Reference on EC 2.7.1.21 - thymidine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okazaki, R.; Kornberg, A.
Deoxythymidine kinase of Escherichia coli. I. Purification and some properties of the enzyme
J. Biol. Chem.
239
269-274
1964
Escherichia coli
Okazaki, R.; Kornerg, A.
Deoxythymidine kinase of Escherichia coli. II. Kinetics and feedback control
J. Biol. Chem.
239
275-284
1964
Escherichia coli
Kizer, D.E.; Hollman, L.
Purification and properties of thymidine kinase from regenerating rat liver
Biochim. Biophys. Acta
350
193-200
1974
Rattus norvegicus
Kinyanjui, P.W.; Pearlman, R.E.
Thymidine kinase from Tetrahymena thermophila. Purification and immunological analysis
Eur. J. Biochem.
195
55-63
1991
Tetrahymena thermophila
Tsukamoto, I.; Taniguchi, Y.; Miyoshi, M.; Kojo, S.
Purification and characterization of thymidine kinase from regenerating rat liver
Biochim. Biophys. Acta
1079
348-352
1991
Rattus norvegicus
Sanderson, M.R.; Freemont, P.S.; Murthy, H.M.K.; Krane, J.F.; Summers, W.C.; Steitz, T.A.
Purification and crystallization of thymidine kinase from herpes simplex virus type 1
J. Mol. Biol.
202
917-919
1988
Herpes simplex virus
Sherley, J.L.; Kelly, T.J.
Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells
J. Biol. Chem.
263
375-382
1988
Homo sapiens
Chen, M.S.; Prusoff, W.H.
Thymidine kinase from Escherichia coli
Methods Enzymol.
51
354-360
1978
Escherichia coli
Bresnick, E.
Deoxythymidine kinase in regenerating rat liver
Methods Enzymol.
51
360-365
1978
Rattus norvegicus
Cheng, Y.C.
Thymidine kinase from blast cells of myelocytic leukemia
Methods Enzymol.
51
365-371
1978
Homo sapiens
Bone, R.; Cheng, Y.C.; Wolfenden, R.
Inhibition of thymidine kinase by P1-(adenosine-5)-P5-(thymidine-5)-pentaphosphate
J. Biol. Chem.
261
5731-5735
1986
Homo sapiens
Kit, S.
Thymidine kinase
Microbiol. Sci.
2
369-375
1985
Gallus gallus, Cytomegalovirus, Homo sapiens, Betapolyomavirus macacae
Waldman, A.S.; Haeusslein, E.; Milman, G.
Purification and characterization of herpes simplex virus (type 1) thymidine kinase produced in Escherichia coli by a high efficiency expression plasmid utilizing a lambda PL promoter and cI857 temperature-sensitive repressor
J. Biol. Chem.
258
11571-11575
1983
Herpes simplex virus
Gan, T.E.; Brumley, J.L.; van der Weyden, M.B.
Human thymidine kinase. Purification and properties of the cytosolic enzyme of placenta
J. Biol. Chem.
258
7000-7004
1983
Homo sapiens
Chraibi, R.; Wright, M.
Characterization of the thymidine kinase of Physarum polycephalum
J. Biochem.
93
323-330
1983
Physarum polycephalum
Ellims, P.H.; van der Weyden, M.B.
Kinetic mechanism and inhibition of human liver thymidine kinase
Biochim. Biophys. Acta
660
238-242
1981
Homo sapiens
Sandlie, I.; Kleppe, K.
Mechanism of inhibition of thymidine kinase from Escherichia coli by caffeine
FEBS Lett.
110
223-226
1980
Escherichia coli
Ellims, P.H.; van der Weyden, M.B.
Human liver thymidine kinase. Purification and some properties of the enzyme
J. Biol. Chem.
255
11290-11295
1980
Homo sapiens
Grbner, P.
Thymidine kinase enzyme variants in Physarum polycephalum. Kinetics and properties of the enzyme variants
J. Biochem.
86
1607-1614
1979
Physarum polycephalum
Swinton, D.C.; Chiang, K.S.
Characterization of thymidine kinase and phosphorylation of deoxyribonucleosides in Chlamydomonas reinhardti
Mol. Gen. Genet.
