Reference on EC 2.5.1.47 - cysteine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Flint, D.H.; Tuminello, J.F.; Miller, T.J.
Studies on the synthesis of the Fe-S cluster of dihydroxy-acid dehydratase in escherichia coli crude extract. Isolation of O-acetylserine sulfhydrylases A and B and beta-cystathionase based on their ability to mobilize sulfur from cysteine and to participate in Fe-S cluster synthesis
J. Biol. Chem.
271
16053-16067
1996
Escherichia coli
Burnell, J.N.; Whatley, F.R.
Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of serine transacetylase, O-acetylserine sulphydrylase and beta-cystathionase
Biochim. Biophys. Acta
481
246-265
1977
Paracoccus denitrificans
Burnell, J.N.
Sulfate assimilation in C4 plants. Intercellular and intracellular location of ATP sulfurylase, cysteine synthase, and cystathionine beta-lyase in maize leaves
Plant Physiol.
75
873-875
1984
Zea mays
Maruyama, A.; Ishizawa, K.; Takagi, T.; Esashi, Y.
Cytosolic beta-cyanoalanine synthase activity attributed to cysteine synthases in cocklebur seeds. Purification and characterization of cytosolic cysteine synthases
Plant Cell Physiol.
39
671-680
1998
Xanthium pennsylvanicum
Droux, M.; Ruffet, M.L.; Douce, R.; Job, D.
Interactions between serine acetyltransferase and O-acetylserine (thiol) lyase in higher plants. Structural and kinetic properties of the free and bound enzymes
Eur. J. Biochem.
255
235-245
1998
Arabidopsis thaliana
Noji, M.; Saito, K.
Molecular and biochemical analysis of serine acetyltransferase and cysteine synthase towards sulfur metabolic engineering in plants
Amino Acids
22
231-243
2002
Arabidopsis thaliana, Spinacia oleracea, Triticum aestivum, Zea mays
Kredich, N.M.; Becker, M.A.
Cysteine biosynthesis: serine transacetylase and O-acetylserine sulfhydrylase
Methods Enzymol.
17 B
459-470
1971
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
-
Thompson, J.F.; Moore, D.P.
Enzymatic synthesis of cysteine and S-methylcysteine in plant extracts
Biochem. Biophys. Res. Commun.
31
281-287
1968
Brassica rapa, Saccharomyces cerevisiae, Neurospora crassa
Becker, M.A.; Kredich, N.M.; Tomkins, G.M.
The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium
J. Biol. Chem.
244
2418-2427
1969
Salmonella enterica subsp. enterica serovar Typhimurium
Yamagata, S.; Takeshima, K.; Naiki, N.
Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast
J. Biochem.
75
1221-1229
1974
Saccharomyces cerevisiae
Tamura, G.; Iwasawa, T.; Masada, M.; Fukushima, K.
Some properties of cysteine synthase from radish roots
Agric. Biol. Chem.
40
637-638
1976
Raphanus sativus
-
Yamagata, S.; Takeshima, K.
O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Further purification and characterization as a pyridoxal enzyme
J. Biochem.
80
777-785
1976
Saccharomyces cerevisiae
Yamagata, S.
O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Subunit structure
J. Biochem.
80
787-797
1976
Saccharomyces cerevisiae
Ascano, A.; Nicholas, D.J.D.
Purification and properties of O-acetyl-L-serine sulphhydrolase from wheat leaves
Phytochemistry
16
889-893
1977
Triticum aestivum
-
Hock Ng, B.; Anderson, J.W.
Chloroplast cysteine synthases of Trifolium repens and Pisum sativum
Biochemistry
17
879-885
1978
Pisum sativum, Trifolium repens
-
Cook, P.F.; Wedding, R.T.
Cysteine synthetase from Salmonella typhimurium LT-2. Aggregation, kinetic behavior, and effect of modifiers
J. Biol. Chem.
253
7874-7879
1978
Salmonella enterica subsp. enterica serovar Typhimurium
Fankhauser, H.; Brunold, C.
Localization of O-acetyl-L-serine sulphydrylase in Spinacia oleracea L
Plant Sci. Lett.
14
185-192
1979
Spinacia oleracea
-
Yamagata, S.
Occurrence of low molecular weight O-acetylserine sulfhydrylase in the yeast Saccharomyces cerevisiae
J. Biochem.
88
1419-1423
1980
Saccharomyces cerevisiae
Diessner, W.; Schmidt, A.
Isoenzymes of cysteine synthase in the cyanobacterium Synechococcus 6301
Z. Pflanzenphysiol.
102
57-68
1981
Synechococcus sp., Synechococcus sp. 6301
-
Yamagata, S.
Low-molecular-weight O-acetylserine sulfhydrylase and serine sulfhydrylase of Saccharomyces cerevisiae are the same protein
J. Bacteriol.
147
688-690
1981
Saccharomyces cerevisiae
Hensel, G.; Trueper, H.G.
O-acetylserine sulfhydrylase and S-sulfocysteine synthase activities of Chromatium vinosum
Arch. Microbiol.
130
228-233
1981
Allochromatium vinosum
-
Yanase, H.; Sakai, T.; Tonumura, K.
Purification and crystallization of a beta-cyanoalanine-forming enzyme from Enterobacter sp. 10-1
Agric. Biol. Chem.
46
355-361
1982
Enterobacter sp., Enterobacter sp. 10-1
-
Yanase, H.; Sakai, T.; Tonomura, K.
Some properties of a beta-cyanoalanine-forming enzyme of Enterobacter sp. 10-1
Agric. Biol. Chem.
46
363-369
1982
Enterobacter sp., Enterobacter sp. 10-1
-
Yamagata, S.; Kawai, T.; Takeshima, K.
Partial purification and comparison of some properties of L-serine sulfhydro-lyase of Saccharomyces cerevisiae
Biochim. Biophys. Acta
701
334-338
1982
Saccharomyces cerevisiae
Hensel, G.; Trueper, H.G.
O-Acetylserine sulfhydrylase and S-sulfocysteine synthase activities of Rhodospirillum tenue
Arch. Microbiol.
134
227-232
1983
Rhodocyclus purpureus, Rhodomicrobium vannielii, Rhodoblastus acidophilus, Rhodocyclus tenuis, Thiocystis violacea
Rosichan, J.L.; Blake, N.; Stallard, R.; Owais, W.M.; Kleinhofs, A.; Nilan, R.A.
O-acetylserine (thiol)-lyase from barley converts sodium azide to a mutagenic metabolite
Biochim. Biophys. Acta
748
367-373
1983
Hordeum vulgare
-
Nakamura, T.; Iwahashi, A.; Eguchi, Y.
Enzymatic proof for the identity of the S-sulfocysteine synthase and cysteine synthase B of Salmonella typhimurium
J. Bacteriol.
158
1122-1127
1984
Salmonella enterica subsp. enterica serovar Typhimurium
Nagasawa, T.; Dhillon, G.S.; Ishii, T.; Yamada, H.
Enzymatic synthesis of L-cysteine by O-acetylserine sulfhydrylase of 3-chloro-L-alanine resistant Bacillus sphaericus L-118
J. Bacteriol.
2
365-367
1985
Lysinibacillus sphaericus
-
Murakoshi, I.; Ikegami, F.; Kaneko, M.
Purification and properties of cysteine synthase from Spinacia oleracea
Phytochemistry
24
1907-1911
1985
Spinacia oleracea
-
Byrne, C.R.; Monroe, R.S.; Ward, K.A.; Kredich, N.M.
DNA sequences of the cysK regions of Salmonella typhimurium and Escherichia coli and linkage of the cysK regions to ptsH
J. Bacteriol.
170
3150-3157
1988
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Ikegami, F.; Kaneko, M.; Kobori, M.; Murakoshi, I.
Purification and characterization of cysteine synthase from Brassica juncea
Phytochemistry
27
3379-3383
1988
Brassica juncea
-
Ikegami, F.; Kaneko, M.; Kamiyama, H.; Murakoshi, I.
Purification and characterization of cysteine synthases from Citrullus vulgaris
Phytochemistry
27
697-701
1988
Citrullus lanatus subsp. vulgaris
-
Ikegami, F.; Kaneko, M.; Lambein, F.; Kuo, Y.H.; Murakoshi, I.
Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum
Phytochemistry
26
2699-2704
1987
Pisum sativum
-
Leon, J.; Romero, L.C.; Galvan, F.; Vega, J.M.
Purification and physicochemical characterization of O-acetyl-L-serine sulfhydrylase from Chlamydomonas reinhardtii
Plant Sci.
53
93-99
1953
Chlamydomonas reinhardtii
-
Krauss, F.; Schmidt, A.
Sulfur sources for growth of Chlorella fusca and their influence on key enzymes of sulfur metabolism
J. Gen. Microbiol.
133
1209-1319
1987
[Chlorella] fusca
-
Ostergaard, S.; Theilgaard, H.B.A.; Nielsen, J.
Identification and purification of O-acetyl-L-serine sulphhydrylase in Penicillium chrysogenum
Appl. Microbiol. Biotechnol.
50
663-668
1998
Penicillium chrysogenum
-
Yamaguchi, T.; Masada, M.
Comparative studies on cysteine synthase isozymes from spinach leaves
Biochim. Biophys. Acta
1251
91-98
1995
Spinacia oleracea
Ikegami, F.; Itagaki, S.; Murakoshi, I.
Purification and characterization of two forms of cysteine synthase from Allium tuberosum
Phytochemistry
32
31-34
1993
Allium tuberosum
-
Leon, J.; Vega, J.M.
Separation and regulatory properties of O-acetyl-L-serine sulfhydrylase isoenzymes from Chlamydomonas reinhardtii
Plant Physiol. Biochem.
29
595-599
1991
Chlamydomonas reinhardtii
-
Leon, J.; Vega, J.M.
Effect of immobilization on the kinetic ans stability properties of o-acetyl-L-serine sulfhydrylase from Chlamydomonas reinhardtii
Biocatalysis
7
29-35
1992
Chlamydomonas reinhardtii
-
Roemer, S.; d'Harlingue, A.; Camara, B.; Schantz, R.; Kuntz, M.
Cysteine synthase from Capsicum annuum chromoplasts. Characterization and cDNA cloning of an up-regulated enzyme during fruit development
J. Biol. Chem.
267
17966-17970
1992
Capsicum annuum
Hell, R.; Bork, C.; Bogdanova, N.; Frolov, I.; Hauschild, R.
Isolation and characterization of two cDNAs encoding for compartment specific isoforms of O-acetylserine (thiol) lyase from Arabidopsis thaliana
FEBS Lett.
351
257-262
1994
Arabidopsis thaliana
Kuske, C.R.; Ticknor, L.O.; Guzman, E.; Gurley, L.R.; Valdez, J.G.; Thompson, M.E.; Jackson, P.J.
Purification and characterization of O-acetylserine sulfhydrylase isoenzymes from Datura innoxia
J. Biol. Chem.
269
6223-6232
1994
Datura inoxia
Rolland, N.; Ruffet, M.L.; Job, D.; Douce, R.; Droux, M.
Spinach chloroplast 0-acetylserine (thiol)-lyase exhibits two catalytically non-equivalent pyridoxal-5 -phosphate-containing active sites
Eur. J. Biochem.
236
272-282
1996
Spinacia oleracea
Burkhard, P.; Rao, G.S.J.; Hohenester, E.; Schnackerz, K.D.; Cook, P.F.; Jansonius, J.N.
Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium
J. Mol. Biol.
283
121-133
1998
Salmonella enterica subsp. enterica serovar Typhimurium
Yamaguchi, T.; Zhu, X.; Masada, M.
Purification and characterization of a novel cysteine synthase isozyme from spinach hydrated seeds
Biosci. Biotechnol. Biochem.
62
501-507
1998
Spinacia oleracea
Zhu, X.; Yamaguchi, T.; Masada, M.
Complexes of serine acetyltransferase and isoenzymes of cysteine synthase in spinach leaves
Biosci. Biotechnol. Biochem.
62
947-952
1997
Spinacia oleracea
Droux, M.; Martin, J.; Sajus, P.; Douce, R.
Purification and characterization of O-acetylserine (thiol) lyase from spinach chloroplasts
Arch. Biochem. Biophys.
295
379-390
1992
Spinacia oleracea
Rolland, N.; Droux, M.; Lebrun, M.; Douce, R.
O-acetylserine(thiol)lyase from spinach (Spinacia oleracea L.) leaf: cDNA cloning, characterization, and overexpression in Escherichia coli of the chloroplast isoform
Arch. Biochem. Biophys.
300
213-222
1993
Spinacia oleracea
Tai, C.H.; Nalabolu, S.R.; Jacobson, T.M.; Minter, D.E.; Cook, P.F.
Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants
Biochemistry
32
6433-6442
1993
Salmonella enterica subsp. enterica serovar Typhimurium
Schnackerz, K.D.; Tai, C.H.; Simmons, J.W.; Jacobson, T.M.; Rao, G.S.J.; Cook, P.F.
Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction
Biochemistry
34
12152-12160
1995
Salmonella enterica subsp. enterica serovar Typhimurium
Owais, W.M.; Gharaibeh, R.
Cloning of the E. coli O-acetylserine sulfhydrylase gene: ability of the clone to produce a mutagenic product from azide and O-acetylserine
Mutat. Res.
245
151-155
1990
Escherichia coli
Ikegami, F.; Kamiya, M.; Kuo, Y.H.; Lambein, F.; Murakoshi, I.
Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species
Biol. Pharm. Bull.
19
1214-1215
1996
Lathyrus odoratus, Lathyrus sativus
Warrilow, A.G.S.; Hawkesford, M.J.
Cysteine synthase (O-acetylserine (thiol) lyase) substrate specificities classify the mitochondrial isoform as a cyanoalanine synthase
J. Exp. Bot.
51
985-993
2000
Spinacia oleracea
Romero, L.C.; Dominguez-Solis, J.R.; Gutierrez-Alcala, G.; Gotor, C.
Salt regulation of O-acetylserine(thiol)lyase in Arabidopsis thaliana and increased tolerance in yeast
Plant Physiol. Biochem.
39
643-647
2001
Arabidopsis thaliana
-
Tai, C.H.; Burkhard, P.; Gani, D.; Jenn, T.; Johnson, C.; Cook, P.F.
Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase
Biochemistry
40
7446-7452
2001
Salmonella enterica subsp. enterica serovar Typhimurium
Mino, K.; Yamanoue, T.; Sakiyama, T.; Eisaki, N.; Matsuyama, A.; Nakanishi, K.
Effects of bienzyme complex formation of cysteine synthetase from Escherichia coli on some properties and kinetics
Biosci. Biotechnol. Biochem.
64
1628-1640
2000
Escherichia coli
Mizuno, Y.; Miyashita, Y.; Yamagata, S.; Iwama, T.; Akamatsu, T.
Cysteine synthase of an extremely thermophilic bacterium, Thermus thermophilus HB8
Biosci. Biotechnol. Biochem.
66
549-557
2002
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Borup, B.; Ferry, J.G.
Cysteine biosynthesis in the Archaea: Methanosarcina thermophila utilizes O-acetylserine sulfhydrylase
FEMS Microbiol. Lett.
189
205-210
2000
Methanosarcina thermophila
Mino, K.; Ishikawa, K.
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1
J. Bacteriol.
185
2277-2284
2003
Aeropyrum pernix, Arabidopsis thaliana
Borup, B.; Ferry, J.G.
O-Acetylserine sulfhydrylase from Methanosarcina thermophila
J. Bacteriol.
182
45-50
2000
Methanosarcina thermophila
Burandt, P.; Schmidt, A.; Papenbrock, J.
Three O-acetyl-L-serine(thiol)lyase isoenzymes from Arabidopsis catalyse cysteine synthesis and cysteine desulfuration at different pH values
J. Plant Physiol.
159
111-119
2002
Arabidopsis sp.
-
Maruyama, A.; Saito, K.; Ishizawa, K.
beta-Cyanoalanine synthase and cysteine synthase from potato: molecular cloning, biochemical characterization, and spatial and hormonal regulation
Plant Mol. Biol.
46
749-760
2001
Solanum tuberosum
Bettati, S.; Benci, S.; Campanini, B.; Raboni, S.; Chirico, G.; Beretta, S.; Schnackerz, K.D.; Hazlett, T.L.; Gratton, E.; Mozzarelli, A.
Role of pyridoxal 5'-phosphate in the structural stabilization of O-acetylserine sulfhydrylase
J. Biol. Chem.
275
40244-40251
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Daum, S.; Tai, C.H.; Cook, P.F.
Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction
Biochemistry
42
106-113
2003
Salmonella enterica subsp. enterica serovar Typhimurium
Burkhard, P.; Tai, C.H.; Jansonius, J.N.; Cook, P.F.
Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound
J. Mol. Biol.
303
279-286
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Omura, H.; Kuroda, M.; Kobayashi, M.; Shimizu, S.; Yoshida, T.; Nagasawa, T.
Purification, characterization and gene cloning of thermostable O-acetyl-L-serine sulfhydrylase forming b-cyano-L-alanine
J. Biosci. Bioeng.
95
470-475
2003
Geobacillus stearothermophilus (Q84IF9)
Mino, K.; Oda, Y.; Ataka, M.; Ishikawa, K.
Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1
Acta Crystallogr. Sect. D
59
338-340
2003
Aeropyrum pernix
Claus, M.T.; Zocher, G.E.; Maier, T.H.; Schulz, G.E.
Structure of the O-acetylserine sulfhydrylase isoenzyme CysM from Escherichia coli
Biochemistry
44
8620-8626
2005
Escherichia coli (P16703), Escherichia coli
Saavedra, C.P.; Encinas, M.V.; Araya, M.A.; Perez, J.M.; Tantalean, J.C.; Fuentes, D.E.; Calderon, I.L.; Pichuantes, S.E.; Vasquez, C.C.
Biochemical characterization of a thermostable cysteine synthase from Geobacillus stearothermophilus V
Biochimie
86
481-485
2004
Geobacillus stearothermophilus
Wada, M.; Awano, N.; Yamazawa, H.; Takagi, H.; Nakamori, S.
Purification and characterization of O-acetylserine sulfhydrylase of Corynebacterium glutamicum
Biosci. Biotechnol. Biochem.
68
1581-1583
2004
Corynebacterium glutamicum
Kawashima, C.G.; Noji, M.; Nakamura, M.; Ogra, Y.; Suzuki, K.T.; Saito, K.
Heavy metal tolerance of transgenic tobacco plants over-expressing cysteine synthase
Biotechnol. Lett.
26
153-157
2004
Spinacia oleracea
Chronis, D.; Krishnan, H.B.
Sulfur assimilation in soybean: molecular cloning and characterization of O-acetylserine (thiol) lyase (cysteine synthase)
Crop Sci.
43
1819-1827
2003
Glycine max (Q8W1A0)
-
Lithgow, J.K.; Hayhurst, E.J.; Cohen, G.; Aharonowitz, Y.; Foster, S.J.
Role of a cysteine synthase in Staphylococcus aureus
J. Bacteriol.
186
1579-1590
2004
Staphylococcus aureus, Staphylococcus aureus SH1000
Huang, B.; Vetting, M.W.; Roderick, S.L.
The active site of O-acetylserine sulfhydrylase is the anchor point for bienzyme complex formation with serine acetyltransferase
J. Bacteriol.
187
3201-3205
2005
Haemophilus influenzae
Campanini, B.; Raboni, S.; Vaccari, S.; Zhang, L.; Cook, P.F.; Hazlett, T.L.; Mozzarelli, A.; Bettati, S.
Surface-exposed tryptophan residues are essential for O-acetylserine sulfhydrylase structure, function, and stability
J. Biol. Chem.
278
37511-37519
2003
Salmonella enterica subsp. enterica serovar Typhimurium
Bonner, E.R.; Cahoon, R.E.; Knapke, S.M.; Jez, J.M.
Molecular basis of cysteine biosynthesis in plants: Structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana
J. Biol. Chem.
280
38803-38813
2005
Arabidopsis thaliana
Wirtz, M.; Droux, M.; Hell, R.
O-acetylserine (thiol) lyase: an enigmatic enzyme of plant cysteine biosynthesis revisited in Arabidopsis thaliana
J. Exp. Bot.
55
1785-1798
2004
Arabidopsis thaliana
Fediuc, E.; Lips, S.H.; Erdei, L.
