Reference on EC 2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Radaev, S.; Dastidar, P.; Patel, M.; Woodard, R.W.; Gatti, D.L.
Structure and mechanism of 3-deoxy-D-manno-octulosonate 8-phosphate synthase
J. Biol. Chem.
275
9476-9484
2000
Escherichia coli
Howe, D.L.; Sundaram, A.K.; Wu, J.; Gatti, D.L.; Woodard, R.W.
Mechanistic insight into 3-deoxy-D-manno-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase utilizing phosphorylated monosaccharide analogues
Biochemistry
42
4843-4854
2003
Escherichia coli
Srinivasan, P.R.; Sprinson, D.B.
2-Keto-3-deoxy-D-arabo-heptonic acid 7-phosphate synthetase
J. Biol. Chem.
234
716-722
1954
Escherichia coli
Grisch, H.; Lingens, F.
2-Deoxy-D-arabino-heptulosonate-7-phosphate synthase of Streptomyces aureofaciens T 24
Biochim. Biophys. Acta
242
617-629
1971
Kitasatospora aureofaciens, Kitasatospora aureofaciens Tu24
Grisch, H.; Lingens, F.
3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase of Streptomyces aureofaciens T 24
Biochim. Biophys. Acta
242
630-636
1971
Kitasatospora aureofaciens, Kitasatospora aureofaciens Tu24
DeLeo, A.B.; Dayan, J.; Sprinson, D.B.
Purification and kinetics of tyrosine-sensitive 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthetase from Salmonella
J. Biol. Chem.
248
2344-2353
1973
Salmonella enterica subsp. enterica serovar Typhimurium
Friedrich, C.G.; Schlegel, H.G.
Aromatic amino acid biosynthesis in Alcaligenes eutrophus H16. I. Properties and regulation of 3-deoxy-D-arabino heptulosonate 7-phosphate synthase
Arch. Microbiol.
103
133-140
1975
Cupriavidus necator, Alcaligenes faecalis, Xanthobacter autotrophicus, Xanthobacter autotrophicus 7C, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
Dusha, I.; Dnes, G.
Purification and properties of tyrosine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthetase of Escherichia coli K12
Biochim. Biophys. Acta
438
563-573
1976
Escherichia coli
Schoner, R.; Herrmann, K.M.
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase. Purification, properties, and kinetics of the tyrosine-sensitive isoenzyme from Escherichia coli
J. Biol. Chem.
251
5440-5447
1976
Escherichia coli
Simpson, R.J.; Davidson, B.E.
Studies on 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe) from Escherichia coli. Purification and subunit structure
Eur. J. Biochem.
70
493-500
1976
Escherichia coli
Simpson, R.J.; Davidson, B.E.
Studies on 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe) from Escherichia coli K12. 2. Kinetic properties
Eur. J. Biochem.
70
501-507
1976
Escherichia coli
Simpson, R.J.; Davidson, B.E.
Studies on 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe) from Escherichia coli K12. 3. Structural studies
Eur. J. Biochem.
70
509-516
1976
Escherichia coli
Hu, Ch.Y.; Sprinson, D.B.
Properties of tyrosine-inhibitable 3-deoxy-D-arabinoheptulosonic acid-7-phosphate synthase from Salmonella
J. Bacteriol.
129
177-183
1977
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium SG12
Bracher, M.; Schweingruber, M.E.
Purification of the tyrosine inhibitable 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Schizosaccharomyces pombe
Biochim. Biophys. Acta
485
446-451
1977
Schizosaccharomyces pombe
McCandliss, R.J.; Poling, M.D.; Herrmann, K.M.
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase. Purification and molecular characterization of the phenylalanine-sensitive isoenzyme from Escherichia coli
J. Biol. Chem.
253
4259-4265
1978
Escherichia coli, Escherichia coli HE 401
Ganson, R.J.; Jensen, R.A.
The essential role of cobalt in the inhibition of the cytosolic isoenzyme of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Nicotiana silvestris by glyphosate
Arch. Biochem. Biophys.
260
85-93
1988
Nicotiana sylvestris
Pinto, J.E.B.P.; Dyer, W.E.; Weller, S.C.; Herrmann, K.M.
