Reference on EC 2.5.1.63 - adenosyl-fluoride synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schaffrath, C.; Deng, H.; OHagan, D.
Isolation and characterisation of 5-fluorodeoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya
FEBS Lett.
547
111-114
2003
Streptomyces cattleya
OHagan, D.; Schaffrath, C.; Cobb, L.; Hamilton, J.T.G.; Murphy, C.D.
Biosynthesis of an organofluorine molecule
Nature
416
279
2002
Streptomyces cattleya
Cadicamo, C.D.; Courtieu, J.; Deng, H.; Meddour, A.; O'Hagan, D.
Enzymatic fluorination in Streptomyces cattleya takes place with an inversion of configuration consistent with an SN2 reaction mechanism
Chembiochem
5
685-690
2004
Streptomyces cattleya
Dong, C.; Huang, F.; Deng, H.; Schaffrath, C.; Spencer, J.B.; O'Hagan, D.; Naismith, J.H.
Crystal structure and mechanism of a bacterial fluorinating enzyme
Nature
427
561-565
2004
Streptomyces cattleya
Deng, H.; Cobb, S.L.; Gee, A.D.; Lockhart, A.; Martarello, L.; McGlinchey, R.P.; OHagan, D.; Onega, M.
Fluorinase mediated C-18F bond formation, an enzymatic tool for PET labelling
Chem. Commun. (Camb. )
2006
652-654
2006
Streptomyces cattleya
-
O'Hagan, D.
Recent developments on the fluorinase from Streptomyces cattleya
J. Fluor. Chem.
127
1479-1483
2006
Streptomyces cattleya
-
Cobb, S.L.; Deng, H.; McEwan, A.R.; Naismith, J.H.; OHagan, D.; Robinson, D.A.
Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2-deoxyadenosine substrates
Org. Biomol. Chem.
4
1458-1460
2006
Streptomyces cattleya
Zhu, X.; Robinson, D.A.; McEwan, A.R.; OHagan, D.; Naismith, J.H.
Mechanism of enzymatic fluorination in Streptomyces cattleya
J. Am. Chem. Soc.
129
14597-14604
2007
Streptomyces cattleya
Deng, H.; Cross, S.M.; McGlinchey, R.P.; Hamilton, J.T.; OHagan, D.
In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase
Chem. Biol.
15
1268-1276
2008
Streptomyces cattleya
Winkler, M.; Domarkas, J.; Schweiger, L.; OHagan, D.
Fluorinase-coupled base swaps: Synthesis of 18F-5'-Deoxy-5'-fluorouridines
Angew. Chem. Int. Ed. Engl.
47
10141-10143
2008
Streptomyces cattleya
Iwai, N.; Tanaka, T.; Kitazume, T.
Utility of ionic liquid for improvement of fluorination reaction with immobilized fluorinase
J. Mol. Catal. B
59
131-133
2009
Streptomyces cattleya
-
Deng, H.; Cobb, S.L.; McEwan, A.R.; McGlinchey, R.P.; Naismith, J.H.; OHagan, D.; Robinson, D.A.; Spencer, J.B.
The fluorinase from Streptomyces cattleya is also a chlorinase
Angew. Chem.
45
759-762
2006
Streptomyces cattleya
Zhao, C.; Li, P.; Deng, Z.; Ou, H.Y.; McGlinchey, R.P.; OHagan, D.
Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants
Bioorg. Chem.
44
1-7
2012
Streptomyces cattleya (F8JPG4), Streptomyces cattleya DSM 46488 (F8JPG4)
Li, X.G.; Domarkas, J.; OHagan, D.
Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate
Chem. Commun. (Camb. )
46
7819-7821
2010
Streptomyces cattleya (F8JPG4), Streptomyces cattleya ATCC 35852 (F8JPG4)
Iwai, N.; Kitahara, Y.; Kitazume, T.
One-pot three-step continuous enzymatic synthesis of 5-fluoro-5-deoxy-D-ribose
J. Mol. Catal. B
73
1-4
2011
Streptomyces cattleya (F8JPG4), Streptomyces cattleya NBRC14057 (F8JPG4)
-
Eustaquio, A.S.; OHagan, D.; Moore, B.S.
Engineering fluorometabolite production: fluorinase expression in Salinispora tropica yields fluorosalinosporamide
J. Nat. Prod.
73
378-382
2010
Streptomyces cattleya (F8JPG4), Streptomyces cattleya, Streptomyces cattleya ATCC 35852 (F8JPG4)
Thompson, S.; Zhang, Q.; Onega, M.; McMahon, S.; Fleming, I.; Ashworth, S.; Naismith, J.H.; Passchier, J.; O'Hagan, D.
A localized tolerance in the substrate specificity of the fluorinase enzyme enables last-step 18F fluorination of a RGD peptide under ambient aqueous conditions
Angew. Chem. Int. Ed. Engl.
53
8913-8918
2014
Streptomyces cattleya (Q70GK9)
Thompson, S.; McMahon, S.A.; Naismith, J.H.; OHagan, D.
Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme
Bioorg. Chem.
64
37-41
2016
Streptomyces cattleya (Q70GK9)
Thompson, S.; Onega, M.; Ashworth, S.; Fleming, I.N.; Passchier, J.; OHagan, D.
A two-step fluorinase enzyme mediated (18)F labelling of an RGD peptide for positron emission tomography
Chem. Commun. (Camb.)
51
13542-13545
2015
Streptomyces cattleya (Q70GK9)
O'Hagan, D.; Deng, H.
Enzymatic fluorination and biotechnological developments of the fluorinase
Chem. Rev.
115
634-649
2015
Nocardia brasiliensis, Streptomyces xinghaiensis (A0A068VNW5), Streptomyces cattleya (Q70GK9), Actinoplanes sp. (R4LHX8), Streptomyces sp. (W0W999), Streptomyces xinghaiensis NRRL B-24674 (A0A068VNW5), Actinoplanes sp. N902-109 (R4LHX8)
Wang, Y.; Deng, Z.; Qu, X.
Characterization of a SAM-dependent fluorinase from a latent biosynthetic pathway for fluoroacetate and 4-fluorothreonine formation in Nocardia brasiliensis
F1000Res.
3
61-73
2014
Streptomyces cattleya (Q70GK9), Streptomyces cattleya, Nocardia brasiliensis (W8JNL4), Nocardia brasiliensis, Nocardia brasiliensis ATCC 700358 (W8JNL4), Nocardia brasiliensis ATCC 700358, Streptomyces cattleya DSM 46488 (Q70GK9)
Sergeev, M.; Morgia, F.; Javed, M.; Doi, M.; Keng, P.
Polymer-immobilized fluorinase: recyclable catalyst for fluorination reactions
J. Mol. Catal. B
92
51-56
2013
Streptomyces cattleya (F8JPG4), Streptomyces cattleya NBRC14057 (F8JPG4)
-
Sergeev, M.; Morgia, F.; Javed, M.; Doi, M.; Keng, P.
Enzymatic radiofluorination: fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis
J. Mol. Catal. B
97
74-79
2013
Streptomyces cattleya (F8JPG4), Streptomyces cattleya NBRC14057 (F8JPG4)
-
Thompson, S.; Fleming, I.N.; OHagan, D.
Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase
Org. Biomol. Chem.
14
3120-3129
2016
Streptomyces cattleya (Q70GK9)
Sun, H.; Yeo, W.L.; Lim, Y.H.; Chew, X.; Smith, D.J.; Xue, B.; Chan, K.P.; Robinson, R.C.; Robins, E.G.; Zhao, H.; Ang, E.L.
Directed evolution of a fluorinase for improved fluorination efficiency with a non-native substrate
Angew. Chem. Int. Ed. Engl.
55
14277-14280
2016
Streptomyces sp. MA37 (W0W999)
Tu, C.; Zhou, J.; Peng, L.; Man, S.; Ma, L.
Self-assembled nano-aggregates of fluorinases demonstrate enhanced enzymatic activity, thermostability and reusability
Biomater. Sci.
8
648-656
2020
Streptomyces xinghaiensis (A0A068VNW5)
Yeo, W.; Chew, X.; Smith, D.; Chan, K.; Sun, H.; Zhao, H.; Lim, Y.; Ang, E.
Probing the molecular determinants of fluorinase specificity
Chem. Commun. (Camb.)
53
2559-2562
2017
Streptomyces sp. MA37 (W0W999)
Sun, H.; Zhao, H.; Ang, E.
A coupled chlorinase-fluorinase system with a high efficiency of trans-halogenation and a shared substrate tolerance
Chem. Commun. (Camb.)
54
9458-9461
2018
Streptomyces sp. MA37 (W0W999)
Lowe, P.T.; Cobb, S.L.; OHagan, D.
An enzymatic Finkelstein reaction fluorinase catalyses direct halogen exchange
Org. Biomol. Chem.
17
7493-7496
2019
Streptomyces cattleya (Q70GK9), Streptomyces cattleya
Sooklal, S.; De Koning, C.; Brady, D.; Rumbold, K.
Identification and characterisation of a fluorinase from Actinopolyspora mzabensis
Protein Expr. Purif.
166
105508
2020
Actinopolyspora mzabensis (A0A1G9FQX8), Actinopolyspora mzabensis
Ma, L.; Li, Y.; Meng, L.; Deng, H.; Li, Y.; Zhang, Q.; Diao, A.
Biological fluorination from the sea Discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674
RSC Adv.
6
27047-27051
2016
Streptomyces xinghaiensis (A0A068VNW5)
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