Reference on EC 2.7.1.105 - 6-phosphofructo-2-kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Francois, J.; Van Schaftingen, E.; Hers, H.G.
Characterization of phosphofructokinase 2 and of enzymes involved in the degradation of fructose 2,6-bisphosphate in yeast
Eur. J. Biochem.
171
599-608
1988
Saccharomyces cerevisiae
Walker, G.H.; Huber, S.C.
ATP-dependent activation of a new form of spinach leaf 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
Arch. Biochem. Biophys.
258
58-64
1987
Spinacia oleracea
Kretschmer, M.; Schellenberger, W.; Otto, A.; Kessler, R.; Hofmann, E.
Fructose-2,6-bisphosphatase and 6-phosphofructo-2-kinase are separable in yeast
Biochem. J.
246
755-759
1987
Saccharomyces cerevisiae
Loiseau, A.M.; Rider, M.H.; Hue, L.
Purification and properties of 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase from rat hepatoma cells
Biochem. Soc. Trans.
15
384-385
1987
Rattus norvegicus
-
El-Maghrabi, M.R.; Correia, J.J.; Heil, P.J.; Pate, T.M.; Cobb, C.E.; Pilkis, S.J.
Tissue distribution, immunoreactivity, and physical properties of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Proc. Natl. Acad. Sci. USA
83
5005-5009
1986
Bos taurus, Canis lupus familiaris, Rattus norvegicus
Van Schaftingen, E.; Hers, H.G.
Purification and properties of phosphofructokinase 2/fructose 2,6-bisphosphatase from chicken liver and from pigeon muscle
Eur. J. Biochem.
159
359-365
1986
Gallus gallus, Columba sp.
Draborg, H.; Villadsen, D.; Nielsen, T.H.
Cloning, characterization and expression of a bifunctional fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase from potato
Plant Mol. Biol.
39
709-720
1999
Solanum tuberosum (O81398)
Sakurai, T.; Johnson, J.H.; Uyeda, K.
Islet fructose 6-phosphate, 2-kinase: fructose 2,6-bisphosphatase: isozymic form, expression, and characterization
Biochem. Biophys. Res. Commun.
218
159-163
1996
Bos taurus, Rattus norvegicus
Sakata, J.; Uyeda, K.
Characterization of two isozymic forms of heart fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase
Biochem. Biophys. Res. Commun.
180
470-474
1991
Bos taurus
Sakakibara, R.; Uemura, M.; Hirata, T.; Okamura, N.; Kato, M.
Human placental fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase: its isozymic form, expression and characterization
Biosci. Biotechnol. Biochem.
61
1949-1952
1997
Homo sapiens
Sakakibara, R.; Kato, M.; Okamura, N.; Nakagawa, T.; Komada, Y.; Tominaga, N.; Shimojo, M.; Fukasawa, M.
Characterization of a human placental fructose-6-phosphate,2-kinase fructose-2,6-bisphosphatase
J. Biochem.
122
122-128
1997
Homo sapiens
Pyko, M.; Rider, M.H.; Hue, L.; Wegener, G.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase from frog skeletal muscle: purification, kinetics and immunological properties
J. Comp. Physiol. B
163
89-98
1993
Pelophylax lessonae
Van Schaftingen, E.; Hers, H.G.
Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP
Biochem. Biophys. Res. Commun.
101
1078-1084
1981
Rattus norvegicus
El-Maghrabi, M.R.; Claus, T.H.; Pilkis, J.; Pilkis, S.J.
Partial purification of a rat liver enzyme that catalyzes the formation of fructose 2,6-bisphosphate
Biochem. Biophys. Res. Commun.
101
1071-1077
1981
Rattus norvegicus
El-Maghrabi, M.R.; Fox, E.; Pilkis, J.; Pilkis, S.J.
Cyclic AMP-dependent phosphorylation of rat liver 6-phosphofructo 2-kinase, fructose 2,6-bisphosphatase
Biochem. Biophys. Res. Commun.
106
794-802
1982
Rattus norvegicus
Kretschmer, M.; Hofmann, E.
Inhibition of rat liver phosphofructokinase-2 by phosphoenolpyruvate and ADP
Biochem. Biophys. Res. Commun.
124
793-796
1984
Rattus norvegicus
Sakakibara, R.; Kitajima, S.; Uyeda, K.
Differences in kinetic properties of phospho and dephospho forms of fructose-6-phosphate, 2-kinase and fructose 2,6-bisphosphatase
J. Biol. Chem.
259
41-46
1984
Rattus norvegicus
Pilkis, S.J.; Regen, D.M.; Stewart, H.B.; Pilkis, J.; Pate, T.M.; El-Maghrabi, M.R.
Evidence for two catalytic sites on 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase. Dynamics of substrate exchange and phosphoryl enzyme formation
J. Biol. Chem.
259
949-958
1984
Rattus norvegicus
Kitajima, S.; Sakakibara, R.; Uyeda, K.
Kinetic studies of fructose 6-phosphate,2-kinase and fructose 2,6-bisphosphatase
J. Biol. Chem.
259
6896-6903
1984
Rattus norvegicus
Laloux, M.; Van Schaftingen, E.; Francois, J.; Hers, H.G.
Phosphate dependency of phosphofructokinase 2
Eur. J. Biochem.
148
155-159
1985
Saccharomyces cerevisiae, Rattus norvegicus, Spinacia oleracea
Sakakibara, R.; Tanaka, T.; Uyeda, K.; Richards, E.G.; Thomas, H.
Studies of the structure of fructose-6-phosphate 2-kinase:fructose-2,6-bisphosphatase
Biochemistry
24
6818-6824
1985
Rattus norvegicus
Kountz, P.D.; McCain, R.W.; El-Maghrabi, M.R.; Pilkis, S.J.
Hepatic 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase: phosphate dependence and effects of other oxyanions
Arch. Biochem. Biophys.
251
110-113
1986
Rattus norvegicus
-
Lively, M.O.; El-Maghrabi, M.R.; Pilkis, J.; D'Angelo, G.; Colosia, A.D.; Ciavola, J.A.; Fraser, B.A.; Pilkis, S.J.
Complete amino acid sequence of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Biol. Chem.
263
839-849
1988
Rattus norvegicus
Martn-Sanz, P.; Cascales, M.; Bosc, L.
Characterization of 6-phosphofructo-2-kinase from foetal-rat liver
Biochem. J.
281
457-463
1992
Rattus norvegicus
-
Van Schaftingen, E.; Davies, D.R.; Hers, H.G.
Inactivation of phosphofructokinase 2 by cyclic AMP - dependent protein kinase
Biochem. Biophys. Res. Commun.
103
362-368
1981
Rattus norvegicus
Kitamura, K.; Uyeda, K.; Kangawa, K.; Matsuo, H.
Purification and characterization of rat skeletal muscle fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
J. Biol. Chem.
264
9799-9806
1989
Rattus norvegicus
Pilkis, S.J.; Pilkis, J.; El-Maghrabi, M.R.; Claus, T.H.
The sugar phosphate specificity of rat hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Biol. Chem.
260
7551-7556
1985
Rattus norvegicus
Rider, M.H.; Foret, D.; Hue, L.
Comparison of purified bovine heart and rat liver 6-phosphofructo-2-kinase. Evidence for distinct isoenzymes
Biochem. J.
231
193-196
1985
Bos taurus, Rattus norvegicus
Sakata, J.; Uyeda, K.
Bovine heart fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase: complete amino acid sequence and localization of phosphorylation sites
Proc. Natl. Acad. Sci. USA
87
4951-4955
1990
Bos taurus
Kountz, P.D.; El-Maghrabi, M.R.; Pilkis, S.J.
Isolation and characterization of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from bovine liver
Arch. Biochem. Biophys.
238
531-543
1985
Bos taurus, Rattus norvegicus
Rider, M.H.; Vandamme, J.; Lebeau, E.; Vertommen, D.; Vidal, H.; Rousseau, G.G.; Vanderkerkhove, J.; Hue, L.
The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing
Biochem. J.
285
405-411
1992
Bos taurus, Rattus norvegicus
-
Kitamura, K.; Uyeda, K.
Purification and characterization of myocardial fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase [published erratum appears in J Biol Chem 1989 Jan 25;264(3):1901]
J. Biol. Chem.
263
9027-9033
1988
Bos taurus, Rattus norvegicus
Ventura, F.; Rosa, J.L.; Ambrosio, S.; Pilkis, S.J.; Bartrons, R.
Bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Evidence for a neural-specific isozyme
J. Biol. Chem.
267
17939-17943
1992
Bos taurus
Lange, A.J.; Li, L.; Vargas, A.M.; Pilkis, S.J.
Expression of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Escherichia coli. Role of N-2 proline in degradation of the protein
J. Biol. Chem.
268
8078-8084
1993
Homo sapiens, Rattus norvegicus
Rider, M.H.
Regulation of fructose-2,6-bisphosphate synthesis and breakdown in heart and skeletal muscle
Biochem. Soc. Trans.
15
988-991
1987
Bos taurus, Columba sp., Rattus norvegicus
Li, L.; Lange, A.J.; Pilkis, S.J.
Isolation of a cDNA for chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase [published erratum appears in Biochem Biophys Res Commun 1999 Jun 16;259(3):711]
Biochem. Biophys. Res. Commun.
190
397-405
1993
Gallus gallus, Rattus norvegicus
Rider, M.H.; Hue, L.
Inactivation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by o-phthalaldehyde
Biochem. J.
262
97-102
1989
Gallus gallus
Garca de Frutos, P.; Baanante, I.V.
6-Phosphofructo 2-kinase/fructose 2,6-bisphosphatase in liver of the teleost Sparus aurata
Arch. Biochem. Biophys.
308
461-468
1994
Sparus aurata
Vsquez-Illanes, M.D.; Barcia, R.I.; Ibarguren, I.; Villamarin, J.; Ramos-Martinez, J.I.
Regulation of fructose-2,6-bisphosphate content in mantle tissue of the sea mussel Mytilus galloprovincialis. I. purification and properties of 6-phosphofructo-2-kinase
Mar. Biol.
112
277-281
1992
Mytilus galloprovincialis
-
Bedri, A.; Kretschmer, M.; Schellenberger, W.; Hofmann, E.
Kinetics of 6-phosphofructo-2-kinase from Saccharomyces cerevisiae: inhibition of the enzyme by ATP
Biomed. Biochim. Acta
48
403-411
1989
Saccharomyces cerevisiae
Vsquez-Illanes, M.D.; Ramos-Martinez, J.I.
Phosphorylation-activated 6-phosphofructo-2-kinase from mantle tissue of marine mussels
FEBS Lett.
295
176-178
1991
Mytilus galloprovincialis
Larondelle, Y.; Mertens, E.; Van Schaftingen, E.; Hers, H.G.
Purification and properties of spinach leaf phosphofructokinase 2/fructose 2,6-bisphosphatase [published erratum appears in Eur J Biochem 1987 Feb 2;162(3):699]
Eur. J. Biochem.
161
351-357
1986
Helianthus tuberosus, Ricinus communis, Spinacia oleracea
Walker, G.H.; Huber, S.C.
Spinach leaf 6-phosphofructo-2-kinase, isolation of a new enzyme form that undergoes ATP-dependent modification
FEBS Lett.
213
375-380
1987
Spinacia oleracea
-
Harmsen, H.J.M.; Kubicek-Pranz, E.M.; Rhr, M.; Visser, J.; Kubicek, C.P.
Regulation of 6-phosphofructo-2-kinase from the citric-acid-accumulating fungus Aspergillus niger
Appl. Microbiol. Biotechnol.
37
784-788
1992
Aspergillus niger
-
Yamashoji, S.; Hess, B.
Yeast 6-phosphpfructo-2-kinase
FEBS Lett.
172
51-54
1984
Saccharomyces cerevisiae
-
Aragn, J.J.; Gmez, M.E.; Gancedo, C.
Identification of two forms of 6-phosphofructo-2-kinase in yeast
FEBS Lett.
226
121-124
1987
Saccharomyces cerevisiae
Guix, V.; Babul, J.
Effect of ATP on phosphofructokinase-2 from Escherichia coli. A mutant enzyme altered in the allosteric site for MgATP
J. Biol. Chem.
260
11001-11005
1985
Escherichia coli
Rider, M.H.; Hue, L.
Bifunctionality of muscle and heart 6-phosphofructo-2-kinase: skeletal muscle 6-phosphofructo-2-kinase catalyses fructose 2,6-bisphosphate hydrolysis whereas heart 6-phophofructo-2-kinase contains little fructose-2,6-bisphphophatase
Biochem. Soc. Trans.
15
379-380
1987
Rattus norvegicus
-
Kurland, I.J.; Chapman, B.; El-Maghrabi, M.R.