Glyphosate induces 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in potato (Solanum tuberosum L.) Cells grown in suspension culture
Plant Physiol.
87
891-893
1988
Solanum tuberosum
Pinto, J.E.B.P.; Suzich, J.A.; Herrmann, K.M.
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from potato tuber (Solanum tuberosum L.)
Plant Physiol.
82
1040-1044
1986
Solanum tuberosum
Teshiba, S.; Furter, R.; Niederberger, P.; Braus, G.; Paravicini, G.; Htter, R.
Cloning of the ARO3 gene of Saccharomyces cerevisiae and its regulation
Mol. Gen. Genet.
205
353-357
1986
Saccharomyces cerevisiae
Suzich, J.A.; Dean, J.F.D.; Herrmann, K.M.
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from carrot root (Daucus carota) is a hysteretic enzyme
Plant Physiol.
79
765-770
1985
Daucus carota
Berry, A.; Johnson, J.L.; Jensen, R.A.
Phenylalanine hydroxylase and isozymes of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in relationship to the phylogenetic position of Pseudomonas acidovorans (Ps. Sp. ATCC 11299a)
Arch. Microbiol.
141
32-39
1985
Delftia acidovorans, Comamonas testosteroni, Hydrogenophaga palleronii
Whitaker, R.J.; Fiske, M.J.; Jensen, R.A.
Pseudomonas aeruginosa possesses two novel regulatory isozymes of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
J. Biol. Chem.
257
12789-12794
1982
Pseudomonas aeruginosa
Reinink, M.; Borstlap, A.C.
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from pea leaves: inhibition by L-tyrosine
Plant Sci. Lett.
26
167-171
1982
Pisum sativum
-
Nimmo, G.A.; Coggins, J.R.
Some kinetic properties of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Neurospora crassa
Biochem. J.
199
657-665
1981
Neurospora crassa
Nimmo, G.A.; Coggins, J.R.
The purification and molecular properties of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Neurospora crassa
Biochem. J.
197
427-436
1981
Neurospora crassa, Neurospora crassa 74-OR23-1A
Ip, K.M.; Doy, C.H.
The kinetic of a purified form of 3-deoxy-D-arabino heptulosonate-7-phosphate synthase (tryptophan) from Neurospora crassa
Eur. J. Biochem.
98
431-440
1979
Neurospora crassa, Neurospora crassa 74A
Suzuki, N.; Sakuta, M.; Shimizu, S.
Purification and characterization of a cytosolic isozyme of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from cultured carrot cells
J. Plant Physiol.
149
19-22
1996
Daucus carota
-
Schnappauf, G.; Hartmann, M.; Knzler, M.; Braus, G.H.
The two 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isoenzymes from Saccharomyces cerevisiae show different kinetic modes of inhibition
Arch. Microbiol.
169
517-524
1998
Saccharomyces cerevisiae
Akowski, J.P.; Bauerle, R.
Steady state kinetics and inhibitor binding of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tryptophan sensitive) from Escherichia coli
Biochemistry
36
15817-15822
1997
Escherichia coli
Ray, J.M.; Bauerle, R.
Purification and properties of tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli
J. Bacteriol.
173
1894-1901
1991
Escherichia coli
Tianhui, X.; Chiao, J.S.
Purification and properties of DAHP synthase from Nocardia mediterranei
Biochim. Biophys. Acta
991
1-5
1989
Amycolatopsis mediterranei, Amycolatopsis mediterranei U-32
Paravicini, G.; Schmidheini, T.; Braus, G.
Purification and properties of the 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (phenylalanine-inhibitable) of Saccharomyces cerevisiae
Eur. J. Biochem.
186
361-366
1989
Saccharomyces cerevisiae
Park, O.K.; Bauerle, R.
Metal-catalyzed oxidation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli: inactivation and destabilization by oxidation of active-site cysteine
J. Bacteriol.
181
1636-1642
1999
Escherichia coli
Keith, B.; Dong, X.; Ausubel, F.M.; Fink, G.R.
Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack
Proc. Natl. Acad. Sci. USA
88
8821-8825
1991
Arabidopsis thaliana, Solanum tuberosum
McCue, K.F.; Conn, E.E.
Induction of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase activity by fungal elicitor in cultures of Petroselinum crispum
Proc. Natl. Acad. Sci. USA
86
7374-7377
1989
Petroselinum crispum
Sheflyan, G.Y.; Howe, D.L.; Wilson, T.L.; Woodard, R.W.
Enzymatic synthesis of 3-deoxy-D-manno-octulosonate 8-phosphate 3-deoxy-D-altro-octulosonate 8-phosphate, 3,5-dideoxy-D-gluco(manno)-octulosonate 8-phosphate by 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
J. Am. Chem. Soc.
120
11027-11032
1998
Escherichia coli
-
Stephens, C.M.; Bauerle, R.
Analysis of the metal requirement of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli
J. Biol. Chem.
266
20810-20817
1991
Escherichia coli
Shumilin, I.A.; Kretsinger, R.H.; Bauerle, R.
Purification, crystallization, and preliminary crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli
Proteins Struct. Funct. Genet.
24
404-406
1996
Escherichia coli
Ramilo, C.A.; Evans, J.N.S.
Overexpression, purification, and characterization of tyrosine-sensitive 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase from Escherichia coli
Protein Expr. Purif.
9
253-261
1997
Escherichia coli
Euverink, G.J.W.; Hessels, G.I.; Franke, C.; Dijkhuizen, L.
Chorismate mutase and 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the methylotrophic actinomycete Amycolatopsis methanolica
Appl. Environ. Microbiol.
61
3796-3803
1995
Amycolatopsis methanolica
Walker, G.E.; Dunbar, B.; Hunter, I.S.; Nimmo, H.G.; Coggins, J.R.
Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces rimosus and Neurospora crassa
Microbiology
142
1973-1982
1996
Neurospora crassa, Streptomyces coelicolor, Streptomyces rimosus, Streptomyces coelicolor A3(2)
-
Doong, R.L.; Gander, J.E.; Ganson, R.J.; Jensen, R.A.
The cytosolic isoenzyme of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in Spinacia oleracea and other higher plants: extreme substrate ambiguity and other properties
Physiol. Plant.
84
351-360
1992
Nicotiana sylvestris, Vigna radiata, Pisum sativum, Solanum tuberosum, Spinacia oleracea
-
Stuart, F.; Hunter, I.S.
Purification and characterisation of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Streptomyces rimosus
Biochim. Biophys. Acta
1161
209-215
1993
Streptomyces rimosus
Rubin, J.L.; Jensen, R.A.
Differentially regulated isoenzymes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from seedlings of Vigna radiata
Plant Physiol.
79
711-718
1985
Vigna radiata
Flores, N.; Xiao, J.; Berry, A.; Bolivar, F.; Valle, F.
Pathway engineering for the production of aromatic compouds in Escherichia coli
Nat. Biotechnol.
14
620-623
1996
Escherichia coli
Schneider, T.R.; Hartmann, M.; Braus, G.H.
Crystallization and preliminary X-ray analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tyrosine inhibitable) from Saccharomyces cerevisiae
Acta Crystallogr. Sect. D
55
1586-1588
1999
Saccharomyces cerevisiae, Saccharomyces cerevisiae RH1326
-
Sharma, R.; Jain, M.; Bhatnagar, R.K.; Bhalla-Sarin, N.
Differential expression of DAHP synthase and chorismate mutase in various organs of Brassica juncea and the effect of external factors on enzyme activity
Physiol. Plant.
105
739-745
1999
Brassica juncea
-
Wagner, T.; Shumilin, I.A.; Bauerle, R.; Kretsinger, R.H.
Structure of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli: Comparison of the Mn2+*2-phosphoglycolate and the Pb2+*2-phosphoenolpyruvate complexes and Implications for catalysis
J. Mol. Biol.
301
389-399
2000
Escherichia coli (P0AB91), Escherichia coli
Howe, D.L.; Duewel, H.S.; Woodard, R.W.
Histidine 268 in 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase plays the same role as histidine 202 in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
J. Biol. Chem.
275
40258-40265
2000
Escherichia coli
Jain, M.; Bhalla-Sarin, N.
Effect of glyphosate on the activity of DAHP synthase isozymes in callus cultures of groundnut (Arachis hypogaea L.) selected in vitro
Indian J. Biochem. Biophys.