175
399-409
1979
Chlamydomonas reinhardtii
-
Iwasuki, N.
Purification and properties of deoxythymidine kinase induced by bacteriophage T4 infection
J. Biochem.
82
1347-1359
1977
Tequatrovirus T4
Rohde, W.
Irreversible inhibition of thymidine kinase from Escherichia coli
FEBS Lett.
82
118-120
1977
Escherichia coli
Kit, S.; Leung, W.C.; Trkula, D.; Dubbs, D.R.
Characterization of nucleoside phosphotransferase and thymidine kinase activities of chick embryo cells and of chick-mouse somatic cell hybrids
Arch. Biochem. Biophys.
169
66-76
1975
Anas sp., Gallus gallus
Lee, L.S.; Cheng, Y.C.
Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia
J. Biol. Chem.
251
2600-2604
1976
Homo sapiens
Cheng, Y.C.; Ostrander, M.
Deoxythymidine kinase induced in HeLa TK- cells by Herpes simplex virus type I and type II. II. Purification and characterization
J. Biol. Chem.
251
2605-2610
1976
Herpes simplex virus
Cheng, Y.C.; Prusoff, W.H.
Mouse ascites Sarcoma 180 deoxythymidine kinase. General properties and inhibition studies
Biochemistry
13
1179-1185
1974
Mus musculus
Kit, S.; Leung, W.C.; Trkula, D.
Properties of mitochondrial thymidine kinases of parental and enzyme-deficient HeLa cells
Arch. Biochem. Biophys.
158
503-513
1973
Homo sapiens
Taylor, A.T.; Stafford, M.A.; Jones, O.W.
Properties of thymidine kinase partially purified from human fetal and adult tissue
J. Biol. Chem.
247
1930-1935
1972
Homo sapiens
Rohde, W.; Lezius, A.G.
The purification of thymidine kinase from Escherichia coli by affinity chromatography
Hoppe-Seyler's Z. Physiol. Chem.
352
1507-1516
1971
Escherichia coli
Her, M.O.; Momparler, R.L.
Mammalian deoxynucleoside kinases. IV. Deoxythymidine kinase: purification, properties, and kinetic studies
J. Biol. Chem.
246
6152-6158
1971
Bos taurus
Roberts, G.B.; Fyfe, J.A.; McKee, S.A.; Rahim, S.; Koszalka, G.W.; Krenitsky, T.A.
Varicella-zoster virus thymidine kinase. Characterization and substrate specificity
Biochem. Pharmacol.
46
2209-2218
1993
Human alphaherpesvirus 3
Gruidl, M.E.; Hall, R.L.; Moyer, R.W.
Mapping and molecular characterization of a functional thymidine kinase from Amsacta moorei entomopoxvirus
Virology
186
507-516
1992
unidentified entomopoxvirus
Insler, G.D.; Halikias, F.J.
Independent characterization of thymidine transport and subsequent metabolism in Hymenolepis diminuta--II. Purification and preliminary analysis of thymidine kinase
Comp. Biochem. Physiol. B
98
181-186
1991
Hymenolepis diminuta
Chello, P.L.; Jaffe, J.J.
Comparative properties of trypanosomal and mammalian thymidine kinases
Comp. Biochem. Physiol. B
43
543-562
1972
Rattus norvegicus, Trypanosoma brucei rhodesiense
Wang, L.; Saada, A.; Eriksson, S.
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy
J. Biol. Chem.
278
6963-6968
2003
Homo sapiens (O00142), Homo sapiens
Connolly, Y.; Littler, E.; Sun, N.; Chen, X.; Huang, P.C.; Stacey, S.N.; Arrand, J.R.
Antibodies to Epstein-Barr virus thymidine kinase: a characteristic marker for the serological detection of nasopharyngeal carcinoma
Int. J. Cancer
91
692-697
2001
Human gammaherpesvirus 4
Zhang, F.; Shao, X.; Li, H.; Robison, J.G.; Murray, B.K.; O'Neill, K.L.
A monoclonal antibody specific for human thymidine kinase 1
Hybridoma
20
25-34
2001
Homo sapiens
Vogt, J.; Perozzo, R.; Pautsch, A.; Prota, A.; Schelling, P.; Pilger, B.; Folkers, G.; Scapozza, L.; Schulz, G.E.
Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography
Proteins
41
545-553
2000
Herpes simplex virus
Champness, J.N.; Bennett, M.S.; Wien, F.; Visse, R.; Summers, W.C.; Herdewijn, P.; de Clerq, E.; Ostrowski, T.; Jarvest, R.L.; Sanderson, M.R.
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with acyclovir and other ligands
Proteins
32
350-361
1998
Herpes simplex virus
Wild, K.; Bohner, T.; Aubry, A.; Folkers, G.; Schulz, G.E.
The three-dimensional structure of thymidine kinase from herpes simplex virus type 1
FEBS Lett.
368
289-292
1995
Herpes simplex virus
Brown, D.G.; Visse, R.; Sandhu, G.; Davies, A.; Rizkallah, P.J.; Melitz, C.; Summers, W.C.; Sanderson, M.R.
Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir
Nat. Struct. Biol.
2
876-881
1995
Herpes simplex virus
Amrhein, I.; Wurth, C.; Bohner, T.; Hofbauer, R.; Folkers, G.; Scapozza, L.
Highly purified recombinant varicella Zoster virus thymidine kinase is a homodimer
Protein Expr. Purif.
18
338-345
2000
Human alphaherpesvirus 3
Berenstein, D.; Christensen, J.F.; Kristensen, T.; Hofbauer, R.; Munch-Petersen, B.
Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1). Impact on oligomerization, stability, and kinetic properties
J. Biol. Chem.
275
32187-32192
2000
Homo sapiens
Creuven, I.; Evrard, C.; Olivier, A.; Evrard, G.; Van Aerschot, A.; Wigerinck, P.; Herdewijn, P.; Durant, F.
Relationship between structural properties and affinity for Herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines
Antiviral Res.
30
63-74
1996
Herpes simplex virus
Degreve, B.; Esnouf, R.; De Clercq, E.; Balzarini, J.
Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine
Mol. Pharmacol.
58
1326-1332
2000
Herpes simplex virus
Kokoris, M.S.; Black, M.E.
Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity
Protein Sci.
11
2267-2272
2002
Herpes simplex virus
Gustafson, E.A.; Chillemi, A.C.; Sage, D.R.; Fingeroth, J.D.
The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase
Antimicrob. Agents Chemother.
42
2923-2931
1998
Human gammaherpesvirus 4, Herpes simplex virus
Hinds, T.A.; Compadre, C.; Hurlburt, B.K.; Drake, R.R.
Conservative mutations of glutamine-125 in Herpes simplex virus type 1 thymidine kinase result in a Ganciclovir kinase with minimal deoxypyrimidine kinase activities
Biochemistry
39
4105-4111
2000
Herpes simplex virus
Liu, Y.; Santi, D.V.
A continuous spectrophotometric assay for thymidine and deoxycytidine kinases
Anal. Biochem.
264
259-262
1998
Herpes simplex virus
Mao, F.; Rechtin, T.M.; Jones, R.; Cantu, A.A.; Anderson, L.S.; Radominska, A.; Moyer, M.P.; Drake, R.R.
Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpes virus thymidine kinase and cellular enzymes
J. Biol. Chem.
270
13660-13664
1995
Herpes simplex virus
Prota, A.; Vogt, J.; Pilger, B.; Perozzo, R.; Wurth, C.; Marquez, V.E.; Russ, P.; Schulz, G.E.; Folkers, G.; Scapozza, L.
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine
Biochemistry
39
9597-9603
2000
Herpes simplex virus
Rechtin, T.M.; Black, M.E.; Mao, F.; Lewis, M.L.; Drake, R.R.
Purification and photoaffinity labeling of herpes simplex virus type-1 thymidine kinase
J. Biol. Chem.
270
7055-7060
1995
Herpes simplex virus
Tsukifuji-Nabeya, R.; Yusa, T.; Kuroiwa, N.; Kumazawa, T.; Tamiya, N.; Moriyama, Y.; Okamoto, S.; Yamaguchi, Y.; Fujimura, S.
