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Reference on EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takahashi, I.; Ogura, K.
Farnesyl pyrophosphate synthetase from Bacillus subtilis
J. Biochem.
89
1581-1587
1981
Bacillus subtilis
Manually annotated by BRENDA team
Ogura, K.; Nishino, T.; Seto, S.
The purification of prenyltransferase and isopentenyl pyrophosphate isomerase of pumpkin fruit and their some properties
J. Biochem.
64
197-203
1968
Pumpkin
Manually annotated by BRENDA team
Green, T.R.; West, C.A.
Purification and characterization of two forms of geranyl transferase from Ricinus communis
Biochemistry
13
4720-4729
1974
Ricinus communis
Manually annotated by BRENDA team
Barnard, G.F.
Prenyltransferase from human liver
Methods Enzymol.
110
155-171
1985
Homo sapiens
Manually annotated by BRENDA team
Cornforth, J.W.; Cornforth, R.H.; Popjak, G.; Yengoyan, L.
Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate
J. Biol. Chem.
241
3970-3987
1966
Sus scrofa
Manually annotated by BRENDA team
Bartlett, D.L.; King, C.H.R.; Poulter, C.D.
Purification of farnesylpyrophosphate synthetase by affinity chromatography
Methods Enzymol.
110
171-184
1985
Saccharomyces cerevisiae, Gallus gallus
Manually annotated by BRENDA team
Koyama, T.; Obata, S.; Saito, K.; Takeshita-Koike, A.; Ogura, K.
Structural and functional roles of the cysteine residues of Bacillus stearothermophilus farnesyl diphosphate synthase
Biochemistry
33
12644-12648
1994
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Tholl, D.; Croteau, R.; Gershenzon, J.
Partial purification and characterization of the short-chain prenyltransferases, gernayl diphospate synthase and farnesyl diphosphate synthase, from Abies grandis (grand fir)
Arch. Biochem. Biophys.
386
233-242
2001
Abies grandis
Manually annotated by BRENDA team
Narita, K.; Ohnuma, S.I.; Nishino, T.
Protein design of geranyl diphosphate synthase. Structural features that define the product specificities of prenyltransferases
J. Biochem.
126
566-571
1999
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Kawasaki, T.; Hamano, Y.; Kuzuyama, T.; Itoh, N.; Seto, H.; Dairi, T.
Interconversion of the product specificity of type I eubacterial farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase through one amino acid substitution
J. Biochem.
133
83-91
2003
Streptomyces argenteolus
Manually annotated by BRENDA team
Szkopinska, A.; Plochocka, D.
Farnesyl diphosphate synthase; regulation of product specificity
Acta Biochim. Pol.
52
45-55
2005
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Dhiman, R.K.; Schulbach, M.C.; Mahapatra, S.; Baulard, A.R.; Vissa, V.; Brennan, P.J.; Crick, D.C.
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis
J. Lipid Res.
45
1140-1147
2004
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Thulasiram, H.V.; Poulter, C.D.
Farnesyl diphosphate synthase: the art of compromise between substrate selectivity and stereoselectivity
J. Am. Chem. Soc.
128
15819-15823
2006
Escherichia coli, Artemisia tridentata
Manually annotated by BRENDA team
Deprele, S.; Kashemirov, B.A.; Hogan,J.M.; Ebetino, F.H.; Barnett, B.L.; Evdokimov, A.; McKenna, C.E.
Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies
Bioorg. Med. Chem. Lett.
18
2878-2882
2008
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Nagaki, M.; Nakada, M.; Musashi, T.; Kawakami, J.; Ohya, N.; Kurihara, M.; Maki, Y.; Nishino, T.; Koyama, T.
Substrate specificities of wild and mutated farnesyl diphosphate synthases from Bacillus stearothermophilus with artificial substrates
Biosci. Biotechnol. Biochem.
71
1657-1662
2007
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Vandermoten, S.; Charloteaux, B.; Santini, S.; Sen, S.E.; Beliveau, C.; Vandenbol, M.; Francis, F.; Brasseur, R.; Cusson, M.; Haubruge, E.
Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity
FEBS Lett.
582
1928-1934
2008
Myzus persicae
Manually annotated by BRENDA team
Szajnman, S.H.; Garcia Linares, G.E.; Li, Z.H.; Jiang, C.; Galizzi, M.; Bontempi, E.J.; Ferella, M.; Moreno, S.N.; Docampo, R.; Rodriguez, J.B.
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase
Bioorg. Med. Chem.
