Reference on EC 2.7.1.36 - mevalonate kinase
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Tchen, T.T.
Mevalonic kinase: purification and properties
J. Biol. Chem.
233
1100-1103
1958
Saccharomyces cerevisiae
Markley, K.; Smallan, E.
Mevalonic kinase in rabbit liver
Biochim. Biophys. Acta
47
327-335
1961
Oryctolagus cuniculus
-
Porter, J.W.
Mevalonate kinase
Methods Enzymol.
110
71-78
1985
Agave americana, Saccharomyces cerevisiae, Citrus sp., Cucumis melo, Cucurbita pepo, Oryctolagus cuniculus, Hevea brasiliensis, Kalanchoe crenata, Staphylococcus aureus, Sarcophaga bullata, Phaseolus vulgaris, Pinus pinaster, Pinus radiata, Rattus norvegicus, Sus scrofa
Soler, M.; Jabalquinto, A.M.; Beytia, E.
Hog liver mevalonate kinase: inactivation by pyridoxal-5-phosphate and evidence of dead-end inhibition by one of the substrates
Int. J. Biochem.
10
931-935
1979
Sus scrofa
Shewry, P.R.; Stobart, A.K.
Properties of castor bean mevalonic acid kinase
Plant Sci. Lett.
1
473-477
1973
Ricinus communis
-
Goodfellow, R.D.; Barnes, F.J.
Mevalonate kinase from the larva of the fleshfly, Sarcophaga bullata
Insect Biochem.
1
271-282
1971
Sarcophaga bullata
-
Soong Lee, C.; O'Sullivan, W.J.
An improved purification procedure, an alternative assay and activation of mevalonate kinase by ATP
Biochim. Biophys. Acta
747
215-224
1983
Rattus norvegicus, Sus scrofa
Gray, J.C.; Kekwick, R.G.O.
The inhibition of plant mevalonate kinase preparations by prenyl pyrophosphates
Biochim. Biophys. Acta
279
290-296
1972
Saccharomyces cerevisiae, Cucumis melo, Hevea brasiliensis, Phaseolus vulgaris
Gray, J.C.; Kekwick, R.G.O.
Mevalonate kinase in green leaves and etiolated cotyledons of the french bean Phaseolus vulgaris
Biochem. J.
133
335-347
1973
Phaseolus vulgaris
Tanaka, R.D.; Schafer, B.L.; Lee, L.Y.; Freudenberger, J.S.; Mosley, S.T.
Purification and regulation of mevalonate kinase from rat liver
J. Biol. Chem.
265
2391-2398
1990
Rattus norvegicus
Suarez, D.; Garcia-Peregrin, E.
Properties and partial purification of mevalonate kinase from Agave americana
Phytochemistry
16
661-665
1977
Agave americana
-
Soong Lee, C.; O'Sullivan, W.J.O.
Phosphorothioate analogues of adenosine triphosphate as substrates of the mevalonate kinase reaction
Biochim. Biophys. Acta
787
131-137
1984
Sus scrofa
Garcia-Peregrin, E.; Suarez, M.D.; Mayor, F.
Isolation of two fractions with mevalonate kinase activity from Pinus pinaster and Agave americana
FEBS Lett.
30
15-17
1973
Agave americana, Pinus pinaster
Williamson, I.P.; Kekwick, R.G.O.
The formation of 5-phosphomevalonate by mevalonate kinase in Hevea brasiliensis latex
Biochem. J.
96
862-871
1965
Hevea brasiliensis
Suarez, D.; Garcia-Peregrin, E.; Mayor, F.
Mevalonate kinase from Pinus pinaster seedlings
Phytochemistry
13
1059-1063
1974
Pinus pinaster
-
Gray, J.C.; Kekwick, R.G.O.
An assessment of some molecular parameters of mevalonate kinase from plant and animal sources
Arch. Biochem. Biophys.
