Reference on EC 2.5.1.78 - 6,7-dimethyl-8-ribityllumazine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kis, K.; Bacher, A.
Substrate channeling in the lumazine synthase/riboflavin synthase complex of Bacillus subtilis
J. Biol. Chem.
270
16788-16795
1995
Bacillus subtilis
Cushman, M.; Yang, D.; Gerhardt, S.; Huber, R.; Fischer, M.; Kis, K.; Bacher, A.
Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase
J. Org. Chem.
67
5807-5816
2002
Bacillus subtilis
Cushman, M.; Yang, D.; Mihalic, J.T.; Chen, J.; Gerhardt, S.; Huber, R.; Fischer, M.; Kis, K.; Bacher, A.
Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase
J. Org. Chem.
67
6871-6877
2002
Bacillus subtilis
Rodriguez-Fernandez, L.; Lopez-Jaramillo, F.J.; Bacher, A.; Fischer, M.; Weinkauf, S.
Improvement of the quality of lumazine synthase crystals by protein engineering
Acta Crystallogr. Sect. F
64
625-628
2008
Bacillus subtilis (P11998), Bacillus subtilis
Grill, S.; Yamaguchi, H.; Wagner, H.; Zwahlen, L.; Kusch, U.; Mack, M.
Identification and characterization of two Streptomyces davawensis riboflavin biosynthesis gene clusters
Arch. Microbiol.
188
377-387
2007
Streptomyces davaonensis
Klinke, S.; Zylberman, V.; Bonomi, H.R.; Haase, I.; Guimaraes, B.G.; Braden, B.C.; Bacher, A.; Fischer, M.; Goldbaum, F.A.
Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales
J. Mol. Biol.
373
664-680
2007
Brucella abortus, Brucella melitensis, Mesorhizobium loti (Q983B0), Mesorhizobium loti (Q986N2)
Talukdar, A.; Illarionov, B.; Bacher, A.; Fischer, M.; Cushman, M.
Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase
J. Org. Chem.
72
7167-7175
2007
Bacillus subtilis, Mycobacterium tuberculosis, Schizosaccharomyces pombe
Zhang, Y.; Jin, G.; Illarionov, B.; Bacher, A.; Fischer, M.; Cushman, M.
A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation
J. Org. Chem.
72
7176-7184
2007
Candida albicans, Pyricularia grisea, Mycobacterium tuberculosis
Zhang, Y.; Illarionov, B.; Morgunova, E.; Jin, G.; Bacher, A.; Fischer, M.; Ladenstein, R.; Cushman, M.
A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications
J. Org. Chem.
73
2715-2724
2008
Bacillus subtilis, Mycobacterium tuberculosis, Schizosaccharomyces pombe
Morgunova, E.; Meining, W.; Illarionov, B.; Haase, I.; Jin, G.; Bacher, A.; Cushman, M.; Fischer, M.; Ladenstein, R.
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors
Biochemistry
44
2746-2758
2005
Mycobacterium tuberculosis
Yu, T.Y.; O'Connor, R.D.; Sivertsen, A.C.; Chiauzzi, C.; Poliks, B.; Fischer, M.; Bacher, A.; Haase, I.; Cushman, M.; Schaefer, J.
15N(31)P REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase
Biochemistry
47
13942-13951
2008
Saccharomyces cerevisiae
Fischer, M.; Haase, I.; Feicht, R.; Richter, G.; Gerhardt, S.; Changeux, J.P.; Huber, R.; Bacher A.
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe
Eur. J. Biochem.
269
519-526
2002
Schizosaccharomyces pombe (Q9UUB1), Schizosaccharomyces pombe
Haase, I.; Mörtl, S.; Köhler, P.; Bacher, A.; Fischer, M.
Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii
Eur. J. Biochem.
270
1025-1032
2003
Aquifex aeolicus, Methanocaldococcus jannaschii (Q57751), Methanocaldococcus jannaschii
Koch, M.; Breithaupt, C.; Gerhardt, S.; Haase, I.; Weber, S.; Cushman, M.; Huber, R.; Bacher, A.; Fischer, M.
Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase
Eur. J. Biochem.
271
3208-3214
2004
Schizosaccharomyces pombe
Morgunova, E.; Illarionov, B.; Sambaiah, T.; Haase, I.; Bacher, A.; Cushman, M.; Fischer, M.; Ladenstein, R.
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis
FEBS J.
273
4790-4804
2006
Mycobacterium tuberculosis
Zylberman, V.; Klinke, S.; Haase, I.; Bacher, A.; Fischer, M.; Goldbaum, F.A.
Evolution of vitamin B2 biosynthesis: 6,7-dimethyl-8-ribityllumazine synthases of Brucella
J. Bacteriol.
188
6135-6142
2006
Brucella sp.
Garcia-Ramirez, J.J.; Santos, M.A.; Revuelta, J.L.
The Saccharomyces cerevisiae RIB4 gene codes for 6,7-dimethyl-8-ribityllumazine synthase involved in riboflavin biosynthesis. Molecular characterization of the gene and purification of the encoded protein
J. Biol. Chem.
270
23801-23807
1995
Saccharomyces cerevisiae (P50861), Saccharomyces cerevisiae
Mörtl, S.; Fischer, M.; Richter, G.; Tack, J.; Weinkauf, S.; Bacher, A.
Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli
J. Biol. Chem.
271
33201-33207
1996
Escherichia coli, Saccharomyces cerevisiae
Jordan, D.B.; Bacot, K.O.; Carlson, T.J.; Kessel, M.; Viitanen, P.V.
Plant riboflavin biosynthesis. Cloning, chloroplast localization, expression, purification, and partial characterization of spinach lumazine synthase
J. Biol. Chem.
274
22114-22121
1999
Arabidopsis thaliana, Nicotiana tabacum, Spinacia oleracea
Haase, I.; Fischer, M.; Bacher, A.; Schramek, N.
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus
J. Biol. Chem.
278
37909-37915
2003
Aquifex aeolicus
Zylberman, V.; Craig, P.O.; Klinkem, S.; Braden, B.C.; Cauerhff, A.; Goldbaum, F.A.
High order quaternary arrangement confers increased structural stability to Brucella sp. lumazine synthase
J. Biol. Chem.
279
8093-8101
2003
Brucella sp.
Morgunova, E.; Saller, S.; Haase, I.; Cushman, M.; Bacher, A.; Fischer, M.; Ladenstein, R.
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design
J. Biol. Chem.
282
17231-17241
2007
Candida albicans
Goldbaum, F.A.; Velikovsky, C.A.; Baldi, P.C.; Mörtl, S.; Bacher, A.; Fossati, C.A.
The 18-kDa cytoplasmic protein of Brucella species - an antigen useful for diagnosis - is a lumazine synthase
J. Med. Microbiol.
48
833-839
1999
Brucella sp. (P61711)
Ritsert, K.; Huber, R.; Turk, D.; Ladenstein, R.; Schmidt-Bäse, K.; Bacher, A.
Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution
J. Mol. Biol.
253
151-167
1995
Bacillus subtilis
Braden, B.C.; Velikovsky, C.A.; Cauerhff, A.A.; Polikarpov, I.; Goldbaum, F.A.
Divergence in macromolecular assembly: X-ray crystallographic structure analysis of lumazine synthase from Brucella abortus
J. Mol. Biol.
297
1031-1036
2000
Brucella abortus (P61711), Brucella abortus
Meining, W.; Mörtl, S.; Fischer, M.; Cushman, M.; Bacher, A.; Ladenstein, R.
The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue
J. Mol. Biol.
299
181-197
2000
Saccharomyces cerevisiae
Zhang, X.; Meining, W.; Fischer, M.; Bacher, A.; Ladenstein, R.
X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons
J. Mol. Biol.
306
1099-1114
2001
Aquifex aeolicus
Gerhardt, S.; Haase, I.; Steinbacher, S.; Kaiser, J.T.; Cushman, M.; Bacher, A.; Huber, R.; Fischer, M.
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase
J. Mol. Biol.
318
1317-1329
2002
Schizosaccharomyces pombe
Fischer, M.; Haase, I.; Kis, K.; Meining, W.; Ladenstein, R.; Cushman, M.; Schramek, N.; Huber, R.; Bacher, A.
Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase
J. Mol. Biol.
326
783-793
2003
Bacillus subtilis
Zhang, X.; Meining, W.; Cushman, M.; Haase, I.; Fischer, M.; Bacher, A.; Ladenstein, R.
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus
J. Mol. Biol.
328
167-182
2003
Aquifex aeolicus
Klinke, S.; Zylberman, V.; Vega, D.R.; Guimaraes, B.G.; Braden, B.C.; Goldbaum, F.A.
Crystallographic studies on decameric Brucella spp. lumazine synthase: a novel quaternary arrangement evolved for a new function?
J. Mol. Biol.
353
124-137
2005
Brucella sp.
Cushman, M.; Sambaiah, T.; Jin, G.; Illarionov, B.; Fischer, M.; Bacher, A.
Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of riboflavin synthase and lumazine synthase
J. Org. Chem.
69
601-612
2004
Bacillus subtilis, Mycobacterium tuberculosis
Chen, J.; Sambaiah, T.; Illarionov, B.; Fischer, M.; Bacher, A.; Cushman, M.
Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes
J. Org. Chem.
69
6996-7003
2004
Bacillus subtilis, Mycobacterium tuberculosis
Cushman, M.; Jin, G.; Sambaiah, T.; Illarionov, B.; Fischer, M.; Ladenstein, R.; Bacher, A.
Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase
J. Org. Chem.
70
8162-8170
2005
Bacillus subtilis, Mycobacterium tuberculosis
Zhang, Y.; Illarionov, B.; Bacher, A.; Fischer, M.; Georg, G.I.; Ye, Q.Z.; Vander Velde, D.; Fanwick, P.E.; Song, Y.; Cushman, M.
A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative
J. Org. Chem.
72
2769-2776
2007
Schizosaccharomyces pombe
Talukdar, A.; Breen, M.; Bacher, A.; Illarionov, B.; Fischer, M.; Georg, G.; Ye, Q.Z.; Cushman, M.
Discovery and development of a small molecule library with lumazine synthase inhibitory activity
J. Org. Chem.
74
5123-5134
2009
Mycobacterium tuberculosis, Schizosaccharomyces pombe
Dantas, S.F.; Vieira de Rezende, T.C.; Bailao, A.M.; Taborda, C.P.; da Silva Santos, R.; Pacheco de Castro, K.; Maria de Almeida Soares, C.
Identification and characterization of antigenic proteins potentially expressed during the infectious process of Paracoccidioides brasiliensis
Microbes Infect.
11
895-903
2009
Paracoccidioides brasiliensis
Rosas, G.; Fragoso, G.; Ainciart, N.; Esquivel-Guadarrama, F.; Santana, A.; Bobes, R.J.; Ramirez-Pliego, O.; Toledo, A.; Cruz-Revilla, C.; Meneses, G.M.; Berguer, P.; Goldbaum, F.A.; Sciutto, E.
Brucella spp. lumazine synthase: a novel adjuvant and antigen delivery system to effectively induce oral immunity
Microbes Infect.
8
1277-1286
2006
Brucella sp.
Fornasari, M.S.; Laplagne, D.A.; Frankel, N.; Cauerhff, A.A.; Goldbaum, F.A.; Echave, J.
Sequence determinants of quaternary structure in lumazine synthase
Mol. Biol. Evol.