16
3283-3290
2008
Toxoplasma gondii, Trypanosoma cruzi
Manually annotated by BRENDA team
Taban, A.H.; Tittiger, C.; Blomquist, G.J.; Welch, W.H.
Isolation and characterization of farnesyl diphosphate synthase from the cotton boll weevil, Anthonomus grandis
Arch. Insect Biochem. Physiol.
71
88-104
2009
Anthonomus grandis
Manually annotated by BRENDA team
Li, L.; Chen, G.P.; Yang, Y.; Ye, Y.; Yao, L.; Hu, S.J.
Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats
Biochem. Pharmacol.
79
399-406
2010
Rattus norvegicus
Manually annotated by BRENDA team
Kim, O.; Bang, K.; Jung, S.; Kim, Y.; Hyun, D.; Kim, S.; Cha, S.
Molecular characterization of ginseng farnesyl diphosphate synthase gene and its up-regulation by methyl jasmonate
Biol. Plant.
54
47-53
2010
Panax ginseng (Q4JHN6)
-
Manually annotated by BRENDA team
Vandermoten, S.; Santini, S.; Haubruge, E.; Heuze, F.; Francis, F.; Brasseur, R.; Cusson, M.; Charloteaux, B.
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase
Insect Biochem. Mol. Biol.
39
707-716
2009
Acyrthosiphon pisum (Q1X877)
Manually annotated by BRENDA team
Lewis, M.J.; Prosser, I.M.; Mohib, A.; Field, L.M.
Cloning and characterisation of a prenyltransferase from the aphid Myzus persicae with potential involvement in alarm pheromone biosynthesis
Insect Mol. Biol.
17
437-443
2008
Myzus persicae (Q1X876), Myzus persicae
Manually annotated by BRENDA team
Li, J.; Herold, M.J.; Kimmel, B.; Mueller, I.; Rincon-Orozco, B.; Kunzmann, V.; Herrmann, T.
Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells
J. Immunol.
182
8118-8124
2009
Homo sapiens
Manually annotated by BRENDA team
Mukkamala, D.; No, J.H.; Cass, L.M.; Chang, T.K.; Oldfield, E.
Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data
J. Med. Chem.
51
7827-7833
2008
Plasmodium vivax
Manually annotated by BRENDA team
Nagaki, M.; Musashi, T.; Hirano, Y.; Tanaka, H.; Ichita, J.; Maki, Y.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases of Bacillus stearothermophilus and porcine liver with allylic substrate homologs having vinyl or ethynyl group
J. Mol. Catal. B
59
163-167
2009
Geobacillus stearothermophilus, Sus scrofa
-
Manually annotated by BRENDA team
Nagaki, M.; Nakada, M.; Musashi, T.; Kawakami, J.; Endo, T.; Maki, Y.; Koyama, T.
Substrate specificities of wild and mutated farnesyl diphosphate synthases: Reactivity of allylic substrate homologs having hydrophilic groups at omega-position
J. Mol. Catal. B
59
225-230
2009
Geobacillus stearothermophilus, Sus scrofa
-
Manually annotated by BRENDA team
Nagaki, M.; Kanno, H.; Musashi, T.; Shimizu, R.; Maki, Y.; Sagami, H.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases from Bacillus stearothermophilus and porcine liver with cyclic substrate homologs
J. Mol. Catal. B
60
186-190
2009
Geobacillus stearothermophilus, Sus scrofa
-
Manually annotated by BRENDA team
Huang, C.H.; Gabelli, S.B.; Oldfield, E.; Amzel, L.M.
Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer
Proteins
78
888-899
2010
Trypanosoma cruzi (Q8WS25), Trypanosoma cruzi
Manually annotated by BRENDA team
Li, Z.H.; Cintron, R.; Koon, N.A.; Moreno, S.N.
The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase
Biochemistry
51
7533-7540
2012
Toxoplasma gondii (Q197X6), Toxoplasma gondii, Toxoplasma gondii RH (Q197X6)
Manually annotated by BRENDA team
De Schutter, J.; Zaretsky, S.; Welbourn, S.; Pause, A.; Tsantrizos, Y.
Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase
Bioorg. Med. Chem. Lett.
20
5781-5786
2010
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Rosso, V.S.; Szajnman, S.H.; Malayil, L.; Galizzi, M.; Moreno, S.N.; Docampo, R.; Rodriguez, J.B.
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase
Bioorg. Med. Chem.