159
458-462
1973
Saccharomyces cerevisiae, Gallus gallus, Cucumis melo, Oryctolagus cuniculus, Hevea brasiliensis, Phaseolus vulgaris
Graef, E.; Caselmann, W.H.; Hofschneider, P.H.; Koshy, R.
Enzymic properties of overexpressed HBV-mevalonate kinase fusion proteins and mevalonate kinase proteins in the human hepatoma cell line PLC/PRF/5
Virology
208
696-703
1995
Homo sapiens
Hinson, D.D.; Chambliss, K.L.; Toth, M.J.; Tanaka, R.D.; Gibson, K.M.
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways
J. Lipid Res.
38
2216-2223
1997
Homo sapiens
Potter, D.; Wojnar, J.M.; Narasimhan, C.; Miziorko, H.M.
Identification and functional characterization of an active-site lysine in mevalonate kinase
J. Biol. Chem.
272
5741-5746
1997
Rattus norvegicus
Bishop, R.W.; Chambliss, K.L.; Hoffmann, G.F.; Tanaka, R.D.; Gibson, K.M.
Characterization of the mevalonate kinase 5'-untranslated region provides evidence for coordinate regulation of cholesterol biosynthesis
Biochem. Biophys. Res. Commun.
242
518-524
1998
Homo sapiens
Huang, K.X.; Scott, A.I.; Bennett, G.N.
Overexpression, purification, and characterization of the thermostable mevalonate kinase from Methanococcus jannaschii
Protein Expr. Purif.
17
33-40
1999
Methanocaldococcus jannaschii
Schulte, A.E.; van der Heijden, R.; Verpoorte, R.
Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharanthus roseus (L.) G. Don
Arch. Biochem. Biophys.
378
287-298
2000
Catharanthus roseus
Schulte, A.E.; Llamas Duran, E.M.; Van der Heijden, R.; Verpoorte, R.
Mevalonate kinase activity in Catharanthus roseus plants and suspension cultured cells
Plant Sci.
150
59-69
2000
Arabidopsis thaliana, Catharanthus roseus, Homo sapiens, Nepeta cataria, Parthenium argentatum, Rattus norvegicus, Saccharomyces cerevisiae, Spinacia oleracea
-
Houten, S.M.; Wanders, R.J.; Waterham, H.R.
Biochemical and genetic aspects of mevalonate kinase and its deficiency
Biochim. Biophys. Acta
1529
19-32
2000
Methanocaldococcus jannaschii, Sus scrofa, Rattus norvegicus (P17256), Homo sapiens (Q03426), Homo sapiens
Rios, S.E.; Cho, Y.K.; Miziorko, H.M.
Characterization of mevalonate kinase V377I, a mutant implicated in defective isoprenoid biosynthesis and HIDS/periodic fever syndrome
Biochim. Biophys. Acta
1531
165-168
2001
Homo sapiens
Cho, Y.K.; Rios, S.E.; Kim, J.J.; Miziorko, H.M.
Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease
J. Biol. Chem.
276
12573-12578
2001
Homo sapiens
Houten, S.M.; Frenkel, J.; Rijkers, G.T.; Wanders, R.J.; Kuis, W.; Waterham, H.R.
Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome
Hum. Mol. Genet.
11
3115-3124
2002
Homo sapiens
Fu, Z.; Wang, M.; Potter, D.; Miziorko, H.M.; Kim, J.J.
The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease
J. Biol. Chem.
277
18134-18142
2002
Rattus norvegicus
Chu, X.; Li, D.
Cloning, expression, and purification of His-tagged rat mevalonate kinase
Protein Expr. Purif.
27
165-170
2003
Rattus norvegicus
Chu, X.; Liu, X.; Yau, M.; Leung, Y.C.; Li, D.
Expression and purification of Arg196 and Lys272 mutants of mevalonate kinase from Methanococcus jannaschii
Protein Expr. Purif.
30
210-218
2003
Methanocaldococcus jannaschii
Voynova, N.E.; Rios, S.E.; Miziorko, H.M.
Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway
J. Bacteriol.
186
61-67
2004
Homo sapiens, Staphylococcus aureus, Rattus norvegicus
Hogenboom, S.; Tuyp, J.J.; Espeel, M.; Koster, J.; Wanders, R.J.; Waterham, H.R.
Mevalonate kinase is a cytosolic enzyme in humans
J. Cell Sci.
117
631-639
2004
Homo sapiens
Chu, X.; Li, D.
Expression, purification, and characterization of His20 mutants of rat mevalonate kinase
Protein Expr. Purif.
32
75-82
2003
Rattus norvegicus
Hedl, M.; Rodwell, V.W.
Enterococcus faecalis mevalonate kinase
Protein Sci.
13
687-693
2004
Enterococcus faecalis
Sgraja, T.; Smith, T.K.; Hunter, W.N.
Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase
BMC Struct. Biol.
7
20
2007
Leishmania major, Leishmania major (Q4Q6K7), Trypanosoma brucei
Hoffmann, F.; Lohse, P.; Stojanov, S.; Shin, Y.S.; Renner, E.D.; Kery, A.; Zellerer, S.; Belohradsky, B.H.
Identification of a novel mevalonate kinase gene mutation in combination with the common MVK V377I substitution and the low-penetrance TNFRSF1A R92Q mutation
Eur. J. Hum. Genet.
13
510-512
2005
Homo sapiens
Qiu, Y.; Li, D.
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase
Org. Lett.
8
1013-1016
2006
Rattus norvegicus
Andreassi, J.L.; Bilder, P.W.; Vetting, M.W.; Roderick, S.L.; Leyh, T.S.
Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate
Protein Sci.
16
983-989
2007
Streptococcus pneumoniae
Tang, W.; Newton, R.J.
Mevalonate kinase activity during different stages of plant regeneration from nodular callus cultures in white pine (Pinus strobus)
Tree Physiol.
26
195-200
2006
Pinus strobus
Kone-Paut, I.; Sanchez, E.; Le Quellec, A.; Manna, R.; Touitou, I.
Autoinflammatory gene mutations in Behcet's disease
Ann. Rheum. Dis.
66
832-834
2007
Homo sapiens
Murphy, C.; Murray, A.M.; Meaney, S.; Gafvels, M.
Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism
Biochem. Biophys. Res. Commun.
355
359-364
2007
Homo sapiens, Mus musculus
Fu, Z.; Voynova, N.E.; Herdendorf, T.J.; Miziorko, H.M.; Kim, J.J.
Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism
Biochemistry
47
3715-3724
2008
Rattus norvegicus (P17256), Homo sapiens (Q03426), Homo sapiens
Chu, X.; Yu, W.; Wu, L.; Liu, X.; Li, N.; Li, D.
Effect of a disulfide bond on mevalonate kinase
Biochim. Biophys. Acta
1774
1571-1581
2007
Methanocaldococcus jannaschii, Rattus norvegicus
Kuijk, L.M.; Beekman, J.M.; Koster, J.; Waterham, H.R.; Frenkel, J.; Coffer, P.J.
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation
Blood
112
3563-3573
2008
Homo sapiens
Topaloglu, R.; Ayaz, N.A.; Waterham, H.R.; Yuece, A.; Gumruk, F.; Sanal, O.
Hyperimmunoglobulinemia D and periodic fever syndrome; treatment with etanercept and follow-up
Clin. Rheumatol.
27
1317-1320
2008
Homo sapiens
Schirra, F.; Richards, S.M.; Sullivan, D.A.
Androgen influence on cholesterogenic enzyme mRNA levels in the mouse meibomian gland
Curr. Eye Res.
32
393-398
2007
Mus musculus (Q9R008), Mus musculus
Ikeda, S.; Nakamura, K.; Kogure, K.; Omori, Y.; Yamashita, S.; Kubota, K.; Mizutani, T.; Miyamoto, K.; Minegishi, T.
Effect of estrogen on the expression of luteinizing hormone-human chorionic gonadotropin receptor messenger ribonucleic acid in cultured rat granulosa cells
Endocrinology
149
1524-1533
2008
Rattus norvegicus
Sornsakrin, M.; Wenner, K.; Ganschow, R.
