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Disease on EC 2.7.1.91 - sphingosine kinase

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DISEASE
TITLE OF PUBLICATION
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Aberrant Crypt Foci
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Abortion, Spontaneous
Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.
Acquired Immunodeficiency Syndrome
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Acute Lung Injury
Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition.
CALCIUM ENTRY INHIBITION DURING RESUSCITATION FROM SHOCK ATTENUATES INFLAMMATORY LUNG INJURY.
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Adenocarcinoma
Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549?cells in a synergistic manner.
Down regulation of lncRNA MEG3 promotes colorectal adenocarcinoma cell proliferation and inhibits the apoptosis by up-regulating TGF-?1 and its downstream sphingosine kinase 1.
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXR? by K48/K63-linked polyubiquitination.
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells.
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.
Adenocarcinoma of Lung
Sphingosine-1-Phosphate Contributes to TLR9-Induced TNF-? Release in Lung Tumor Cells.
Adenoma
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Role for sphingosine kinase 1 in colon carcinogenesis.
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Adrenocortical Carcinoma
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Albuminuria
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Alveolar Bone Loss
Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice.
Alzheimer Disease
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.
Effects of small interfering RNA targeting sphingosine kinase-1 gene on the animal model of Alzheimer's disease.
MicroRNA?125b regulates Alzheimer's disease through SphK1 regulation.
Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain.
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.
Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.
Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival.
Amyotrophic Lateral Sclerosis
Autophagy and ALS: mechanistic insights and therapeutic implications.
Anaphylaxis
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.
Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo.
The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.
Anemia
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Anemia, Sickle Cell
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.
Ankylosis
The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes.
Arteriosclerosis
The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment.
Arthritis
Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis.
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis.
Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Impact of Sphingosine Kinase on Inflammatory Pathways in Fibroblast-Like Synoviocytes.
Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis.
Sphingosine kinase 1/sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 pathway: A novel target of geniposide to inhibit angiogenesis.
Sphingosine kinase 2: a controversial role in arthritis.
Arthritis, Experimental
Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis.
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
S1P Increases VEGF Production in Osteoblasts and Facilitates Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-16-5p Expression via the c-Src/FAK Signaling Pathway in Rheumatoid Arthritis.
The interplay between fibroblast-like synovial and vascular endothelial cells leads to angiogenesis via the sphingosine-1-phosphate-induced RhoA-F-Actin and Ras-Erk1/2 pathways and the intervention of geniposide.
Arthritis, Rheumatoid
Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines.
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Impact of Sphingosine Kinase on Inflammatory Pathways in Fibroblast-Like Synoviocytes.
Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro.
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.
Sphingosine-1-Phosphate Promotes the Persistence of Activated CD4 T Cells in Inflamed Sites.
Asthma
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
Ceramide Signaling and Metabolism in Pathophysiological States of the Lung.
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.
Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models.
SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice.
Sphingosine kinase and sphingosine 1-phosphate in asthma.
The role of sphingosine kinase in a murine model of allergic asthma.
Astrocytoma
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival.
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.
Atherosclerosis
Elevating Endogenous Sphingosine-1-Phosphate (S1P) Levels Improves Endothelial Function and Ameliorates Atherosclerosis in Low Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice.
High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL.
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet.
Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells.
Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.
Autoimmune Diseases
Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis.
Bone Resorption
Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts.
Brain Edema
Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice.
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Brain Injuries
Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice.
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Isoflurane cerebral preconditioning in a spontaneous hypertension rat model is associated with sphingosine kinases.
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Post-injury administration of allicin attenuates ischemic brain injury through sphingosine kinase 2: In vivo and in vitro studies.
Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
Brain Ischemia
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival.
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-?B pathways in activated microglia in cerebral ischemia reperfusion.
Brain Neoplasms
Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells.
Breast Neoplasms
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells.
A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.
ABCC1-exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1 Shortens Survival of Mice and Patients with Breast Cancer.
An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines.
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis.
C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.
Correlation Between Doppler Ultrasound Blood Flow Parameters and Angiogenesis and Proliferation Activity in Breast Cancer.
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid.
Divergence of Intracellular Trafficking of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 3 in MCF-7 Breast Cancer Cells and MCF-7-Derived Stem Cell-Enriched Mammospheres.
Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation.
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.
Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance.
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.
Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming.
