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2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
?
-
very low activity, almost 400-fold lower than the activity shown by the thiE-encoded thiamine-phosphate diphosphatase of Escherichia coli
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine phosphate + diphosphate
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-beta-hydroxyethylthiazole phosphate
thiamine phosphate + diphosphate
-
-
-
-
?
4-amino-5-(hydroxymethyl)-2-(trifluoromethyl)pyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
?
-
poor substrate
-
-
?
4-amino-5-(hydroxymethyl)-2-methoxypyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
?
-
good substrate
-
-
?
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 4-methyl-5-(2-hydroxyethyl)thiazole phosphate
thiamine monophosphate + diphosphate + phosphate
-
-
-
?
additional information
?
-
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
involved in biosynthesis of thiamine
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
expression is negatively regulated by thiamin
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
involved in biosynthesis of thiamine
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
the bifunctional enzyme hydroxyethylthiazole kinase/thiamine-phosphate pyrophosphorylase catalyzes two sequential steps in the synthesis of thiamin monophosphate from hydroxyethylthiazole
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the tautomerization and decarboxylation of the intermediate (2R,5Z)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethylidene]-2,5-dihydro-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the tautomerization and decarboxylation of the intermediate (2R,5Z)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethylidene]-2,5-dihydro-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the decarboxylation of the intermediate 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the decarboxylation of the intermediate 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
r
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine phosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine phosphate + diphosphate
-
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
thiamin biosynthesis
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
-
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
thiamin biosynthesis
-
-
?
additional information
?
-
-
the condensation of 5-(2-hydroxyethyl)-4-methylthiazole phosphate and 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate into thiamine monophosphate is catalyzed by the bifunctional TMP diphosphorylase/HET kinase encoded by the THI6 gene
-
-
?
additional information
?
-
substrate 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate cannot be replaced by 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate or 4-amino-5-hydroxymethyl-2-methylpyrimidine, nor substrate 4-methyl-5-(2-hydroxyethyl)thiazole phosphate by 4-methyl-5-(2-hydroxyethyl)thiazole
-
-
?
additional information
?
-
-
the N-terminal domain of the bifunctional enzyme THI6 catalyzes the ligation of the thiamin thiazole and pyrimidine moieties to form thiamine phosphate, and the C-terminal domain catalyzes the phosphorylation of 4-methyl-5-hydroxyethylthiazole in a salvage pathway. Adenosine diphospho-5beta-ethyl-4-methylthiazole-2-carboxylic acid is not a substrate
-
-
?
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2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
involved in biosynthesis of thiamine
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
expression is negatively regulated by thiamin
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
involved in biosynthesis of thiamine
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
the bifunctional enzyme hydroxyethylthiazole kinase/thiamine-phosphate pyrophosphorylase catalyzes two sequential steps in the synthesis of thiamin monophosphate from hydroxyethylthiazole
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the tautomerization and decarboxylation of the intermediate (2R,5Z)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethylidene]-2,5-dihydro-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the tautomerization and decarboxylation of the intermediate (2R,5Z)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethylidene]-2,5-dihydro-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the decarboxylation of the intermediate 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the decarboxylation of the intermediate 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
thiamin biosynthesis
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
thiamin biosynthesis
-
-
?
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Camiener, G.W.; Brown, G.M.
The biosynthesis of thiamine. 2. Fractionation of enzyme system and identification of thiazole monophosphate and thiamine monophosphate as intermediates
J. Biol. Chem.
235
2411-2417
1960
Saccharomyces cerevisiae
brenda
Kawasaki, Y.
Copurification of hydroxyethylthiazole kinase and thiamine-phosphate pyrophosphorylase of Saccharomyces cerevisiae: characterization of hydroxyethylthiazole kinase as a bifunctional enzyme in the thiamine biosynthetic pathway
J. Bacteriol.
175
5153-5158
1993
Saccharomyces cerevisiae
brenda
Leder, I.G.
The enzymatic synthesis of thiamine monophosphate
J. Biol. Chem.
236
3066-3071
1961
Saccharomyces cerevisiae
brenda
Kayama, Y.; Kawasaki, T.
Purification and properties of thiaminephosphate pyrophosphorylase of Escherichia coli
Arch. Biochem. Biophys.
158
242-248
1973
Escherichia coli
brenda
Kawasaki, T.
Thiamine phosphate pyrophosphorylase
Methods Enzymol.
62
69-73
1979
Escherichia coli
brenda
Reddick, J.J.; Nicewonger, R.; Begley, T.P.
Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism
Biochemistry
40
10095-10102
2001
Bacillus subtilis
brenda
Nosaka, K.; Nishimura, H.; Kawasaki, Y.; Tsujihara, T.; Iwashima, A.
Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae
J. Biol. Chem.
269
30510-30516
1994
Saccharomyces cerevisiae
brenda
Kim, Y.S.; Nosaka, K.; Downs, D.M.; Kwak, J.M.; Park, D.; Chung, I.K.; Nam, H.G.
A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase involved in thiamin biosynthesis
Plant Mol. Biol.
37
955-966
1998
Brassica napus
brenda
Chiu, H.J.; Reddick, J.J.; Begley, T.P.; Ealick, S.E.
Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution
Biochemistry
38
6460-6470
1999
Bacillus subtilis (P39594), Bacillus subtilis
brenda
Golda, A.; Szyniarowski, P.; Ostrowska, K.; Kozik, A.; Rapala-Kozik, M.
Thiamine binding and metabolism in germinating seeds of selected cereals and legumes
Plant Physiol. Biochem.
42
187-195
2004
Avena sativa, Vicia faba, Pisum sativum, Zea mays
brenda
Ajjawi, I.; Tsegaye, Y.; Shintani, D.
Determination of the genetic, molecular, and biochemical basis of the Arabidopsis thaliana thiamin auxotroph th1
Arch. Biochem. Biophys.
459
107-114
2007
Arabidopsis thaliana
brenda
Rapala-Kozik, M.; Olczak, M.; Ostrowska, K.; Starosta, A.; Kozik, A.
Molecular characterization of thi3 gene involved in thiamine biosynthesis in Zea mays: cDNA sequence and enzymatic and structural properties of recombinant bifunctional protein with 4-amino-5-hydroxymethyl-2-methylpyrimidine (phosphate) kinase and thiamin
Biochem. J.
408
149-159
2007
Zea mays (Q2UVH9)
brenda
Karunakaran, R.; Ebert, K.; Harvey, S.; Leonard, M.E.; Ramachandran, V.; Poole, P.S.
Thiamine is synthesized by a salvage pathway in Rhizobium leguminosarum bv. viciae strain 3841
J. Bacteriol.
188
6661-6668
2006
Escherichia coli
brenda
Morett, E.; Saab-Rincon, G.; Olvera, L.; Olvera, M.; Flores, H.; Grande, R.
Sensitive genome-wide screen for low secondary enzymatic activities: the YjbQ family shows thiamin phosphate synthase activity
J. Mol. Biol.
376
839-853
2008
Escherichia coli, Pyrococcus furiosus (Q8U3C6), Saccharolobus solfataricus (Q97VS8), Saccharolobus solfataricus P2 (Q97VS8), Thermotoga maritima (Q9WZI2), Thermotoga maritima (Q9X2I5), Thermotoga maritima DSM 3109 (Q9WZI2), Thermotoga maritima DSM 3109 (Q9X2I5)
brenda
Kowalska, E.; Kozik, A.
The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts
Cell. Mol. Biol. Lett.
13
271-282
2008
Saccharomyces cerevisiae
brenda
Hazra, A.B.; Han, Y.; Chatterjee, A.; Zhang, Y.; Lai, R.Y.; Ealick, S.E.; Begley, T.P.
A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase
J. Am. Chem. Soc.
133
9311-9319
2011
Bacillus subtilis (P39594), Bacillus subtilis 168 (P39594)
brenda
Paul, D.; Chatterjee, A.; Begley, T.P.; Ealick, S.E.
Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes
Biochemistry
49
9922-9934
2010
[Candida] glabrata
brenda
Saab-Rincon, G.; Olvera, L.; Olvera, M.; Rudino-Pinera, E.; Benites, E.; Soberon, X.; Morett, E.
Evolutionary walk between (beta/alpha)8 barrels: catalytic migration from triosephosphate isomerase to thiamin phosphate synthase
J. Mol. Biol.
416
255-270
2012
Escherichia coli
brenda
Khare, G.; Kar, R.; Tyagi, A.K.
Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs
PLoS ONE
6
e22441
2011
Mycobacterium tuberculosis
brenda
Hayashi, M.; Kobayashi, K.; Esaki, H.; Konno, H.; Akaji, K.; Tazuya, K.; Yamada, K.; Nakabayashi, T.; Nosaka, K.
Enzymatic and structural characterization of an archaeal thiamin phosphate synthase
Biochim. Biophys. Acta
1844
803-809
2014
Pyrobaculum calidifontis (A3MSR0), Pyrobaculum calidifontis, Pyrobaculum calidifontis JCM 11548 (A3MSR0)
brenda
Tian, K.; Niu, D.; Liu, X.; Prior, B.A.; Zhou, L.; Lu, F.; Singh, S.; Wang, Z.
Limitation of thiamine pyrophosphate supply to growing Escherichia coli switches metabolism to efficient D-lactate formation
Biotechnol. Bioeng.
113
182-188
2016
Escherichia coli, Escherichia coli B0013
brenda