O-acetylserine (thiol) lyase activity in Phragmites and Typha plants under cadmium and NaCl stress conditions and the involvement of ABA in the stress response
J. Plant Physiol.
162
865-872
2005
Typha latifolia, Phragmites australis
Heine, A.; Canaves, J.M.; Von Delft, F.; Brinen, L.S.; Dai, X.; Deacon, A.M.; Elsliger, M.A.; Eshaghi, S.; Floyd, R.; Godzik, A.; Grittini, C.; Grzechnik, S.K.; Guda, C.; Jaroszewski, L.; Karlak, C.; Klock, H.E.; Koesema, E.; Kovarik, J.S.; Kreusch, A.; Kuhn, P.; Lesley, S.A.; McMullan, D.; McPhillips, T.M.; Miller, M.A.; Miller, M.D.; Morse, A.; Moy, K.; Ouyang, J.; Page, R.; Robb, A.; Rodrigues, K.; Schwarzenbacher, R.; Selby, T.L.; Spraggon, G.; Stevens, R.C.; Van Den Bedem, H.; Velasquez, J.; Vincent, J.; Wang, X.; West, B.; Wolf, G.; Hodgson, K.O.; Wooley, J.; Wilson, I.A.
Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution
Proteins Struct. Funct. Bioinform.
56
387-391
2004
Thermotoga maritima
Liszewska, F.; Gaganidze, D.; Sirko, A.
Isolation of Nicotiana plumbaginifolia cDNAs encoding isoforms of serine acetyltransferase and O-acetylserine (thiol) lyase in a yeast two-hybrid system with Escherichia coli cysE and cysK genes as baits
Acta Biochim. Pol.
52
117-128
2005
Nicotiana plumbaginifolia (Q6STL6), Nicotiana plumbaginifolia
Krishna, C.; Jain, R.; Kashav, T.; Wadhwa, D.; Alam, N.; Gourinath, S.
Crystallization and preliminary crystallographic analysis of cysteine synthase from Entamoeba histolytica
Acta Crystallogr. Sect. F
F63
512-515
2007
Entamoeba histolytica
Rabeh, W.M.; Alguindigue, S.S.; Cook, P.F.
Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction
Biochemistry
44
5541-5550
2005
Salmonella enterica subsp. enterica serovar Typhimurium
Kumaran, S.; Jez, J.M.
Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase
Biochemistry
46
5586-5594
2007
Arabidopsis thaliana
Chattopadhyay, A.; Meier, M.; Ivaninskii, S.; Burkhard, P.; Speroni, F.; Campanini, B.; Bettati, S.; Mozzarelli, A.; Rabeh, W.M.; Li, L.; Cook, P.F.
Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes
Biochemistry
46
8315-8330
2007
Salmonella enterica subsp. enterica serovar Typhimurium (P0A1E3), Salmonella enterica subsp. enterica serovar Typhimurium (P29848), Salmonella enterica subsp. enterica serovar Typhimurium
Liszewska, F.; Lewandowska, M.; Plochocka, D.; Sirko, A.
Mutational analysis of O-acetylserine (thiol) lyase conducted in yeast two-hybrid system
Biochim. Biophys. Acta
1774
450-455
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae P169-4A
Ramirez, A.; Castaneda, M.; Xiqui, M.L.; Sosa, A.; Baca, B.E.
Identification, cloning and characterization of cysK, the gene encoding O-acetylserine (thiol)-lyase from Azospirillum brasilense, which is involved in tellurite resistance
FEMS Microbiol. Lett.
261
272-279
2006
Azospirillum brasilense (Q2PZM5), Azospirillum brasilense, Azospirillum brasilense Sp7 (Q2PZM5), Azospirillum brasilense Sp7
Albanesi, D.; Mansilla, M.C.; Schujman, G.E.; de Mendoza, D.
Bacillus subtilis cysteine synthetase is a global regulator of the expression of genes involved in sulfur assimilation
J. Bacteriol.
187
7631-7638
2005
Bacillus subtilis
Hullo, M.F.; Auger, S.; Soutourina, O.; Barzu, O.; Yvon, M.; Danchin, A.; Martin-Verstraete, I.
Conversion of methionine to cysteine in Bacillus subtilis and its regulation
J. Bacteriol.
189
187-197
2007
Bacillus subtilis
Westrop, G.D.; Goodall, G.; Mottram, J.C.; Coombs, G.H.
Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine
J. Biol. Chem.
281
25062-25075
2006
Trichomonas vaginalis
Schnell, R.; Oehlmann, W.; Singh, M.; Schneider, G.
Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis: Crystal structures of the enzyme - alpha -aminoacrylate intermediate and an enzyme-inhibitor complex
J. Biol. Chem.
282
23473-23481
2007
Mycobacterium tuberculosis
Zhang, C.; Meng, Q.; Gai, J.; Yu, D.
Cloning and functional characterization of an O-acetylserine(thiol)lyase-encoding gene in wild soybean (Glycine soja)
Mol. Biol. Rep.
35
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2008
Glycine max
Yamaguchi, Y.; Nakamura, T.; Tatsumi, Y.; Nakamura, K.; Sano, H.
Efficient assimilation of sulfide by transgenic rice plants over-expressing a rice cysteine synthase
Plant Biotechnol.
23
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2006
Oryza sativa (Q9XEA6)
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Meerak, J.; Akaracharanya, A.; Leepipatpiboon, N.; Chadchawan, S.; Kaothien-Nakayama, P.; Shinmyo, A.; Sano, H.
Simultaneous expression of serine acetyltransferase and cysteine synthase results in enhanced sulfate uptake and increased biomass in Ipomaea aquatica
Plant Biotechnol.
23
185-189
2006
Oryza sativa
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Francois, J.A.; Kumaran, S.; Jez, J.M.
Structural basis for interaction of O-acetylserine sulfhydrylase and serine acetyltransferase in the Arabidopsis cysteine synthase complex
Plant Cell
18
3647-3655
2006
Arabidopsis thaliana
Wirtz, M.; Hell, R.
Dominant-negative modification reveals the regulatory function of the multimeric cysteine synthase protein complex in transgenic tobacco
Plant Cell
19
625-639
2007
Nicotiana tabacum
Riemenschneider, A.; Riedel, K.; Hoefgen, R.; Papenbrock, J.; Hesse, H.
Impact of reduced O-acetylserine(thiol)lyase isoform contents on potato plant metabolism
Plant Physiol.
137
892-900
2005
Solanum tuberosum (O81154), Solanum tuberosum (O81155), Solanum tuberosum
Zhao, C.; Kumada, Y.; Imanaka, H.; Imamura, K.; Nakanishi, K.
Cloning, overexpression, purification, and characterization of O-acetylserine sulfhydrylase-B from Escherichia coli
Protein Expr. Purif.
47
607-613
2006
Escherichia coli
Campanini, B.; Speroni, F.; Salsi, E.; Cook, P.F.; Roderick, S.L.; Huang, B.; Bettati, S.; Mozzarelli, A.
Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy
Protein Sci.
14
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2005
Haemophilus influenzae
Yang, Q.; Wang, Y.; Zhang, J.; Shi, W.; Qian, C.; Peng, X.
