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Disease on EC 2.5.1.46 - deoxyhypusine synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.
Carcinogenesis
Hypusine biosynthesis in ? cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Carcinoma
Independent roles of eIF5A and polyamines in cell proliferation.
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
Diabetes Mellitus, Type 1
Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
Diabetes Mellitus, Type 2
Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.
Glioblastoma
Expression of Eukaryotic Initiation Factor 5A and Hypusine Forming Enzymes in Glioblastoma Patient Samples: Implications for New Targeted Therapies.
Hyperglycemia
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
Leishmaniasis
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Leukemia
Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias.
[The effect of eIF-5A on the G1-S in cell cycle regulation]
Leukemia, Erythroblastic, Acute
Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells.
Malaria
A suggested vital function for eIF-5A and dhs genes during murine malaria blood-stage infection.
Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax.
Piperidones with activity against Plasmodium falciparum.
Melanoma
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Neoplasm Metastasis
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
Neoplasms
Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells.
Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.
Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells.
Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias.
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of acute lymphoblastic leukemia cells to vincristine through inhibition of eif5a-2 activation.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
The polyamine-derived amino acid hypusine: its post-translational formation in eIF-5A and its role in cell proliferation.
Neuroblastoma
Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells.
Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.
Effects of inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and erythroleukemia cells.
Pancreatitis
[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism]
Squamous Cell Carcinoma of Head and Neck
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.