21
97-107
2003
Spinacia oleracea, Corynebacterium ammoniagenes (O24753), Helicobacter pylori (O24854), Methanothermobacter thermautotrophicus (O27443), Archaeoglobus fulgidus (O28152), Aquifex aeolicus (O66529), Sulfurospirillum multivorans (O68250), Arabidopsis thaliana (O80575), Chlamydia trachomatis (O84737), Bacillus subtilis (P11998), Haemophilus influenzae (P45149), Actinobacillus pleuropneumoniae (P50856), Saccharomyces cerevisiae (P50861), Photobacterium phosphoreum (P51963), Pasteurella multocida (P57869), Brucella abortus (P61711), Synechocystis sp. (P73527), Photobacterium leiognathi (Q01994), Photobacterium leiognathi (Q93E92), Bacillus amyloliquefaciens (Q44681), Rhodococcus erythropolis (Q53107), Methanocaldococcus jannaschii (Q57751), Buchnera aphidicola (Q8K9A6), Buchnera aphidicola (Q9ZNM0), Chlorobaculum tepidum (Q8KAW4), Corynebacterium glutamicum (Q8NQ53), Xanthomonas campestris (Q8PCM7), Xanthomonas citri (Q8PPD6), Methanosarcina mazei (Q8Q093), Fusobacterium nucleatum (Q8RIR4), Methanosarcina acetivorans (Q8TPT7), Methanopyrus kandleri (Q8TYL5), Agrobacterium tumefaciens (Q8UG70), Clostridium perfringens (Q8XMW9), Ralstonia solanacearum (Q8Y1H8), Anabaena sp. (Q8YQ43), Yersinia pestis (Q8ZC41), Pyrobaculum aerophilum (Q8ZTE3), Sinorhizobium meliloti (Q92NI1), Sinorhizobium meliloti (Q92QU0), Sulfurisphaera tokodaii (Q975M5), Clostridium acetobutylicum (Q97LG8), Mesorhizobium loti (Q983B0), Mesorhizobium loti (Q986N2), Caulobacter vibrioides (Q9A8J4), Caulobacter vibrioides (Q9A9S4), Mycobacterium leprae (Q9CCP3), Lactococcus lactis subsp. lactis (Q9CGU6), Streptomyces coelicolor (Q9EWJ9), Halobacterium salinarum (Q9HRM5), Pseudomonas aeruginosa (Q9HWX5), Halalkalibacterium halodurans (Q9KCL4), Vibrio cholerae (Q9KPU4), Xylella fastidiosa (Q9PES4), Campylobacter jejuni (Q9PIB9), Chlamydia muridarum (Q9PLJ4), Bartonella henselae (Q9REF4), Deinococcus radiodurans (Q9RXZ8), Schizosaccharomyces pombe (Q9UUB1), Pyricularia grisea (Q9UVT8), Thermotoga maritima (Q9X2E5), Nicotiana tabacum (Q9XH13), Chlamydia pneumoniae (Q9Z733), Helicobacter pylori J99 (Q9ZN56), Agrobacterium tumefaciens C58 / ATCC 33970 (Q8UG70)
Sciutto, E.; Toledo, A.; Cruz, C.; Rosas, G.; Meneses, G.; Laplagne, D.; Ainciart, N.; Cervantes, J.; Fragoso, G.; Goldbaum, F.A.
Brucella spp. lumazine synthase: a novel antigen delivery system
Vaccine
23
2784-2790
2005
Brucella sp.
Bellido, D.; Craig, P.O.; Mozgovoj, M.V.; Gonzalez, D.D.; Wigdorovitz, A.; Goldbaum, F.A.; Dus Santos, M.J.
Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system
Vaccine
27
136-145
2009
Brucella sp.
Morgunova, E.; Illarionov, B.; Saller, S.; Popov, A.; Sambaiah, T.; Bacher, A.; Cushman, M.; Fischer, M.; Ladenstein, R.
Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis
Acta Crystallogr. Sect. D
66
1001-1011
2010
Bacillus anthracis
Kumar, P.; Singh, M.; Karthikeyan, S.