N- and C-termini modulate the effects of pH and phosphorylation on hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Biochem. J.
347
459-467
2000
Escherichia coli, Rattus norvegicus
Hasemann, C.A.; Istvan, E.S.; Uyeda, K.; Deisenhofer, J.
The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies
Structure
4
1017-1029
1996
Rattus norvegicus
Watanabe, F.; Jameson, D.M.; Uyeda, K.
Enzymic and fluorescence studies of four single-tryptophan mutants of rat testis fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase
Protein Sci.
5
904-913
1996
Rattus norvegicus
Mizuguchi, H.; Cook, P.F.; Hasemann, C.A.; Uyeda, K.
Chemical mechanism of the fructose-6-phosphate,2-kinase reaction from the pH dependence of kinetic parameters of site-directed mutants of active site basic residues
Biochemistry
36
8775-8784
1997
Rattus norvegicus
Tominaga, N.; Tsujikawa, T.; Minami, Y.; Wu, R.F.; Watanabe, F.; Sakakibara, R.; Uyeda, K.
Effect of replacement of the amino and the carboxyl termini of rat testis fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase with those of the liver and heart isozymes
Arch. Biochem. Biophys.
347
275-281
1997
Bos taurus, Rattus norvegicus
Yuen, M.H.; Wang, X.L.; Mizuguchi, H.; Uyeda, K.; Hasemann, C.A.
A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Biochemistry
38
12333-12342
1999
Rattus norvegicus (P25114)
Lee, Y.H.; Li, Y.; Uyeda, K.; Hasemann, C.A.
Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Biol. Chem.
278
523-530
2003
Homo sapiens (P16118)
Sakakibara, R.; Okudaira, T.; Fujiwara, K.; Kato, M.; Hirata, T.; Yamanaka, S.; Naito, M.; Fukasawa, M.
Tissue distribution of placenta-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Biochem. Biophys. Res. Commun.
257
177-181
1999
Homo sapiens, Rattus norvegicus
Harada, Y.; Tominaga, N.; Watanabe, M.; Shimokawa, R.; Ishiguro, M.; Sakakibara, R.
Inhibition of fructose-6-phosphate,2-kinase by N-bromoacetylethanolamine phosphate in vitro and in vivo
J. Biochem.
121
724-730
1997
Mus musculus, Rattus norvegicus
Villadsen, D.; Nielsen, T.H.
N-terminal truncation affects the kinetics and structure of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana
Biochem. J.
359
591-597
2001
Arabidopsis thaliana (Q9MB58)
Zhu, Z.; Ling, S.; Yang, Q.H.; Li, L.
Involvement of the chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase sequence His444-Arg-Glu-Arg in modulation of the bisphosphatase activity by its kinase domain
Biochem. J.
357
513-520
2001
Gallus gallus, Rattus norvegicus
Garcia de Frutos, P.; Baanante, I.V.
The muscle isoform of 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase of the teleost Sparus aurata: relationship with the liver isoform
Arch. Biochem. Biophys.
321
297-302
1995
Sparus aurata
Bruni, P.; Vandoolaeghe, P.; Rousseau, G.G.; Hue, L.; Rider, M.H.
Expression and regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isozymes in white adipose tissue
Eur. J. Biochem.
259
756-761
1999
Rattus norvegicus
Bertrand, L.; Alessi, D.R.; Deprez, J.; Deak, M.; Viaene, E.; Rider, M.H.; Hue, L.
Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B
J. Biol. Chem.
274
30927-30933
1999
Bos taurus
Goldstein, B.N.; Maevsky, A.A.
Critical switch of the metabolic fluxes by phosphofructo-2-kinase:fructose-2,6-bisphosphatase. A kinetic model
FEBS Lett.
532
295-299
2002
Rattus norvegicus
Markham, J.E.; Kruger, N.J.
Kinetic properties of bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from spinach leaves
Eur. J. Biochem.
269
1267-1277
2002
Spinacia oleracea (O64983), Spinacia oleracea
Chesney, J.; Mitchell, R.; Benigni, F.; Bacher, M.; Spiegel, L.; Al-Abed, Y.; Han, J.H.; Metz, C.; Bucala, R.
An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect
Proc. Natl. Acad. Sci. USA
96
3047-3052
1999
Faxonius limosus, Homo sapiens (Q16875), Homo sapiens
Guixe, V.
Chemical modification of SH groups of E. coli phosphofructokinase-2 induces subunit dissociation: monomers are inactive but preserve ligand binding properties
Arch. Biochem. Biophys.
376
313-319
2000
Escherichia coli
Manes, N.P.; El-Maghrabi, M.R.
The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate
Arch. Biochem. Biophys.
438
125-136
2005
Homo sapiens (Q16875)
Baez, M.; Rodriguez, P.H.; Babul, J.; Guixe, V.
Structural and functional roles of Cys-238 and Cys-295 in Escherichia coli phosphofructokinase-2
Biochem. J.
376
277-283
2003
Escherichia coli
Payne, V.A.; Arden, C.; Wu, C.; Lange, A.J.; Agius, L.
Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes
Diabetes
54
1949-1957
2005
Rattus norvegicus
Chevalier, N.; Bertrand, L.; Rider, M.H.; Opperdoes, F.R.; Rigden, D.J.; Michels, P.A.
6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis
FEBS J.
272
3542-3560
2005
Trypanosoma brucei (Q52MQ5), Trypanosoma brucei (Q6PY95), Trypanosoma brucei
Caniuguir, A.; Cabrera, R.; Baez, M.; Vasquez, C.C.; Babul, J.; Guixe, V.
Role of Cys-295 on subunit interactions and allosteric regulation of phosphofructokinase-2 from Escherichia coli
FEBS Lett.
579
2313-2318
2005
Escherichia coli
Kim, S.G.; Manes, N.P.; El-Maghrabi, M.R.; Lee, Y.H.
Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy
J. Biol. Chem.
281
2939-2944
2006
Homo sapiens (P16118), Homo sapiens
Cabrera, R.; Caniuguir, A; Ambrosio, A.L.B.; Guixe, V.; Garratt, R.C.
Crystallization and preliminary crystallographic analysis of the tetrameric form of phosphofructokinase-2 from Escherichia coli, a member of the ribokinase family
Acta Crystallogr. Sect. F
62
935-937
2006
Escherichia coli
Payne, V.A.; Arden, C.; Lange, A.J.; Agius, L.
Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
293
R618-R625
2007
Rattus norvegicus
Parducci, R.E.; Cabrera, R.; Baez, M.; Guixe, V.
Evidence for a catalytic Mg2+ ion and effect of phosphate on the activity of Escherichia coli phosphofructokinase-2: regulatory properties of a ribokinase
Biochemistry
45
9291-9299
2006
Escherichia coli
Baez, M.; Cabrera, R.; Guixe, V.; Babul, J.
Unfolding pathway of the dimeric and tetrameric forms of phosphofructokinase-2
Biochemistry
46
6141-6148
2007
Escherichia coli
Mouton, V.; Vertommen, D.; Bertrand, L.; Hue, L.; Rider, M.H.
Evaluation of the role of protein kinase Czeta in insulin-induced heat 6-phosphofructo-2-kinase activation
Cell. Signal.
19
52-61
2007
Homo sapiens
Chesney, J.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis
Curr. Opin. Clin. Nutr. Metab. Care
9
535-539
2006
Homo sapiens
Meton, I.; Egea, M.; Anemaet, I.G.; Fernandez, F.; Baanante, I.V.
: Sterol regulatory element binding protein-1a transactivates 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene promoter
Endocrinology
147
3446-3456
2006
Sparus aurata
Kim, S.G.; Cavalier, M.; El-Magrabi, M.R.; Lee, Y.M.
A direct substratesubstrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Biol. Chem.
370
14-26
2007
Rattus norvegicus
Lee, Y.H.; Lee, D.S.; Lim, J.M.; Yoon, J.M.; Bhoo, S.H.; Jeon, J.S.; Hahn, T.R.
Carbon-partitioning in Arabidopsis is regulated by the fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase enzyme
J. Plant Biol.
49
70-79
2006
Arabidopsis sp.
-
Smith, W.E.; Langer, S.; Wu, C.; Baltrusch, S.; Okar, D.A.
Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex
Mol. Endocrinol.
21
1478-1487
2007
Rattus norvegicus
Telang, S.; Yalcin, A.; Clem, A.L.; Bucala, R.; Lane, A.N.; Eaton, J.W.; Chesney, J.
