Reference on EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walter, R.D.; Koenigk, E.
Hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase from Plasmodium chabaudi, purification and properties
Tropenmed. Parasitol.
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227-235
1974
Plasmodium chabaudi
Nagy, M.; Ribet, A.M.
Purification and comparative study of adenine and guanine phosphoribosyltransferases from Schizosaccharomyces pombe
Eur. J. Biochem.
77
77-85
1977
Schizosaccharomyces pombe
Montero, C.; Llorente, P.
Artemia purine phosphoribosyltransferases. Purification and characterization
Biochem. J.
275
327-334
1991
Artemia sp.
Allen, T.; Henschel, E.V.; Coons, T.; Cross, L.; Conley, J.; Ullman, B.
Purification and characterization of the adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase activities from Leishmania donovani
Mol. Biochem. Parasitol.
33
273-281
1989
Leishmania donovani
Flaks, J.G.
Nucleotide synthesis from 5-phosphoribosylpyrophosphate
Methods Enzymol.
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1963
Bos taurus
-
Lukens, L.N.; Herrington, K.A.
Enzymic formation of 6-mercaptopurine ribotide
Biochim. Biophys. Acta
24
432-433
1957
Bos taurus
Schimandle, C.M.; Mole, L.A.; Sherman, I.W.
Purification of hypoxanthine-guanine phosphoribosyltransferase of Plasmodium lophurae
Mol. Biochem. Parasitol.
23
39-45
1987
Plasmodium lophurae
Smithers, G.W.; O'Sullivan, W.J.
Hypoxanthine phosphoribosyltransferase from human brain: purification and partial characterization
Biochem. Med.
32
106-121
1984
Homo sapiens
Olsen, A.S.; Milman, G.
Hypoxanthine phosphoribosyltransferase from Chinese hamster brain and human erythrocytes
Methods Enzymol.
51
543-549
1978
Cricetulus griseus, Homo sapiens
Hochstadt, J.
Hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase from enteric bacteria
Methods Enzymol.
51
549-558
1978
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Veres, G.; Monostori, E.; Rasko, I.
Purification and characterisation of chicken brain hypoxanthine-guanine phosphoribosyltransferase
FEBS Lett.
184
299-303
1985
Gallus gallus
Ohe, T.; Watanabe, Y.
Purification and properties of hypoxanthine phosphoribosyltransferase from Streptomyces cyanogenus
Agric. Biol. Chem.
44
1999-2006
1980
Streptomyces cyanogenus
-
Schmidt, R.; Wiegand, H.; Reichert, U.
Purification and characterization of the hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae
Eur. J. Biochem.
93
355-361
1979
Saccharomyces cerevisiae
Gutensohn, W.; Huber, M.; Jahn, H.
Facilitated purification of hypoxanthine phosphoribosyltransferase
Hoppe-Seyler's Z. Physiol. Chem.
357
1379-1385
1976
Homo sapiens, Rattus norvegicus
Arnold, W.J.; Kelley, W.N.
Human hypoxanthine-guanine phosphoribosyltransferase. Purification and subunit structure
J. Biol. Chem.
246
7398-7404
1971
Homo sapiens
Olsen, A.S.; Milman, G.
Chinese hamster hypoxanthine-guanine phosphoribosyltransferase. Purification, structural, and catalytic properties
J. Biol. Chem.
249
4030-4037
1974
Cricetulus griseus
Hughes, S.H.; Wahl, G.M.; Capecchi, M.R.
Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase
J. Biol. Chem.
250
120-126
1975
Mus musculus
Olsen, A.S.; Milman, G.
Human hypoxanthine phosphoribosyltransferase. Purification and properties
Biochemistry
16
2501-2505
1977
Homo sapiens
Miller, R.L.; Ramsey, G.A.; Krenitsky, T.A.; Elion, G.B.
Guanine phosphoribosyltransferase from Escherichia coli, specificity and properties
Biochemistry
11
4723-4731
1972
Escherichia coli
Nussbaum, R.L.; Caskey, C.T.
Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae
Biochemistry
20
4584-4590
1981
Saccharomyces cerevisiae
Dovey, H.F.; McKerrow, J.H.; Aldritt, S.M.; Wang, C.C.
Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy
J. Biol. Chem.
261
944-948
1986
Schistosoma mansoni
Aldritt, S.M.; Wang, C.C.
Purification and characterization of guanine phosphoribosyltransferase from Giardia lamblia
J. Biol. Chem.
261
8528-8533
1986
Giardia intestinalis, Giardia intestinalis Portland
Yuan, L.; Craig, S.P.; McKerrow, J.H.; Wang, C.C.
The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherichia coli
J. Biol. Chem.
265
13528-13532
1990
Schistosoma mansoni
Muench, H.; Yoshida, A.
Purification and characterization of human hypoxanthine/guanine phosphoribosyltransferase
Eur. J. Biochem.
76
107-112
1977
Homo sapiens
Heroux, A.; White, E.L.; Ross, L.J.; Davis, R.L.; Borhani, D.W.
Crystal structure of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase with XMP, pyrophosphate, and two Mg2+ Ions Bound: insights into the catalytic mechanism
Biochemistry
38
14495-14506
1999
Toxoplasma gondii (Q26997), Toxoplasma gondii
Heroux, A.; White, E.L.; Ross, L.J.; Borhani, D.W.
Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex
Biochemistry
38
14485-14494
1999
Toxoplasma gondii (Q26997), Toxoplasma gondii
Jardim, A.; Ullman, B.
The conserved serine-tyrosine dipeptide in Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase is essential for catalytic activity
J. Biol. Chem.
272
8967-8973
1997
Leishmania donovani
Xu, Y.; Eads, J.; Sacchettini, J.C.; Grubmeyer, C.
Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry
Biochemistry
36
3700-3712
1997
Homo sapiens
Munagala, N.R.; Chin, M.S.; Wang, C.C.
Steady-state kinetics of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus: the role of threonine-47
Biochemistry
37
4045-4051
1998
Tritrichomonas suis
Doyle, P.S.; Kanaani, J.; Wang, C.C.
Hypoxanthine, guanine, xanthine phosphoribosyltransferase activity in Cryptosporidium parvum
Exp. Parasitol.
89
9-15
1998
Cryptosporidium parvum
Munagala, N.R.; Wang, C.C.
Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein
Biochemistry
37
16612-16619
1998
Tritrichomonas suis
Shih, S.; Hwang, H.Y.; Carter, D.; Stenberg, P.; Ullman, B.
Localization and targeting of the Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase to the glycosome
J. Biol. Chem.
273
1534-1541
1998
Leishmania donovani
Keough, D.T.; Ng, A.L.; Winzor, D.J.; Emmerson, B.T.; de Jersey, J.
Purification and characterization of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase and comparison with the human enzyme
Mol. Biochem. Parasitol.
98
29-41
1999
Homo sapiens, Plasmodium falciparum
Page, J.P.; Munagala, N.R.; Wang, C.C.
Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis
Eur. J. Biochem.
259
565-571
1999
Giardia intestinalis
Sujay Subbayya, I.N.; Sukumaran, S.; Shivashankar, K.; Balaram, H.
Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes
Biochem. Biophys. Res. Commun.
272
596-602
2000
Homo sapiens, Plasmodium falciparum
Heroux, A.; White, E.L.; Ross, L.J.; Kuzin, A.P.; Borhani, D.W.
Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis
Structure Fold. Des.
8
1309-1318
2000
Toxoplasma gondii
Wang, F.; Shi, W.; Nieves, E.; Angeletti, R.H.; Schramm, V.L.; Grubmeyer, C.
A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase
Biochemistry
40
8043-8054
2001
Homo sapiens
Lee, C.C.; Medrano, F.J.; Craig, S.P., 3rd; Eakin, A.E.
Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase
Biochim. Biophys. Acta
1537
63-70
2001
Homo sapiens, Trypanosoma cruzi
Monzani, P.S.; Alfonzo, J.D.; Simpson, L.; Oliva, G.; Thiemann, O.H.
Cloning, characterization and preliminary crystallographic analysis of Leishmania hypoxanthine-guanine phosphoribosyltransferase
Biochim. Biophys. Acta
1598
3-9
2002
Leishmania tarentolae (Q9NJI5), Leishmania tarentolae
Micheli, V.; Gathof, B.S.; Rocchigiani, M.; Jacomelli, G.; Sestini, S.; Peruzzi, L.; Notarantonio, L.; Cerboni, B.; Hayek, G.; Pompucci, G.
Biochemical and molecular study of mentally retarded patient with partial deficiency of hypoxanthine-guanine phosphoribosyltransferase
Biochim. Biophys. Acta
1587
45-52
2002
Homo sapiens
Sauve, A.A.; Cahill, S.M.; Zech, S.G.; Basso, L.A.; Lewandowicz, A.; Santos, D.S.; Grubmeyer, C.; Evans, G.B.; Furneaux, R.H.; Tyler, P.C.; McDermott, A.; Girvin, M.E.; Schramm, V.L.
Ionic States of Substrates and Transition State Analogues at the Catalytic Sites of N-Ribosyltransferases
Biochemistry
42
5694-5705
2003
Tritrichomonas suis
Somoza, J.R.; Chin, M.S.; Wang, C.C.; Fletterick, R.J.
Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus
Biochemistry
35
7032-7040
1996
Tritrichomonas suis
You, D.; Chen, Q.; Liang, Y.; An, J.; Li, R.; Gu, X.; Luo, M.; Su, X.D.
Protein preparation, crystallization and preliminary X-ray crystallographic studies of a thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis
Acta Crystallogr. Sect. D
59
1863-1865
2003
Caldanaerobacter subterraneus subsp. tengcongensis
Raman, J.; Sumathy, K.; Anand, R.P.; Balaram, H.
A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity
Arch. Biochem. Biophys.
427
116-122
2004
Plasmodium falciparum, Homo sapiens (P00492), Homo sapiens
Medrano, F.J.; Wenck, M.A.; Eakin, A.E.; Craig, S.P., 3rd
Functional roles for amino acids in active site loop II of a hypoxanthine phosphoribosyltransferase
Biochim. Biophys. Acta
1650
105-116
2003
Trypanosoma cruzi
Butterworth, A.C.; Medrano, F.J.; Eakin, A.E.; Craig, S.P., 3rd
Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi
Biochim. Biophys. Acta
1699
87-94
2004
Trypanosoma cruzi
Wenck, M.A.; Medrano, F.J.; Eakin, A.E.; Craig, S.P.
Steady-state kinetics of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi
Biochim. Biophys. Acta
1700
11-18
2004
Trypanosoma cruzi
Raman, J.; Ashok, C.S.; Subbayya, S.I.; Anand, R.P.; Selvi, S.T.; Balaram, H.
Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase. Stability studies on the product-activated enzyme
FEBS J.
272
1900-1911
2005
Plasmodium falciparum
Chen, Q.; Liang, Y.; Su, X.; Gu, X.; Zheng, X.; Luo, M.
Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis
J. Mol. Biol.
348
1199-1210
2005
Caldanaerobacter subterraneus subsp. tengcongensis
Keough, D.T.; Brereton, I.M.; de Jersey, J.; Guddat, L.W.
The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle
J. Mol. Biol.
351
170-181
2005
Homo sapiens
Zoref-Shani, E.; Bromberg, Y.; Hirsch, J.; Feinstein, S.; Frishberg, Y.; Sperling, O.
A novel point mutation (I137T) in the conserved 5-phosphoribosyl-1-pyrophosphate binding motif of hypoxanthine-guanine phosphoribosyltransferase (HPRTJerusalem) in a variant of Lesch-Nyhan syndrome
Mol. Genet. Metab.
