Information on EC 2.6.1.89 - dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase

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The expected taxonomic range for this enzyme is: Streptomyces fradiae

EC NUMBER
COMMENTARY hide
2.6.1.89
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RECOMMENDED NAME
GeneOntology No.
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis
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dTDP-alpha-D-mycaminose biosynthesis
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Polyketide sugar unit biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. The reaction occurs in the reverse direction. The enzyme is involved in biosynthesis of D-mycaminose.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
CDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2-oxoglutarate
show the reaction diagram
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?
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
show the reaction diagram
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the enzyme is involved in biosynthesis of D-mycaminose
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r
dTDP-3-dehydro-2,6-dideoxy-alpha-D-glucose + L-glutamate
TDP-3-amino-2,3,6-trideoxy-alpha-D-glucose + 2-oxoglutarate
show the reaction diagram
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?
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
show the reaction diagram
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no formation of TDP-4-oxo-6-deoxy-alpha-D-glucose
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r
additional information
?
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no activity with TDP-4-keto-6-deoxy-D-glucose
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
show the reaction diagram
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the enzyme is involved in biosynthesis of D-mycaminose
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r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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a pyridoxal-phosphate protein
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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