Information on EC 2.6.1.106 - dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase

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The expected taxonomic range for this enzyme is: Streptomyces venezuelae

EC NUMBER
COMMENTARY hide
2.6.1.106
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RECOMMENDED NAME
GeneOntology No.
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dTDP-D-desosamine biosynthesis
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Polyketide sugar unit biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate
dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate
dTDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
Q9ZGH4
the enzyme is involved in biosynthesis of desosamine
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
a pyridoxal-phosphate protein. The pyridoxal 5'-phosphate cofactor is held in place by residues contributed from both subunits (Asp164 and Gln167 from subunit I and Tyr221 and Asn235 from subunit II)
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
DesV is a homodimer with each subunit containing 12 alpha-helical regions and 12 beta-strands that together form three layers of sheet
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
hanging drop method of vapor diffusion, three-dimensional structures of both the internal aldimine and the ketimine intermediate with glutamate are determined to 2.05 A resolution
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli