Information on EC 2.7.1.64 - inositol 3-kinase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.7.1.64
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RECOMMENDED NAME
GeneOntology No.
inositol 3-kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)
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1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)
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Inositol phosphate metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
ATP:myo-inositol 1-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
37278-07-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
spinach
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Manually annotated by BRENDA team
wheat
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-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1D-myo-inositol
ADP + 1D-myo-inositol 1-phosphate
show the reaction diagram
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-
-
-
?
ATP + myo-inositol
ADP + 1L-myo-inositol 1-phosphate
show the reaction diagram
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-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
show the reaction diagram
CTP + myo-inositol
CDP + myo-inositol 1-phosphate
show the reaction diagram
GTP + myo-inositol
GDP + myo-inositol 1-phosphate
show the reaction diagram
UTP + myo-inositol
UDP + myo-inositol 1-phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
show the reaction diagram
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biosynthesis of phytic acid
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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required for activity
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0531
1D-myo-inositol
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in 20 mM HEPES (pH 7.2), 6 mM MgCl2, 10 mM LiCl, 1 mM dithiothreitol, at 30°C
0.036
ATP
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in 20 mM HEPES (pH 7.2), 6 mM MgCl2, 10 mM LiCl, 1 mM dithiothreitol, at 30°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.7 - 8.7
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approx. 25% of maximal activity at pH 6.7, approx. 75% of maximal activity at pH 8.7
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
UNIPROT
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, density-gradient centrifugation, partial purification
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ammonium sulfate, partial purification
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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