Characterization of the purified cytosolic thymidine kinase from murine ehrlich ascites tumor: interconversion of two different relative molecular weight forms
Biochem. Mol. Biol. Int.
40
379-388
1996
Mus musculus
Tzeng, H.F.; Chang, Z.F.; Peng, S.E.; Wang, C.H.; Lin, J.Y.; Kou, G.H.; Lo, C.F.
Chimeric polypeptide of thymidine kinase and thymidylate kinase of shrimp white spot syndrome virus: Thymidine kinase activity of the recombinant protein expressed in a baculovirus/insect cell system
Virology
299
248-255
2002
Shrimp white spot syndrome virus
Wang, L.; Eriksson, S.
Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria
Biochem. J.
351
469-476
2000
Mus musculus (Q9R088), Mus musculus
Wang, L.; Munch-Petersen, B.; Herrstrom Sjoberg, A.; Hellman, U.; Bergman, T.; Jornvall, H.; Eriksson, S.
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates
FEBS Lett.
443
170-174
1999
Homo sapiens (O00142), Homo sapiens
Pepper, S.D.; Stewart, J.P.; Arrand, J.R.; Mackett, M.
Murine Gammaherpesvirus-68 encodes homologues of thymidine kinase and glycoprotein H: sequence, expression, and characterization of pyrimidine kinase activity
Virology
219
475-479
1996
Murine gammaherpesvirus-68 (Q83342)
Frobert, E.; Ooka, T.; Cortay, J.C.; Lina, B.; Thouvenot, D.; Morfin, F.
Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis study
Antimicrob. Agents Chemother.
49
1055-1059
2005
Human alphaherpesvirus 1
Li, C.L.; Lu, C.Y.; Ke, P.Y.; Chang, Z.F.
Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site
Biochem. Biophys. Res. Commun.
313
587-593
2004
Homo sapiens
O'Day, D.H.; Chatterjee-Chakraborty, M.; Wagler, S.; Myre, M.A.
Isolation and characterization of Dictyostelium thymidine kinase 1 as a calmodulin-binding protein
Biochem. Biophys. Res. Commun.
331
1494-1502
2005
Dictyostelium discoideum (Q27564), Dictyostelium discoideum
Barroso, J.F.; Elholm, M.; Flatmark, T.
Tight binding of deoxyribonucleotide triphosphates to human thymidine kinase 2 expressed in Escherichia coli. Purification and partial characterization of its dimeric and tetrameric forms
Biochemistry
42
15158-15169
2003
Homo sapiens (O00142), Homo sapiens
Wu, C.C.; Hsu, T.Y.; Chen, J.Y.
Characterization of three essential residues in the conserved ATP-binding region of Epstein-Barr virus thymidine kinase
Biochemistry
44
4785-4793
2005
Human gammaherpesvirus 4
Barroso, J.F.; Carvalho, R.N.; Flatmark, T.
Kinetic analysis and ligand-induced conformational changes in dimeric and tetrameric forms of human thymidine kinase 2
Biochemistry
44
4886-4896
2005
Homo sapiens
Frederiksen, H.; Berenstein, D.; Munch-Petersen, B.
Effect of valine 106 on structure-function relation of cytosolic human thymidine kinase. Kinetic properties and oligomerization pattern of nine substitution mutants of V106
Eur. J. Biochem.
271
2248-2256
2004
Homo sapiens
Birringer, M.S.; Claus, M.T.; Folkers, G.; Kloer, D.P.; Schulz, G.E.; Scapozza, L.
Structure of a type II thymidine kinase with bound dTTP
FEBS Lett.
579
1376-1382
2005
Leishmania major, Vaccinia virus (O57203), Homo sapiens (P04183), Homo sapiens, Mycoplasma pneumoniae (P75070)
Bird, L.E.; Ren, J.; Wright, A.; Leslie, K.D.; Degreve, B.; Balzarini, J.; Stammers, D.K.
Crystal structure of Varicella zoster virus thymidine kinase
J. Biol. Chem.
278
24680-24687
2003
Human alphaherpesvirus 3
Welin, M.; Kosinska, U.; Mikkelsen, N.E.; Carnrot, C.; Zhu, C.; Wang, L.; Eriksson, S.; Munch-Petersen, B.; Eklund, H.