78
158-161
2003
Homo sapiens
Chen, Q.; You, D.; Hu, M.; Gu, X.; Luo, M.; Lu, S.
Cloning, purification, and characterization of thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis
Protein Expr. Purif.
32
239-245
2003
Caldanaerobacter subterraneus subsp. tengcongensis (Q8R7L0), Caldanaerobacter subterraneus subsp. tengcongensis
Zheng, K.C.; Yalowich, J.C.; Kagan, V.E.; Keohavong, P.
Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone
Cell Biol. Toxicol.
22
361-370
2006
Homo sapiens
Allegretta, M.; Ardell, S.K.; Sullivan, L.M.; Jacobson, S.; Mortreux, F.; Wattel, E.; Albertini, R.J.
HPRT mutations, TCR gene rearrangements, and HTLV-1 integration sites define in vivo T-cell clonal lineages
Environ. Mol. Mutagen.
45
326-337
2005
Homo sapiens
Chaudhary, K.; Donald, R.G.; Nishi, M.; Carter, D.; Ullman, B.; Roos, D.S.
Differential localization of alternatively spliced hypoxanthine-xanthine-guanine phosphoribosyltransferase isoforms in Toxoplasma gondii
J. Biol. Chem.
280
22053-22059
2005
Toxoplasma gondii
Kalra, S.; Paul, M.K.; Balaram, H.; Mukhopadhyay, A.K.
Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase - an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine
J. Chromatogr. B
850
7-14
2007
Homo sapiens
Wu, C.H.; Lai, H.M.; Yang, M.C.; Liaw, C.C.; Chang, S.J.; Ko, Y.C.; Chen, C.J.
Identification of a new single-nucleotide mutation on the hypoxanthine-guanine phosphoribosyltransferase gene from 983 cases with gout in Taiwan
J. Rheumatol.
34
794-797
2007
Homo sapiens
Larovere, L.E.; ONeill, J.P.; Randall, M.; Fairbanks, L.D.; Guelbert, N.; Czornyj, L.; de Kremer, R.D.
Hypoxanthine-guanine phosphoribosyltransferase deficiency: biochemical and molecular findings in six Argentine patients
Nucleosides Nucleotides Nucleic Acids
26
255-258
2007
Homo sapiens
Mbewe, B.; Chibale, K.; McIntosh, D.B.
Purification of human malaria parasite hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) using immobilized Reactive Red 120
Protein Expr. Purif.
52
153-158
2007
Plasmodium falciparum
Kumar, P.R.; Mohankumar, M.N.; Hamza, V.Z.; Jeevanram, R.K.
Dose-rate effect on the induction of HPRT mutants in human G0 lymphocytes exposed in vitro to gamma radiation
Radiat. Res.
165
43-50
2006
Homo sapiens
de Souza Dantas, D.; Ramos Dos Santos, C.; Guimaraes Pereira, G.A.; Medrano, F.J.
Biochemical and structural characterization of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Pyrococcus horikoshii
Biochim. Biophys. Acta
1784
953-960
2008
Pyrococcus horikoshii
Keebaugh, A.C.; Sullivan, R.T.; Thomas, J.W.
Gene duplication and inactivation in the HPRT gene family
Genomics
89
134-142
2007
Mus musculus
Kinashi, Y.; Suzuki, M.; Masunaga, S.; Ono, K.
Bystander effect-induced mutagenicity in HPRT locus of CHO cells following BNCT neutron irradiation: characteristics of point mutations by sequence analysis
Appl. Radiat. Isot.
67
S325-S327
2009
Cricetulus griseus
Ea, H.K.; Bardin, T.; Jinnah, H.A.; Aral, B.; Liote, F.; Ceballos-Picot, I.
Severe gouty arthritis and mild neurologic symptoms due to F199C, a newly identified variant of the hypoxanthine guanine phosphoribosyltransferase
Arthritis Rheum.
