Reference on EC 2.5.1.6 - methionine adenosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cantoni, G.L.; Durell, J.
Activation of methionine for transmethylation. The methionine-activating enzyme: studies on the mechanism of the reaction
J. Biol. Chem.
225
1033-1048
1957
Oryctolagus cuniculus
Geller, A.M.; Kotb, M.Y.S.; Jernigan, H.M.; Kredich, N.M.
Purification and properties of rat lens methionine adenosyltransferase
Exp. Eye Res.
43
997-1008
1986
Rattus norvegicus
Aarnes, H.
Partial purification and characterization of methionine adenosyltransferase from pea seedlings
Plant Sci. Lett.
10
381-390
1977
Pisum sativum
-
Tallan, H.H.; Cohen, P.A.
Methionine adenosyltransferase: kinetic properties of human and rat liver enzymes
Biochem. Med.
16
234-250
1976
Homo sapiens, Rattus norvegicus
Liau, M.C.; Lin, G.W.; Hurlbert, R.B.
Partial purification and characterization of tumor and liver S-adenosylmethionine synthetases
Cancer Res.
37
427-435
1977
Rattus norvegicus
Sullivan, D.M.; Hoffman, J.L.
Fractionation and kinetic properties of rat liver and kidney methionine adenosyltransferase isozymes
Biochemistry
22
1636-1641
1983
Rattus norvegicus
Hoffman, J.L.
Fractionation of methionine adenosyltransferase isozymes (rat liver)
Methods Enzymol.
94
223-228
1983
Rattus norvegicus
Markham, G.D.; Hafner, E.W.; White Tabor, C.; Tabor, H.
S-adenosylmethionine synthetase (methionine adenosyltransferase) (Escherichia coli)
Methods Enzymol.
94
219-222
1983
Escherichia coli
Yarlett, N.; Garofalo, J.; Goldberg, B.; Ciminelli, M.A.; Ruggiero, V.; Sufrin, J.R.; Bacchi, C.J.
S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei
Biochim. Biophys. Acta
1181
68-76
1993
Trypanosoma brucei brucei
Sufrin, J.R.; Lombardini, J.B.; Alks, V.
Differential kinetic properties of L-2-amino-4-methylthio-cis-but-3-enoic acid, a methionine analog inhibitor of S-adenosylmethionine synthetase
Biochim. Biophys. Acta
1202
87-91
1993
Mus musculus
Porcelli, M.; Cacciapuoti, G.; Carteni-Farina, M.; Gambacorta, A.
S-adenosylmethionine synthetase in the thermophilic archaebacterium Sulfolobus solfataricus. Purification and characterization of two isoforms
Eur. J. Biochem.
177
273-280
1988
Saccharolobus solfataricus
Gilliland, G.L.; Markham, G.D.; Davies, D.R.
S-adenosylmethionine synthetase from Escherichia coli. Crystallization and preliminary X-ray diffraction studies
J. Biol. Chem.
258
6963-6964
1983
Escherichia coli
Chou, T.C.; Talalay, P.
Inhibition of ATP: L-methionine S-adenosyltransferase of bakers yeast by structural analogues of ATP
Biochim. Biophys. Acta
321
467-474
1973
Saccharomyces cerevisiae
Chou, T.C.; Talalay, P.
The mechanism of S-adenosyl-L-methionine synthesis by purified preparations of bakers yeast
Biochemistry
11
1065-1073
1972
Saccharomyces cerevisiae
Kotb, M.; Kredich, N.M.
S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterization
J. Biol. Chem.
260
3923-3930
1985
Homo sapiens
Cabrero, C.; Puerta, J.; Alemany, S.
Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver
Eur. J. Biochem.
170
299-304
1987
Rattus norvegicus
Okada, G.; Teraoka, H.; Tsukada, K.
Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization
Biochemistry
20
934-940
1981
Rattus norvegicus
Chiang, P.K.; Cantoni, G.L.
Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers yeast and its separation into two forms
J. Biol. Chem.
252
4506-4513
1977
Saccharomyces cerevisiae
Markham, G.D.; Hafner, E.W.; White Tabor, C.; Tabor, H.
S-Adenosylmethionine synthetase from Escherichia coli
J. Biol. Chem.
255
9082-9092
1980
Escherichia coli
Mitsui, K.i.; Teraoka, H.; Tsukada, K.
Complete purification and immunochemical analysis of S-adenosylmethionine synthetase from bovine brain
J. Biol. Chem.
263
11211-11216
1988
Bos taurus
Suman, Y.; Shimizu, K.; Tsukada, K.
Isozymes of S-adenosylmethionine synthetase from rat liver: isolation and characterization
J. Biochem.
100
67-75
1986
Rattus norvegicus
Langkamp-Henken, B.; Geller, A.M.; LeGros, H.L., Jr.; Price, J.O.; De la Rosa, J.; Kotb, M.
Characterization of distinct forms of methionine adenosyltransferase in nucleated, and mature human erythrocytes and erythroleukemic cells
Biochim. Biophys. Acta
1201
397-404
1994
Homo sapiens
De La Rosa, J.; Ostrowski, J.; Hryniewicz, M.M.; Kredich, N.M.; Kotb, M.; LeGros, H.L., Jr.; Valentine, M.; Geller, A.M.
Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase
J. Biol. Chem.
270
21860-21868
1995
Homo sapiens
Takusagawa, F.; Kamitori, S.; Markham, G.D.
Structure and function of S-adenosylmethionine synthetase: Crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 2.8.ANG. resolution
Biochemistry
35
2586-2596
1996
Escherichia coli (P0A817), Escherichia coli
Mingorance, J.; Alvarez, L.; Pajares, M.A.; Mato, J.M.
Recombinant rat liver S-adenosyl-L-methionine synthetase tetramers and dimers are in equilibrium
Int. J. Biochem. Cell Biol.
29
485-491
1997
Rattus norvegicus
Schroeder, G.; Eichel, J.; Breinig, S.; Schroeder, J.
Three differentially expressed S-adenosylmethionine synthetases from Catharanthus roseus: molecular and functional characterization
Plant Mol. Biol.
33
211-222
1997
Catharanthus roseus (Q96551), Catharanthus roseus (Q96552), Catharanthus roseus (Q96553), Catharanthus roseus
Avila, M.A.; Corrales, F.J.; Ruiz, F.; Sanchez-Gongora, E.; Mingorance, J.; Carretero, M.V.; Mato, J.M.
Specific interaction of methionine adenosyltransferase with free radicals
Biofactors
8
27-32
1998
Rattus norvegicus
Halim, A.B.; LeGros, L.; Geller, A.; Kotb, M.
Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells
J. Biol. Chem.
274
29720-29725
1999
Homo sapiens
Taylor, J.C.; Markham, G.D.
The bifunctional active site of S-adenosylmethionine synthetase. Roles of the active site aspartates
J. Biol. Chem.
274
32909-32914
1999
Escherichia coli (P0A817), Escherichia coli, Escherichia coli XL1-Blue (P0A817)
Chamberlin, M.E.; Ubagai, T.; Pao, V.Y.; Pearlstein, R.A.; Yang Chou, J.
Structural requirements for catalysis and dimerization of human methionine adenosyltransferase I/III
Arch. Biochem. Biophys.
373
56-62
2000
Homo sapiens
del Pino, M.M.; Corrales, F.J.; Mato, J.M.
Hysteretic behavior of methionine adenosyltransferase III. Methionine switches between two conformations of the enzyme with different specific activity
J. Biol. Chem.
275
23476-23482
2000
Rattus norvegicus
Ekegren, T.; Aquilonius, S.M.; Gomes-Trolin, C.
A comparative study of methionine adenosyltransferase activity and regional distribution in mammalian spinal cord
Biochem. Pharmacol.
60
441-445
2000
Bos taurus, Felis catus, Macaca mulatta, Rattus norvegicus, Sus scrofa
LeGros, H.L., Jr.; Halim, A.B.; Geller, A.M.; Kotb, M.
Cloning, expression, and functional characterization of the b regulatory subunit of human methionine adenosyltransferase (MAT II)
J. Biol. Chem.
275
2359-2366
2000
Escherichia coli, Homo sapiens, Homo sapiens (Q9NZL9)
Lopez-Vara, M.C.; Gasset, M.; Pajares, M.A.
Refolding and characterization of rat liver methionine adenosyltransferase from Escherichia coli inclusion bodies
Protein Expr. Purif.
19
219-226
2000
Rattus norvegicus
Lu, S.C.; Alvarez L.A.; Huang, Z.Z.; Chen, L.; An, W.; Corrales F.J.; Avila, M.A.; Kanel, G.; Mato, J.A.
Methionine adenosyltransferase 1 knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation
Proc. Natl. Acad. Sci. USA
98
5560-5565
2001
Mus musculus
Corrales, F.J.; Perez-Mato, I.; Sanchez Del Pino, M.M.; Ruiz, F.; Castro, C.; Garcia-Trevijano, E.R.; Latasa, U.; Martinez-Chantar, M.L.; Martinez-Cruz, A.; Avila, M.A.; Mato, J.M.
Regulation of mammalian liver methionine adenosyltransferase
J. Nutr.
132
2377S-2381S
2002
Escherichia coli, Homo sapiens, Rattus norvegicus
Lu, Z.J.; Markham, G.D.
Enzymatic properties of S-adenosylmethionine synthetase from the archaeon Methanococcus jannaschii
J. Biol. Chem.
277
16624-16631
2002
Methanocaldococcus jannaschii
Reguera, R.M.; Balana-Fouce, R.; Perez-Pertejo, Y.; Fernandez, F.J.; Garcia-Estrada, C.; Cubria, J.C.; Ordonez, C.; Ordonez, D.
Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotes
J. Biol. Chem.
277
3158-3167
2002
Leishmania infantum
Taylor, J.C.; Takusagawa, F.; Markham, G.D.
The active site loop of S-adenosylmethionine synthetase modulates catalytic efficiency
Biochemistry
41
9358-9369
2002
Escherichia coli (P0A817), Escherichia coli, Escherichia coli XL1-Blue (P0A817)
Okamoto, S.; Lezhava, A.; Hosaka, T.; Okamoto-Hosoya, Y.; Ochi, K.
Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2)
J. Bacteriol.
185
601-609
2003
Streptomyces coelicolor (Q9L0Y3), Streptomyces coelicolor A3(2) (Q9L0Y3), Streptomyces coelicolor A3(2)
Perez-Pertejo, Y.; Reguera, R.M.; Villa, H.; Garcia-Estrada, C.; Balana-Fouce, R.; Pajares, M.A.; Ordonez, D.
Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme
Eur. J. Biochem.
270
28-35
2003
Leishmania donovani (Q9U6Q8), Leishmania donovani
Lu, S.C.; Mato, J.M.
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer
Alcohol
35
227-234
2005
Homo sapiens, Rattus norvegicus
Wang, S.H.; Kuo, S.C.; Chen, S.C.
High-performance liquid chromatography determination of methionine adenosyltransferase activity using catechol-O-methyltransferase-coupled fluorometric detection
Anal. Biochem.
319
13-20
2003
Homo sapiens
Taylor, J.C.; Markham, G.D.
Conformational dynamics of the active site loop of S-adenosylmethionine synthetase illuminated by site-directed spin labeling
Arch. Biochem. Biophys.
415
164-171
2003
Escherichia coli (P0A817)
Komoto, J.; Yamada, T.; Takata, Y.; Markham, G.D.; Takusagawa, F.
Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met
Biochemistry
43
1821-1831
2004
Escherichia coli (P0A817), Escherichia coli
Markham, G.D.; Reczkowski, R.S.
Structural studies of inhibition of S-adenosylmethionine synthetase by slow, tight-binding intermediate and product analogues
Biochemistry
43
3415-3425
2004
Escherichia coli (P0A817)
Iloro, I.; Chehin, R.; Goni, F.M.; Pajares, M.A.; Arrondo, J.L.
Methionine adenosyltransferase alpha-helix structure unfolds at lower temperatures than beta-sheet: a 2D-IR study
Biophys. J.
86
3951-3958
2004
Rattus norvegicus
Berger, B.J.; Knodel, M.H.
Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis
BMC Microbiol.
3
12
2003
Mycolicibacterium smegmatis (Q7WYN1), Mycolicibacterium smegmatis
Perez-Pertejo, Y.; Reguera, R.M.; Garcia-Estrada, C.; Balana-Fouce, R.; Ordonez, D.
Mutational analysis of methionine adenosyltransferase from Leishmania donovani
Eur. J. Biochem.
271
2791-2798
2004
Leishmania donovani (Q9U6Q8), Leishmania donovani
Slapeta, J.; Stejskal, F.; Keithly, J.S.
Characterization of S-adenosylmethionine synthetase in Cryptosporidium parvum (Apicomplexa)
FEMS Microbiol. Lett.
225
271-277
2003
Cryptosporidium parvum
Sanchez-Perez, G.F.; Gasset, M.; Calvete, J.J.; Pajares, M.A.
Role of an intrasubunit disulfide in the association state of the cytosolic homo-oligomer methionine adenosyltransferase
J. Biol. Chem.
278
7285-7293
2003
Rattus norvegicus (P13444)
Kim, J.S.; Coon, S.L.; Blackshaw, S.; Cepko, C.L.; Moller, M.; Mukda, S.; Zhao, W.Q.; Charlton, C.G.; Klein, D.C.
Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression
J. Biol. Chem.
280
677-684
2005
Rattus norvegicus
Gonzalez, B.; Pajares, M.A.; Hermoso, J.A.; Guillerm, D.; Guillerm, G.; Sanz-Aparicio, J.
Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism
J. Mol. Biol.
331
407-416
2003
Rattus norvegicus (P13444)
Khedkar, S.A.; Malde, A.K.; Coutinho, E.C.
Comparative protein modeling of methionine S-adenosyltransferase (MAT) enzyme from Mycobacterium tuberculosis: a potential target for antituberculosis drug discovery
J. Mol. Graph. Model.
23
355-366
2005
Mycobacterium tuberculosis
Tabuchi, T.; Kawaguchi, Y.; Azuma, T.; Nanmori, T.; Yasuda, T.
Similar regulation patterns of choline monooxygenase, phosphoethanolamine N-methyltransferase and S-adenosyl-L-methionine synthetase in leaves of the halophyte Atriplex nummularia L
Plant Cell Physiol.
46
505-513
2005
Atriplex nummularia (Q6F3F0), Atriplex nummularia (Q6F3F1), Atriplex nummularia (Q6F3F3), Atriplex nummularia (Q7XZR1), Atriplex nummularia
Sanchez-Aguayo, I.; Rodriguez-Galan, J.M.; Garcia, R.; Torreblanca, J.; Pardo, J.M.
