Information on EC 2.7.1.103 - viomycin kinase

Word Map on EC 2.7.1.103
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.1.103
-
RECOMMENDED NAME
GeneOntology No.
viomycin kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + viomycin = ADP + O-phosphoviomycin
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:viomycin O-phosphotransferase
Acts also on capreomycins. A serine residue in the peptide antibiotics acts as phosphate-acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
77000-11-4
-
77000-12-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Streptomyces coelicolor
strain A, standard reference actinomycete, sensitive to viomycin and capreomycin
-
-
Manually annotated by BRENDA team
no activity in Streptomyces coelicolor A
strain A, standard reference actinomycete, sensitive to viomycin and capreomycin
-
-
Manually annotated by BRENDA team
NCIB 8852
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + capreomycin IA
ADP + O-phosphocapreomycin IA
show the reaction diagram
ATP + capreomycin IIA
ADP + O-phosphocapreomycin IIA
show the reaction diagram
ATP + viomycin
ADP + O-phosphoviomycin
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + viomycin
ADP + O-phosphoviomycin
show the reaction diagram
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
shotgun cloning, resistance to viomycin is cloned into Streptomyces lividans, recombinant clones are cross resistant to capreomycin IA, but not to capreomycin IB
-
vph gene of plasmid pVE138 is expressed and confers resistance to viomycin in Streptomyces spp. and Salmonella typhimurium MJ1
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine