Reference on EC 2.7.1.48 - uridine/cytidine kinase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Skld, O.
Uridine kinase from ehrlich ascites tumor: purification and properties
J. Biol. Chem.
235
3273-3279
1960
Mus musculus
-
Orengo, A.; Saunders, G.F.
Regulation of a thermostable pyrimidine ribonucleoside kinase by cytidine triphosphate
Biochemistry
11
1761-1767
1972
Geobacillus stearothermophilus, Rattus norvegicus
Ahmed, N.K.; Baker, D.R.
Properties of uridine-cytidine kinase derived from L1210 leukemia cells
Cancer Res.
40
3559-3563
1980
Mus musculus
Drake, J.C.; Stoller, R.G.; Chabner, B.A.
Characteristics of the enzyme uridine-cytidine kinase isolated from a cultured human cell line
Biochem. Pharmacol.
26
64-66
1977
Homo sapiens
Krystal, G.; Scholefield, P.G.
The partial purification and properties of uridine kinase from Ehrlich ascites tumor cells
Can. J. Biochem.
51
379-389
1973
Mus musculus
Orengo, A.; Kobayashi, S.H.
Uridine-cytidine kinase from Novikoff ascites rat tumor and Bacillus stearothermophilus
Methods Enzymol.
51
299-307
1978
Geobacillus stearothermophilus, Rattus norvegicus
Valentin-Hansen, P.
Uridine-cytidine kinase from Escherichia coli
Methods Enzymol.
51
308-314
1978
Escherichia coli
Anderson, E.P.
Uridine-cytidine kinase from a murine neoplasm
Methods Enzymol.
51
314-321
1978
Mus musculus
Orengo, A.
Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor
J. Biol. Chem.
244
2204-2209
1969
Rattus norvegicus
Payne, R.C.; Cheng, N.; Traut, T.W.
Uridine kinase from Ehrlich ascites carcinoma. Purification and properties of homogeneous enzyme
J. Biol. Chem.
260
10242-10247
1985
Mus musculus
Fulchignoni-Lataud, M.C.; Tuilie, M.; Roux, J.M.
Uridine--cytidine kinase from foetal and adult rat liver. Purification and study of some properties
Eur. J. Biochem.
69
217-222
1976
Rattus norvegicus
Liacouras, A.S.; Anderson, E.P.
Uridine-cytidine kinase. Purification from a murine neoplasm and characterization of the enzyme
Arch. Biochem. Biophys.
168
66-73
1975
Mus musculus
Liacouras, A.S.; Garvey, T.Q.; Millar, F.K.; Anderson, E.P.
Uridine-cytidine kinase. Kinetic studies and reaction mechanism
Arch. Biochem. Biophys.
168
74-80
1975
Mus musculus
Cihak, A.
Pb-precipitated protein fraction from calf brain containing highly active uridine kinase with different molecular properties
FEBS Lett.
51
133-136
1975
Bos taurus
Cihak, A.
Stability of the insoluble form of uridine kinase coupled to Zn2+ or Pb2+ ions
Hoppe-Seyler's Z. Physiol. Chem.
357
345-350
1976
Bos taurus
Shen, F.; Look, K.Y.; Yeh, Y.A.; Weber, G.
Increased uridine kinase (ATP: uridine 5'-phosphotransferase; EC 2.7.1.48) activity in human and rat tumors
Cancer Biochem. Biophys.
16
1-15
1998
Homo sapiens, Rattus norvegicus
Koizumi, K.; Shimamoto, Y.; Azuma, A.; Wataya, Y.; Matsuda, A.; Sasaki, T.; Fukushima, M.
Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells
Int. J. Mol. Med.
8
273-278
2001
Escherichia coli, Homo sapiens, Mus musculus, Saccharomyces cerevisiae
Van Rompay, A.R.; Norda, A.; Linden, K.; Johansson, M.; Karlsson, A.
Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
Mol. Pharmacol.
59
1181-1186
2001
Homo sapiens (Q9BZX2), Homo sapiens (Q9HA47)
Suzuki, N.N.; Koizumi, K.; Fukushima, M.; Matsuda, A.; Inagaki, F.
Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2
Acta Crystallogr. Sect. D
59
1477-1478
2003
Homo sapiens (Q9BZX2), Homo sapiens
Appleby, T.C.; Larson, G.; Cheney, I.W.; Walker, H.; Wu, J.Z.; Zhong, W.; Hong, Z.; Yao, N.
Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative
Acta Crystallogr. Sect. D
61
278-284
2005
Homo sapiens (Q9BZX2), Homo sapiens
Murata, D.; Endo, Y.; Obata, T.; Sakamoto, K.; Syouji, Y.; Kadohira, M.; Matsuda, A.; Sasaki, T.
A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides
Drug Metab. Dispos.
32
1178-1182
2004
Homo sapiens
Vidair, C.; Rubin, H.
Mg2+ as activator of uridine phosphorylation in coordination with other cellular responses to growth factors
Proc. Natl. Acad. Sci. USA
102
662-666
2005
Mus musculus
Suzuki, N.N.; Koizumi, K.; Fukushima, M.; Matsuda, A.; Inagaki, F.
Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase
Structure
12
751-764
2004
Homo sapiens (Q9BZX2), Homo sapiens
Glavas-Obrovac, L.; Karner, I.; Stefanic, M.; Kasnar-Samprec, J.; Zinic, B.
Metabolic effects of novel N-1-sulfonylpyrimidine derivatives on human colon carcinoma cells
Farmaco
60
479-483
2005
Homo sapiens
Balestri, F.; Barsotti, C.; Lutzemberger, L.; Camici, M.; Ipata, P.L.
Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain
Neurochem. Int.
51
517-523
2007
Rattus norvegicus
Niemeyer, T.; Dietz, C.; Fairbanks, L.; Schroeder-Printzen, I.; Henkel, R.; Loeeffler, M.
Evaluation of uridine metabolism in human and animal spermatozoa
Nucleosides Nucleotides Nucleic Acids
25
1215-1219
2006
Homo sapiens
Islam, M.R.; Kim, H.; Kang, S.W.; Kim, J.S.; Jeong, Y.M.; Hwang, H.J.; Lee, S.Y.; Woo, J.C.; Kim, S.G.
Functional characterization of a gene encoding a dual domain for uridine kinase and uracil phosphoribosyltransferase in Arabidopsis thaliana
Plant Mol. Biol.
63
465-477
2007
Arabidopsis thaliana (Q9FKS0), Arabidopsis thaliana
Jukic, L.V.; Duvnjak, M.; Wu, C.H.; Wu, G.Y.
Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins
J. Biomed. Sci.
15
205-213
2008
Homo sapiens
Qimron, U.; Kulczyk, A.W.; Hamdan, S.M.; Tabor, S.; Richardson, C.C.
Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk
Mol. Microbiol.
67
448-457
2008
Escherichia coli
Smith, A.J.; Li, Y.; Houk, K.N.
Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2
Org. Biomol. Chem.
7
2716-2724
2009
Homo sapiens (Q9BZX2), Homo sapiens
Lossani, A.; Torti, A.; Gatti, S.; Bruno, A.; Maserati, R.; Wright, G.E.; Focher, F.
Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors
Parasitology
136
595-602
2009
Entamoeba histolytica (C4M4T4), Entamoeba histolytica
Tomoike, F.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
A single amino acid limits the substrate specificity of Thermus thermophilus uridine-cytidine kinase to cytidine
Biochemistry
50
4597-4607
2011
Thermus thermophilus, Thermus thermophilus (Q5SKR5), Thermus thermophilus HB8 / ATCC 27634 / DSM 579, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SKR5)
van Kuilenburg, A.B.; Meinsma, R.
The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma
Biochim. Biophys. Acta
1862
1504-1512
2016
Homo sapiens (Q9BZX2), Homo sapiens (Q9HA47)
Qian, Y.; Ding, Q.; Li, Y.; Zou, Z.; Yan, B.; Ou, L.