Ras transformation requires metabolic control by 6-phosphofructo-2-kinase
Oncogene
25
7225-7234
2006
Homo sapiens, Mus musculus
Kessler, R.; Bleichert, F.; Warnke, J.P.; Eschrich, K.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas
J. Neurooncol.
86
257-264
2008
Homo sapiens (O60825), Homo sapiens (P16118), Homo sapiens (Q16875), Homo sapiens (Q16877)
Park, S.; Cho, M.; Bhoo, S.H.; Jeon, J.; Kwon, Y.; Hahn, T.
Altered sucrose synthesis in rice plants with reduced activity of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase
J. Plant Biol.
50
38-43
2007
Oryza sativa, Oryza sativa (Q75IQ9)
-
Mukhtar, M.H.; Payne, V.A.; Arden, C.; Harbottle, A.; Khan, S.; Lange, A.J.; Agius, L.
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R766-R774
2008
Rattus norvegicus (Q9JJH5)
Wang, Q.; Donthi, R.V.; Wang, J.; Lange, A.J.; Watson, L.J.; Jones, S.P.; Epstein, P.N.
Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia
Am. J. Physiol. Heart Circ. Physiol.
294
H2889-H2897
2008
Mus musculus (P70265)
Duran, J.; Navarro-Sabate, A.; Pujol, A.; Perales, J.C.; Manzano, A.; Obach, M.; Gomez, M.; Bartrons, R.
Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain
Biochem. Biophys. Res. Commun.
365
291-297
2008
Homo sapiens (Q16875)
Baez, M.; Merino, F.; Astorga, G.; Babul, J.
Uncoupling the MgATP-induced inhibition and aggregation of Escherichia coli phosphofructokinase-2 by C-terminal mutations
FEBS Lett.
582
1907-1912
2008
Escherichia coli
Cabrera, R.; Ambrosio, A.L.; Garratt, R.C.; Guixe, V.; Babul, J.
Crystallographic Structure of Phosphofructokinase-2 from Escherichia coli in Complex with Two ATP Molecules. Implications for Substrate Inhibition
J. Mol. Biol.
383
588-602
2008
Escherichia coli
Clem, B.; Telang, S.; Clem, A.; Yalcin, A.; Meier, J.; Simmons, A.; Rasku, M.A.; Arumugam, S.; Dean, W.L.; Eaton, J.; Lane, A.; Trent, J.O.; Chesney, J.
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
Mol. Cancer Ther.
7
110-120
2008
Homo sapiens (Q16875), Homo sapiens
Mykhalchenko, V.G.; Minchenko, D.O.; Tsuchihara, K.; Moenner, M.; Komisarenko, S.V.; Bikfalvi, A.; Esumi, H.; Minchenko, O.H.
Expression of mouse 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 mRNA alternative splice variants in hypoxia
Ukr. Biokhim. Zh.
80
19-25
2008
Rattus norvegicus (A7UAK3), Mus musculus (A7UAK4), Mus musculus (A7UAK5), Mus musculus (A7UAK6), Mus musculus
Gomez, M.; Navarro-Sabate, A.; Manzano, A.; Duran, J.; Obach, M.; Bartrons, R.
Switches in 6-phosphofructo-2-kinase isoenzyme expression during rat sperm maturation
Biochem. Biophys. Res. Commun.
387
330-335
2009
Rattus norvegicus
Baez, M.; Babul, J.
Reversible unfolding of dimeric phosphofructokinase-2 from Escherichia coli reveals a dominant role of inter-subunit contacts for stability
FEBS Lett.
583
2054-2060
2009
Escherichia coli
Yalcin, A.; Clem, B.F.; Simmons, A.; Lane, A.; Nelson, K.; Clem, A.L.; Brock, E.; Siow, D.; Wattenberg, B.; Telang, S.; Chesney, J.
Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases
J. Biol. Chem.
284
24223-24232
2009
Homo sapiens (Q16875), Homo sapiens
Langer, S.; Kaminski, M.T.; Lenzen, S.; Baltrusch, S.
Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent
Mol. Endocrinol.
24
1988-1997
2010
Rattus norvegicus
Baltrusch, S.; Schmitt, H.; Brix, A.; Langer, S.; Lenzen, S.
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
Biochem. Pharmacol.
83
1300-1306
2012
Rattus norvegicus
Ros, S.; Santos, C.R.; Moco, S.; Baenke, F.; Kelly, G.; Howell, M.; Zamboni, N.; Schulze, A.