Salt stress enhances xylem development and expression of S-adenosyl-L-methionine synthase in lignifying tissues of tomato plants
Planta
220
278-285
2004
Solanum lycopersicum
Wang, Y.; Wang, Y.; Chu, J.; Zhuang, Y.; Zhang, L.; Zhang, S.
Improved production of erythromycin A by expression of a heterologous gene encoding S-adenosylmethionine synthetase
Appl. Microbiol. Biotechnol.
75
837-842
2007
Streptomyces spectabilis
Perez-Pertejo, Y.; Reguera, R.M.; Ordonez, D.; Balana-Fouce, R.
Characterization of a methionine adenosyltransferase over-expressing strain in the trypanosomatid Leishmania donovani
Biochim. Biophys. Acta
1760
10-19
2006
Leishmania donovani
Yoon, G.; Ko, K.; Kang, H.; Suh, J.; Kim, Y.; Ryu, Y.
Characterization of S-adenosylmethionine synthetase from Streptomyces avermitilis NRRL8165 and its effect on antibiotic production
Enzyme Microb. Technol.
39
466-473
2006
Streptomyces avermitilis (Q3HW35), Streptomyces avermitilis NRRL 8165 (Q3HW35)
-
Hu, X.; Chu, J.; Zhang, S.; Zhuang, Y.; Wang, Y.; Zhu, S.; Zhu, Z.; Yuan, Z.
A novel feeding strategy during the production phase for enhancing the enzymatic synthesis of S-adenosyl-L-methionine by methylotrophic Pichia pastoris
Enzyme Microb. Technol.
40
669-674
2007
Komagataella pastoris, Komagataella pastoris GS115
-
Panayiotidis, M.I.; Stabler, S.P.; Ahmad, A.; Pappa, A.; Legros, L.H.; Hernandez-Saavedra, D.; Schneider, B.K.; Allen, R.H.; Vasiliou, V.; McCord, J.M.; Kotb, M.; White, C.W.
Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia
Free Radic. Biol. Med.
40
348-358
2006
Homo sapiens (P31153), Homo sapiens
Driskell, L.O.; Tucker, A.M.; Winkler, H.H.; Wood, D.O.
Rickettsial metK-encoded methionine adenosyltransferase expression in an Escherichia coli metK deletion strain
J. Bacteriol.
187
5719-5722
2005
Escherichia coli, Rickettsia prowazekii, Rickettsia typhi
McDaniel, B.A.; Grundy, F.J.; Kurlekar, V.P.; Tomsic, J.; Henkin, T.M.
Identification of a mutation in the Bacillus subtilis S-adenosylmethionine synthetase gene that results in derepression of S-box gene expression
J. Bacteriol.
188
3674-3681
2006
Bacillus subtilis
Lindermayr, C.; Saalbach, G.; Bahnweg, G.; Durner, J.
Differential inhibition of Arabidopsis methionine adenosyltransferases by protein S-nitrosylation
J. Biol. Chem.
281
4285-4291
2006
Arabidopsis thaliana
Lu, S.C.; Martinez-Chantar, M.L.; Mato, J.M.
Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease
J. Gastroenterol. Hepatol.
21
S61-S64
2006
Homo sapiens
-
Sakata, S.F.; Okumura, S.; Matsuda, K.; Horikawa, Y.; Maeda, M.; Kawasaki, K.; Chou, J.Y.; Tamaki, N.
Effect of fasting on methionine adenosyltransferase expression and the methionine cycle in the mouse liver
J. Nutr. Sci. Vitaminol.
51
118-123
2005
Mus musculus
Fuchs, R.T.; Grundy, F.J.; Henkin, T.M.
The S(MK) box is a new SAM-binding RNA for translational regulation of SAM synthetase
Nat. Struct. Mol. Biol.
13
226-233
2006
Enterococcus faecalis
Jesudhasan, P.R.; Woo, P.T.
A S-adenosylmethionine synthetase gene from the pathogenic piscine hemoflagellate, Cryptobia salmositica
Parasitol. Res.
100
1401-1406
2007
Cryptobia salmositica (Q6J2L0), Cryptobia salmositica
Hacham, Y.; Song, L.; Schuster, G.; Amir, R.
Lysine enhances methionine content by modulating the expression of S-adenosylmethionine synthase
Plant J.
51
850-861
2007
Arabidopsis thaliana, Nicotiana tabacum
Hote, P.T.; Sahoo, R.; Jani, T.S.; Ghare, S.S.; Chen, T.; Joshi-Barve, S.; McClain, C.J.; Barve, S.S.
Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression
J. Nutr. Biochem.
19
384-391
2007
Homo sapiens (P31153)
Chen, H.; Chu, J.; Zhang, S.; Zhuang, Y.; Qian, J.; Wang, Y.; Hu, X.
Intracellular expression of Vitreoscilla hemoglobin improves S-adenosylmethionine production in a recombinant Pichia pastoris
Appl. Microbiol. Biotechnol.
74
1205-1212
2007
Streptomyces spectabilis (Q9X4Q2), Streptomyces spectabilis
Zhang, X.; Fen, M.; Shi, X.; Bai, L.; Zhou, P.