Phosphorylation of uridine and cytidine by uridine-cytidine kinase
J. Biotechnol.
188
81-87
2014
Escherichia coli, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842
Malami, I.; Abdul, A.B.; Abdullah, R.; Bt Kassim, N.K.; Waziri, P.; Christopher Etti, I.
In silico discovery of potential uridine-cytidine kinase 2 inhibitors from the rhizome of Alpinia mutica
Molecules
21
417
2016
Homo sapiens (Q9BZX2)
Tomoike, F.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
Structural and biochemical studies on the reaction mechanism of uridine-cytidine kinase
Protein J.
34
411-420
2015
Thermus thermophilus (Q5SKR5), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SKR5)
Sato, A.; Takano, T.; Hiramoto, A.; Naito, T.; Matsuda, A.; Fukushima, M.; Wataya, Y.; Kim, H.S.
Role of the uridine/cytidine kinase 2 mutation in cellular sensitiveness toward 3-ethynylcytidine treatment of human cancer cells
Anticancer Drugs
28
781-786
2017
Homo sapiens (Q9BZX2), Homo sapiens
Tomoike, F.; Nakagawa, N.; Fukui, K.; Yano, T.; Kuramitsu, S.; Masui, R.
Indispensable residue for uridine binding in the uridine-cytidine kinase family
Biochem. Biophys. Rep.
11
93-98
2017
Thermus thermophilus (Q5SKR5), Homo sapiens (Q9BZX2), Homo sapiens, Thermus thermophilus DSM 579 (Q5SKR5), Thermus thermophilus ATCC 27634 (Q5SKR5)
Malami, I.; Abdul, A.B.
Involvement of the uridine cytidine kinase 2 enzyme in cancer cell death a molecular crosstalk between the enzyme and cellular apoptosis induction
Biomed. Pharmacother.
109
1506-1510
2019
Homo sapiens (Q9BZX2)
Okesli-Armlovich, A.; Gupta, A.; Jimenez, M.; Auld, D.; Liu, Q.; Bassik, M.C.; Khosla, C.
Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening
Bioorg. Med. Chem. Lett.
29
2559-2564
2019
Homo sapiens (Q9BZX2), Homo sapiens
Tanaka, W.; Shoji, M.; Tomoike, F.; Ujiie, Y.; Hanaoka, K.; Harada, R.; Kayanuma, M.; Kamiya, K.; Ishida, T.; Masui, R.; Kuramitsu, S.; Shigeta, Y.
Molecular mechanisms of substrate specificities of uridine-cytidine kinase
Biophys. Physicobiol.
13
77-84
2016
Thermus thermophilus (Q5SKR5), Thermus thermophilus DSM 579 (Q5SKR5), Thermus thermophilus ATCC 27634 (Q5SKR5)
Mohamed, M.; Dirar, A.; Hamdoun, S.
Discovery of two diacetylene glycosides as human uridine-cytidine kinase 2 inhibitors An in silico approach
J. Appl. Pharm. Sci.
6
034-039
2016
Homo sapiens (Q9BZX2)
-
Shen, G.; He, P.; Mao, Y.; Li, P.; Luh, F.; Ding, G.; Liu, X.; Yen, Y.
Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis
J. Breast Cancer
20
132-141
2017
Homo sapiens (Q9BZX2), Homo sapiens
Meinsma, R.; van Kuilenburg, A.B.
Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines
Nucleosides Nucleotides Nucleic Acids
35
613-618
2016
Homo sapiens (Q9BZX2), Homo sapiens (Q9HA47), Homo sapiens
Sarkisjan, D.; Julsing, J.R.; Smid, K.; de Klerk, D.; van Kuilenburg, A.B.; Meinsma, R.; Lee, Y.B.; Kim, D.J.; Peters, G.J.
The cytidine analog fluorocyclopentenylcytosine (RX-3117) is activated by uridine-cytidine kinase 2
PLoS ONE
11
e0162901
2016
Homo sapiens (Q9BZX2), Homo sapiens
html completed
