Information on EC 2.6.1.41 - D-methionine-pyruvate transaminase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.6.1.41
-
RECOMMENDED NAME
GeneOntology No.
D-methionine-pyruvate transaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
alanine metabolism
-
-
D-Alanine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
D-methionine:pyruvate aminotransferase
Oxaloacetate can replace pyruvate.
CAS REGISTRY NUMBER
COMMENTARY hide
37277-93-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
peanut cv. Starr
-
-
Manually annotated by BRENDA team
cauliflower
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-methionine + 2-oxoglutarate
4-methylthio-2-oxobutanoate + L-glutamate
show the reaction diagram
D-methionine + oxaloacetate
4-methylthio-2-oxobutanoate + L-aspartate
show the reaction diagram
D-methionine + pyruvate
4-methylthio-2-oxobutanoate + L-alanine
show the reaction diagram
L-methionine + pyruvate
4-methylthio-2-oxobutanoate + L-alanine
show the reaction diagram
-
one third of activity compared to D-methionine
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-methionine + pyruvate
4-methylthio-2-oxobutanoate + L-alanine
show the reaction diagram
-
involved in ethylene synthesis from methionine
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
required for full enzyme activity
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
10061 units/mg, 1 unit is defined as the quantity of enzyme that produces 1 nanoliter of ethylene per h of dark reaction
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 8
-
15% of maximal activity at pH 6.0, 66% of maximal activity at pH 8.0
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
31
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
germinating
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
pyridoxal 5'-phosphate stabilizes
-
reducing agents, such as cysteine, 2-mercaptoethanol or dithiothreitol, are essential for maintaining activity during purification
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, cold precipitation, acetone precipitation, partial purification
-
partial
-