Overexpression of yeast S-adenosylmethionine synthetase metK in Streptomyces actuosus leads to increased production of nosiheptide
Appl. Microbiol. Biotechnol.
78
991-995
2008
Saccharomyces cerevisiae (P19358), Saccharomyces cerevisiae
Kamarthapu, V.; Rao, K.V.; Srinivas, P.N.; Reddy, G.B.; Reddy, V.D.
Structural and kinetic properties of Bacillus subtilis S-adenosylmethionine synthetase expressed in Escherichia coli
Biochim. Biophys. Acta
1784
1949-1958
2008
Bacillus subtilis (P54419), Bacillus subtilis
Luo, Y.; Yuan, Z.; Luo, G.; Zhao, F.
Expression of secreted His-tagged S-adenosylmethionine synthetase in the methylotrophic yeast Pichia pastoris and its characterization, one-step purification, and immobilization
Biotechnol. Prog.
24
214-220
2008
Saccharomyces cerevisiae (P19358), Saccharomyces cerevisiae
Ho, P.; Kong, K.F.; Chan, Y.H.; Tsang, J.S.; Wong, J.T.
An unusual S-adenosylmethionine synthetase gene from dinoflagellate is methylated
BMC Mol. Biol.
8
87
2007
Crypthecodinium cohnii, Crypthecodinium cohnii Biecheler 1649
Delgado, M.; Perez-Miguelsanz, J.; Garrido, F.; Rodriguez-Tarduchy, G.; Perez-Sala, D.; Pajares, M.A.
Early effects of copper accumulation on methionine metabolism
Cell. Mol. Life Sci.
65
2080-2090
2008
Rattus norvegicus, Rattus norvegicus (P13444), Rattus norvegicus (P18298)
Kutty, G.; Hernandez-Novoa, B.; Czapiga, M.; Kovacs, J.A.
Pneumocystis encodes a functional S-adenosylmethionine synthetase gene
Eukaryot. Cell
7
258-267
2008
Pneumocystis carinii (B0YIL6), Pneumocystis carinii, Pneumocystis jirovecii (B0YIL4), Pneumocystis murina (B0YIL2), Pneumocystis murina
Chen, H.; Xia, M.; Lin, M.; Yang, H.; Kuhlenkamp, J.; Li, T.; Sodir, N.M.; Chen, Y.H.; Josef-Lenz, H.; Laird, P.W.; Clarke, S.; Mato, J.M.; Lu, S.C.
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells
Gastroenterology
133
207-218
2007
Homo sapiens, Mus musculus (Q3TH56)
Yang, H.; Ara, A.I.; Magilnick, N.; Xia, M.; Ramani, K.; Chen, H.; Lee, T.D.; Mato, J.M.; Lu, S.C.
Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells
Gastroenterology
134
281-291
2008
Homo sapiens
Garcia-Estrada, C.; Perez-Pertejo, Y.; Ordonez, D.; Balana-Fouce, R.; Reguera, R.M.
Analysis of genetic elements regulating the methionine adenosyltransferase gene in Leishmania infantum
Gene
389
163-173
2007
Leishmania infantum, Leishmania infantum LEM75
Ramani, K.; Yang, H.; Xia, M.; Ara, A.I.; Mato, J.M.; Lu, S.C.
Leptins mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta
Hepatology
47
521-531
2008
Homo sapiens
Rodriguez, J.L.; Boukaba, A.; Sandoval, J.; Georgieva, E.I.; Latasa, M.U.; Garcia-Trevijano, E.R.; Serviddio, G.; Nakamura, T.; Avila, M.A.; Sastre, J.; Torres, L.; Mato, J.M.; Lopez-Rodas, G.
Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells
Int. J. Biochem. Cell Biol.
39
842-850
2007
Rattus norvegicus (P18298)
Zhang, J.G.; Wang, X.D.; Zhang, J.N.; Wei, D.Z.
Oxygen vectors used for S-adenosylmethionine production in recombinant Pichia pastoris with sorbitol as supplemental carbon source
J. Biosci. Bioeng.
105
335-340
2008
Saccharomyces cerevisiae (P19358)
Zheng, S.; Shuman, S.; Schwer, B.
Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase
Nucleic Acids Res.
35
6895-6903
2007
Saccharomyces cerevisiae W303
Roeder, S.; Dreschler, K.; Wirtz, M.; Cristescu, S.M.; van Harren, F.J.; Hell, R.; Piechulla, B.
SAM levels, gene expression of SAM synthetase, methionine synthase and ACC oxidase, and ethylene emission from N. suaveolens flowers
Plant Mol. Biol.
70
535-546
2009
Nicotiana suaveolens (Q069K3), Nicotiana suaveolens
Markham, G.D.; Takusagawa, F.; Dijulio, A.M.; Bock, C.W.
An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations
Arch. Biochem. Biophys.
492
82-92
2009
Escherichia coli (P0A817)
Garrido, F.; Alfonso, C.; Taylor, J.C.; Markham, G.D.; Pajares, M.A.
Subunit association as the stabilizing determinant for archaeal methionine adenosyltransferases
Biochim. Biophys. Acta
1794
1082-1090
2009
Methanocaldococcus jannaschii (Q58605), Methanocaldococcus jannaschii
Sakajiri, T.; Asano, K.; Hirooka, S.; Tashiro, K.; Misumi, O.; Fujiwara, T.; Kuroiwa, T.
Microarray analysis reveals S-adenosylmethionine (SAM) synthetase involvement in salt tolerance of Cyanidioschyzon merolae
Cytologia
73
341-348
2008
Cyanidioschyzon merolae
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Reytor, E.; Perez-Miguelsanz, J.; Alvarez, L.; Perez-Sala, D.; Pajares, M.A.
Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution
FASEB J.
23
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2009
Rattus norvegicus
Vazquez-Chantada, M.; Ariz, U.; Varela-Rey, M.; Embade, N.; Martinez-Lopez, N.; Fernandez-Ramos, D.; Gomez-Santos, L.; Lamas, S.; Lu, S.C.; Martinez-Chantar, M.L.; Mato, J.M.
Evidence for LKB1/AMP-activated protein kinase/endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation
Hepatology
49
608-617
2009
Homo sapiens
Ramani, K.; Yang, H.; Kuhlenkamp, J.; Tomasi, L.; Tsukamoto, H.; Mato, J.M.; Lu, S.C.
Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation
Hepatology
51
986-995
2010
Homo sapiens, Rattus norvegicus
Oh, T.J.; Niraula, N.P.; Liou, K.; Sohng, J.K.
Identification of the duplicated genes for S-adenosyl-L-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952
J. Appl. Microbiol.
109
398-407
2010
Streptomyces peucetius (Q05H71), Streptomyces peucetius (Q05H72), Streptomyces peucetius
Sabaty, M.; Adryanczyk, G.; Roustan, C.; Cuine, S.; Lamouroux, C.; Pignol, D.
Coproporphyrin excretion and low thiol levels caused by point mutation in the Rhodobacter sphaeroides S-adenosylmethionine synthetase gene
J. Bacteriol.
192
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2010
Cereibacter sphaeroides (C8ZLJ7), Cereibacter sphaeroides
Hu, H.; Qian, J.; Chu, J.; Wang, Y.; Zhuang, Y.; Zhang, S.
DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris
J. Biotechnol.
141
97-103
2009
Streptomyces spectabilis, Escherichia coli (P0A817), Escherichia coli, Saccharomyces cerevisiae (P19358)
Taylor, J.C.; Bock, C.W.; Takusagawa, F.; Markham, G.D.
Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening
J. Med. Chem.
52
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Escherichia coli (P0A817)
Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
J. Nutr.
139
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Sus scrofa
Fang, Q.; Yin, J.; Li, F.; Zhang, J.; Watford, M.
Characterization of methionine adenosyltransferase 2beta gene expression in skeletal muscle and subcutaneous adipose tissue from obese and lean pigs
Mol. Biol. Rep.
37
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Sus scrofa (B7SU41), Sus scrofa
Qi, Y.; Ma, L.; Wang, F.; Liu, W.
Overexpression of S-adenosylmethionine synthetase promote polyamine biosynthesis in transgenic tobacco
Plant Physiol. Commun.
45
791-793
2009
Suaeda salsa
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Zhou, J.; Chu, J.; Wang, Y.; Zhang, S.; Zhuang, Y.; Yuan, Z.
Purification and properties of Saccharomyces cerevisiae S-adenosylmethionine synthetase expressed in recombinant Pichia pastoris
World J. Microbiol. Biotechnol.
24
789-796
2008
Saccharomyces cerevisiae
Garrido, F.; Taylor, J.C.; Alfonso, C.; Markham, G.D.; Pajares, M.A.
Structural basis for the stability of a thermophilic methionine adenosyltransferase against guanidinium chloride
Amino Acids
42
361-373
2010
Methanocaldococcus jannaschii (Q58605), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58605)
Wang, F.; Singh, S.; Zhang, J.; Huber, T.D.; Helmich, K.E.; Sunkara, M.; Hurley, K.A.; Goff, R.D.; Bingman, C.A.; Morris, A.J.; Thorson, J.S.; Phillips, G.N.
Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus
FEBS J.
281
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2014
Saccharolobus solfataricus (Q980S9), Saccharolobus solfataricus P2 (Q980S9)
Graham, D.E.; Bock, C.L.; Schalk-Hihi, C.; Lu, Z.J.; Markham, G.D.
Identification of a highly diverged class of S-adenosylmethionine synthetases in the archaea
J. Biol. Chem.
275
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Methanocaldococcus jannaschii (Q58605), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58605)
Porcelli, M.; Ilisso, C.P.; De Leo, E.; Cacciapuoti, G.
Biochemical characterization of a thermostable adenosylmethionine synthetase from the archaeon Pyrococcus furiosus with high catalytic power
Appl. Biochem. Biotechnol.
175
2916-33
2015
Pyrococcus furiosus (Q8TZW1), Pyrococcus furiosus
Zano, S.P.; Pavlovsky, A.G.; Viola, R.E.
Structure of an unusual S-adenosylmethionine synthetase from Campylobacter jejuni
Acta Crystallogr. Sect. D
70
442-450
2014
Campylobacter jejuni
Yao, G.; Qin, X.; Chu, J.; Wu, X.; Qian, J.
Expression, purification, and characterization of a recombinant methionine adenosyltransferase pDS16 in Pichia pastoris
Appl. Biochem. Biotechnol.
172
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2014
Escherichia coli
Shafqat, N.; Muniz, J.R.; Pilka, E.S.; Papagrigoriou, E.; von Delft, F.; Oppermann, U.; Yue, W.W.
Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits
Biochem. J.
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Homo sapiens (P31153), Homo sapiens (Q00266), Homo sapiens
Wijayasinghe, Y.S.; Blumenthal, R.M.; Viola, R.E.
Producing proficient methyl donors from alternative substrates of S-adenosylmethionine synthetase
Biochemistry
53
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2014
Campylobacter jejuni, Neisseria meningitidis
Han, G.; Hu, X.; Wang, X.
Overexpression of methionine adenosyltransferase in Corynebacterium glutamicum for production of S-adenosyl-L-methionine
Biotechnol. Appl. Biochem.
63
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2016
Corynebacterium glutamicum (Q9K5E4), Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032 (Q9K5E4)
Schlesier, J.; Siegrist, J.; Gerhardt, S.; Erb, A.; Blaesi, S.; Richter, M.; Einsle, O.; Andexer, J.N.
Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis
BMC Struct. Biol.
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Thermococcus kodakarensis
Dippe, M.; Brandt, W.; Rost, H.; Porzel, A.; Schmidt, J.; Wessjohann, L.A.
Rationally engineered variants of S-adenosylmethionine (SAM) synthase: reduced product inhibition and synthesis of artificial cofactor homologues
Chem. Commun. (Camb.)
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3637-3640
2015
Bacillus subtilis, Bacillus subtilis ATCC 6051
Pajares, M.A.; Alvarez, L.; Perez-Sala, D.
How are mammalian methionine adenosyltransferases regulated in the liver? A focus on redox stress
FEBS Lett.
587
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2013
Rattus norvegicus
Cha, I.; Nam, Y.; Seo, M.
Isolation, expression, and characterization of S-adenosyl-L-methionine synthetase from Lactobacillus paraplantarum 72815
Food Sci. Biotechnol.
24
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Lactiplantibacillus paraplantarum, Lactiplantibacillus paraplantarum 72815
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Liu, Y.; Chen, B.; Wang, Z.; Liu, L.; Tan, T.
Functional characterization of a thermostable methionine adenosyltransferase from Thermus thermophilus HB27
Front. Chem. Sci. Engin.
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2016
Thermus thermophilus (Q72I53), Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 (Q72I53)
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Guo, Z.; Tan, J.; Zhuo, C.; Wang, C.; Xiang, B.; Wang, Z.
Abscisic acid, H2O2 and nitric oxide interactions mediated cold-induced S-adenosylmethionine synthetase in Medicago sativa subsp. falcata that confers cold tolerance through up-regulating polyamine oxidation
Plant Biotechnol. J.
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Medicago sativa (A4ULF8)
Gong, B.; Li, X.; VandenLangenberg, K.M.; Wen, D.; Sun, S.; Wei, M.; Li, Y.; Yang, F.; Shi, Q.; Wang, X.
Overexpression of S-adenosyl-L-methionine synthetase increased tomato tolerance to alkali stress through polyamine metabolism
Plant Biotechnol. J.
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2014
Solanum lycopersicum (P43280), Solanum lycopersicum
Gong, B.; Wang, X.; Wei, M.; Yang, F.; Li, Y.; Shi, Q.
Overexpression of S-adenosylmethionine synthetase 1 enhances tomato callus tolerance to alkali stress through polyamine and hydrogen peroxide cross-linked networks
Plant Cell
124
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2016
Solanum lycopersicum (P43280)
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Murray, B.; Antonyuk, S.V.; Marina, A.; Lu, S.C.; Mato, J.M.; Hasnain, S.S.; Rojas, A.L.
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes
Proc. Natl. Acad. Sci. USA
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Homo sapiens (Q9NZL9), Homo sapiens
Elremaly, W.; Mohamed, I.; Rouleau, T.; Lavoie, J.C.
Impact of glutathione supplementation of parenteral nutrition on hepatic methionine adenosyltransferase activity
Redox Biol.
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Cavia porcellus
Liu, Y.; Wang, W.; Zhang, W.; Dong, Y.; Han, F.; Raza, M.; Liu, L.; Tan, T.; Feng, Y.
Structure of a thermostable methionine adenosyltransferase from: Thermus thermophilus HB27 reveals a novel fold of the flexible loop
RSC Adv.
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Thermus thermophilus (Q72I53), Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 (Q72I53)
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Huber, T.D.; Clinger, J.A.; Liu, Y.; Xu, W.; Miller, M.D.; Phillips, G.N.; Thorson, J.S.