Structures of thymidine kinase 1 of human and mycoplasmic origin
Proc. Natl. Acad. Sci. USA
101
17970-17975
2004
Ureaplasma urealyticum, Homo sapiens (P04183), Homo sapiens
Gardberg, A.; Shuvalova, L.; Monnerjahn, C.; Konrad, M.; Lavie, A.
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases
Structure
11
1265-1277
2003
Herpes simplex virus type 4
Votava, T.; Topolcan, O.; Holubec, L.; Cerna, Z.; Sasek, L.; Finek, J.; Kormunda, S.
Changes of serum thymidine kinase in children with acute leukemia
Anticancer Res.
27
1925-1928
2007
Homo sapiens
Prichard, M.N.; Williams, A.D.; Keith, K.A.; Harden, E.A.; Kern, E.R.
Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs
Antiviral Res.
71
1-6
2006
cowpox virus, Human alphaherpesvirus 1
Perez-Perez, M.J.; Hernandez, A.I.; Priego, E.M.; Rodriguez-Barrios, F.; Gago, F.; Camarasa, M.J.; Balzarini, J.
Mitochondrial thymidine kinase inhibitors
Curr. Top. Med. Chem.
5
1205-1219
2005
Human alphaherpesvirus 1, Homo sapiens (O00142), Homo sapiens (P04183)
Wang, K.; Mahalingam, G.; Hoover, S.E.; Mont, E.K.; Holland, S.M.; Cohen, J.I.; Straus, S.E.
Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia
J. Virol.
81
6817-6826
2007
Human alphaherpesvirus 1 (P03176), Human alphaherpesvirus 1
Wang, J.; Heflich, R.H.; Moore, M.M.
A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay
Mutat. Res.
626
185-190
2007
Mus musculus
Sandrini, M.P.; Clausen, A.R.; Munch-Petersen, B.; Piskur, J.
Thymidine kinase diversity in bacteria
Nucleosides Nucleotides Nucleic Acids
25
1153-1158
2006
Bacillus cereus, Bacillus subtilis, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Xanthomonas campestris, Streptomyces coelicolor (O50519), Gallus gallus (P04047), Homo sapiens (P04183), Mus musculus (P04184), Yersinia enterocolitica (Q0H7D6), Solanum lycopersicum (Q71F77), Salmonella enterica subsp. enterica serovar Typhi (Q8XFQ8), Clostridium acetobutylicum (Q97F65), Arabidopsis thaliana (Q9FN47), Arabidopsis thaliana (Q9S750), Ureaplasma parvum (Q9PPP5), Deinococcus radiodurans (Q9RSY5)
Clausen, A.R.; Matakos, A.; Sandrini, M.P.; Piskur, J.
Thymidine kinases in archaea
Nucleosides Nucleotides Nucleic Acids
25
1159-1163
2006
Halobacterium sp., Pyrobaculum aerophilum, Thermococcus kodakarensis, Thermoplasma acidophilum, Ferroplasma acidarmanus, Pyrobaculum aerophilum IM2, Ferroplasma acidarmanus Fer1, Halobacterium sp. NRC-1
Zhu, C.; Harlow, L.S.; Berenstein, D.; Munch-Petersen, S.; Munch-Petersen, B.
Effect of C-terminal of human cytosolic thymidine kinase (TK1) on in vitro stability and enzymatic properties
Nucleosides Nucleotides Nucleic Acids
25
1185-1188
2006
Homo sapiens
Solaroli, N.; Johansson, M.; Balzarini, J.; Karlsson, A.
Substrate specificity of three viral thymidine kinases (TK): vaccinia virus TK, feline herpesvirus TK, and canine herpesvirus TK
Nucleosides Nucleotides Nucleic Acids
25
1189-1192
2006
Canid alphaherpesvirus 1, Felid alphaherpesvirus 1, Vaccinia virus
Hussein, I.T.; Menashy, R.V.; Field, H.J.