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor negative breast cancer.
Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation and actin rearrangement in MCF-7 breast cancer cells.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Genome-wide DNA methylation assessment of 'BRCA1-like' early-onset breast cancer: Data from the Australian Breast Cancer Family Registry.
High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients.
High Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer.
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Identification of copy number alterations associated with the progression of DCIS to invasive ductal carcinoma.
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.
Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer.
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer.
Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin.
Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway.
Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.
Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Pharmacological Inhibition of Sphingosine Kinase Isoforms Alters Estrogen Receptor Signaling in Human Breast Cancer.
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer.
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration.
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate.
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway.
Resveratrol Dimers Are Novel Sphingosine Kinase 1 Inhibitors and Affect Sphingosine Kinase 1 Expression and Cancer Cell Growth and Survival.
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Significance of sphingosine kinase 1 expression in feline mammary tumors.
Sphingosine 1-phosphate signaling induces SNAI2 expression to promote cell invasion in breast cancer cells.
Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action.
Sphingosine kinase 1 activation by estrogen receptor ?36 contributes to tamoxifen resistance in breast cancer.
Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer.
Sphingosine Kinase 1 in Breast Cancer-A New Molecular Marker and a Therapy Target.
Sphingosine kinase 1 in breast cancer.
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.
Sphingosine Kinase 1 is Associated With Immune Cell-Related Gene Expressions in Human Breast Cancer.
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
Sphingosine kinase 1 isoform-specific interactions in breast cancer.
Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
Sphingosine kinase transmits estrogen signaling in human breast cancer cells.
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Sphingosine kinase type 2 activation by ERK-mediated phosphorylation.
Sphingosine-1-phosphate and estrogen signaling in breast cancer.
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Sphingosine-1-phosphate receptor 1 transmits estrogens' effects in endothelial cells.
Sphk1 participates in malignant progression of breast cancer by regulating epithelial-mesenchymal transition and stem cell characteristics.
SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.
Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.
TGF?-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
The Importance of Sphingosine Kinase in Breast Cancer: A Potential for Breast Cancer Management.
The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ER? expression and enhances hormonal therapy for breast cancer.
The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells.
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
[TNF-? regulates the proliferation of human breast cancer cells via regulation of ceramide content].
Bronchopulmonary Dysplasia
Hyperoxia-induced S1P1 signaling reduced angiogenesis by suppression of TIE-2 leading to experimental bronchopulmonary dysplasia.
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia.
Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins.
Carcinogenesis
A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells.
A role of sphingosine kinase 1 in head and neck carcinogenesis.
Coumestrol suppresses hypoxia inducible factor 1? by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells.
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation.
Effect of sphingosine kinase 1 inhibition on blood pressure.
Functional Genetic Variants in SPHK1 Affect Susceptibility to Gastric Cancer in a Chinese Population.
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
HULC: an oncogenic long non-coding RNA in human cancer.
In vitro anti-leukaemia activity of sphingosine kinase inhibitor.
Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer.
Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma.
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.
New insights into the roles and regulation of SphK2 as a therapeutic target in cancer chemoresistance.
NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.
Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects.
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling.
Prognostic role of lipid phosphate phosphatases in non-smoker, lung adenocarcinoma patients.
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Role for sphingosine kinase 1 in colon carcinogenesis.
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Sphingosine kinase 1 expression enhances colon tumor growth.
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Sphingosine kinase 1 is up-regulated in colon carcinogenesis.
Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1? inactivation in hypoxic PC-3 prostate cancer cells.
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again.
SphK1 promotes tumor cell migration and invasion in colorectal cancer.
Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.
Targeting SphK1 as a new strategy against cancer.
The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?
[Sphingosine kinase 1 and tumor].
Carcinoma
A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma.
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
Correction: Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis.
Enhancement of SPHK1 in vitro by carbon ion irradiation in oral squamous cell carcinoma.
Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell.
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma.
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin.
KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2.
LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR?378a?5p to enhance SPHK1 expression.
LOSS OF SPHINGOSINE KINASE-1 IN CARCINOMA CELLS INCREASES FORMATION OF REACTIVE OXYGEN SPECIES AND SENSITIVITY TO DOXORUBICIN-INDUCED DNA DAMAGE.
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy.
Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis.
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma.
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Sphingosine Kinase-1 Activation Causes Acquired Resistance Against Sunitinib in Renal Cell Carcinoma Cells.
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells.
Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis.
Targeting sphingosine kinase 2 by ABC294640 inhibits human skin squamous cell carcinoma cell growth.
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
The expression of sphingosine kinase-1 in head and neck carcinoma.
The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth.
[Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells]
[The expression and clinical significance of SphK1 and nuclear factor-?B p65 in human colon carcinoma].
Carcinoma, Ductal
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Carcinoma, Hepatocellular
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling.
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma.
Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2.
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.
Sphingosine kinase 1 overexpression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma.
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice.
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.
Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.
Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor.
Sphingosine kinase: A promising cancer therapeutic target.
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.
SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/?-catenin signaling pathway.
SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-?B pathway in hepatocellular carcinoma.
Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA.
Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma.
The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells.
The impact of sphingosine kinase 1 on the prognosis of hepatocellular carcinoma patients with portal vein tumor thrombus.
The role of sphingosine kinase 2 in alcoholic liver disease.
[Inhibitions of SphK1 inhibitor SKI II on cell cycle progression and cell invasion of hepatoma HepG2 cells].
Carcinoma, Non-Small-Cell Lung
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer.
Atorvastatin partially inhibits the epithelial-mesenchymal transition in A549 cells induced by TGF-?1 by attenuating the upregulation of SphK1.
LncRNA HULC promotes non-small cell lung cancer cell proliferation and inhibits the apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and its downstream PI3K/Akt pathway.
LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1.
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer.
Sphingosine kinase 1 enhances the invasion and migration of non-small cell lung cancer cells via the AKT pathway.
Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-{kappa}B Pathway in Human Non-Small Cell Lung Cancer.
Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine.
Carcinoma, Ovarian Epithelial
Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation.
Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer.
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.
Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.
Carcinoma, Renal Cell
A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma.
Sphingosine Kinase-1 Activation Causes Acquired Resistance Against Sunitinib in Renal Cell Carcinoma Cells.
Carcinoma, Squamous Cell
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells.
Targeting sphingosine kinase 2 by ABC294640 inhibits human skin squamous cell carcinoma cell growth.
The expression of sphingosine kinase-1 in head and neck carcinoma.
Cardiomegaly
Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1.
Cardiomyopathies
Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy.
Cardiovascular Diseases
Implication of sphingosin-1-phosphate in cardiovascular regulation.
Regulation and function of sphingosine kinase 2 in diseases.
Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site.
Sphingosine kinase: a closer look at last.
Cerebral Infarction
Neuroprotective Effects of Danshen Chuanxiongqin Injection Against Ischemic Stroke: Metabolomic Insights by UHPLC-Q-Orbitrap HRMS Analysis.
Chagas Disease
Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy.
Cholangiocarcinoma
Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.
Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.
Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma.
Targeting sphingosine kinase 2 suppresses cell growth and synergizes with BCL2/BCL-XL inhibitors through NOXA-mediated MCL1 degradation in cholangiocarcinoma.
Chondrosarcoma
Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells.
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression.
Chordoma
High expression of SPHK1 in sacral chordoma and association with patients' poor prognosis.
Colitis
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice.
Digestive Disease Week 2010. Turning Science into Medicine--part 2.
Effect of the Sphingosine Kinase 1 Selective Inhibitor, PF543 on Dextran Sodium Sulfate-Induced Colitis in Mice.
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-?/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study.
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.
Sphingosine-1-phosphate: Driver of NF?B and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer.
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Colitis, Ulcerative
Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Sphk1 promotes ulcerative colitis via activating JAK2/STAT3 signaling pathway.
Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase.
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Colitis-Associated Neoplasms
Digestive Disease Week 2010. Turning Science into Medicine--part 2.
Effects of triptolide on the sphingosine kinase - Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer.
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Sphingosine-1-phosphate: Driver of NF?B and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer.
Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
Colonic Neoplasms
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells.
Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.
Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXR? by K48/K63-linked polyubiquitination.
Role for sphingosine kinase 1 in colon carcinogenesis.
Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Sodium Butyrate Induces Apoptosis of Human Colon Cancer Cells by Modulating ERK and Sphingosine Kinase 2.
Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.
Sphingosine kinase 1 expression enhances colon tumor growth.
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells.
Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells.
Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target.
Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
SphK1 Promotes Cancer Progression through Activating JAK/STAT Pathway and Up-Regulating S1PR1 Expression in Colon Cancer Cells.
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.
[Down-regulation of sphingosine kinase 1 (SphK1) enhances the chemosensitivity to cisplatin in human colon cancer RKO cells].
[Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer TH-29 cells and its molecular mechanisms].
[Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer Lovo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1].
Colorectal Neoplasms
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer.
Inhibition of SPHK1 suppresses phorbol 12-myristate 13-acetate-induced metastatic phenotype in colorectal cancer HT-29 cells.
MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells.
MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2.
miR-659-3p is involved in the regulation of the chemotherapy response of colorectal cancer via modulating the expression of SPHK1.
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer.
Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer.
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases.
SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.
SphK1 promotes tumor cell migration and invasion in colorectal cancer.
SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression.
Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
Communicable Diseases
Cutting Edge: Modulation of Intestinal Autoimmunity and IL-2 Signaling by Sphingosine Kinase 2 Independent of Sphingosine 1-Phosphate.
Coronary Artery Disease
Transforming Growth Factor ?1 (TGF-?1) Appears to Promote Coronary Artery Disease by Upregulating Sphingosine Kinase 1 (SPHK1) and Further Upregulating Its Downstream TIMP-1.
COVID-19
Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19.
Crohn Disease
Digestive Disease Week 2010. Turning Science into Medicine--part 2.
Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease.
Cryptococcosis
Role of host sphingosine kinase 1 in the lung response against Cryptococcosis.
The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway.
Demyelinating Diseases
Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.
Dengue
Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs.
In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways.
Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.
Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type -2 RNA.
Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses.
RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.
Sphingosine kinase 1 in viral infections.
Tumour necrosis factor alpha (TNF-{alpha}) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-{alpha} to activate nuclear factor {kappa}B and reduced sphingosine kinase-1 activity.
Diabetes Mellitus
Role of Sphingosine Kinase in Type 2 Diabetes Mellitus.
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice.
Diabetes Mellitus, Type 1
Abnormal islet sphingolipid metabolism in type 1 diabetes.
Diabetes Mellitus, Type 2
Role of Sphingosine Kinase in Type 2 Diabetes Mellitus.
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice.
Diabetic Nephropathies
AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose.
Berberine suppresses high glucose-induced TGF-?1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway.
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy.
Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.
Diffuse Intrinsic Pontine Glioma
Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG).
Encephalomyelitis
Effect of sphingosine kinase modulators on interleukin-1? release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Encephalomyelitis, Autoimmune, Experimental
Effect of sphingosine kinase modulators on interleukin-1? release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Endometriosis
Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells.
Targeting sphingosine kinase-1 with the low MW inhibitor SKI-5C suppresses the development of endometriotic lesions in mice.
Epilepsy
Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy.
[Altered expressions of SphK1 and S1PR2 in hippocampus of epileptic rats].
Epilepsy, Temporal Lobe
Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy.
Epstein-Barr Virus Infections
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3.
Esophageal Neoplasms
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR?378a?5p to enhance SPHK1 expression.
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Fatty Liver
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases.
Fetal Death
Sphingolipid Pathway Regulates Innate Immune Responses at the Fetomaternal Interface during Pregnancy.
Fibroadenoma
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Frontotemporal Dementia
Autophagy and ALS: mechanistic insights and therapeutic implications.
Gastrointestinal Diseases
Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target.
Glioblastoma
A bidirectional crosstalk between glioblastoma and brain endothelial cells potentiates the angiogenic and proliferative signaling of sphingosine-1-phosphate in the glioblastoma microenvironment.
A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy.
A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
Comparative analysis of the effects of a sphingosine kinase inhibitor to temozolomide and radiation treatment on glioblastoma cell lines.
Cross-talk between sphingosine-1-phosphate and EGFR signaling pathways enhances human glioblastoma cell invasiveness.
Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.
Sphingosine Kinase Inhibitors as Maintenance Therapy of Glioblastoma After Ceramide-Induced Response.
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.
[Sphingosine kinase 1 promotes glioma cell proliferation under hypoxia via calcium signaling].
Glioma
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase.
Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines.
Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells.
MicroRNA-28-5p regulates glioma cell proliferation, invasion and migration by targeting SphK1.
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.
Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma.
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.