Identification of aluminum-responsive proteins in rice roots by a proteomic approach: cysteine synthase as a key player in Al response
Proteomics
7
737-749
2007
Oryza sativa
Tai, C.H.; Rabeh, W.M.; Guan, R.; Schnackerz, K.D.; Cook, P.F.
Role of histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction
Arch. Biochem. Biophys.
472
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2008
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium DW378
Tai, C.H.; Rabeh, W.M.; Guan, R.; Schnackerz, K.D.; Cook, P.F.
Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium
Biochim. Biophys. Acta
1784
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2008
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium DW378
Zocher, G.; Wiesand, U.; Schulz, G.E.
High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli
FEBS J.
274
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Escherichia coli
Feldman-Salit, A.; Wirtz, M.; Hell, R.; Wade, R.C.
A mechanistic model of the cysteine synthase complex
J. Mol. Biol.
386
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2009
Escherichia coli (P16703), Escherichia coli, Arabidopsis thaliana (P47998), Arabidopsis thaliana
Pajuelo, E.; Carrasco, J.A.; Romero, L.C.; Chamber, M.A.; Gotor, C.
Evaluation of the metal phytoextraction potential of crop legumes. Regulation of the expression of O-acetylserine (thiol)lyase under metal stress
Plant Biol.
9
672-681
2007
Lotus japonicus, Medicago sativa
Moontongchoon, P.; Chadchawan, S.; Leepipatpiboon, N.; Akaracharanya, A.; Shinmyo, A.; Sano, H.
Cadmium-tolerance of transgenic Ipomoea aquatica expressing serine acetyltransferase and cysteine synthase
Plant Biotechnol.
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Oryza sativa
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Heeg, C.; Kruse, C.; Jost, R.; Gutensohn, M.; Ruppert, T.; Wirtz, M.; Hell, R.
Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis
Plant Cell
20
168-185
2008
Arabidopsis thaliana
Lopez-Martin, M.C.; Becana, M.; Romero, L.C.; Gotor, C.
Knocking out cytosolic cysteine synthesis compromises the antioxidant capacity of the cytosol to maintain discrete concentrations of hydrogen peroxide in Arabidopsis
Plant Physiol.
147
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2008
Arabidopsis thaliana
Chinthalapudi, K.; Kumar, M.; Kumar, S.; Jain, S.; Alam, N.; Gourinath, S.
Crystal structure of native O-acetyl-serine sulfhydrylase from Entamoeba histolytica and its complex with cysteine: structural evidence for cysteine binding and lack of interactions with serine acetyl transferase
Proteins
72
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2008
Entamoeba histolytica, Entamoeba histolytica (O15570)
Brzywczy, J.; Natorff, R.; Sie?ko, M.; Paszewski, A.
Multiple fungal enzymes possess cysteine synthase activity in vitro
Res. Microbiol.
158
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2007
Aspergillus nidulans
Guan, R.; Nimmo, S.A.; Schnackerz, K.D.; Cook, P.F.
(31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium
Arch. Biochem. Biophys.
487
85-90
2009
Salmonella enterica subsp. enterica serovar Typhimurium
Ning, H.; Zhang, C.; Yao, Y.; Yu, D.
Overexpression of a soybean O-acetylserine (thiol) lyase-encoding gene GmOASTL4 in tobacco increases cysteine levels and enhances tolerance to cadmium stress
Biotechnol. Lett.
32
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2010
Glycine max (A3RM06), Glycine max
Zheng, C.; Nie, L.; Qian, L.; Wang, Z.; Liu, G.; Liu, J.
K30, H150, and H168 Are Essential Residues for Coordinating Pyridoxal 5-Phosphate of O-Acetylserine Sulfhydrylase from Acidithiobacillus ferrooxidans
Curr. Microbiol.
60
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Acidithiobacillus ferrooxidans, Acidithiobacillus ferrooxidans ATCC 23270
Ozaki, S.; Nakahara, A.; Sakaguchi, C.
Mutagenesis of Gln-142 and Phe-143 of O-acetylserine sulfhydrylase
J. Biochem. Mol. Biol. Biophys.
4
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Escherichia coli
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Kumaran, S.; Yi, H.; Krishnan, H.B.; Jez, J.M.
Assembly of the cysteine synthase complex and the regulatory role of protein-protein interactions
J. Biol. Chem.
284
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Glycine max (Q8W1A0), Glycine max
Salsi, E.; Campanini, B.; Bettati, S.; Raboni, S.; Roderick, S.L.; Cook, P.F.; Mozzarelli, A.
A two-step process controls the formation of the bienzyme cysteine synthase complex
J. Biol. Chem.
285
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2010
Haemophilus influenzae
Salsi, E.; Bayden, A.S.; Spyrakis, F.; Amadasi, A.; Campanini, B.; Bettati, S.; Dodatko, T.; Cozzini, P.; Kellogg, G.E.; Cook, P.F.; Roderick, S.L.; Mozzarelli, A.
Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature
J. Med. Chem.
53
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2010
Haemophilus influenzae, Haemophilus influenzae (P45040)
Bermudez, M.A.; Paez-Ochoa, M.A.; Gotor, C.; Romero, L.C.
Arabidopsis S-sulfocysteine synthase activity is essential for chloroplast function and long-day light-dependent redox control
Plant Cell
22
403-416
2010
Arabidopsis thaliana
Zhang, C.; Meng, Q.; Zhang, M.; Huang, F.; Gai, J.; Yu, D.
Characterization of O-acetylserine(thiol)lyase-encoding genes reveals their distinct but cooperative expression in cysteine synthesis of soybean [Glycine max (L.) Merr.]
Plant Mol. Biol. Rep.
26
277-291
2008
Glycine max (A3RM03), Glycine max (A3RM04), Glycine max (A3RM05), Glycine max (A3RM06), Glycine max (A5YT86), Glycine max (A5YT88)
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Ozaki, S.; Yoshiya, M.
Mutagenesis of arginine-186 located on a helix interacting with pyridoxal 5'-phosphate in O-acetylserine sulfhydrylase
Asian J. Biochem.
3
351-358
2008
Salmonella enterica subsp. enterica serovar Typhimurium
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Fyfe, P.K.; Westrop, G.D.; Ramos, T.; Mueller, S.; Coombs, G.H.; Hunter, W.N.
Structure of Leishmania major cysteine synthase
Acta Crystallogr. Sect. F
68
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2012
Leishmania major
Wirtz, M.; Heeg, C.; Samami, A.A.; Ruppert, T.; Hell, R.
Enzymes of cysteine synthesis show extensive and conserved modifications patterns that include Nalpha-terminal acetylation
Amino Acids
39
1077-1086
2010
Arabidopsis thaliana
Uda, N.; Matoba, Y.; Kumagai, T.; Oda, K.; Noda, M.; Sugiyama, M
. Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway
Antimicrob. Agents Chemother.
57
2603-2612
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Streptomyces lavendulae (D2Z027), Streptomyces lavendulae ATCC 11924 (D2Z027)
Bogicevic, B.; Berthoud, H.; Portmann, R.; Meile, L.; Irmler, S.