Penciclovir is a potent inhibitor of feline herpesvirus-1 with susceptibility determined at the level of virus-encoded thymidine kinase
Antiviral Res.
78
268-274
2008
Felid alphaherpesvirus 1
Saijo, M.; Suzutani, T.; Mizuta, K.; Kurane, I.; Morikawa, S.
Characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons
Arch. Virol.
153
303-314
2008
Human alphaherpesvirus 1 (Q9QNF7), Human alphaherpesvirus 1
van Calenbergh, S.; van Daele, I.; van Poecke, S.; Froeyen, M.; Lehmann, H.M.; Balzarini, J.
From M. tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitors towards mitochondrial thymidine kinase (TK-2) inhibitors
Collect. Symp. Ser.
10
87-93
2008
Mycobacterium tuberculosis
-
Salama, S.A.; Kamel, M.; Christman, G.; Wang, H.Q.; Fouad, H.M.; Al-Hendy, A.
Gene therapy of uterine leiomyoma: adenovirus-mediated Herpes simplex virus thymidine kinase/ganciclovir treatment inhibits growth of human and rat leiomyoma cells in vitro and in a nude mouse model
Gynecol. Obstet. Invest.
63
61-70
2007
Mus musculus
Iqbal, J.; Scapozza, L.; Folkers, G.; Mueller, C.E.
Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors
J. Chromatogr. B
846
281-290
2007
Herpes simplex virus
Desbouis, D.; Schubiger, P.A.; Schibli, R.
Synthesis of tricarbonyl rhenium and technetium complexes of a 5-carboxamide 5-ethyl-2-deoxyuridine for selective inhibition of herpes simplex virus thymidine kinase 1
J. Organomet. Chem.
692
1340-1347
2007
Herpes simplex virus
-
Smith, R.F.; Freyer, M.W.; Lewis, E.A.
Biophysical characterization of vaccinia virus thymidine kinase substrate utilization
J. Virol. Methods
142
151-158
2007
Vaccinia virus
Perez-Perez, M.J.; Priego, E.M.; Hernandez, A.I.; Familiar, O.; Camarasa, M.J.; Negri, A.; Gago, F.; Balzarini, J.
Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future
Med. Res. Rev.
28
797-820
2008
Homo sapiens
Azab, W.; Tsujimura, K.; Kato, K.; Arii, J.; Morimoto, T.; Kawaguchi, Y.; Tohya, Y.; Matsumura, T.; Akashi, H.
Characterization of a thymidine kinase-deficient mutant of equine herpesvirus 4 and in vitro susceptibility of the virus to antiviral agents
Antiviral Res.
85
389-395
2010
Equid alphaherpesvirus 4, Equid alphaherpesvirus 4 TH20p
Leyton, J.; Smith, G.; Lees, M.; Perumal, M.; Nguyen, Q.D.; Aigbirhio, F.I.; Golovko, O.; He, Q.; Workman, P.; Aboagye, E.O.
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901
Mol. Cancer Ther.
7
3112-3121
2008
Homo sapiens
Balzarini, J.; Van Daele, I.; Negri, A.; Solaroli, N.; Karlsson, A.; Liekens, S.; Gago, F.; Van Calenbergh, S.
Human mitochondrial thymidine kinase is selectively inhibited by 3-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity
Mol. Pharmacol.
75
1127-1136
2009
Homo sapiens, Human alphaherpesvirus 1 (P03176), Human alphaherpesvirus 1
Lossani, A.; Torti, A.; Gatti, S.; Bruno, A.; Maserati, R.; Wright, G.E.; Focher, F.
Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors
Parasitology
136
595-602
2009
Entamoeba histolytica (Q6S4W2), Entamoeba histolytica
Lin, J.; Roy, V.; Wang, L.; You, L.; Agrofoglio, L.A.; Deville-Bonne, D.; McBrayer, T.R.; Coats, S.J.; Schinazi, R.F.; Eriksson, S.
3-(1,2,3-Triazol-1-yl)-3-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations
Bioorg. Med. Chem.
18
3261-3269
2010
Homo sapiens (P04183), Homo sapiens, Ureaplasma parvum (Q9PPP5), Ureaplasma parvum
Agarwal, H.K.; McElroy, C.A.; Sjuvarsson, E.; Eriksson, S.; Darby, M.V.; Tjarks, W.