19
2211-2217
2011
Trypanosoma cruzi, Toxoplasma gondii (Q197X6), Toxoplasma gondii
Manually annotated by BRENDA team
Demoro, B.; Caruso, F.; Rossi, M.; Benitez, D.; Gonzalez, M.; Cerecetto, H.; Galizzi, M.; Malayil, L.; Docampo, R.; Faccio, R.; Mombru, A.W.; Gambino, D.; Otero, L.
Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase
Dalton Trans.
41
6468-6476
2012
Trypanosoma cruzi
Manually annotated by BRENDA team
Aripirala, S.; Szajnman, S.H.; Jakoncic, J.; Rodriguez, J.B.; Docampo, R.; Gabelli, S.B.; Amzel, L.M.
Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase
J. Med. Chem.
55
6445-6454
2012
Trypanosoma cruzi
Manually annotated by BRENDA team
Nagaki, M.; Ichijo, T.; Kobashi, R.; Yagihashi, Y.; Musashi, T.; Kawakami, J.; Ohya, N.; Gotoh, T.; Sagami, H.
Substrate specificities of E- and Z-farnesyl diphosphate synthases with substrate analogs
J. Mol. Catal. B
80
1-6
2012
Geobacillus stearothermophilus (Q08291), Geobacillus stearothermophilus ATCC 10149 (Q08291)
-
Manually annotated by BRENDA team
Thabet, I.; Guirimand, G.; Courdavault, V.; Papon, N.; Godet, S.; Dutilleul, C.; Bouzid, S.; Giglioli-Guivarch, N.; Clastre, M.; Simkin, A.
The subcellular localization of periwinkle farnesyl diphosphate synthase provides insight into the role of peroxisome in isoprenoid biosynthesis
J. Plant Physiol.
168
2110-2116
2011
Catharanthus roseus (Q42698), Catharanthus roseus
Manually annotated by BRENDA team
Xiang, L.; Zhao, K.; Chen, L.
Molecular cloning and expression of Chimonanthus praecox farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral volatile sesquiterpenoids
Plant Physiol. Biochem.
48
845-850
2010
Chimonanthus praecox (B8XPY7), Chimonanthus praecox
Manually annotated by BRENDA team
Frick, S.; Nagel, R.; Schmidt, A.; Bodemann, R.R.; Rahfeld, P.; Pauls, G.; Brandt, W.; Gershenzon, J.; Boland, W.; Burse, A.
Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway
Proc. Natl. Acad. Sci. USA
110
4194-4199
2013
Phaedon cochleariae
Manually annotated by BRENDA team
Fischer, M.J.; Meyer, S.; Claudel, P.; Bergdoll, M.; Karst, F.
Identification of a lysine residue important for the catalytic activity of yeast farnesyl diphosphate synthase
Protein J.
30
334-339
2011
Saccharomyces cerevisiae (P08524), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Sun, X.F.; Li, Z.X.
In silico and in vitro analyses identified three amino acid residues critical to the catalysis of two aphid farnesyl diphosphate synthase
Protein J.
31
417-424
2012
Rhopalosiphum padi (G0YZR3), Rhopalosiphum padi (G0YZR4), Rhopalosiphum padi
Manually annotated by BRENDA team
Aripirala, S.; Gonzalez-Pacanowska, D.; Oldfield, E.; Kaiser, M.; Amzel, L.M.; Gabelli, S.B.
Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates
Acta Crystallogr. Sect. D
70
802-810
2014
Leishmania major
Manually annotated by BRENDA team
Schmidberger, J.W.; Schnell, R.; Schneider, G.
Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa
Acta Crystallogr. Sect. D
71
721-731
2015
Pseudomonas aeruginosa (Q9HWY4), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Das, S.; Edwards, P.A.; Crockett, J.C.; Rogers, M.J.
Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells
Biochim. Biophys. Acta
1841
569-573
2014
Homo sapiens
Manually annotated by BRENDA team
Gritzalis, D.; Park, J.; Chiu, W.; Cho, H.; Lin, Y.S.; De Schutter, J.W.; Lacbay, C.M.; Zielinski, M.; Berghuis, A.M.; Tsantrizos, Y.S.
Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase
Bioorg. Med. Chem. Lett.
25
1117-1123
2015
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Leung, C.Y.; Langille, A.M.; Mancuso, J.; Tsantrizos, Y.S.
Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase - parallel synthesis of analogs via a trimethylsilyl ylidene intermediate
Bioorg. Med. Chem.
21
2229-2240
2013
Homo sapiens
Manually annotated by BRENDA team
Sharifirad, A.; Mohammadian, S.; Yakhchali, B.; Mehrpooyan, S.; Fatemi, S.S.
Characterization of a farnesyl diphosphate synthase gene from Penicillium brevicompactum MUCL 19011
Biotechnol. Lett.
38
71-79
2016
Penicillium brevicompactum (G0ZGT0), Penicillium brevicompactum, Penicillium brevicompactum MUCL 19011 (G0ZGT0), Penicillium brevicompactum MUCL 19011
Manually annotated by BRENDA team
Marzinzik, A.L.; Amstutz, R.; Bold, G.; Bourgier, E.; Cotesta, S.; Glickman, J.F.; Goette, M.; Henry, C.; Lehmann, S.; Hartwieg, J.C.; Ofner, S.; Pelle, X.; Roddy, T.P.; Rondeau, J.M.; Stauffer, F.; Stout, S.J.; Widmer, A.; Zimmermann, J.; Zoller, T.; Jahnke, W.
Discovery of novel allosteric non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase by integrated lead finding
ChemMedChem
10
1884-1891
2015
Homo sapiens
Manually annotated by BRENDA team
Su, S.S.; Zhang, H.M.; Liu, X.Y.; Pan, G.F.; Ling, S.P.; Zhang, X.S.; Yang, X.M.; Tai, Y.L.; Yuan, Y.
Cloning and characterization of a farnesyl pyrophosphate synthase from Matricaria recutita L. and its upregulation by methyl jasmonate
Genet. Mol. Res.
14
349-361
2015
Matricaria chamomilla var. recutita (A7L691), Matricaria chamomilla var. recutita
Manually annotated by BRENDA team
Deng, Y.; Sun, M.; Xu, S.; Zhou, J.
Enhanced (S)-linalool production by fusion expression of farnesyl diphosphate synthase and linalool synthase in Saccharomyces cerevisiae
J. Appl. Microbiol.
121
187-195
2016
Actinidia arguta
Manually annotated by BRENDA team
Richter, A.; Seidl-Adams, I.; Koellner, T.G.; Schaff, C.; Tumlinson, J.H.; Degenhardt, J.
A small, differentially regulated family of farnesyl diphosphate synthases in maize (Zea mays) provides farnesyl diphosphate for the biosynthesis of herbivore-induced sesquiterpenes
Planta
241
1351-1361
2015
Zea mays
Manually annotated by BRENDA team
Zhao, Y.J.; Chen, X.; Zhang, M.; Su, P.; Liu, Y.J.; Tong, Y.R.; Wang, X.J.; Huang, L.Q.; Gao, W.
Molecular cloning and characterisation of farnesyl pyrophosphate synthase from Tripterygium wilfordii
PLoS ONE
10
e0125415
2015
Tripterygium wilfordii (A0A0F6PMF9), Tripterygium wilfordii (A0A0F6PN04), Tripterygium wilfordii
Manually annotated by BRENDA team
Alcaino, J.; Romero, I.; Niklitschek, M.; Sepulveda, D.; Rojas, M.C.; Baeza, M.; Cifuentes, V.
Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors
PLoS ONE
9
e96626
2014
Phaffia rhodozyma (X5DUM0), Phaffia rhodozyma, Phaffia rhodozyma ATCC 24230 (X5DUM0)
Manually annotated by BRENDA team
Liu, Y.L.; Lindert, S.; Zhu, W.; Wang, K.; McCammon, J.A.; Oldfield, E.
Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site
Proc. Natl. Acad. Sci. USA
111
E2530-E2539
2014
Trypanosoma brucei, Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Ferriols, V.M.; Yaginuma, R.; Adachi, M.; Takada, K.; Matsunaga, S.; Okada, S.
Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera
Sci. Rep.
5
10246
2015
Rhizosolenia setigera, Rhizosolenia setigera CCMP1694
Manually annotated by BRENDA team
Kumar, S.; Shilpashree, H.; Nagegowda, D.
Terpene moiety enhancement by overexpression of geranyl(geranyl) diphosphate synthase and geraniol synthase elevates monomeric and dimeric monoterpene indole alkaloids in transgenic Catharanthus roseus
Front. Plant Sci.
9
942
2018
Catharanthus roseus (Q42698)
Manually annotated by BRENDA team
Samori, P.Y.; Makabe, K.; Ohya, N.; Hatano, B.; Murakami, S.; Kijima, T.