CysK from Lactobacillus casei encodes a protein with O-acetylserine sulfhydrylase and cysteine desulfurization activity
Appl. Microbiol. Biotechnol.
94
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2012
Lacticaseibacillus casei (E5LPF4), Lacticaseibacillus casei
Tian, H.; Guan, R.; Salsi, E.; Campanini, B.; Bettati, S.; Kumar, V.P.; Karsten, W.E.; Mozzarelli, A.; Cook, P.F.
Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A
Biochemistry
49
6093-6103
2010
Salmonella enterica (P0A1E3)
Spyrakis, F.; Felici, P.; Bayden, A.S.; Salsi, E.; Miggiano, R.; Kellogg, G.E.; Cozzini, P.; Cook, P.F.; Mozzarelli, A.; Campanini, B.
Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase
Biochim. Biophys. Acta
1834
169-181
2013
Haemophilus influenzae (P45040), Haemophilus influenzae, Salmonella enterica (P0A1E3)
Jean Kumar, V.U.; Poyraz, O.; Saxena, S.; Schnell, R.; Yogeeswari, P.; Schneider, G.; Sriram, D.
Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening
Bioorg. Med. Chem. Lett.
23
1182-1186
2013
Mycobacterium tuberculosis (P9WP55), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WP55)
Shibagaki, N.; Grossman, A.R.
Binding of cysteine synthase to the STAS domain of sulfate transporter and its regulatory consequences
J. Biol. Chem.
285
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Arabidopsis thaliana
Alvarez, C.; Lozano-Juste, J.; Romero, L.C.; Garcia, I.; Gotor, C.; Leon, J.
Inhibition of Arabidopsis O-acetylserine(thiol)lyase A1 by tyrosine nitration
J. Biol. Chem.
286
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Arabidopsis thaliana
Wirtz, M.; Beard, K.F.; Lee, C.P.; Boltz, A.; Schwarzlaender, M.; Fuchs, C.; Meyer, A.J.; Heeg, C.; Sweetlove, L.J.; Ratcliffe, R.G.; Hell, R.
Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants
J. Biol. Chem.
287
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Arabidopsis thaliana
Wang, T.; Leyh, T.S.
Three-stage assembly of the cysteine synthase complex from Escherichia coli
J. Biol. Chem.
287
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2012
Escherichia coli
Nakamura, T.; Kawai, Y.; Kunimoto, K.; Iwasaki, Y.; Nishii, K.; Kataoka, M.; Ishikawa, K.
Structural analysis of the substrate recognition mechanism in O-phosphoserine sulfhydrylase from the hyperthermophilic archaeon Aeropyrum pernix K1
J. Mol. Biol.
422
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2012
Aeropyrum pernix (Q9YBL2)
Bermudez, M.A.; Galmes, J.; Moreno, I.; Mullineaux, P.M.; Gotor, C.; Romero, L.C.
Photosynthetic adaptation to length of day is dependent on S-sulfocysteine synthase activity in the thylakoid lumen
Plant Physiol.
160
274-288
2012
Arabidopsis thaliana
Gotor, C.; Romero, L.C.
S-sulfocysteine synthase function in sensing chloroplast redox status
Plant Signal. Behav.
8
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Arabidopsis thaliana (O22682), Arabidopsis thaliana
Nagpal, I.; Raj, I.; Subbarao, N.; Gourinath, S.
Virtual screening, identification and in vitro testing of novel inhibitors of O-acetyl-L-serine sulfhydrylase of Entamoeba histolytica
PLoS ONE
7
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2012
Entamoeba histolytica (O15570), Entamoeba histolytica
Feldman-Salit, A.; Wirtz, M.; Lenherr, E.D.; Throm, C.; Hothorn, M.; Scheffzek, K.; Hell, R.; Wade, R.C.
Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana
Structure
20
292-302
2012
Arabidopsis thaliana
Nakatani, T.; Ohtsu, I.; Nonaka, G.; Wiriyathanawudhiwong, N.; Morigasaki, S.; Takagi, H.
Enhancement of thioredoxin/glutaredoxin-mediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli
Microb. Cell Fact.
11
62
2012
Escherichia coli, Escherichia coli BW25113
Liao, N.; Yao, J.; Li, H.
Identification and bioinformatics analysis of cysteine synthase from the filamentous fungus, Monascus purpureus
AIDS Res. Hum. Retroviruses
522-524
272-275
2014
Monascus purpureus
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Romero, I.; Tellez, J.; Romanha, A.J.; Steindel, M.; Grisard, E.C.
Upregulation of cysteine synthase and cystathionine beta-synthase contributes to Leishmania braziliensis survival under oxidative stress
Antimicrob. Agents Chemother.
59
4770-4781
2015
Leishmania braziliensis (A4HPM6), Leishmania braziliensis, Leishmania braziliensis MHOM/BR/75/M2904 (A4HPM6)
Yafuso, J.T.; Negi, V.S.; Bingham, J.P.; Borthakur, D.
An O-acetylserine (thiol) lyase from Leucaena leucocephala is a cysteine synthase but not a mimosine synthase
Appl. Biochem. Biotechnol.
173
1157-1168
2014
Leucaena leucocephala (W5S3I4), Leucaena leucocephala
Lu, M.; Xu, B.Y.; Zhou, K.; Cheng, W.; Jiang, Y.L.; Chen, Y.; Zhou, C.Z.
Structural and biochemical analyses of Microcystis aeruginosa O-acetylserine sulfhydrylases reveal a negative feedback regulation of cysteine biosynthesis
Biochim. Biophys. Acta
1844
308-315
2014
Microcystis aeruginosa (A8YBP8), Microcystis aeruginosa (A8YBS4), Microcystis aeruginosa
Campanini, B.; Benoni, R.; Bettati, S.; Beck, C.M.; Hayes, C.S.; Mozzarelli, A.
Moonlighting O-acetylserine sulfhydrylase: new functions for an old protein
Biochim. Biophys. Acta
1854
1184-1193
2015
Arabidopsis thaliana (P47998), Bacillus subtilis (P37887), Caenorhabditis elegans (Q93244), Entamoeba histolytica (Q401L7), Escherichia coli (P0ABK5), Escherichia coli, Glycine max (A3RM03), Haemophilus influenzae (P45040), Mycobacterium tuberculosis (P9WP55), Salmonella enterica subsp. enterica serovar Typhimurium (P0A1E3), Staphylococcus aureus
Singh, S.; Sablok, G.; Farmer, R.; Singh, A.K.; Gautam, B.; Kumar, S.
Molecular dynamic simulation and inhibitor prediction of cysteine synthase structured model as a potential drug target for trichomoniasis
BioMed Res. Int.
2013
390920
2013
Trichomonas vaginalis (A2GMG5)
Nakamura, T.; Asai, S.; Nakata, K.; Kunimoto, K.; Oguri, M.; Ishikawa, K.
Thermostability and reactivity in organic solvent of O-phospho-L-serine sulfhydrylase from hyperthermophilic archaeon Aeropyrum pernix K1
Biosci. Biotechnol. Biochem.
