Information on EC 2.5.1.38 - isonocardicin synthase

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The expected taxonomic range for this enzyme is: Nocardia uniformis

EC NUMBER
COMMENTARY hide
2.5.1.38
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RECOMMENDED NAME
GeneOntology No.
isonocardicin synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + nocardicin E = S-methyl-5'-thioadenosine + isonocardicin A
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-amino-3-carboxypropyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
nocardicin A biosynthesis
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Monobactam biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase
Involved in the biosynthesis of the beta-lactam antibiotic nocardicin A.
CAS REGISTRY NUMBER
COMMENTARY hide
118246-74-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ssp. tsuyamanensis, ATCC 21806
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + nocardicin E
5'-methylthioadenosine + isonocardicin A
show the reaction diagram
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-
-
-
?
S-adenosyl-L-methionine + nocardicin E
?
show the reaction diagram
-
enzyme is involved in the biosynthesis of the beta-lactam antibiotic nocardicin A
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + nocardicin E
?
show the reaction diagram
-
enzyme is involved in the biosynthesis of the beta-lactam antibiotic nocardicin A
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-
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
partially purified enzyme is stable after dialysis against 50 mM phosphate buffer, pH 7.5, containing 20% glycerol and 10 mM 2-mercaptoethanol
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ssp. tsuyamanensis, ATCC 21806, partial
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