Information on EC 2.6.1.110 - dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase

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The expected taxonomic range for this enzyme is: Saccharopolyspora spinosa

EC NUMBER
COMMENTARY hide
2.6.1.110
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RECOMMENDED NAME
GeneOntology No.
dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dTDP-D-forosamine biosynthesis
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Polyketide sugar unit biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dTDP-2,6-dideoxy-alpha-D-threo-hexopyranos-4-ulose + L-glutamate
dTDP-4-amino-2,4,6-trideoxy-alpha-D-arabino-hexopyranose + 2-oxoglutarate
show the reaction diagram
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in the presence of pyridoxal 5'-phosphate
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ir
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate
dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
show the reaction diagram
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-
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r
dTMP-5-amino-2,6-anhydro-1,3,4,5,7-pentadeoxy-1-phosphono-D-arabino-heptitol + 2-oxoglutarate
dTMP-2,6-anhydro-5-dehydro-1,3,4,7-tetradeoxy-1-phosphono-D-arabino-heptitol + L-glutamate
show the reaction diagram
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in the presence of pyridoxal 5'-phosphate
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r
TDP-4-dehydro-2,6-dideoxy-D-glucose + 2-oxoglutarate
TDP-4-amino-2,4,6-trideoxy-D-glucose + L-glutamate
show the reaction diagram
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r
TDP-4-hehydro-2,3,6-trideoxy-D-glucose + 2-oxoglutarate
TDP-4-amino-2,3,4,6-tetradeoxy-D-glucose + L-glutamate
show the reaction diagram
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-
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r
TDP-C-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate
?
show the reaction diagram
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate
dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
show the reaction diagram
Q9ALN9
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r
TDP-4-hehydro-2,3,6-trideoxy-D-glucose + 2-oxoglutarate
TDP-4-amino-2,3,4,6-tetradeoxy-D-glucose + L-glutamate
show the reaction diagram
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r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
85900
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni-NTA column chromatography and Sephacryl S-200 gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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