60
2201-2204
2009
Homo sapiens (P00492), Homo sapiens
Deng, H.; Callender, R.; Schramm, V.L.; Grubmeyer, C.
Pyrophosphate activation in hypoxanthine-guanine phosphoribosyltransferase with transition state analogue
Biochemistry
49
2705-2714
2010
Homo sapiens (P00492)
Havla, J.B.; Hill, C.E.; Abdel-Rahman, S.Z.; Richter, E.
Evaluation of the mutagenic effects of myosmine in human lymphocytes using the HPRT gene mutation assay
Food Chem. Toxicol.
47
237-241
2009
Homo sapiens
Ceballos-Picot, I.; Mockel, L.; Potier, M.C.; Dauphinot, L.; Shirley, T.L.; Torero-Ibad, R.; Fuchs, J.; Jinnah, H.A.
Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis
Hum. Mol. Genet.
18
2317-2327
2009
Homo sapiens
Bertelli, M.; Alushi, B.; Veicsteinas, A.; Jinnah, H.A.; Micheli, V.
Gene expression and mRNA editing of serotonin receptor 2C in brains of HPRT gene knock-out mice, an animal model of Lesch-Nyhan disease
J. Clin. Neurosci.
16
1061-1063
2009
Mus musculus
Keough, D.T.; Hockova, D.; Holy, A.; Naesens, L.M.; Skinner-Adams, T.S.; Jersey, J.; Guddat, L.W.
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics
J. Med. Chem.
52
4391-4399
2009
Plasmodium falciparum, Homo sapiens (P00492), Homo sapiens
Guibinga, G.H.; Hsu, S.; Friedmann, T.
Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis
Mol. Ther.
18
54-62
2010
Homo sapiens
Yamada, Y.; Nomura, N.; Yamada, K.; Wakamatsu, N.; Kaneko, K.; Fujimori, S.
Molecular analysis of hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiencies: novel mutations and the spectrum of Japanese mutations
Nucleosides Nucleotides Nucleic Acids
27
570-574
2008
Homo sapiens
Canyuk, B.; E-Wan, A.; Keawwijit, W.; Nualnoi, T.; Sirisatean, L.; Tansakul, P.; Tanthana, C.
The role for glutamic acid at position 196 in human hypoxanthine phosphoribosyltransferase (HPRT) as investigated using site-directed mutagenesis
Nucleosides Nucleotides Nucleic Acids
27
894-899
2008
Homo sapiens
Biazus, G.; Schneider, C.Z.; Palma, M.S.; Basso, L.A.; Santos, D.S.
Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization
Protein Expr. Purif.
66
185-190
2009
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Gayathri, P.; Sujay Subbayya, I.; Ashok, C.; Senthamizh Selvi, T.; Balaram, H.; Murthy, M.
Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization
Proteins
73
1010-1020
2008
Homo sapiens (P00492), Homo sapiens, Plasmodium falciparum (P20035), Plasmodium falciparum
Baranowska-Bosiacka, I.; Dziedziejko, V.; Safranow, K.; Gutowska, I.; Marchlewicz, M.; Dolegowska, B.; Rac, M.E.; Wiszniewska, B.; Chlubek, D.
Inhibition of erythrocyte phosphoribosyltransferases (APRT and HPRT) by Pb2+: a potential mechanism of lead toxicity
Toxicology
259
77-83
2009
Homo sapiens, Rattus norvegicus
Kanagawa, M.; Baba, S.; Ebihara, A.; Shinkai, A.; Hirotsu, K.; Mega, R.; Kim, K.; Kuramitsu, S.; Sampei, G.; Kawai, G.
Structures of hypoxanthine-guanine phosphoribosyltransferase (TTHA0220) from Thermus thermophilus HB8
Acta Crystallogr. Sect. F
66
893-898
2010
Thermus thermophilus (Q5SLS3), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SLS3)
Gogia, S.; Balaram, H.; Puranik, M.
Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate
Biochemistry
50
4184-4193
2011
Plasmodium falciparum, Homo sapiens (P00492), Homo sapiens
Garozzo, R.; Sortino, M.A.; Vancheri, C.; Condorelli, D.F.
Antiproliferative effects induced by guanine-based purines require hypoxanthine-guanine phosphoribosyltransferase activity
Biol. Chem.
391
1079-1089
2010
Homo sapiens
Hazleton, K.Z.; Ho, M.C.; Cassera, M.B.; Clinch, K.; Crump, D.R.; Rosario, I.; Merino, E.F.; Almo, S.C.; Tyler, P.C.; Schramm, V.L.
Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Chem. Biol.
19
721-730
2012
Plasmodium falciparum
Seinen, M.; De Boer, N.; Smid, K.; Van Asseldonk, D.; Bouma, G.; Van Bodegraven, A.; Peters, G.
Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: Preliminary data of an ongoing series
Nucleosides Nucleotides Nucleic Acids
30
1085-1090
2011
Homo sapiens
Mastrangelo, L.; Kim, J.E.; Miyanohara, A.; Kang, T.H.; Friedmann, T.
Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase
Proc. Natl. Acad. Sci. USA
109
3377-3382
2012
Homo sapiens (P00492), Homo sapiens
Hansen, M.R.; Jensen, K.S.; Rasmussen, M.S.; Christoffersen, S.; Kadziola, A.; Jensen, K.F.
Specificities and pH profiles of adenine and hypoxanthine-guanine-xanthine phosphoribosyltransferases (nucleotide synthases) of the thermoacidophile archaeon Sulfolobus solfataricus
Extremophiles
18
179-187
2014
Saccharolobus solfataricus (Q97W22), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97W22)
Bowen, T.L.; Lin, W.C.; Whitman, W.B.
Characterization of guanine and hypoxanthine phosphoribosyltransferases in Methanococcus voltae
J. Bacteriol.
178
2521-2526
1996
Methanococcus voltae
Stuer-Lauridsen, B.; Nygaard, P.
Purine salvage in two halophilic archaea: characterization of salvage pathways and isolation of mutants resistant to purine analogs
J. Bacteriol.
180
457-463
1998
Halobacterium salinarum, Haloferax volcanii
Argyros, D.A.; Tripathi, S.A.; Barrett, T.F.; Rogers, S.R.; Feinberg, L.F.; Olson, D.G.; Foden, J.M.; Miller, B.B.; Lynd, L.R.; Hogsett, D.A.; Caiazza, N.C.
High ethanol titers from cellulose by using metabolically engineered thermophilic, anaerobic microbes
Appl. Environ. Microbiol.
77
8288-8294
2011
Acetivibrio thermocellus (A3DHM7), Acetivibrio thermocellus DSM 1237 (A3DHM7)
Clinch, K.; Crump, D.R.; Evans, G.B.; Hazleton, K.Z.; Mason, J.M.; Schramm, V.L.; Tyler, P.C.
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Bioorg. Med. Chem.
21
5629-5646
2013
Homo sapiens, Plasmodium falciparum (P20035)
Karnawat, V.; Gogia, S.; Balaram, H.; Puranik, M.
Differential distortion of purine substrates by human and Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase to catalyse the formation of mononucleotides
ChemPhysChem
16
2172-2181
2015
Homo sapiens (P00492), Homo sapiens, Plasmodium falciparum (P20035), Plasmodium falciparum
Barjau Perez-Milicua, M.; Zenteno-Savin, T.; Crocker, D.E.; Gallo-Reynoso, J.P.
Hypoxanthine-guanine phosphoribosyltransferase and inosine 5-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa)
Front. Physiol.
6
212
2015
Sus scrofa, Lontra longicaudis, Mirounga angustirostris
Patel, M.B.; Kumar, S.P.; Valand, N.N.; Jasrai, Y.T.; Menon, S.K.
Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme
J. Mol. Model.
19
3201-3217
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Zhang, N.; Gong, X.; Lu, M.; Chen, X.; Qin, X.; Ge, H.
Crystal structures of Apo and GMP bound hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis
J. Struct. Biol.
194
311-316
2016
Legionella pneumophila (Q5ZVC1), Legionella pneumophila
Roy, S.; Nagappa, L.K.; Prahladarao, V.S.; Balaram, H.
Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Mol. Biochem. Parasitol.
204
111-120
2015
Plasmodium falciparum (P20035), Plasmodium falciparum
Roy, S.; Karmakar, T.; Prahlada Rao, V.S.; Nagappa, L.K.; Balasubramanian, S.; Balaram, H.
Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
Mol. Biosyst.
11
1410-1424
2015
Plasmodium falciparum (P20035), Plasmodium falciparum
Naesens, L.; Guddat, L.W.; Keough, D.T.; van Kuilenburg, A.B.; Meijer, J.; Vande Voorde, J.; Balzarini, J.
Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)
Mol. Pharmacol.
84
615-629
2013
Homo sapiens (P00492), Homo sapiens
Kang, T.H.; Park, Y.; Bader, J.S.; Friedmann, T.
The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation
PLoS ONE
8
e74967
2013
Mus musculus
Patta, P.; Martinelli, L.; Rotta, M.; Abbadi, B.; Santos, D.; Basso, L.
Mode of action of recombinant hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis
RSC Adv.
5
74671-74683
2015
Mycobacterium tuberculosis (P9WHQ9)
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Keough, D.T.; Rejman, D.; Pohl, R.; Zbornikova, E.; Hockova, D.; Croll, T.; Edstein, M.D.; Birrell, G.W.; Chavchich, M.; Naesens, L.M.J.; Pierens, G.K.; Brereton, I.M.; Guddat, L.W.
Design of Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase inhibitors as potential antimalarial therapeutics
ACS Chem. Biol.
13
82-90
2018
Plasmodium falciparum (A0A1G4HBT9), Plasmodium falciparum (Q8IJS1), Plasmodium falciparum, Homo sapiens (P00492)
Fateev, I.V.; Sinitsina, E.V.; Bikanasova, A.U.; Kostromina, M.A.; Tuzova, E.S.; Esipova, L.V.; Muravyova, T.I.; Kayushin, A.L.; Konstantinova, I.D.; Esipov, R.S.
Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis
Beilstein J. Org. Chem.
14
3098-3105
2018
Thermus thermophilus (Q72GT2), Thermus thermophilus DSM 7039 (Q72GT2), Thermus thermophilus ATCC BAA-163 (Q72GT2)
Ducati, R.G.; Firestone, R.S.; Schramm, V.L.
Kinetic isotope effects and transition state structure for hypoxanthine-guanine-xanthine phosphoribosyltransferase from Plasmodium falciparum
Biochemistry
56
6368-6376
2017
Plasmodium falciparum (Q8IJS1)
Valsecchi, W.M.; Cousido-Siah, A.; Defelipe, L.A.; Mitschler, A.; Podjarny, A.; Santos, J.; Delfino, J.M.
The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase
Biochim. Biophys. Acta
1864
655-666
2016
Trypanosoma cruzi (Q27796), Trypanosoma cruzi
Eng, W.S.; Keough, D.T.; Hockova, D.; Winzor, D.J.; Guddat, L.W.
Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis
Biochimie
135
6-14
2017
Mycobacterium tuberculosis (P9WHQ9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHQ9), Mycobacterium tuberculosis ATCC 25618 (P9WHQ9)
Opoku, F.; Govender, P.P.; Pooe, O.J.; Simelane, M.B.C.
Evaluating iso-mukaadial acetate and ursolic acid acetate as Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase inhibitors
Biomolecules
9
861
2019
Plasmodium falciparum (Q8IJS1)
Eng, W.; Hockova, D.; Spacek, P.; Baszczynski, O.; Janeba, Z.; Naesens, L.; Keough, D.; Guddat, L.