37
235-240
2000
Arachis hypogaea
-
Kim, K.J.
Regulation of 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP) synthase of Bacillus sp. B-6 producing phenazine-1-carboxylic acid
J. Biochem. Mol. Biol.
34
299-304
2001
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) B-6
-
Jossek, R.; Bongaerts, J.; Sprenger, G.A.
Characterization of a new feedback-resistant 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroF of Escherichia coli
FEMS Microbiol. Lett.
202
145-148
2001
Escherichia coli, Escherichia coli W3110 / ATCC 27325
Lin, L.L.; Liao, H.F.; Chien, H.R.; Hsu, W.H.
Identification of essential cysteine residues in 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Corynebacterium glutamicum
Curr. Microbiol.
42
426-431
2001
Corynebacterium glutamicum
Liao, H.F.; Lin, L.L.; Chien, H.R.; Hsu, W.H.
Serine 187 is a crucial residue for allosteric regulation of Corynebacterium glutamicum 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase
FEMS Microbiol. Lett.
194
59-64
2001
Corynebacterium glutamicum
Gosset, G.; Bonner, C.A.; Jensen, R.A.
Microbial origin of plant-type 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate synthases, exemplified by the chorismate- and tryptophan-regulated enzyme from Xanthomonas campestris
J. Bacteriol.
183
4061-4070
2001
Xanthomonas campestris
Parker, E.J.; Bulloch, E.M.M.; Jameson, G.B.; Abell, C.
Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate
Biochemistry
40
14821-14828
2001
Escherichia coli (P0AB91), Escherichia coli
Entus, R.; Poling, M.; Herrmann, K.M.
Redox regulation of Arabidopsis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Plant Physiol.
129
1866-1871
2002
Arabidopsis thaliana
Webby, C.J.; Lott, J.S.; Baker, H.M.; Baker, E.N.; Parker, E.J.
Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F61
403-406
2005
Mycobacterium tuberculosis
Webby, C.J.; Patchett, M.L.; Parker, E.J.
Characterization of a recombinant type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Helicobacter pylori
Biochem. J.
390
223-230
2005
Helicobacter pylori
Wu, J.; Sheflyan, G.Y.; Woodard, R.W.
Bacillus subtilis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase revisited: resolution of two long-standing enigmas
Biochem. J.
390
583-590
2005
Bacillus subtilis
Shumilin, I.A.; Bauerle, R.; Kretsinger, R.H.
The high-resolution structure of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase reveals a twist in the plane of bound phosphoenolpyruvate
Biochemistry
42
3766-3776
2003
Escherichia coli (P0AB91), Escherichia coli
Schofield, L.R.; Anderson, B.F.; Patchett, M.L.; Norris, G.E.; Jameson, G.B.; Parker, E.J.
Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?
Biochemistry
44
11950-11962
2005
Pyrococcus furiosus (Q8U0A9), Pyrococcus furiosus
Furdui, C.M.; Sau, A.K.; Yaniv, O.; Belakhov, V.; Woodard, R.W.; Baasov, T.; Anderson, K.S.
The use of (E)- and (Z)-phosphoenol-3-fluoropyruvate as mechanistic probes reveals significant differences between the active sites of KDO8P and DAHP synthases
Biochemistry
44
7326-7335
2005
Escherichia coli
Hu, C.; Jiang, P.; Xu, J.; Wu, Y.; Huang, W.
Mutation analysis of the feedback inhibition site of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of Escherichia coli
J. Basic Microbiol.
43
399-406
2003
Escherichia coli
Xu, J.; Hu, C.; Shen, S.; Wang, W.; Jiang, P.; Huang, W.
Requirement of the N-terminus for dimer formation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate synthase AroG of Escherichia coli
J. Basic Microbiol.
44
400-406
2004
Escherichia coli
Wu, J.; Howe, D.L.; Woodard, R.W.
Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase?
J. Biol. Chem.
278
27525-27531
2003
Thermotoga maritima
Furdui, C.; Zhou, L.; Woodard, R.W.; Anderson, K.S.
Insights into the mechanism of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (Phe) from Escherichia coli using a transient kinetic analysis
J. Biol. Chem.
279
45618-45625
2004
Escherichia coli
Konig, V.; Pfeil, A.; Braus, G.H.; Schneider, T.R.