Sphingosine?1?phosphate analogue FTY720 exhibits a potent anti?proliferative effect on glioblastoma cells.
SPHK2 protein expression, Ki-67 index and infiltration of tumor-associated macrophages (TAMs) in human glioma.
Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG).
The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
[Sphingosine kinase 1 promotes glioma cell proliferation under hypoxia via calcium signaling].
Glomerulonephritis
Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity.
Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases.
Glomerulosclerosis, Focal Segmental
Resveratrol Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis through C3aR/C5aR- Sphingosine Kinase 1 Pathway.
Glucose Intolerance
Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice.
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Goiter, Nodular
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Granuloma
Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.
The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway.
Head and Neck Neoplasms
The impact of sphingosine kinase-1 in head and neck cancer.
Heart Failure
Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?
Hematologic Neoplasms
Regulation of Sphingosine Kinase in Hematological Malignancies and Other Cancers.
Targeting Sphingosine-1-Phosphate in Hematologic Malignancies.
Hemorrhagic Fever, Ebola
The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection.
Hepatitis B
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
Hepatitis C
Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis.
Hepatoblastoma
Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.
Huntington Disease
Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.
Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model.
Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease.
Hyperalgesia
Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism.
Sphingosine-1-phosphate acting via the S1P? receptor is a downstream signaling pathway in ceramide-induced hyperalgesia.
Hyperglycemia
Activation of sphingosine kinase-1 mediates inhibition of vascular smooth muscle cell apoptosis by hyperglycemia.
Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.
Hyperlipidemias
Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.
Hypersensitivity
Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cells.
Hypertension
Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1.
Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Effect of sphingosine kinase 1 inhibition on blood pressure.
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies.
Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel.
Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-?B activation.
Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension.
Synthesis of selective inhibitors of sphingosine kinase 1.
T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis.
Targeting sphingosine kinase 1 for the treatment of pulmonary arterial hypertension.
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Vascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction.
Hypertension, Pulmonary
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Sphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension.
Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?
Sphingosine Kinases as Druggable Targets.
Hypertrophy, Right Ventricular
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension.
Hypoxia, Brain
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Idiopathic Pulmonary Fibrosis
Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
Immune System Diseases
Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial {alpha}5{beta}1 integrin.
Infarction, Middle Cerebral Artery
Junctional protein regulation by sphingosine kinase 2 contributes to blood-brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance.
Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke.
Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
Infections
Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung.
Human cytomegalovirus regulates bioactive sphingolipids.
In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.
In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways.
Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.
Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice.
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type -2 RNA.
RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.
S1P Increases VEGF Production in Osteoblasts and Facilitates Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-16-5p Expression via the c-Src/FAK Signaling Pathway in Rheumatoid Arthritis.
Sphingolipids Are Dual Specific Drug Targets for the Management of Pulmonary Infections: Perspective.
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages.
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
Tumour necrosis factor alpha (TNF-{alpha}) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-{alpha} to activate nuclear factor {kappa}B and reduced sphingosine kinase-1 activity.
Inflammatory Bowel Diseases
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-?/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study.
Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway.
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases.
Influenza, Human
Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?
Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System.
Sphingolipids in viral infection.
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.
Sphingosine kinase 1 in viral infections.
Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
Insulin Resistance
Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice.
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes.
Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High Fat-Fed Mice.
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance.
Sphk2-/- mice are protected from obesity and insulin resistance.
Insulinoma
Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line.
Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines.
Intestinal Neoplasms
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Keloid
[Expression and function of sphingosine kinases 1 and 2 in human keloid fibroblasts]
Kidney Diseases
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Leiomyoma
Endothelin-1 inhibits apoptosis through a sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells.
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Leishmaniasis
Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence.
Sphingosine-1-phosphate signaling in Leishmania donovani infection in macrophages.
Leukemia
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.
Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent.
Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1.
Cell type-specific localization of sphingosine kinase 1a in human tissues.
Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling.
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.
Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins.
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
Network model of survival signaling in large granular lymphocyte leukemia.
Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1.
Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.
Single-cell sphingosine kinase activity measurements in primary leukemia.
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins.
Leukemia, Erythroblastic, Acute
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity.
Leukemia, Large Granular Lymphocytic
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
MiR-659-3p regulates the progression of chronic myeloid leukemia by targeting SPHK1.
Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells.
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells.
Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells.
Leukemia, Myeloid
Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells.
Leukemia, Myeloid, Acute
Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells.
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1.
Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function.
SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.
SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo.
Targeting sphingosine kinase 1 in acute myeloid leukemia: translation to clinic.
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.
The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.
Liver Cirrhosis
Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-?1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis.
Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway.
Polydatin attenuates hepatic stellate cell proliferation and liver fibrosis by suppressing sphingosine kinase 1.
Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1.
Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2.
Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis is Involved in Liver Fibrosis-Associated Angiogenesis.
Liver Cirrhosis, Alcoholic
The role of sphingosine kinase 2 in alcoholic liver disease.
Liver Diseases
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1.
Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin.
Sphingosine-1-phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
The role of sphingosine kinase 2 in alcoholic liver disease.
Liver Diseases, Alcoholic
The role of sphingosine kinase 2 in alcoholic liver disease.
Liver Failure, Acute
C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure.
Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNF?-dependent inflammation and apoptosis.
Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells.
Sphingosine kinase 1 dependent protein kinase C-? activation plays an important role in acute liver failure in mice.
Sphingosine kinase 1 inhibition improves lipopolysaccharide/D-galactosamine-induced acute liver failure by inhibiting mitogen-activated protein kinases pathway.
Liver Neoplasms
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite.
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
MicroRNA-338-3p suppresses proliferation of human liver cancer cells by targeting SphK2.
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
Lung Diseases, Interstitial
Ceramide and sphingosine-1 phosphate in COPD lungs.
Lung Injury
Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice.
Differential regulation of sphingosine kinases 1 and 2 in lung injury.
Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats.
Expression of sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 in malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model.
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia.
Inhibition of Sphingosine Kinase 1 Attenuates Sepsis-induced Microvascular Leakage via Inhibiting Macrophage NLRP3 Inflammasome Activation in Mice.
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury.
Lung Neoplasms
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer.
Atorvastatin partially inhibits the epithelial-mesenchymal transition in A549 cells induced by TGF-?1 by attenuating the upregulation of SphK1.
Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer.
Discovery of Harmaline as a Potent Inhibitor of Sphingosine Kinase-1: A Chemopreventive Role in Lung Cancer.
DMS triggers apoptosis associated with the inhibition of SPHK1/NF-?B activation and increase in intracellular Ca2+ concentration in human cancer cells.
Epithelial mesenchymal transition of non-small-cell lung cancer cells A549 induced by SPHK1.
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.
Increased SPK1 expression promotes cell growth by activating the ERK1/2 signaling in non-small-cell lung cancer.
Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor.
LncRNA HULC promotes non-small cell lung cancer cell proliferation and inhibits the apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and its downstream PI3K/Akt pathway.
LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1.
MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2.
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.
Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer.
Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer.
Sphingosine kinase 1 enhances the invasion and migration of non-small cell lung cancer cells via the AKT pathway.
Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-{kappa}B Pathway in Human Non-Small Cell Lung Cancer.
Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine.
SphK1 functions downstream of IGF-1 to modulate IGF-1-induced EMT, migration and paclitaxel resistance of A549 cells: A preliminary in vitro study.
SphK1 promotes development of non?small cell lung cancer through activation of STAT3.
The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.
[Role of SPHK1 regulates multi-drug resistance of small cell lung cancer ?and its clinical significance].
Lupus Erythematosus, Systemic
Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.
Lupus Nephritis
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
Lymphatic Metastasis
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis.
Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer.
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
SphK1 promotes tumor cell migration and invasion in colorectal cancer.
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
Lymphocytic Choriomeningitis
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Lymphoma
Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions.
Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma.
Sphingosine kinase is an attractive target for novel pharmacological interventions in non-Hodgkin lymphomas.
Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
Lymphoma, B-Cell
Hesperidin modulates dextran sulfate sodium-induced ulcerative colitis in rats: Targeting sphingosine kinase-1- sphingosine 1 phosphate signaling pathway, mitochondrial biogenesis, inflammation, and apoptosis.
Lymphoma, Large B-Cell, Diffuse
Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors.
Lymphoma, Mantle-Cell
Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma.
Lymphoma, Primary Effusion
Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
Lymphopenia
Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate.
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
Molecular targets of FTY720 (fingolimod).
New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth.
Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia.
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
Macular Degeneration
Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.
Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
Malaria
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes.
Malaria, Falciparum
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Massive Hepatic Necrosis
Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNF?-dependent inflammation and apoptosis.
Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin.
Measles
Sphingosine kinase 1 regulates measles virus replication.
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Melanoma
Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma.
Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration.
Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition.
Involvement of vacuolar H(+) -ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720.
Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity.
Regulation of nonclassical fgf1 release and fgf-dependent cell transformation by CBF1-mediated notch signaling.
Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1.
Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis.
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.
Targeting sphingosine kinase-1 to inhibit melanoma.
Mesothelioma
Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.
Mesothelioma, Malignant
Advances in the management of peritoneal mesothelioma.
Metabolic Diseases
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
Metabolic Syndrome
K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes.
Multiple Endocrine Neoplasia Type 2a
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Multiple Myeloma
Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis.
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
Sphingosine kinase 2 and multiple myeloma.
Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
Multiple Sclerosis
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor.
Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.
Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.
The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Myelodysplastic Syndromes
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.
Myocardial Ischemia
Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.
Nasopharyngeal Carcinoma
High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma.
Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
Neoplasm Metastasis
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase.
An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma.
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis.
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.
Down-regulation of Sphk2 suppresses bladder cancer progression.
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.
Epithelial mesenchymal transition of non-small-cell lung cancer cells A549 induced by SPHK1.
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Functional implications of pH-induced conformational changes in the Sphingosine kinase 1.
Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis.
High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma.
Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat.
HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma.
Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer.
Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer.
Inhibitory effects of novel SphK2 inhibitors on migration of cancer cells.
Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
MiR-128 suppresses the growth of thyroid carcinoma by negatively regulating SPHK1.
MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2.
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Role for sphingosine kinase 1 in colon carcinogenesis.
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Sphingolipid metabolism in cancer signalling and therapy.
Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis.
Sphingosine kinase 1 in breast cancer.
Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.
Sphingosine kinase 2 promotes colorectal cancer cell proliferation and invasion by enhancing MYC expression.
Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells.
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression.
Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.
SPHK1 promotes metastasis of thyroid carcinoma through activation of the S1P/S1PR3/Notch signaling pathway.
SphK1 promotes tumor cell migration and invasion in colorectal cancer.
SphK1-driven autophagy potentiates focal adhesion paxillin-mediated metastasis in colorectal cancer.
SphK2/S1P Promotes Metastasis of Triple-Negative Breast Cancer Through the PAK1/LIMK1/Cofilin1 Signaling Pathway.
TGF?-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.
The impact of sphingosine kinase-1 in head and neck cancer.
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
[Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells]
[Relationship between sphingosine kinase 1 expression and tumor invasion, metastasis and prognosis in gastric cancer].
Neoplasms
"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer.
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.
213Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G2 arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe.
A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay.
A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
A novel sphingosine kinase 1 inhibitor (SKI-5C) induces cell death of Wilms' tumor cells
A novel sphingosine kinase inhibitor induces autophagy in tumor cells.
A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
A role of sphingosine kinase 1 in head and neck carcinogenesis.
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
A Stilbenoid Isorhapontigenin as a Potential Anti-Cancer Agent against Breast Cancer through Inhibiting Sphingosine Kinases/Tubulin Stabilization.
ABC294640, a novel sphingosine kinase 2 inhibitor induces oncogenic virus infected cell autophagic death and represses tumor growth.
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer.
ABCC1-exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1 Shortens Survival of Mice and Patients with Breast Cancer.
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells.
Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting.
Advances in the management of peritoneal mesothelioma.
Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes.
Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts.
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Aminoacylase 1 is a sphingosine kinase 1-interacting protein.
An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines.
An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.
Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice.
Anti-cancer effect of pristimerin by inhibition of HIF-1? involves the SPHK-1 pathway in hypoxic prostate cancer cells.
Anticancer agents based on vulnerable components in a signalling pathway.
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.
Automated Capillary Electrophoresis System for Fast Single-Cell Analysis.
Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.
Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis.
Building a better sphingosine kinase-1 inhibitor.
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.
Cellular signalling by sphingosine kinase and sphingosine 1-phosphate.
Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression.
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.
Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer.
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Defining a role for sphingosine kinase 1 in p53-dependent tumors.
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.
Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1.
Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors.
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor.
Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry.
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.