Methionine adenosyltransferase engineering to enable bioorthogonal platforms for AdoMet-utilizing enzymes
ACS Chem. Biol.
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695-705
2020
Homo sapiens (P31153), Homo sapiens
Sun, M.; Guo, H.; Lu, G.; Gu, J.; Wang, X.; Zhang, X.E.; Deng, J.
Lysine acetylation regulates the activity of Escherichia coli S-adenosylmethionine synthase
Acta Biochim. Biophys. Sin. (Shanghai)
48
723-731
2016
Escherichia coli (P0A817), Escherichia coli
Ohren, J.; Parungao, G.G.; Viola, R.E.
Structure of a critical metabolic enzyme S-adenosylmethionine synthetase from Cryptosporidium parvum
Acta Crystallogr. Sect. F
75
290-298
2019
Cryptosporidium parvum (Q5CYE4), Cryptosporidium parvum, Cryptosporidium parvum Iowa II (Q5CYE4)
Zhao, W.; Shi, F.; Hang, B.; Huang, L.; Cai, J.; Xu, Z.
The improvement of SAM accumulation by integrating the endogenous methionine adenosyltransferase gene SAM2 in genome of the industrial Saccharomyces cerevisiae strain
Appl. Biochem. Biotechnol.
178
1263-1272
2016
Saccharomyces cerevisiae (P19358), Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741 (P19358)
Niu, W.; Cao, S.; Yang, M.; Xu, L.
Enzymatic synthesis of S-adenosylmethionine using immobilized methionine adenosyltransferase variants on the 50-mM scale
Catalysts
7
238
2017
Escherichia coli, Escherichia coli BL21 (DE3)
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Wang, X.; Jiang, Y.; Wu, M.; Zhu, L.; Yang, L.; Lin, J.
Semi-rationally engineered variants of S-adenosylmethionine synthetase from Escherichia coli with reduced product inhibition and improved catalytic activity
Enzyme Microb. Technol.
129
109355
2019
Escherichia coli (P0A817), Escherichia coli, Escherichia coli K12 (P0A817)
Wang, J.; Zhu, Z.H.; Yang, H.B.; Zhang, Y.; Zhao, X.N.; Zhang, M.; Liu, Y.B.; Xu, Y.Y.; Lei, Q.Y.
Cullin 3 targets methionine adenosyltransferase IIalpha for ubiquitylation-mediated degradation and regulates colorectal cancer cell proliferation
FEBS J.
283
2390-2402
2016
Homo sapiens (P31153), Homo sapiens
Yang, H.; Liu, T.; Wang, J.; Li, T.W.; Fan, W.; Peng, H.; Krishnan, A.; Gores, G.J.; Mato, J.M.; Lu, S.C.
Deregulated methionine adenosyltransferase alpha1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans
Hepatology
64
439-455
2016
Homo sapiens (Q00266), Homo sapiens, Mus musculus (Q91X83), Mus musculus
Hayashi, T.; Teruya, T.; Chaleckis, R.; Morigasaki, S.; Yanagida, M.
S-Adenosylmethionine synthetase is required for cell growth, maintenance of G0 phase, and termination of quiescence in fission yeast
iScience
5
38-51
2018
Schizosaccharomyces pombe (O60198), Schizosaccharomyces pombe, Schizosaccharomyces pombe ATCC 24843 (O60198)
Pretzel, J.; Gehr, M.; Eisenkolb, M.; Wang, L.; Fritz-Wolf, K.; Rahlfs, S.; Becker, K.; Jortzik, E.
Characterization and redox regulation of Plasmodium falciparum methionine adenosyltransferase
J. Biochem.
160
355-367
2016
Plasmodium falciparum (Q7K6A4), Plasmodium falciparum
Minici, C.; Mosca, L.; Ilisso, C.P.; Cacciapuoti, G.; Porcelli, M.; Degano, M.
Structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues
J. Struct. Biol.
210
107462
2020
Pyrococcus furiosus (Q8TZW1), Pyrococcus furiosus, Pyrococcus furiosus ATCC 43587 (Q8TZW1)
Chen, Y.; Zou, T.; McCormick, S.
S-Adenosylmethionine synthetase 3 is important for pollen tube growth
Plant Physiol.
172
244-253
2016
Arabidopsis thaliana (Q9SJL8)
Meng, J.; Wang, L.; Wang, J.; Zhao, X.; Cheng, J.; Yu, W.; Jin, D.; Li, Q.; Gong, Z.
METHIONINE ADENOSYLTRANSFERASE4 mediates DNA and histone methylation
Plant Physiol.
177
652-670
2018
Arabidopsis thaliana (Q9LUT2), Arabidopsis thaliana
Seong, E.; Jeon, M.; Choi, J.; Yoo, J.; Lee, J.; Na, J.; Kim, N.; Yu, C.
Overexpression of S-adenosylmethionine synthetase enhances tolerance to cold stress in tobacco
Russ. J. Plant Physiol.
67
242-249
2020
Miscanthus sinensis, Miscanthus sinensis Andersson
-
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