Information on EC 2.6.1.12 - alanine-oxo-acid transaminase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.6.1.12
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RECOMMENDED NAME
GeneOntology No.
alanine-oxo-acid transaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-alanine + a 2-oxo carboxylate = pyruvate + an L-amino acid
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Alanine, aspartate and glutamate metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
L-alanine:2-oxo-acid aminotransferase
A pyridoxal-phosphate protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-41-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
enzyme F-II
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxobutanoate
pyruvate + 2-aminobutanoate
show the reaction diagram
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r
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
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at 2% of the activity with 2-oxobutanoate
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r
L-alanine + 2-oxohexanoate
pyruvate + 2-aminohexanoate
show the reaction diagram
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at 81% of the activity with 2-oxobutanoate
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r
L-alanine + 2-oxoisohexanoate
pyruvate + L-leucine
show the reaction diagram
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at 8% of the activity with 2-oxobutanoate
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r
L-alanine + 2-oxoisopentanoate
pyruvate + L-valine
show the reaction diagram
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at 10% of the activity with 2-oxobutanoate
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r
L-alanine + 2-oxopentanoate
pyruvate + L-norvaline
show the reaction diagram
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at 108% of the activity with 2-oxobutanoate
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r
L-alanine + glyoxylate
pyruvate + glycine
show the reaction diagram
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53% of the activity with 2-oxobutanoate
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?
L-alanine + oxaloacetate
pyruvate + L-aspartate
show the reaction diagram
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at 16% of the activity with 2-oxobutanoate
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r
pyruvate + L-2-aminobutanoate
L-alanine + 2-oxobutanoate
show the reaction diagram
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preferred amino donor
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r
pyruvate + L-aspartate
L-alanine + oxaloacetate
show the reaction diagram
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4% of the activity with L-2-aminobutanoate
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?
pyruvate + L-glutamate
L-alanine + 2-oxoglutarate
show the reaction diagram
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4% of the activity with L-2-aminobutanoate
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r
pyruvate + L-isoleucine
L-alanine + 3-methyl-2-oxopentanoate
show the reaction diagram
pyruvate + L-leucine
alanine + 4-methyl-2-oxopentanoate
show the reaction diagram
pyruvate + L-norleucine
L-alanine + 2-oxohexanoate
show the reaction diagram
pyruvate + L-norvaline
L-alanine + 2-oxopentanoate
show the reaction diagram
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84% of the activity with L-2-aminobutanoate
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r
pyruvate + L-phenylalanine
L-alanine + 2-oxo-3-phenylpropanoate
show the reaction diagram
pyruvate + L-threonine
L-alanine + 3-hydroxy-2-oxobutanoate
show the reaction diagram
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3% of the activity with L-2-aminobutanoate
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?
pyruvate + L-valine
L-alanine + 3-methyl-2-oxobutanoate
show the reaction diagram
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8% of the activity with L-2-aminobutanoate
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r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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a pyridoxal phosphate protein
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
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assay at
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
enzyme F-II
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