Role of Cys73 in the thermostability of farnesyl diphosphate synthase from Geobacillus stearothermophilus
3 Biotech
7
236
2017
Geobacillus stearothermophilus (Q08291), Geobacillus stearothermophilus
Manually annotated by BRENDA team
Cheng, Y.J.; Li, Z.X.
Both farnesyl diphosphate synthase genes are involved in the production of alarm pheromone in the green peach aphid Myzus persicae
Arch. Insect Biochem. Physiol.
100
e21530
2019
Myzus persicae (A9Z1D3), Myzus persicae (A9Z1D4), Myzus persicae
Manually annotated by BRENDA team
Maheshwari, S.; Kim, Y.S.; Aripirala, S.; Murphy, M.; Amzel, L.M.; Gabelli, S.B.
Identifying structural determinants of product specificity in Leishmania major farnesyl diphosphate synthase
Biochemistry
59
2751-2759
2020
Leishmania major (Q4QBL1), Leishmania major
Manually annotated by BRENDA team
Takahashi, H.; Aihara, Y.; Ogawa, Y.; Murata, Y.; Nakajima, K.I.; Iida, M.; Shirai, M.; Fujisaki, S.
Suppression of phenotype of Escherichia coli mutant defective in farnesyl diphosphate synthase by overexpression of gene for octaprenyl diphosphate synthase
Biosci. Biotechnol. Biochem.
82
1003-1010
2018
Escherichia coli (P22939), Escherichia coli, Escherichia coli K12 (P22939)
Manually annotated by BRENDA team
Qian, J.; Liu, Y.; Chao, N.; Ma, C.; Chen, Q.; Sun, J.; Wu, Y.
Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants
BMC Mol. Biol.
18
3
2017
Panax ginseng, Eleutherococcus senticosus, Panax quinquefolius, Gynostemma pentaphyllum (A0A076JDS1), Panax notoginseng (Q4TTY7)
Manually annotated by BRENDA team
Gisselberg, J.E.; Herrera, Z.; Orchard, L.M.; Llinas, M.; Yeh, E.
Specific inhibition of the bifunctional farnesyl/geranylgeranyl diphosphate synthase in Malaria parasites via a new small-molecule binding site
Cell Chem. Biol.
25
185-193
2018
Plasmodium falciparum (Q8II79), Plasmodium falciparum
Manually annotated by BRENDA team
Muenzker, L.; Petrick, J.K.; Schleberger, C.; Clavel, D.; Cornaciu, I.; Wilcken, R.; Marquez, J.A.; Klebe, G.; Marzinzik, A.; Jahnke, W.
Fragment-based discovery of non-bisphosphonate binders of Trypanosoma brucei farnesyl pyrophosphate synthase
ChemBioChem
2020
1-17
2020
Trypanosoma brucei (Q86C09), Trypanosoma brucei
Manually annotated by BRENDA team
Kumar, P.; Kumar, A.; Sindhu, J.; Lal, S.
QSAR models for nitrogen containing monophosphonate and bisphosphonate derivatives as human farnesyl pyrophosphate synthase inhibitors based on Monte Carlo method
Drug Res.
69
159-167
2019
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Liu, Q.; Miao, Y.; Wang, X.; Lv, G.; Peng, Y.; Li, K.; Li, M.; Qiu, L.; Lin, J.
Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors
Eur. J. Med. Chem.
186
111905
2020
Homo sapiens (P14324)
Manually annotated by BRENDA team
Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H.
Approaches for designing new potent inhibitors of farnesyl pyrophosphate synthase
Expert Opin. Drug Discov.
11
307-320
2016
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Rubat, S.; Varas, I.; Sepulveda, R.; Almonacid, D.; Gonzalez-Nilo, F.; Agosin, E.
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase
FEMS Yeast Res.
17
fox032
2017
Saccharomyces cerevisiae (P08524), Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741 (P08524)
Manually annotated by BRENDA team
Picard, M.E.; Nisole, A.; Beliveau, C.; Sen, S.; Barbar, A.; Shi, R.; Cusson, M.
Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana Implications for inhibitor design
Insect Biochem. Mol. Biol.
92
84-92
2018
Choristoneura fumiferana (Q1XAB1), Choristoneura fumiferana
Manually annotated by BRENDA team
Lee, J.S.; Pan, J.J.; Ramamoorthy, G.; Poulter, C.D.