Substrate and metal complexes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae provide new insights into the catalytic mechanism
J. Mol. Biol.
337
675-690
2004
Saccharomyces cerevisiae (P32449), Saccharomyces cerevisiae
Shumilin, I.A.; Bauerle, R.; Wu, J.; Woodard, R.W.; Kretsinger, R.H.
Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric regulation
J. Mol. Biol.
341
455-466
2004
Thermotoga maritima
Schofield, L.R.; Patchett, M.L.; Parker, E.J.
Expression, purification, and characterization of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Pyrococcus furiosus
Protein Expr. Purif.
34
17-27
2004
Pyrococcus furiosus
Rizzi, C.; Frazzon, J.; Ely, F.; Weber, P.G.; da Fonseca, I.O.; Gallas, M.; Oliveira, J.S.; Mendes, M.A.; de Souza, B.M.; Palma, M.S.; Santos, D.S.; Basso, L.A.
DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme
Protein Expr. Purif.
40
23-30
2005
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Williamson, R.M.; Pietersma, A.L.; Jameson, G.B.; Parker, E.J.
Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Bioorg. Med. Chem. Lett.
15
2339-2342
2005
Escherichia coli
Walker, S.R.; Parker, E.J.
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase
Bioorg. Med. Chem. Lett.
16
2951-2954
2006
Escherichia coli
Wu, J.; Woodard, R.W.
New insights into the evolutionary links relating to the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subfamilies
J. Biol. Chem.
281
4042-4048
2006
Bacillus subtilis, Porphyromonas gingivalis
Sato, K.; Mase, K.; Nakano, Y.; Nishikubo, N.; Sugita, R.; Tsuboi, Y.; Kajita, S.; Zhou, J.; Kitano, H.; Katayama, Y.
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase is regulated for the accumulation of polysaccharide-linked hydroxycinnamoyl esters in rice (Oryza sativa L.) internode cell walls
Plant Cell Rep.
25
676-688
2006
Oryza sativa
Helmstaedt, K.; Strittmatter, A.; Lipscomb, W.N.; Braus, G.H.
Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
102
9784-9789
2005
Saccharomyces cerevisiae
Ran, N.; Frost, J.W.
Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase
J. Am. Chem. Soc.
129
6130-6139
2007
Escherichia coli
Liu, Y.J.; Li, P.P.; Zhao, K.X.; Wang, B.J.; Jiang, C.Y.; Drake, H.L.; Liu, S.J.
Corynebacterium glutamicum contains 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases that display novel biochemical features
Appl. Environ. Microbiol.
74
5497-5503
2008
Corynebacterium glutamicum
Yakandawala, N.; Romeo, T.; Friesen, A.D.; Madhyastha, S.
Metabolic engineering of Escherichia coli to enhance phenylalanine production
Appl. Microbiol. Biotechnol.
78
283-291
2008
Escherichia coli, Escherichia coli NST 37 / ATCC 31882
Luttik, M.A.; Vuralhan, Z.; Suir, E.; Braus, G.H.; Pronk, J.T.; Daran, J.M.
Alleviation of feedback inhibition in Saccharomyces cerevisiae aromatic amino acid biosynthesis: quantification of metabolic impact
Metab. Eng.
10
141-153
2008
Saccharomyces cerevisiae
Okvist, M.; Sasso, S.; Roderer, K.; Kast, P.; Krengel, U.
A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis
Acta Crystallogr. Sect. F
65
1048-1052
2009
Mycobacterium tuberculosis (O53512), Mycobacterium tuberculosis
Sasso, S.; Okvist, M.; Roderer, K.; Gamper, M.; Codoni, G.; Krengel, U.; Kast, P.
Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner
EMBO J.
28
2128-2142
2009
Mycobacterium tuberculosis (O53512), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (O53512)
Walker, S.; Cumming, H.; Parker, E.
Substrate and reaction intermediate mimics as inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase
Org. Biomol. Chem.
7
3031-3035
2009
Escherichia coli
-
Zhou, L.; Wu, J.; Janakiraman, V.; Shumilin, I.A.; Bauerle, R.; Kretsinger, R.H.; Woodard, R.W.