Synthesis of N3-substituted carboranyl thymidine bioconjugates and their evaluation as substrates of recombinant human thymidine kinase 1
Eur. J. Med. Chem.
60
456-468
2013
Homo sapiens
Skovgaard, T.; Uhlin, U.; Munch-Petersen, B.
Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1
FEBS J.
279
1777-1787
2012
Caenorhabditis elegans, Homo sapiens (P04183), Homo sapiens
Clausen, A.R.; Girandon, L.; Ali, A.; Knecht, W.; Rozpedowska, E.; Sandrini, M.P.; Andreasson, E.; Munch-Petersen, B.; Piskur, J.
Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana
FEBS J.
279
3889-3897
2012
Arabidopsis thaliana (Q8LDP6), Arabidopsis thaliana (Q9FN47), Arabidopsis thaliana
Mutahir, Z.; Clausen, A.R.; Andersson, K.M.; Wisen, S.M.; Munch-Petersen, B.; Piskur, J.
Thymidine kinase 1 regulatory fine-tuning through tetramer formation
FEBS J.
280
1531-1541
2013
Anolis carolinensis (C3VAL3), Caenorhabditis elegans (G5EEZ5), Gallus gallus (P04047), Homo sapiens (P04183), Homo sapiens, Rattus norvegicus (P27158), Bacillus cereus (Q0H0H6), Dictyostelium discoideum (Q27564), Xenopus tropicalis (Q5I0A2), Danio rerio (Q803Y1), Arabidopsis thaliana (Q9S750 and Q9FN47)
Sun, X.E.; Sharling, L.; Muthalagi, M.; Mudeppa, D.G.; Pankiewicz, K.W.; Felczak, K.; Rathod, P.K.; Mead, J.; Striepen, B.; Hedstrom, L.
Prodrug activation by Cryptosporidium thymidine kinase
J. Biol. Chem.
285
15916-15922
2010
Cryptosporidium parvum
Chen, Y.L.; Eriksson, S.; Chang, Z.F.
Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage
J. Biol. Chem.
285
27327-27335
2010
Homo sapiens
Ranjbarian, F.; Vodnala, M.; Vodnala, S.M.; Rofougaran, R.; Thelander, L.; Hofer, A.
Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding
J. Biol. Chem.
287
17628-17636
2012
Trypanosoma brucei, Trypanosoma brucei TC221
Van Poecke, S.; Negri, A.; Gago, F.; Van Daele, I.; Solaroli, N.; Karlsson, A.; Balzarini, J.; Van Calenbergh, S.
3-[4-Aryl-(1,2,3-triazol-1-yl)]-3-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase
J. Med. Chem.
53
2902-2912
2010
Homo sapiens
Munch-Petersen, B.
Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review
Nucleosides Nucleotides Nucleic Acids
29
363-369
2010
Mus musculus
Sun, R.; Eriksson, S.; Wang, L.
Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity
Nucleosides Nucleotides Nucleic Acids
29
382-385
2010
Homo sapiens, Rattus norvegicus
Mutahir, Z.; Larsen, N.B.; Christiansen, L.S.; Andersson, K.M.; Rico, R.; Wisen, S.M.; Clausen, A.R.; Munch-Petersen, B.; Piskur, J.
Characterization of oligomeric and kinetic properties of tomato thymidine kinase 1
Nucleosides Nucleotides Nucleic Acids
30
1223-1226
2011
Solanum lycopersicum (Q71F77), Solanum lycopersicum
Van Poecke, S.; Negri, A.; Janssens, J.; Solaroli, N.; Karlsson, A.; Gago, F.; Balzarini, J.; Van Calenbergh, S.
Synthesis, modeling and evaluation of 3-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors
Org. Biomol. Chem.
9
892-901
2011
Homo sapiens
Stepanenko, V.; Esipov, R.; Miroshnikov, A.; Andronova, V.; Galegov, G.; Yasko, M.; Guskova, A.; Skoblov, A.; Skoblov, Y.