Structure-function studies of Artemisia tridentata farnesyl diphosphate synthase and chrysanthemyl diphosphate synthase by site-directed mutagenesis and morphogenesis
J. Am. Chem. Soc.
139
14556-14567
2017
Artemisia spiciformis (Q7XYS9)
Manually annotated by BRENDA team
Fernandez, D.; Ramis, R.; Ortega-Castro, J.; Casasnovas, R.; Vilanova, B.; Frau, J.
New insights into human farnesyl pyrophosphate synthase inhibition by second-generation bisphosphonate drugs
J. Comput. Aided Mol. Des.
31
675-688
2017
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Han, S.; Li, X.; Xia, Y.; Yu, Z.; Cai, N.; Malwal, S.R.; Han, X.; Oldfield, E.; Zhang, Y.
Farnesyl pyrophosphate synthase as a target for drug development discovery of natural-product-derived inhibitors and their activity in pancreatic cancer cells
J. Med. Chem.
62
10867-10896
2019
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Feng, Y.; Park, J.; Li, S.G.; Boutin, R.; Viereck, P.; Schilling, M.A.; Berghuis, A.M.; Tsantrizos, Y.S.
Chirality-driven mode of binding of alpha-aminophosphonic acid-based allosteric inhibitors of the human farnesyl pyrophosphate synthase (hFPPS)
J. Med. Chem.
62
9691-9702
2019
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Qi, Q.; Li, R.; Gai, Y.; Jiang, X.
Cloning and functional identification of farnesyl diphosphate synthase from Pinus massoniana Lamb
J. Plant Biochem. Biotechnol.
26
132-140
2017
Pinus massoniana (A0A077HCY1)
-
Manually annotated by BRENDA team
Barja, M.V.; Rodriguez-Concepcion, M.
A Simple In vitro assay to measure the activity of geranylgeranyl diphosphate synthase and other short-chain prenyltransferases
Methods Mol. Biol.
2083
27-38
2020
Arabidopsis thaliana (P34802), Arabidopsis thaliana
Manually annotated by BRENDA team
Mukherjee, S.; Basu, S.; Zhang, K.
Farnesyl pyrophosphate synthase is essential for the promastigote and amastigote stages in Leishmania major
Mol. Biochem. Parasitol.
230
8-15
2019
Leishmania major (Q4QBL1), Leishmania major, Leishmania major MHOM (Q4QBL1)
Manually annotated by BRENDA team
Wang, X.; Sun, T.; Sun, J.; Wang, S.; Ma, Y.; Liu, Z.; Zhang, J.; Zhang, G.; Zou, L.
Molecular cloning, characterisation, and heterologous expression of farnesyl diphosphate synthase from Sanghuangporus baumii
Mol. Biotechnol.
62
132-141
2020
Sanghuangporus baumii (A0A5P8U0M0), Sanghuangporus baumii
Manually annotated by BRENDA team
Park, J.; Zielinski, M.; Magder, A.; Tsantrizos, Y.S.; Berghuis, A.M.
Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
Nat. Commun.
8
14132
2017
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Gadelha, A.P.R.; Brigagao, C.M.; da Silva, M.B.; Rodrigues, A.B.M.; Guimaraes, A.C.R.; Paiva, F.; de Souza, W.; Henriques, C.
Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia
Parasit. Vectors
13
168
2020
Giardia intestinalis (A8B433), Leishmania infantum (E9AH04), Leishmania infantum, Giardia intestinalis ATCC 50803 (A8B433)
Manually annotated by BRENDA team
Lao, Y.M.; Jin, H.; Zhou, J.; Zhang, H.J.; Zhu, X.S.; Cai, Z.H.
A Novel Hydrolytic Activity of Tri-Functional Geranylgeranyl Pyrophosphate Synthase in Haematococcus pluvialis
Plant Cell Physiol.
59
2536-2548
2018
Haematococcus lacustris (A0A0K0TQ44), Haematococcus lacustris
Manually annotated by BRENDA team
Park, J.; Rodionov, D.; De Schutter, J.W.; Lin, Y.S.; Tsantrizos, Y.S.; Berghuis, A.M.
Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
PLoS ONE
12
e0186447
2017
Homo sapiens (P14324), Homo sapiens
Manually annotated by BRENDA team
Opassi, G.; Nordstroem, H.; Lundin, A.; Napolitano, V.; Magari, F.; Dzus, T.; Klebe, G.; Danielson, U.H.
Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment-based lead discovery
Protein Sci.
29
991-1003
2020
Trypanosoma cruzi (Q8WS25), Trypanosoma cruzi
Manually annotated by BRENDA team