Structure and characterization of the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Aeropyrum pernix
Bioorg. Chem.
40
79-86
2012
Aeropyrum pernix (Q9YEJ7), Aeropyrum pernix
Walker, S.R.; Jiao, W.; Parker, E.J.
Synthesis and evaluation of dual site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Bioorg. Med. Chem. Lett.
21
5092-5097
2011
Escherichia coli
Tzin, V.; Malitsky, S.; Ben Zvi, M.M.; Bedair, M.; Sumner, L.; Aharoni, A.; Galili, G.
Expression of a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway in Arabidopsis elucidates potential metabolic bottlenecks between primary and secondary metabolism
New Phytol.
194
430-439
2012
Escherichia coli (P0AB91)
Bhattacharya, S.; Kumar, P.
An insilico approach to structural elucidation of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Arabidopsis thaliana: hints for herbicide design
Phytochemistry
73
7-14
2012
Arabidopsis thaliana (P29976), Arabidopsis thaliana
Ma, N.; Wei, L.; Fan, Y.; Hua, Q.
Heterologous expression and characterization of soluble recombinant 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Actinosynnema pretiosum ssp. auranticum ATCC31565 through co-expression with Chaperones in Escherichia coli
Protein Expr. Purif.
82
263-269
2012
Actinosynnema pretiosum subsp. auranticum (O68903), Actinosynnema pretiosum subsp. auranticum ATCC 31565 (O68903)
Light, S.H.; Halavaty, A.S.; Minasov, G.; Shuvalova, L.; Anderson, W.F.
Structural analysis of a 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with an N-terminal chorismate mutase-like regulatory domain
Protein Sci.
21
887-895
2012
Listeria monocytogenes
Nazmi, A.R.; Schofield, L.R.; Dobson, R.C.; Jameson, G.B.; Parker, E.J.
Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity
J. Mol. Biol.
426
656-673
2014
Pyrococcus furiosus (Q8U0A9), Pyrococcus furiosus
Heyes, L.C.; Reichau, S.; Cross, P.J.; Jameson, G.B.; Parker, E.J.
Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water
Bioorg. Chem.
57
242-250
2014
Neisseria meningitidis (Q9K169), Neisseria meningitidis
Nirmal, C.R.; Rao, R.; Hopper, W.
Inhibition of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis: in silico screening and in vitro validation
Eur. J. Med. Chem.
105
182-193
2015
Mycobacterium tuberculosis (O53512), Mycobacterium tuberculosis
Cross, P.J.; Parker, E.J.
Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
FEBS Lett.
587
3063-3068
2013
Thermotoga maritima (Q9WYH8), Thermotoga maritima
Zhang, C.; Kang, Z.; Zhang, J.; Du, G.; Chen, J.; Yu, X.
Construction and application of novel feedback-resistant 3-deoxy-D-arabino-heptulosonate-7-phosphate synthases by engineering the N-terminal domain for L-phenylalanine synthesis
FEMS Microbiol. Lett.
353
11-18
2014
Corynebacterium glutamicum (P35170), Corynebacterium glutamicum ATCC 13032 (P35170)
Sobota, J.M.; Gu, M.; Imlay, J.A.
Intracellular hydrogen peroxide and superoxide poison 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, the first committed enzyme in the aromatic biosynthetic pathway of Escherichia coli
J. Bacteriol.
196
1980-1991
2014
Escherichia coli (P0AB91), Escherichia coli
Pagor, R.; Sikdar, M.; Moon, E.; Kim, J.
Characterization of a gene encoding 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from rice
J. Biol. Sci.
15
33-39
2015
Oryza sativa (Q0D4J5)
-
Tzin, V.; Rogachev, I.; Meir, S.; Moyal Ben Zvi, M.; Masci, T.; Vainstein, A.; Aharoni, A.; Galili, G.
Tomato fruits expressing a bacterial feedback-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the shikimate pathway possess enhanced levels of multiple specialized metabolites and upgraded aroma
J. Exp. Bot.
64
4441-4452
2013
Escherichia coli (P0AB91)
Yang, J.; Ji, L.; Wang, X.; Zhang, Y.; Wu, L.; Yang, Y.; Ma, Z.
Overexpression of 3-deoxy-7-phosphoheptulonate synthase gene from Gossypium hirsutum enhances Arabidopsis resistance to Verticillium wilt
Plant Cell Rep.
34
1429-1441
2015
Gossypium hirsutum (A0A0D5ZBC4), Gossypium hirsutum
Cross, P.J.; Heyes, L.C.; Zhang, S.; Nazmi, A.R.; Parker, E.J.
The functional unit of Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase is dimeric
PLoS ONE
11
e0145187
2016
Neisseria meningitidis (Q9K169), Neisseria meningitidis
Cross, P.J.; Pietersma, A.L.; Allison, T.M.; Wilson-Coutts, S.M.; Cochrane, F.C.; Parker, E.J.
Neisseria meningitidis expresses a single 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine
Protein Sci.
22
1087-1099
2013
Neisseria meningitidis (Q9K169), Neisseria meningitidis, Neisseria meningitidis MC58 (Q9K169), no activity in Homo sapiens
Wu, W.B.; Guo, X.L.; Zhang, M.L.; Huang, Q.G.; Qi, F.; Huang, J.Z.
Enhancement of L-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin
Biotechnol. Appl. Biochem.
65
476-483
2018
Escherichia coli (P00888), Escherichia coli, Escherichia coli K12 (P00888)
Pratap, S.; Dev, A.; Kumar, V.; Yadav, R.; Narwal, M.; Tomar, S.; Kumar, P.
Structure of chorismate mutase-like domain of DAHPS from Bacillus subtilis complexed with novel inhibitor reveals conformational plasticity of active site
Sci. Rep.
7
6364
2017
Bacillus subtilis (P39912), Bacillus subtilis, Bacillus subtilis 168 (P39912)
Zhao, H.; Gao, H.; Ji, K.; Yan, B.; Li, Q.; Mo, S.; Zheng, M.; Ou, Q.; Wu, B.; Li, N.; Jiang, C.
Isolation and biochemical characterization of a metagenome-derived 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase gene from subtropical marine mangrove wetland sediments
AMB Express
9
19
2019
uncultured bacterium (A0A482F152)
Balachandran, N.; Heimhalt, M.; Liuni, P.; To, F.; Wilson, D.J.; Junop, M.S.; Berti, P.J.
Potent inhibition of 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP) synthase by DAHP oxime, a phosphate group mimic
Biochemistry
55
6617-6629
2016
Escherichia coli (C3TIE2)
Balachandran, N.; To, F.; Berti, P.J.
Linear free energy relationship analysis of transition state mimicry by 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) oxime, a DAHP synthase inhibitor and phosphate mimic
Biochemistry
56
592-601
2017
Escherichia coli (C3TIE2)
Heimhalt, M.; Jiang, S.; Berti, P.J.
Eliminating competition Characterizing and eliminating competitive binding at separate sites between DAHP synthases essential metal ion and the inhibitor DAHP oxime
Biochemistry
57
6679-6687
2018
Escherichia coli (C3TIE2)
Sterritt, O.; Lang, E.; Kessans, S.; Ryan, T.; Demeler, B.; Jameson, G.; Parker, E.
Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subclass
Biosci. Rep.
38
BSR20181605
2018
Pseudomonas aeruginosa (G3XCJ9), Pseudomonas aeruginosa, Pseudomonas aeruginosa DSM 22644 (G3XCJ9)
de Lima, L.A.; Ventorim, R.Z.; de Andrade Bianchini, I.; de Queiroz, M.V.; Fietto, L.G.; da Silveira, W.B.
Obtainment, selection and characterization of a mutant strain of Kluyveromyces marxianus that displays improved production of 2-phenylethanol and enhanced DAHP synthase activity
J. Appl. Microbiol.
130
878-890
2020
Kluyveromyces marxianus, Kluyveromyces marxianus CCT 7735
Cui, D.; Deng, A.; Bai, H.; Yang, Z.; Liang, Y.; Liu, Z.; Qiu, Q.; Wang, L.; Liu, S.; Zhang, Y.; Shi, Y.; Qi, J.; Wen, T.
Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli
J. Struct. Biol.
206
322-334
2019
Escherichia coli (P00888), Escherichia coli, Escherichia coli K12 (P00888)
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