Crystal structure analysis of icosahedral lumazine synthase from Salmonella typhimurium, an antibacterial drug target
Acta Crystallogr. Sect. D
67
131-139
2011
Salmonella enterica subsp. enterica serovar Typhimurium (P66038), Salmonella enterica subsp. enterica serovar Typhimurium
Talukdar, A.; Morgunova, E.; Duan, J.; Meining, W.; Foloppe, N.; Nilsson, L.; Bacher, A.; Illarionov, B.; Fischer, M.; Ladenstein, R.; Cushman, M.
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase
Bioorg. Med. Chem.
18
3518-3534
2010
Mycobacterium tuberculosis
Tuan, P.A.; Kim, J.K.; Lee, S.; Chae, S.C.; Park, S.U.
Riboflavin accumulation and characterization of cDNAs encoding lumazine synthase and riboflavin synthase in bitter melon (Momordica charantia)
J. Agric. Food Chem.
60
11980-11986
2012
Momordica charantia (L0C9N6), Momordica charantia
Talukdar, A.; Zhao, Y.; Lv, W.; Bacher, A.; Illarionov, B.; Fischer, M.; Cushman, M.
O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase
J. Org. Chem.
77
6239-6261
2012
Bacillus subtilis, Mycobacterium tuberculosis, Schizosaccharomyces pombe (Q9UUB1)
Bonomi, H.; Marchesini, M.; Klinke, S.; Ugalde, J.; Zylberman, V.; Ugalde, R.; Comerci, D.; Goldbaum, F.
An atypical riboflavin pathway is essential for Brucella abortus virulence
PLoS ONE
5
e9435
2010
Brucella abortus (P61711), Brucella abortus (Q57DY1), Brucella abortus
Shankar, M.; Wilbanks, S.M.; Nakatani, Y.; Monk, B.C.; Tyndall, J.D.
Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata
Acta Crystallogr. Sect. D
69
1580-1586
2013
[Candida] glabrata (Q6FXA8), [Candida] glabrata
Du, Z.; Li, X.; Wang, J.
Immunogenicity analysis of a novel subunit vaccine candidate molecule - recombinant L7/L12 ribosomal protein of Brucella suis
Appl. Biochem. Biotechnol.
179
1445-1455
2016
Brucella suis (P61711), Brucella suis
Birkenmeier, M.; Neumann, S.; Roeder, T.
Kinetic modeling of riboflavin biosynthesis in Bacillus subtilis under production conditions
Biotechnol. Lett.
36
919-928
2014
Bacillus subtilis (P11998), Bacillus subtilis
Ladenstein, R.; Fischer, M.; Bacher, A.
The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system
FEBS J.
280
2537-2563
2013
Aquifex aeolicus (O66529), Bacillus subtilis (P11998), Brucella abortus (Q2YKV1), Brucella abortus (Q2YNC6), Saccharomyces cerevisiae (P50861)
Alfano, E.; Lentz, E.; Bellido, D.; Dus Santos, M.; Goldbaum, F.; Wigdorovitz, A.; Bravo-Almonacid, F.
Expression of the multimeric and highly immunogenic Brucella spp. lumazine synthase fused to bovine rotavirus VP8D as a scaffold for antigen production in tobacco chloroplasts
Front. Plant Sci.
6
1170
2015
Brucella sp. (P61711), Brucella sp. 9-941 (P61711)
Du, Z.Q.; Wang, J.Y.
A novel lumazine synthase molecule from Brucella significantly promotes the immune-stimulation effects of antigenic protein
Genet. Mol. Res.
14
13084-13095
2015
Brucella suis (P61711), Brucella suis
Mejias, M.P.; Cabrera, G.; Fernandez-Brando, R.J.; Baschkier, A.; Ghersi, G.; Abrey-Recalde, M.J.; Miliwebsky, E.; Meiss, R.; Goldbaum, F.; Zylberman, V.; Rivas, M.; Palermo, M.S.
Protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera
Infect. Immun.
82
1491-1499
2014
Brucella sp.
Mejias, M.P.; Ghersi, G.; Craig, P.O.; Panek, C.A.; Bentancor, L.V.; Baschkier, A.; Goldbaum, F.A.; Zylberman, V.; Palermo, M.S.
Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and Brucella lumazine synthase confers total protection against Shiga toxins in mice
J. Immunol.
191
2403-2411
2013
Brucella sp.
Tuan, P.; Zhao, S.; Kim, J.; Kim, Y.; Yang, J.; Li, C.; Kim, S.; Arasu, M.; Al-Dhabi, N.; Park, S.
Riboflavin accumulation and molecular characterization of cDNAs encoding bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase, lumazine synthase, and riboflavin synthase in different organs of Lycium chinense plant
Molecules
19
17141-17153
2014
Lycium chinense (W0FEU6), Lycium chinense (W0FJR2)
Rossi, A.H.; Farias, A.; Fernandez, J.E.; Bonomi, H.R.; Goldbaum, F.A.; Berguer, P.M.
Brucella spp. lumazine synthase induces a TLR4-mediated protective response against B16 melanoma in mice
PLoS ONE
10
e0126827
2015
Brucella sp. (P61711)
Min, J.; Kim, S.; Lee, J.; Kang, S.
Lumazine synthase protein cage nanoparticles as modular delivery platforms for targeted drug delivery
RSC Adv.
4
48596-48600
2014
Aquifex aeolicus
-
Song, Y.; Kang, Y.J.; Jung, H.; Kim, H.; Kang, S.; Cho, H.
Lumazine synthase protein nanoparticle-Gd(III)-DOTA conjugate as a T1 contrast agent for high-field MRI
Sci. Rep.
5
15656
2015
Aquifex aeolicus (O66529), Aquifex aeolicus
Akbari, R.; Sekhavati, M.H.; Bahrami, A.; Majidzadeh Heravi, R.; Yousefi, S.
Production of Brucella lumazine synthase recombinant protein to pesign a subunit vaccine against undulant fever
Arch. Razi Inst.
74
1-6
2019
Brucella melitensis (X5DV28)
Han, X.; Woycechowsky, K.J.
Encapsulation and controlled release of protein guests by the Bacillus subtilis lumazine synthase capsid
Biochemistry
56
6211-6220
2017
Bacillus subtilis
Azuma, Y.; Herger, M.; Hilvert, D.
Diversification of protein cage structure using circularly permuted subunits
J. Am. Chem. Soc.
140
558-561
2018
Aquifex aeolicus (O66529), Aquifex aeolicus
Azuma, Y.; Zschoche, R.; Hilvert, D.
The C-terminal peptide of Aquifex aeolicus riboflavin synthase directs encapsulation of native and foreign guests by a cage-forming lumazine synthase
J. Biol. Chem.
292
10321-10327
2017
Aquifex aeolicus, Aquifex aeolicus (O66529)
Wei, Y.; Wahome, N.; Kumar, P.; Whitaker, N.; Picking, W.L.; Middaugh, C.R.
Effect of phosphate ion on the structure of lumazine synthase, an antigen presentation system from Bacillus anthracis
J. Pharm. Sci.
107
814-823
2018
Bacillus anthracis
Hiriart, Y.; Rossi, A.H.; Biedma, M.E.; Errea, A.J.; Moreno, G.; Cayet, D.; Rinaldi, J.; Blanca, B.; Sirard, J.C.; Goldbaum, F.; Berguer, P.; Rumbo, M.
Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella
Protein Sci.
26
1049-1059
2017
Brucella abortus (Q2YKV1), Brucella abortus 2308 (Q2YKV1)
Wei, Y.; Wahome, N.; VanSlyke, G.; Whitaker, N.; Kumar, P.; Barta, M.L.; Picking, W.L.; Volkin, D.B.; Mantis, N.J.; Middaugh, C.R.
Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display
Protein Sci.
26
2059-2072
2017
Bacillus anthracis
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