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
Cancer Discov.
2
328-343
2012
Homo sapiens (Q16877)
Langer, S.; Okar, D.A.; Schultz, J.; Lenzen, S.; Baltrusch, S.
Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation
FEBS Lett.
586
1419-1425
2012
Rattus norvegicus (P07953)
Li, H.; Guo, X.; Xu, H.; Woo, S.; Halim, V.; Morgan, C.; Wu, C.
A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis
J. Nutr. Biochem.
24
:1153-1158
2012
Mus musculus (Q7TS91), Mus musculus
Brooke, D.G.; van Dam, E.M.; Watts, C.K.; Khoury, A.; Dziadek, M.A.; Brooks, H.; Graham, L.J.; Flanagan, J.U.; Denny, W.A.
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
Bioorg. Med. Chem.
22
1029-1039
2014
Homo sapiens (Q16875)
Pegoraro, C.; Maczkowiak, F.; Monsoro-Burq, A.H.
Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) isoforms display a tissue-specific and dynamic expression during Xenopus laevis development
Gene Expr. Patterns
13
203-211
2013
Xenopus laevis, Xenopus laevis (Q5U4Z6), Xenopus laevis (Q6NRY0)
Novellasdemunt, L.; Tato, I.; Navarro-Sabate, A.; Ruiz-Meana, M.; Mendez-Lucas, A.; Perales, J.C.; Garcia-Dorado, D.; Ventura, F.; Bartrons, R.; Rosa, J.L.
Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids
J. Biol. Chem.
288
10640-10651
2013
Homo sapiens (O60825), Homo sapiens, Rattus norvegicus (Q9JJH5), Rattus norvegicus Sprague-Dawley (Q9JJH5)
Chesney, J.; Clark, J.; Klarer, A.C.; Imbert-Fernandez, Y.; Lane, A.N.; Telang, S.
Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth
Oncotarget
5
6670-6686
2014
Homo sapiens (Q16877)
Cullen, K.S.; Al-Oanzi, Z.H.; OHarte, F.P.; Agius, L.; Arden, C.
Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein
Biochim. Biophys. Acta
1843
1123-1134
2014
Rattus norvegicus (P07953), Rattus norvegicus Wistar (P07953)
Ros, S.; Schulze, A.
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
Cancer Metab.
1
8
2013
Homo sapiens (O60825), Homo sapiens (P16118), Homo sapiens (Q16875), Homo sapiens (Q16877)
Klarer, A.C.; ONeal, J.; Imbert-Fernandez, Y.; Clem, A.; Ellis, S.R.; Clark, J.; Clem, B.; Chesney, J.; Telang, S.
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
Cancer Metab.
2
2
2014
Homo sapiens (Q16875), Homo sapiens
Yalcin, A.; Clem, B.F.; Imbert-Fernandez, Y.; Ozcan, S.C.; Peker, S.; ONeal, J.; Klarer, A.C.; Clem, A.L.; Telang, S.; Chesney, J.
6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27
Cell Death Dis.
5
e1337
2014
Homo sapiens (Q16875), Homo sapiens
Li, H.; Guo, X.; Xu, H.; Woo, S.; Halim, V.; Morgan, C.; Wu, C.
A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis
J. Nutr. Biochem.
24
1153-1158
2013
Mus musculus (A7UAK5), Mus musculus, Mus musculus C57/BL6J (A7UAK5)
Clem, B.F.; ONeal, J.; Tapolsky, G.; Clem, A.L.; Imbert-Fernandez, Y.; Kerr, D.A.; Klarer, A.C.; Redman, R.; Miller, D.M.; Trent, J.O.; Telang, S.; Chesney, J.
Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer
Mol. Cancer Ther.
12
1461-1470
2013
Homo sapiens (Q16875), Homo sapiens
Mehrotra, A.; Trigun, S.K.
Moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices
Mol. Cell. Biochem.
381
157-161
2013
Mus musculus
Strohecker, A.M.; Joshi, S.; Possemato, R.; Abraham, R.T.; Sabatini, D.M.; White, E.
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening
Oncogene
34
5662-5676
2015
Homo sapiens (Q16877)
Wang, J.; Xu, J.; Wang, Q.; Brainard, R.E.; Watson, L.J.; Jones, S.P.; Epstein, P.N.
Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction
PLoS ONE
8
e53951
2013
Mus musculus (P70265)
Minchenko, D.; Lypova, N.; Harmash, Y.; Kulinich, A.; Marunych, R.; Karbovskyi, L.; Minchenko, O.
Expression of genes encoded 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and 6-phosphofructo-1-kinase in U87 glioma cells with ERN1 loss of function: hypoxic regulation
Res. J. Pharm. Biol. Chem. Sci.
4
28-42
2013
Homo sapiens (O60825), Homo sapiens (P16118), Homo sapiens (Q16875), Homo sapiens (Q16877)
-
Lea, M.A.; Guzman, Y.; Desbordes, C.
Inhibition of growth by combined treatment with inhibitors of lactate dehydrogenase and either phenformin or inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Anticancer Res.
36
1479-1488
2016
Homo sapiens (Q16875)
Yalcin, A.; Solakoglu, T.H.; Ozcan, S.C.; Guzel, S.; Peker, S.; Celikler, S.; Balaban, B.D.; Sevinc, E.; Gurpinar, Y.; Chesney, J.A.
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor beta1-enhanced invasion of Panc1 cells invitro
Biochem. Biophys. Res. Commun.
484
687-693
2017
Homo sapiens (Q16875)
Ros, S.; Floeter, J.; Kaymak, I.; Da Costa, C.; Houddane, A.; Dubuis, S.; Griffiths, B.; Mitter, R.; Walz, S.; Blake, S.; Behrens, A.; Brindle, K.M.; Zamboni, N.; Rider, M.H.; Schulze, A.
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells
Oncogene
36
3287-3299
2017
Homo sapiens (Q16877)
Du, J.Y.; Wang, L.F.; Wang, Q.; Yu, L.D.
miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells
Oncol. Rep.
33
1890-1898
2015
Homo sapiens (Q16875)
Yan, S.; Wei, X.; Xu, S.; Sun, H.; Wang, W.; Liu, L.; Jiang, X.; Zhang, Y.; Che, Y.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway
Oncotarget
8
80909-80922
2017
Homo sapiens (Q16875)
Crochet, R.; Kim, J.; Lee, H.; Yim, Y.; Kim, S.; Neau, D.; Lee, Y.
Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding
Proteins
85
117-124
2017
Homo sapiens (O60825), Bos taurus (P26285)
Langer, S.; Hofmeister-Brix, A.; Waterstradt, R.; Baltrusch, S.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms
Biochem. Pharmacol.
168
149-161
2019
Homo sapiens (O60825)
Yang, H.; Shu, Z.; Jiang, Y.; Mao, W.; Pang, L.; Redwood, A.; Jeter-Jones, S.L.; Jennings, N.B.; Ornelas, A.; Zhou, J.; Rodriguez-Aguayo, C.; Bartholomeusz, G.; Iles, L.R.; Zacharias, N.M.; Millward, S.W.; Lopez-Berestein, G.; Le, X.F.; Ahmed, A.A.; Piwnica-Worms, H.; Sood, A.K.; Bast, R.C.; Lu, Z.
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase-2 regulates TP53-dependent paclitaxel sensitivity in ovarian and breast cancers
Clin. Cancer Res.
25
5702-5716
2019
Homo sapiens (O60825)
Emini Veseli, B.; Perrotta, P.; Van Wielendaele, P.; Lambeir, A.M.; Abdali, A.; Bellosta, S.; Monaco, G.; Bultynck, G.; Martinet, W.; De Meyer, G.R.Y.
Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)
FEBS Lett.
594
3067-3075
2020
Homo sapiens (Q16875)
Sellem, C.H.; Humbert, A.; Sainsard-Chanet, A.
Mutations in the phosphatase domain of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase result in the transcriptional activation of the alternative oxidase and gluconeogenic pathways in Podospora anserina
Fungal Genet. Biol.
130
1-10
2019
Podospora anserina
Lypova, N.; Telang, S.; Chesney, J.; Imbert-Fernandez, Y.
Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival
J. Biol. Chem.
294
10530-10543
2019
Homo sapiens (Q16875)
Bao, J.; Wu, Y.; Wang, L.; Zhu, Y.
The role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 in esophageal squamous cell carcinoma
Medicine (Baltimore)
99
e19626
2020
Homo sapiens (Q16875)
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