finnis, C.; Acharya, K.R.
Structures of native human thymidine phosphorylase and in complex with 5-iodouracil
Biochem. Biophys. Res. Commun.
386
666-670
2009
Homo sapiens (P19971), Homo sapiens
Bronckaers, A.; Aguado, L.; Negri, A.; Camarasa, M.J.; Balzarini, J.; Perez-Perez, M.J.; Gago, F.; Liekens, S.
Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule crystallization chaperone 5'-O-tritylinosine (KIN59)
Biochem. Pharmacol.
78
231-240
2009
Homo sapiens (P19971), Homo sapiens
Jain, H.V.; Rasheed, R.; Kalman, T.I.
The role of phosphate in the action of thymidine phosphorylase inhibitors: implications for the catalytic mechanism
Bioorg. Med. Chem. Lett.
20
1648-1651
2010
Escherichia coli, Homo sapiens (P19971)
Kocalka, P.; Rejman, D.; Vanek, V.; Rinnova, M.; Tomeckova, I.; Kralikova, S.; Petrova, M.; Pav, O.; Pohl, R.; Budesinsky, M.; Liboska, R.; Tocik, Z.; Panova, N.; Votruba, I.; Rosenberg, I.
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase
Bioorg. Med. Chem. Lett.
20
862-865
2010
Rattus norvegicus
Khan, K.M.; Ambreen, N.; Hussain, S.; Perveen, S.; Choudhary, M.I.
Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors
Bioorg. Med. Chem.
17
2983-2988
2009
Escherichia coli
Pula, G.; Mayr, U.; Evans, C.; Prokopi, M.; Vara, D.S.; Yin, X.; Astroulakis, Z.; Xiao, Q.; Hill, J.; Xu, Q.; Mayr, M.
Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures
Circ. Res.
104
32-40
2009
Homo sapiens
Birck, M.; Clinch, K.; Gainsford, G.; Schramm, V.; Tyler, P.
Syntheses of 5-chlorouracils/thymines with 1-[phosphono(methyl/difluoromethyl)]-1,2-unsaturated-moiety-substituted methyl groups at N(1) and human thymidine phosphorylase inhibitory activity
Helv. Chim. Acta
92
823-838
2009
Homo sapiens
-
Lopez, L.C.; Akman, H.O.; Garcia-Cazorla, A.; Dorado, B.; Marti, R.; Nishino, I.; Tadesse, S.; Pizzorno, G.; Shungu, D.; Bonilla, E.; Tanji, K.; Hirano, M.
Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice
Hum. Mol. Genet.
18
714-722
2009
Mus musculus, Mus musculus C57Bl6/J
Miszczak-Zaborska, E.; Kubiak, R.; Bienkiewicz, A.; Bartkowiak, J.
The cytosol activity of thymidine phosphorylase in endometrial cancer
J. Exp. Clin. Cancer Res.
27
64
2008
Homo sapiens
Brockenbrough, J.S.; Morihara, J.K.; Hawes, S.E.; Stern, J.E.; Rasey, J.S.; Wiens, L.W.; Feng, Q.; Vesselle, H.
Thymidine kinase 1 and thymidine phosphorylase expression in non-small-cell lung carcinoma in relation to angiogenesis and proliferation
J. Histochem. Cytochem.
57
1087-1097
2009
Homo sapiens
Bakker, J.A.; Schlesser, P.; Smeets, H.J.; Francois, B.; Bierau, J.
Biochemical abnormalities in a patient with thymidine phosphorylase deficiency with fatal outcome
J. Inherit. Metab. Dis.
33
S139-143
2010
Homo sapiens
Bronckaers, A.; Gago, F.; Balzarini, J.; Liekens, S.
The dual role of thymidine phosphorylase in cancer development and chemotherapy
Med. Res. Rev.
29
903-953
2009
Geobacillus stearothermophilus, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium
Panova, N.; Alexeev, C.; Polyakov, K.; Gavryushov, S.; Kritzyn, A.; Mikhailov, S.
Substrate specificity of thymidine phosphorylase of E. coli: role of hydroxyl groups
Nucleosides Nucleotides Nucleic Acids
27
1211-1214
2008
Escherichia coli
Chen, L.C.; Liu, H.P.; Li, H.P.; Hsueh, C.; Yu, J.S.; Liang, C.L.; Chang, Y.S.
Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells
Oncogene
28
1904-1915
2009
Homo sapiens
Yue, H.; Tanaka, K.; Furukawa, T.; Karnik, S.S.; Li, W.
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3
Biochim. Biophys. Acta
1823
1316-1323
2012
Homo sapiens
Marak, D.; Otmar, M.; Votruba, I.; Dracinsky, M.; Krecmerova, M.
8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase
Bioorg. Med. Chem. Lett.
21
652-654
2011
Escherichia coli, Homo sapiens
Serra, I.; Serra, C.D.; Rocchietti, S.; Ubiali, D.; Terreni, M.
Stabilization of thymidine phosphorylase from Escherichia coli by immobilization and post immobilization techniques
Enzyme Microb. Technol.
49
52-58
2011
Escherichia coli
Rajabi, M.; Mansell, D.; Freeman, S.; Bryce, R.A.
Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase
Eur. J. Med. Chem.
46
1165-1171
2011
Escherichia coli
Marti, R.; Lopez, L.C.; Hirano, M.
Assessment of thymidine phosphorylase function: measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity
Methods Mol. Biol.
837
121-133
2012
Homo sapiens
Ding, Q.; Ou, L.; Wei, D.; Wei, X.
Optimum induction of recombinant thymidine phosphorylase and its application
Nucleosides Nucleotides Nucleic Acids
30
360-368
2011
Escherichia coli
Thanasai, J.; Limpaiboon, T.; Jearanaikoon, P.; Sripa, B.; Pairojkul, C.; Tantimavanich, S.; Miwa, M.
Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma
World J. Gastroenterol.
16
1631-1638
2010
Homo sapiens
Balaev, V.V.; Lashkov, A.A.; Gabdulkhakov, A.G.; Dontsova, M.V.; Seregina, T.A.; Mironov, A.S.; Betzel, C.; Mikhailov, A.M.
Structural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine
Acta Crystallogr. Sect. F
72
224-233
2016
Salmonella enterica subsp. enterica serovar Typhimurium (Q7CP66), Salmonella enterica subsp. enterica serovar Typhimurium
Ko, J.C.; Chiu, H.C.; Syu, J.J.; Jian, Y.J.; Chen, C.Y.; Jian, Y.T.; Huang, Y.J.; Wo, T.Y.; Lin, Y.W.
Tamoxifen enhances erlotinib-induced cytotoxicity through down-regulating AKT-mediated thymidine phosphorylase expression in human non-small-cell lung cancer cells
Biochem. Pharmacol.
88
119-127
2014
Homo sapiens
Javaid, S.; Saad, S.M.; Perveen, S.; Khan, K.M.; Choudhary, M.I.
2-Arylquinazolin-4(3H)-ones: A novel class of thymidine phosphorylase inhibitors
Bioorg. Chem.
63
142-151
2015
Escherichia coli
Shahzad, S.A.; Yar, M.; Bajda, M.; Jadoon, B.; Khan, Z.A.; Naqvi, S.A.; Shaikh, A.J.; Hayat, K.; Mahmmod, A.; Mahmood, N.; Filipek, S.
Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents
Bioorg. Med. Chem.
22
1008-1015
2014
Escherichia coli
Bera, H.; Dolzhenko, A.V.; Sun, L.; Dutta Gupta, S.; Chui, W.K.
Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors
Chem. Biol. Drug Des.
