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Disease on EC 2.5.1.22 - spermine synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells.
Association between plasma diacetylspermine and tumor spermine synthase with outcome in triple negative breast cancer.
Carcinogenesis
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Carcinoma
Independent roles of eIF5A and polyamines in cell proliferation.
Carcinoma, Hepatocellular
Fluorinated analogues of spermidine as substrates of spermine synthase.
Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells.
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.
Colorectal Neoplasms
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression.
Supramolecular Chemotherapy: Host-Guest Complexes of Heptaplatin-Cucurbit[7]uril toward Colorectal Normal and Tumor Cells.
Supramolecular Chemotherapy: Noncovalent Bond Synergy of Cucurbit[7]uril against Human Colorectal Tumor Cells.
Deafness
Aminopropyltransferases: function, structure and genetics.
Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.
Spermine synthase.
Hypophosphatemia
Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse.
Infertility
Aminopropyltransferases: function, structure and genetics.
Spermine synthase.
Intellectual Disability
(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome.
Aminopropyltransferases: function, structure and genetics.
Myosin Va and spermine synthase: partners in exosome transport.
New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder-Robinson X-linked recessive mental retardation syndrome.
Polyamine Homeostasis in Snyder-Robinson Syndrome.
Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach.
Snyder-Robinson syndrome.
Snyder-Robinson syndrome: A novel nonsense mutation in spermine synthase and expansion of the phenotype.
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.
Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).
The complete loss of function of the SMS gene results in a severe form of Snyder-Robinson syndrome.
Whole-exome sequencing identifies a novel mutation in spermine synthase gene (SMS) associated with Snyder-Robinson Syndrome.
Leukemia
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
Mental Retardation, X-Linked
New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder-Robinson X-linked recessive mental retardation syndrome.
The impact of spermine synthase (SMS) mutations on brain morphology.
Muscle Hypotonia
Aminopropyltransferases: function, structure and genetics.
Polyamine Homeostasis in Snyder-Robinson Syndrome.
Neoplasm Metastasis
Association between plasma diacetylspermine and tumor spermine synthase with outcome in triple negative breast cancer.
Neoplasms
Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells.
Association between plasma diacetylspermine and tumor spermine synthase with outcome in triple negative breast cancer.
Comparative antitumor properties in rodents of irreversible inhibitors of L-ornithine decarboxylase, used as such or as prodrugs.
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Supramolecular Chemotherapy: Host-Guest Complexes of Heptaplatin-Cucurbit[7]uril toward Colorectal Normal and Tumor Cells.
Osteoporosis
Polyamine Homeostasis in Snyder-Robinson Syndrome.
Snyder-Robinson syndrome: A novel nonsense mutation in spermine synthase and expansion of the phenotype.
Seizures
Polyamine Homeostasis in Snyder-Robinson Syndrome.
spermine synthase deficiency
Diagnostic screening for spermine synthase deficiency by liquid chromatography tandem mass spectrometry.
Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea.
Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.
Snyder-Robinson syndrome.
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.
Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.
Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).
Triple Negative Breast Neoplasms
Association between plasma diacetylspermine and tumor spermine synthase with outcome in triple negative breast cancer.