Crystal structures of acyclic nucleoside phosphonates in complex with Escherichia coli hypoxanthine phosphoribosyltransferase
ChemistrySelect
1
6267-6276
2016
Escherichia coli (P0A9M2)
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Acosta, J.; Del Arco, J.; Del Pozo, M.L.; Herrera-Tapias, B.; Clemente-Suarez, V.J.; Berenguer, J.; Hidalgo, A.; Fernandez-Lucas, J.
Hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase from Zobellia galactanivorans a bifunctional catalyst for the synthesis of nucleoside-5-mono-, di- and triphosphates
Front. Bioeng. Biotechnol.
8
677
2020
Zobellia galactanivorans (G0LC40), Zobellia galactanivorans, Zobellia galactanivorans CCUG 47099 (G0LC40), Zobellia galactanivorans CIP 106680 (G0LC40), Zobellia galactanivorans Dsij (G0LC40), Zobellia galactanivorans DSM 12802 (G0LC40), Zobellia galactanivorans NCIMB 13871 (G0LC40)
Lopez-Cruz, R.I.; Crocker, D.E.; Gaxiola-Robles, R.; Bernal, J.A.; Real-Valle, R.A.; Lugo-Lugo, O.; Zenteno-Savin, T.
Plasma hypoxanthine-guanine phosphoribosyl transferase activity in bottlenose dolphins contributes to avoiding accumulation of non-recyclable purines
Front. Physiol.
7
213
2016
Tursiops truncatus, Homo sapiens (P00492), Homo sapiens
Knejzlik, Z.; Herkommerova, K.; Hockova, D.; Pichova, I.
Hypoxanthine-guanine phosphoribosyltransferase is dispensable for Mycobacterium smegmatis viability
J. Bacteriol.
202
e00710-19
2020
Mycolicibacterium smegmatis (A0R593), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084 (A0R593), Mycolicibacterium smegmatis mc(2)155 (A0R593)
Spacek, P.; Keough, D.T.; Chavchich, M.; Dracinsky, M.; Janeba, Z.; Naesens, L.; Edstein, M.D.; Guddat, L.W.; Hockova, D.
Synthesis and evaluation of asymmetric acyclic nucleoside bisphosphonates as inhibitors of Plasmodium falciparum and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferase
J. Med. Chem.
60
7539-7554
2017
Homo sapiens (P00492), Homo sapiens, Plasmodium falciparum (Q8IJS1), Plasmodium falciparum
Romanello, L.; Zeraik, A.E.; de Freitas Fernandes, A.; Torini, J.R.; Bird, L.E.; Nettleship, J.E.; Rada, H.; Reddivari, Y.; Owens, R.J.; Serrao, V.H.B.; DeMarco, R.; Brandao-Neto, J.; Pereira, H.D.
In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases
Mol. Biochem. Parasitol.
229
24-34
2019
Schistosoma mansoni (P09383), Schistosoma mansoni
Townsend, M.H.; Felsted, A.M.; Burrup, W.; Robison, R.A.; O'Neill, K.L.
Examination of hypoxanthine guanine phosphoribosyltransferase as a biomarker for colorectal cancer patients
Mol. Cell. Oncol.
5
e1481810
2018
Homo sapiens (P00492), Homo sapiens
Nguyen, K.V.; Naviaux, R.K.; Nyhan, W.L.
Lesch-Nyhan disease I. Construction of expression vectors for hypoxanthine-guanine phosphoribosyltransferase (HGprt) enzyme and amyloid precursor protein (APP)
Nucleosides Nucleotides Nucleic Acids
39
905-922
2020
Homo sapiens (P00492), Homo sapiens
Roy, S.; Karmakar, T.; Nagappa, L.K.; Prahlada Rao, V.S.; Balasubramanian, S.; Balaram, H.
Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
Proteins
84
1658-1669
2016
Plasmodium falciparum (Q8IJS1), Plasmodium falciparum
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