82
351-360
2013
Homo sapiens
Li, W.; Gigante, A.; Perez-Perez, M.J.; Yue, H.; Hirano, M.; McIntyre, T.M.; Silverstein, R.L.
Thymidine phosphorylase participates in platelet signaling and promotes thrombosis
Circ. Res.
115
997-1006
2014
Mus musculus
Petaccia, M.; Gentili, P.; Besker, N.; DAbramo, M.; Giansanti, L.; Leonelli, F.; La Bella, A.; Gradella Villalva, D.; Mancini, G.
Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives
Colloids Surf. B Biointerfaces
140
121-127
2016
Escherichia coli (P07650), Escherichia coli
Xiong, S.; Wang, Y.; Wang, X.; Wang, J.; Li, J.; Zhang, G.; Zhang, R.; Xie, L.; Wang, H.
Enzymatic synthesis of 2-deoxyuridine by whole cell catalyst co-expressing uridine phosphorylase and thymidine phosphorylase through auto-induction system
J. Biosci. Bioeng.
118
723-727
2014
Escherichia coli
Serra, I.; Bavaro, T.; Cecchini, D.; Daly, S.; Albertini, A.; Terreni, M.; Ubiali, D.
A comparison between immobilized pyrimidine nucleoside phosphorylase from Bacillus subtilis and thymidine phosphorylase from Escherichia coli in the synthesis of 5-substituted pyrimidine 2'-deoxyribonucleosides
J. Mol. Catal. B
95
16-22
2013
Escherichia coli
-
Deves, C.; Rostirolla, D.C.; Martinelli, L.K.; Bizarro, C.V.; Santos, D.S.; Basso, L.A.
The kinetic mechanism of human thymidine phosphorylase - a molecular target for cancer drug development
Mol. Biosyst.
10
592-604
2014
Homo sapiens (P19971), Homo sapiens
Wang, L.; Schmidl, S.R.; Stuelke, J.
Mycoplasma pneumoniae thymidine phosphorylase
Nucleosides Nucleotides Nucleic Acids
33
296-304
2014
Mycoplasma pneumoniae (P75052), Mycoplasma pneumoniae, Mycoplasma pneumoniae M129 (P75052)
Taha, M.; Ismail, N.H.; Imran, S.; Rahim, F.; Wadood, A.; Al Muqarrabun, L.M.; Khan, K.M.; Ghufran, M.; Ali, M.
In silico binding analysis and SAR elucidations of newly designed benzopyrazine analogs as potent inhibitors of thymidine phosphorylase
Bioorg. Chem.
68
80-89
2016
Escherichia coli
Javaid, S.; Ishtiaq, M.; Shaikh, M.; Hameed, A.; Choudhary, M.I.
Thymidine esters as substrate analogue inhibitors of angiogenic enzyme thymidine phosphorylase in vitro
Bioorg. Chem.
70
44-56
2017
Escherichia coli (P0C037)
Uddin, I.; Taha, M.; Rahim, F.; Wadood, A.
Synthesis and molecular docking study of piperazine derivatives as potent inhibitor of thymidine phosphorylase
Bioorg. Chem.
78
324-331
2018
Escherichia coli (P0C037)
Iftikhar, F.; Yaqoob, F.; Tabassum, N.; Jan, M.S.; Sadiq, A.; Tahir, S.; Batool, T.; Niaz, B.; Ansari, F.L.; Choudhary, M.I.; Rashid, U.
Design, synthesis, in-vitro thymidine phosphorylase inhibition, in-vivo antiangiogenic and in-silico studies of C-6 substituted dihydropyrimidines
Bioorg. Chem.
80
99-111
2018
Escherichia coli (P0C037)
Shahzad, S.A.; Yar, M.; Khan, Z.A.; Shahzadi, L.; Naqvi, S.A.R.; Mahmood, A.; Ullah, S.; Shaikh, A.J.; Sherazi, T.A.; Bale, A.T.; Kukulowicz, J.; Bajda, M.
Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors future anti-tumor drugs
Bioorg. Chem.
85
209-220
2019
Escherichia coli (P0C037)
Zaman, K.; Rahim, F.; Taha, M.; Wadood, A.; Adnan Ali Shah, S.; Gollapalli, M.; Ullah, F.; Ahmed, A.
Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives
Bioorg. Chem.
89
102999
2019
Escherichia coli (P0C037), Escherichia coli
Taha, M.; Aldhamin, E.A.J.; Almandil, N.B.; Anouar, E.H.; Uddin, N.; Alomari, M.; Rahim, F.; Adalat, B.; Ibrahim, M.; Nawaz, F.; Iqbal, N.; Alghanem, B.; Altolayyan, A.; Khan, K.M.
Synthesis of indole based acetohydrazide analogs Their in vitro and in silico thymidine phosphorylase studies
Bioorg. Chem.
98
103745
2020
Escherichia coli (P0C037)
Tozer, T.; Heale, K.; Manto Chagas, C.; de Barros, A.L.B.; Alisaraie, L.
Interdomain twists of human thymidine phosphorylase and its active-inactive conformations binding of 5-FU and its analogues to human thymidine phosphorylase versus dihydropyrimidine dehydrogenase
Chem. Biol. Drug Des.
94
1956-1972
2019
Homo sapiens (P19971), Homo sapiens
Bajaj, S.; Roy, P.P.; Singh, J.
Synthesis, thymidine phosphorylase inhibitory and computational study of novel 1,3,4-oxadiazole-2-thione derivatives as potential anticancer agents
Comput. Biol. Chem.
76
151-160
2018
Homo sapiens (P19971)
Bera, H.; Chigurupati, S.
Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer
Eur. J. Med. Chem.
124
992-1003
2016
Escherichia coli (P0C037), Homo sapiens (P19971)
Zhao, S.; Li, K.; Jin, Y.; Lin, J.
Synthesis and biological evaluation of novel 1-(aryl-aldehyde-oxime)uracil derivatives as a new class of thymidine phosphorylase inhibitors
Eur. J. Med. Chem.
144
41-51
2018
Homo sapiens (P19971)
Tampellini, M.; Bironzo, P.; Di Maio, M.; Scagliotti, G.V.
Thymidine phosphorylase the unforeseen driver in colorectal cancer treatment?
Future Oncol.
14
1223-1231
2018
Homo sapiens (P19971)
Oh, T.; El Kouni, M.H.
Kinetics mechanism and regulation of native human hepatic thymidine phosphorylase
Int. J. Biochem. Cell Biol.
110
122-129
2019
Homo sapiens (P19971), Homo sapiens, Mus musculus (Q99N42)
de Moura Sperotto, N.D.; Deves Roth, C.; Rodrigues-Junior, V.S.; Ev Neves, C.; Reisdorfer Paula, F.; da Silva Dadda, A.; Bergo, P.; Freitas de Freitas, T.; Souza Macchi, F.; Moura, S.; Duarte de Souza, A.P.; Campos, M.M.; Valim Bizarro, C.; Santos, D.S.; Basso, L.A.; Machado, P.
Design of novel inhibitors of human thymidine phosphorylase synthesis, enzyme inhibition, in vitro toxicity, and impact on human glioblastoma cancer
J. Med. Chem.
62
1231-1245
2019
Homo sapiens (P19971), Homo sapiens
Oh, T.; El Kouni, M.H.
Distinct substrate specificity and physicochemical characterization of native human hepatic thymidine phosphorylase
PLoS ONE
13
e0202826
2018
Homo sapiens (P19971), Homo sapiens
Javaid, S.; Shaikh, M.; Fatima, N.; Choudhary, M.I.
Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors in vitro biochemical inhibition, mechanistic, and in silico modeling studies
PLoS ONE
14
e0225056
2019
Escherichia coli (P0C037)
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