Information on EC 2.7.1.41 - glucose-1-phosphate phosphodismutase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
2.7.1.41
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RECOMMENDED NAME
GeneOntology No.
glucose-1-phosphate phosphodismutase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Starch and sucrose metabolism
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-25-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
wild-type strain 168
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucose 1-phosphate + D-glucose 1-phosphate
D-glucose + D-glucose 1,6-bisphosphate
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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carbohydrate metabolism
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
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inhibits forward reaction above 2 mM
Cu2+
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weak, 0.1 mM
Mg2+
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inhibits reverse reaction at 0.5 mM, forward reaction: activation
Mn2+
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inhibits forward reaction above 0.5 mM
additional information
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not inhibited by 8 mM fluoride, cysteine, histidine, adenylic acid or phosphate
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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forward reaction is not activated by ATP, cysteine, histidine, adenylic acid or phosphate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.021
alpha-D-glucose 1-phosphate
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0.006
beta-D-glucose 1-phosphate
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.6
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forward reaction, in the presence of Mg2+
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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4 different enzymic activities of D-glucose 1,6-bisphosphate synthesis: in muscle glucose 1-phosphate transphosphorylase activity is the major activity, but not in brain
Manually annotated by BRENDA team
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muscles of back and hind legs
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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recombinant PgcM with beta-phosphoglucomutase and glucose 1-phosphate phosphodismutase activities
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Manually annotated by BRENDA team
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
trimer
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3 * 26500, PgcM with beta-phosphoglucomutase and glucose 1-phosphate phosphodismutase activities, SDS-PAGE; 3 * 28000, PgcM with beta-phosphoglucomutase and glucose 1-phosphate phosphodismutase activities, estimated from the amino acid sequence data
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
95
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30 min, stable, PgcM with beta-phosphoglucomutase and glucose 1-phosphate phosphodismutase activities
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
stable to 3-4 h dialysis against distilled water, prolonged or repeated dialysis inactivates
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
6°C, within 1 week, inactivation
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frozen, partially purified preparation, at least 4 weeks, stable
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial, not separated from phosphoglucomutase
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recombinant PgcM expressed in Bacillus megaterium DSM 319
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
pgcM gene, encoding PgcM, a 226 amino acids protein with beta-phosphoglucomutase and glucose 1-phosphate phosphodismutase activities, is cloned, sequenced and used to construct a plasmid-based overexpression system for PcgM in Bacillus megaterium DSM 319
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