79
1280-1286
2015
Escherichia coli, Escherichia coli W3110 / ATCC 27325
Uda, N.; Matoba, Y.; Oda, K.; Kumagai, T.; Sugiyama, M.
The structural and mutational analyses of O-ureido-L-serine synthase necessary for D-cycloserine biosynthesis
FEBS J.
282
3929-3944
2015
Streptomyces lavendulae (D2Z027), Streptomyces lavendulae, Streptomyces lavendulae ATCC 11924 (D2Z027)
Benoni, R.; Pertinhez, T.A.; Spyrakis, F.; Davalli, S.; Pellegrino, S.; Paredi, G.; Pezzotti, A.; Bettati, S.; Campanini, B.; Mozzarelli, A.
Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR
FEBS Lett.
590
943-953
2016
Salmonella enterica subsp. enterica serovar Typhimurium (P0A1E3), Salmonella enterica subsp. enterica serovar Typhimurium (P29848), Salmonella enterica subsp. enterica serovar Typhimurium, Haemophilus influenzae (P45040)
Mori, M.; Jeelani, G.; Masuda, Y.; Sakai, K.; Tsukui, K.; Waluyo, D.; Tarwadi, D.; Watanabe, Y.; Nonaka, K.; Matsumoto, A.; Omura, S.; Nozaki, T.; Shiomi, K.
Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolites
Front. Microbiol.
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962
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no activity in Homo sapiens, Entamoeba histolytica (O15635), Entamoeba histolytica (Q401L7), Entamoeba histolytica
Poyraz, O.; Jeankumar, V.U.; Saxena, S.; Schnell, R.; Haraldsson, M.; Yogeeswari, P.; Sriram, D.; Schneider, G.
Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis
J. Med. Chem.
56
6457-6466
2013
Mycobacterium tuberculosis (P9WP55), Mycobacterium tuberculosis
Pieroni, M.; Annunziato, G.; Beato, C.; Wouters, R.; Benoni, R.; Campanini, B.; Pertinhez, T.A.; Bettati, S.; Mozzarelli, A.; Costantino, G.
Rational design, synthesis, and preliminary structure-activity relationships of alpha-substituted-2-phenylcyclopropane carboxylic acids as inhibitors of Salmonella typhimurium O-acetylserine sulfhydrylase
J. Med. Chem.
59
2567-2578
2016
Salmonella enterica subsp. enterica serovar Typhimurium (P0A1E3), Salmonella enterica subsp. enterica serovar Typhimurium (P29848), Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P0A1E3), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P29848)
Yadava, U.; Shukla, B.K.; Roychoudhury, M.; Kumar, D.
Pyrazolo[3,4-d]pyrimidines as novel inhibitors of O-acetyl-L-serine sulfhydrylase of Entamoeba histolytica: an in silico study
J. Mol. Model.
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96
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Entamoeba histolytica
Salbitani, G.; Wirtz, M.; Hell, R.; Carfagna, S.
Affinity purification of O-acetylserine(thiol)lyase from Chlorella sorokiniana by recombinant proteins from Arabidopsis thaliana
Metabolites
4
629-639
2014
Chlorella sorokiniana, Chlorella sorokiniana 211/8 K
Tahir, J.; Watanabe, M.; Jing, H.; Hunter, D.; Tohge, T.; Nunes-Nesi, A.; Brotman, Y.; Fernie, A.; Hoefgen, R.; Dijkwel, P.
Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis
Plant J.
73
118-130
2013
Arabidopsis thaliana (P47998)
Birke, H.; Heeg, C.; Wirtz, M.; Hell, R.
Successful fertilization requires the presence of at least one major O-acetylserine(thiol)lyase for cysteine synthesis in pollen of Arabidopsis
Plant Physiol.
163
959-972
2013
Arabidopsis thaliana (P47998), Arabidopsis thaliana (P47999), Arabidopsis thaliana (Q43725)
Wawrzynska, A.; Kurzyk, A.; Mierzwinska, M.; Plochocka, D.; Wieczorek, G.; Sirko, A.
Direct targeting of Arabidopsis cysteine synthase complexes with synthetic polypeptides to selectively deregulate cysteine synthesis
Plant Sci.
207
148-157
2013
Arabidopsis thaliana (Q43725), Arabidopsis thaliana
Spyrakis, F.; Singh, R.; Cozzini, P.; Campanini, B.; Salsi, E.; Felici, P.; Raboni, S.; Benedetti, P.; Cruciani, G.; Kellogg, G.E.; Cook, P.F.; Mozzarelli, A.
Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target
PLoS ONE
8
e77558
2013
Salmonella enterica subsp. enterica serovar Typhimurium (P0A1E3), Salmonella enterica subsp. enterica serovar Typhimurium (P29848), Salmonella enterica subsp. enterica serovar Typhimurium
Qabazard, B.; Ahmed, S.; Li, L.; Arlt, V.M.; Moore, P.K.; Stuerzenbaum, S.R.
C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2
PLoS ONE
8
e80135
2013
Caenorhabditis elegans (O45679), Caenorhabditis elegans
Jain, S.; Afley, P.; Kumar, S.
Immunological responses to recombinant cysteine synthase A of Brucella abortus in BALB/c mice
World J. Microbiol. Biotechnol.
29
907-913
2013
Brucella abortus (C4ITG6), Brucella abortus
Brunner, K.; Steiner, E.M.; Reshma, R.S.; Sriram, D.; Schnell, R.; Schneider, G.
Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis
Bioorg. Med. Chem. Lett.
27
4582-4587
2017
Mycobacterium tuberculosis (Q79FV4), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (Q79FV4)
Devi, S.; Abdul Rehman, S.A.; Tarique, K.F.; Gourinath, S.
Structural characterization and functional analysis of cystathionine beta-synthase an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis
FEBS J.
284
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2017
Bacillus anthracis (A0A1J9VES8), Bacillus anthracis
Matoba, Y.; Yoshida, T.; Izuhara-Kihara, H.; Noda, M.; Sugiyama, M.
Crystallographic and mutational analyses of cystathionine beta-synthase in the H2S-synthetic gene cluster in Lactobacillus plantarum
Protein Sci.
26
763-783
2017
Lactiplantibacillus plantarum (F9UT54), Lactiplantibacillus plantarum ATCC BAA-793 (F9UT54)
Chakraborty, S.; Mitra, J.; Samanta, M.K.; Sikdar, N.; Bhattacharyya, J.; Manna, A.; Pradhan, S.; Chakraborty, A.; Pati, B.R.
Tissue specific expression and in-silico characterization of a putative cysteine synthase gene from Lathyrus sativus L.
Gene Expr. Patterns
27
128-134
2018
Lathyrus sativus (A0A2H5HU77), Lathyrus sativus
Dharavath, S.; Raj, I.; Gourinath, S.
Structure-based mutational studies of O-acetylserine sulfhydrylase reveal the reason for the loss of cysteine synthase complex formation in Brucella abortus
Biochem. J.
474
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2017
Brucella abortus (A0A0F6AQU1), Brucella abortus, Brucella abortus S19 (A0A0F6AQU1)
Mothersole, R.; Wolthers, K.
Structural and kinetic insight into the biosynthesis of H2S and L-lanthionine from L-cysteine by a pyridoxal L-phosphate-dependent enzyme from Fusobacterium nucleatum
Biochemistry
58
3592-3603
2019
Fusobacterium nucleatum subsp. nucleatum, Fusobacterium nucleatum subsp. nucleatum ATCC 25586
Noda, M.; Nakamura, M.; Takamiya, R.; Tamura, T.; Ito, T.; Kodama, H.
A spinach O-acetylserine(thiol)lyase homologue, SoCSaseLP, suppresses cysteine biosynthesis catalysed by other enzyme isoforms
Biochim. Open
2
24-32
2016
Spinacia oleracea (Q767A2), Spinacia oleracea
Singh, K.; Singh, K.P.; Equbal, A.; Suman, S.S.; Zaidi, A.; Garg, G.; Pandey, K.; Das, P.; Ali, V.
Interaction between cysteine synthase and serine O-acetyltransferase proteins and their stage specific expression in Leishmania donovani
Biochimie
131
29-44
2016
Leishmania donovani (G1C2I2), Leishmania donovani
Ma, W.; Wang, J.; Li, Y.; Wang, X.
Cysteine synthase A overexpression in Corynebacterium glutamicum enhances L-isoleucine production
Biotechnol. Appl. Biochem.
66
74-81
2019
Corynebacterium glutamicum, Corynebacterium glutamicum IWJ001
Benoni, R.; De Bei, O.; Paredi, G.; Hayes, C.S.; Franko, N.; Mozzarelli, A.; Bettati, S.; Campanini, B.
Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex
FEBS Lett.
591
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2017
Escherichia coli (P0ABK5), Escherichia coli, Escherichia coli K12 (P0ABK5)
Mori, M.; Tsuge, S.; Fukasawa, W.; Jeelani, G.; Nakada-Tsukui, K.; Nonaka, K.; Matsumoto, A.; Omura, S.; Nozaki, T.; Shiomi, K.
Discovery of antiamebic compounds that inhibit cysteine synthase from the enteric parasitic protist Entamoeba histolytica by screening of microbial secondary metabolites
Front. Cell. Infect. Microbiol.
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409
2018
Entamoeba histolytica, Entamoeba histolytica (Q401L7)
Khan, M.N.; AlZuaibr, F.M.; Al-Huqail, A.A.; Siddiqui, M.H.; Ali, H.M.; Al-Muwayhi, M.A.; Al-Haque, H.N.
Hydrogen sulfide-mediated activation of O-acetylserine (thiol) lyase and L/D-cysteine desulfhydrase enhance dehydration tolerance in Eruca sativa Mill
Int. J. Mol. Sci.
19
3981
2018
Eruca vesicaria subsp. sativa
Franko, N.; Grammatoglou, K.; Campanini, B.; Costantino, G.; Jirgensons, A.; Mozzarelli, A.
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives
J. Enzyme Inhib. Med. Chem.
33
1343-1351
2018
Salmonella enterica subsp. enterica serovar Typhimurium (P0A1E3), Salmonella enterica subsp. enterica serovar Typhimurium (P29848), Salmonella enterica subsp. enterica serovar Typhimurium
Magalhaes, J.; Franko, N.; Annunziato, G.; Welch, M.; Dolan, S.K.; Bruno, A.; Mozzarelli, A.; Armao, S.; Jirgensons, A.; Pieroni, M.; Costantino, G.; Campanini, B.
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design
J. Enzyme Inhib. Med. Chem.
33
1444-1452
2018
Salmonella enterica subsp. enterica serovar Typhimurium (P0A1E3), Salmonella enterica subsp. enterica serovar Typhimurium (P29848)
Wang, C.; Zheng, L.; Tang, Z.; Sun, S.; Ma, J.F.; Huang, X.Y.; Zhao, F.J.
OASTL-A1 functions as a cytosolic cysteine synthase and affects arsenic tolerance in rice
J. Exp. Bot.
71
3678-3689
2020
Oryza sativa Japonica Group (Q9XEA8)
Harun-Ur-Rashid, M.H.; Iwasaki, H.; Oogai, S.; Fukuta, M.; Parveen, S.; Hossain, M.A.; Anai, T.; Oku, H.
Molecular characterization of cytosolic cysteine synthase in Mimosa pudica
J. Plant Res.
131
319-329
2018
Mimosa pudica (F5HTD7), Mimosa pudica
Harun-Ur-Rashid, M.; Oogai, S.; Parveen, S.; Inafuku, M.; Iwasaki, H.; Fukuta, M.; Amzad Hossain, M.; Oku, H.
Molecular cloning of putative chloroplastic cysteine synthase in Leucaena leucocephala
J. Plant Res.
133
95-108
2020
Leucaena leucocephala, Leucaena leucocephala (A0A2Z6G0Q7)
Burton, N.O.; Riccio, C.; Dallaire, A.; Price, J.; Jenkins, B.; Koulman, A.; Miska, E.A.
Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
Nat. Commun.
11
1741
2020
Caenorhabditis elegans (O45679), Caenorhabditis elegans (Q93244), Caenorhabditis elegans
Shen, J.; Su, Y.; Zhou, C.; Zhang, F.; Zhou, H.; Liu, X.; Wu, D.; Yin, X.; Xie, Y.; Yuan, X.
A putative rice l-cysteine desulfhydrase encodes a true L-cysteine synthase that regulates plant cadmium tolerance
Plant Growth Regul.
89
217-226
2019
Oryza sativa Japonica Group (Q5JNT6)
-
Mueller, S.M.; Wang, S.; Telman, W.; Liebthal, M.; Schnitzer, H.; Viehhauser, A.; Sticht, C.; Delatorre, C.; Wirtz, M.; Hell, R.; Dietz, K.J.
The redox-sensitive module of cyclophilin 20-3, 2-cysteine peroxiredoxin and cysteine synthase integrates sulfur metabolism and oxylipin signaling in the high light acclimation response
Plant J.
91
995-1014
2017
Arabidopsis thaliana (P47999)
Singh, K.; Ali, V.; Pratap Singh, K.; Gupta, P.; Suman, S.S.; Ghosh, A.K.; Bimal, S.; Pandey, K.; Das, P.
Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress
Redox Biol.
12
350-366
2017
Leishmania donovani (G1C2I2), Leishmania donovani
Benoni, R.; Beck, C.M.; Garza-Sanchez, F.; Bettati, S.; Mozzarelli, A.; Hayes, C.S.; Campanini, B.
Activation of an anti-bacterial toxin by the biosynthetic enzyme CysK mechanism of binding, interaction specificity and competition with cysteine synthase
Sci. Rep.
7
8817
2017
Escherichia coli (P0ABK5), Escherichia coli, Escherichia coli K12 (P0ABK5)
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