Cloning, expression, isolation, and properties of thymidine kinase from herpes simplex virus type 1, strain L2
Russ. J. Bioorg. Chem.
37
436-440
2011
Human alphaherpesvirus 1, Human alphaherpesvirus 1 L2
-
Guskova, A.; Skoblov, M.; Andronova, V.; Galegov, G.; Kochetkov, S.; Skoblov, Y.
Enzymatic activity of thymidine kinases of a herpes simplex virus strains resistant to acyclovir H-phosphonates
Russ. J. Bioorg. Chem.
37
560-563
2011
Herpes simplex virus, Herpes simplex virus type-1
-
Jagarlamudi, K.; Hansson, L.; Eriksson, S.
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: Implications of using serum TK1 as a biomarker
BMC Cancer
15
66
2015
Homo sapiens (P04183), Homo sapiens
Jagarlamudi, K.K.; Westberg, S.; Roennberg, H.; Eriksson, S.
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker
BMC Vet. Res.
10
228
2014
Canis lupus familiaris (E2QXP4), Canis lupus familiaris
Timm, J.; Bosch-Navarrete, C.; Recio, E.; Nettleship, J.E.; Rada, H.; Gonzalez-Pacanowska, D.; Wilson, K.S.
Structural and kinetic characterization of thymidine kinase from Leishmania major
PLoS Negl. Trop. Dis.
9
e0003781
2015
Leishmania major (Q4QC75), Leishmania major
Szantho, E.; Bhattoa, H.P.; Csoban, M.; Antal-Szalmas, P.; Ujfalusi, A.; Kappelmayer, J.; Hevessy, Z.
Serum thymidine kinase activity: analytical performance, age-related reference ranges and validation in chronic lymphocytic leukemia
PLoS ONE
9
e91647
2014
Homo sapiens
Lutz, S.; Lichter, J.; Liu, L.
Exploiting temperature-dependent substrate promiscuity for nucleoside analogue activation by thymidine kinase from Thermotoga maritima
J. Am. Chem. Soc.
129
8714-8715
2007
Thermotoga maritima (Q9WYN2), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WYN2)
Zhang, S.Y.; Lin, B.D.; Li, B.R.
Evaluation of the diagnostic value of alpha-L-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma
FEBS open bio
5
240-244
2015
Homo sapiens (P04183), Homo sapiens
Okamura, S.; Osaki, T.; Nishimura, K.; Ohsaki, H.; Shintani, M.; Matsuoka, H.; Maeda, K.; Shiogama, K.; Itoh, T.; Kamoshida, S.
Thymidine kinase-1/CD31 double immunostaining for identifying activated tumor vessels
Biotech. Histochem.
94
60-64
2019
Homo sapiens (P04183)
Cabel, L.; Rosenblum, D.; Lerebours, F.; Brain, E.; Loirat, D.; Bergqvist, M.; Cottu, P.; Donnadieu, A.; Bethune, A.; Kiavue, N.; Rodrigues, M.; Pierga, J.; Tanguy, M.; Bidard, F.
Plasma thymidine kinase 1 activity and outcome of ER+ HER2- metastatic breast cancer patients treated with palbociclib and endocrine therapy
Breast Cancer Res.
22
98
2020
Homo sapiens (P04183), Homo sapiens
Sun, R.; Eriksson, S.; Wang, L.
The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs
Nucleosides Nucleotides Nucleic Acids
39
1347-1358
2020
Homo sapiens (P04183)
Najera-Martinez, M.; Pedroza-Garcia, J.A.; Suzuri-Hernandez, L.J.; Mazubert, C.; Drouin-Wahbi, J.; Vazquez-Ramos, J.; Raynaud, C.; Plasencia, J.
Maize thymidine kinase activity is present throughout plant development and its heterologous expression confers tolerance to an organellar DNA-damaging agent
Plants (Basel)
9
930
2020
Zea mays (B0R217), Zea mays
Larsson, A.M.; Bendahl, P.O.; Aaltonen, K.; Jansson, S.; Forsare, C.; Bergqvist, M.; Jorgensen, C.L.T.; Ryden, L.
Serial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer
Sci. Rep.
10
4484
2020
Homo sapiens (P04183), Homo sapiens
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