B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome
Eur. J. Pediatr.
168
825-831
2008
Homo sapiens
Nair, A.K.; Young, M.A.; Menon, K.M.
Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase - role of the catalytic center in mRNA recognition
FEBS J.
275
3397-3407
2008
Rattus norvegicus
Breton Martinez, J.R.; Canovas Martinez, A.; Casana Perez, S.; Escriba Alepuz, J.; Gimenez Vazquez, F.
Mevalonic aciduria: report of two cases
J. Inherit. Metab. Dis.
30
829
2007
Homo sapiens
Hager, E.J.; Tse, H.M.; Piganelli, J.D.; Gupta, M.; Baetscher, M.; Tse, T.E.; Pappu, A.S.; Steiner, R.D.; Hoffmann, G.F.; Gibson, K.M.
Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome
J. Inherit. Metab. Dis.
30
888-895
2007
Mus musculus
van der hilst, J.C.H.; Kluve-Beckerman, B.; Bodar, E.J.; van der Meer, J.W.M.; Drenth, J.P.H.; Simon, A.
Lovastatin inhibits formation of AA amyloid
J. Leukocyte Biol.
83
1295-1299
2008
Homo sapiens
Anthony, J.R.; Anthony, L.C.; Nowroozi, F.; Kwon, G.; Newman, J.D.; Keasling, J.D.
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
Metab. Eng.
11
13-19
2008
Escherichia coli
Wang, L.; Nair, A.K.; Menon, K.M.
Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: relationship to sterol metabolism
Mol. Endocrinol.
21
2233-2241
2007
Homo sapiens
Marcuzzi, A.; Pontillo, A.; De Leo, L.; Tommasini, A.; Decorti, G.; Not, T.; Ventura, A.
Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency
Pediatr. Res.
64
177-182
2008
Mus musculus
Nevyjel, M.; Pontillo, A.; Calligaris, L.; Tommasini, A.; DOsualdo, A.; Waterham, H.R.; Granzotto, M.; Crovella, S.; Barbi, E.; Ventura, A.
Diagnostics and therapeutic insights in a severe case of mevalonate kinase deficiency
Pediatrics
119
e523-e527
2007
Homo sapiens
Ammouri, W.; Cuisset, L.; Rouaghe, S.; Rolland, M.; Delpech, M.; Grateau, G.; Ravet, N.
Diagnostic value of serum immunoglobulinaemia D level in patients with a clinical suspicion of hyper IgD syndrome
Rheumatology
46
1597-1600
2007
Homo sapiens
Lequerre, T.; Vittecoq, O.; Pouplin, S.; Klemmer, N.; Mejjad, O.; Daragon, A.; Prieur, A.M.; Le Loet, X.
Mevalonate kinase deficiency syndrome with structural damage responsive to anakinra
Rheumatology
46
1860-1862
2007
Homo sapiens
Potter, D.; Miziorko, H.M.
Identification of catalytic residues in human mevalonate kinase
J. Biol. Chem.
272
25449-25454
1997
Homo sapiens
Kudoh, T.; Park, C.S.; Lefurgy, S.T.; Sun, M.; Michels, T.; Leyh, T.S.; Silverman, R.B.
Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae
Bioorg. Med. Chem.
18
1124-1134
2009
Streptococcus pneumoniae (Q8DR51), Streptococcus pneumoniae
Takase, H.; Yano, S.; Yamaguchi, T.; Kanazawa, I.; Hayashi, K.; Yamamoto, M.; Yamauchi, M.; Sugimoto, T.
Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells
Horm. Metab. Res.
41
861-865
2009
Mus musculus
Steichen, O.; van der Hilst, J.; Simon, A.; Cuisset, L.; Grateau, G.
A clinical criterion to exclude the hyperimmunoglobulin D syndrome (mild mevalonate kinase deficiency) in patients with recurrent fever
J. Rheumatol.
36
1677-1681
2009
Homo sapiens
Zhuang, N.; Seo, K.H.; Chen, C.; Zhou, J.; Kim, S.W.; Lee, K.H.
Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei
Acta Crystallogr. Sect. F
68
1560-1563
2012
Methanosarcina mazei (Q8PW39), Methanosarcina mazei
Primak, Y.A.; Du, M.; Miller, M.C.; Wells, D.H.; Nielsen, A.T.; Weyler, W.; Beck, Z.Q.
Characterization of a feedback-resistant mevalonate kinase from the archaeon Methanosarcina mazei
Appl. Environ. Microbiol.
77
7772-7778
2011
Methanosarcina mazei
Nishimura, H.; Azami, Y.; Miyagawa, M.; Hashimoto, C.; Yoshimura, T.; Hemmi, H.
Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus
J. Biochem.
153
415-420
2013
Saccharolobus solfataricus (Q980D2), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q980D2)
Yang, D.; Shipman, L.W.; Roessner, C.A.; Scott, A.I.; Sacchettini, J.C.
Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily
J. Biol. Chem.
277
9462-9467
2002
Methanocaldococcus jannaschii (Q58487), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58487)
Kumari, U.; Vishwakarma, R.K.; Sonawane, P.; Abbassi, S.; Khan, B.M.
Biochemical characterization of recombinant mevalonate kinase from Bacopa monniera
Int. J. Biol. Macromol.
72
776-783
2015
Bacopa monnieri (M1F2U2), Bacopa monnieri
Nyati, P.; Rivera-Perez, C.; Noriega, F.G.
Negative feedbacks by isoprenoids on a mevalonate kinase expressed in the corpora allata of mosquitoes
PLoS ONE
10
e0143107
2015
Aedes aegypti
Ferreira, E.R.; Horjales, E.; Bonfim-Melo, A.; Cortez, C.; da Silva, C.V.; De Groote, M.; Sobreira, T.J.; Cruz, M.C.; Lima, F.M.; Cordero, E.M.; Yoshida, N.; da Silveira, J.F.; Mortara, R.A.; Bahia, D.
Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling
Sci. Rep.
6
24610
2016
Trypanosoma cruzi (Q4CLD0), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4CLD0)
Chen, Q.; Yan, J.; Meng, X.; Xu, F.; Zhang, W.; Liao, Y.; Qu, J.
Molecular cloning, characterization, and functional analysis of acetyl-CoA C-acetyltransferase and mevalonate kinase genes involved in terpene trilactone biosynthesis from Ginkgo biloba
Molecules
22
74
2017
Ginkgo biloba (A0A1S6KJR4), Ginkgo biloba
Li, M.; Min, W.; Wang, J.; Wang, L.; Li, Y.; Zhou, N.; Yang, Z.; Qian, Q.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate
Exp. Therap. Med.
19
2861-2870
2020
Homo sapiens (Q03426), Homo sapiens
Bahia, D.
A new trick for a conserved enzyme Mevalonate kinase, a glycosomal enzyme, can be secreted by Trypanosoma cruzi and modulate cell invasion and signaling. Is it another moonlighting enzyme?
Front. Cell. Infect. Microbiol.
7
426
2017
Trypanosoma cruzi (A0A165UDJ0)
Duarte, D.P.; Ferreira, E.R.; Lima, F.M.; Batista, F.; De Groote, M.; Horjales, E.; Miletti, L.C.; Bahia, D.
Molecular characterization of Trypanosoma evansi mevalonate kinase (TeMVK)
Front. Cell. Infect. Microbiol.
8
223
2018
Trypanosoma evansi, Trypanosoma evansi 29-19
Glinos, G.; Pastar, I.; Giubellino, A.; Tomic-Canic, M.; Miteva, M.; Stone, R.
Novel mevalonate kinase missense mutation in a patient with disseminated superficial actinic porokeratosis
JAAD Case Rep.
4
340-343
2018
Homo sapiens (Q03426)
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