Discovery and evaluation of inhibitors of human sphingosine kinase.
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
Divergence of Intracellular Trafficking of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 3 in MCF-7 Breast Cancer Cells and MCF-7-Derived Stem Cell-Enriched Mammospheres.
Down regulation of lncRNA MEG3 promotes colorectal adenocarcinoma cell proliferation and inhibits the apoptosis by up-regulating TGF-?1 and its downstream sphingosine kinase 1.
Down-regulation of sphingosine kinase 2 (SphK2) increases the effects of all-trans-retinoic acid (ATRA) on colon cancer cells.
Down-regulation of Sphk2 suppresses bladder cancer progression.
Downregulating sphingosine kinase-1 for cancer therapy.
Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.
Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma.
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.
Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.
E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin ?v?6 and maintained through TGF? signalling.
Effect of alkyl chain length on sphingosine kinase 2 selectivity.
Effect of metformin and adriamycin on transplantable tumor model.
Effect of sphingosine kinase 1 inhibition on blood pressure.
Emerging Connections of S1P-Metabolizing Enzymes with Host Defense and Immunity During Virus Infections.
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.
Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium.
Evaluation of binding and inhibition mechanism of dietary phytochemicals with sphingosine kinase 1: Towards targeted anticancer therapy.
Evaluation of ellagic acid as an inhibitor of sphingosine kinase 1: A targeted approach towards anticancer therapy.
Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming.
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma.
Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion.
Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors.
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.
FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression.
Functional implications of pH-induced conformational changes in the Sphingosine kinase 1.
Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis.
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Glabridin Suppresses Intercellular Adhesion Molecule-1 Expression in Tumor Necrosis Factor-{alpha}-Stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-{kappa}B/Rel Signaling Pathways.
Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor.
Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2? and sphingosine kinase 1.
High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma.
High expression of SPHK1 in sacral chordoma and association with patients' poor prognosis.
Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation.
Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat.
HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma.
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.
Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.
Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue.
Importance of Sphingosine Kinase (SphK) as a Target in Developing Cancer Therapeutics and Recent Developments in the Synthesis of Novel SphK Inhibitors.
In Silico Characterization of Structural Distinctions between Isoforms of Human and Mouse Sphingosine Kinases for Accelerating Drug Discovery.
In Silico Identification of Novel Orthosteric Inhibitors of Sphingosine Kinase 1 (SK1).
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer.
Increased SPHK1 expression is associated with poor prognosis in bladder cancer.
Increased SPK1 expression promotes cell growth by activating the ERK1/2 signaling in non-small-cell lung cancer.
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade.
Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor.
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Inhibition of SPHK1 suppresses phorbol 12-myristate 13-acetate-induced metastatic phenotype in colorectal cancer HT-29 cells.
Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3.
Inhibitory effects of novel SphK2 inhibitors on migration of cancer cells.
Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer.
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy.
Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin.
LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients.
Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma.
LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR?378a?5p to enhance SPHK1 expression.
Long Intergenic Nonprotein Coding RNA 173 Inhibits Tumor Growth and Promotes Apoptosis by Repressing Sphingosine Kinase 1 Protein Expression in Pancreatic Cancer.
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).
Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.
Mechanistic insights into the urea-induced denaturation of human sphingosine kinase 1.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
MicroRNA-28-5p regulates glioma cell proliferation, invasion and migration by targeting SphK1.
MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2.
MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2.
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
MiR-128 suppresses the growth of thyroid carcinoma by negatively regulating SPHK1.
MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2.
MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.
MiR-577 inhibits papillary thyroid carcinoma cell proliferation, migration and invasion by targeting SphK2.
miR-613 inhibits bladder cancer proliferation and migration through targeting SphK1.
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth.
New insights into the roles and regulation of SphK2 as a therapeutic target in cancer chemoresistance.
NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.
Oncogenic properties of sphingosine kinases in haematological malignancies.
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy.
Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.
Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway.
Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
Pharmacological Inhibition of Sphingosine Kinase Isoforms Alters Estrogen Receptor Signaling in Human Breast Cancer.
Pharmacology of the sphingosine-1-phosphate signalling system.
Polarization of the innate immune response by prostaglandin E2: a puzzle of receptors and signals.
Predictive and prognostic value of sphingosine kinase 1 expression in patients with invasive ductal carcinoma of the breast.
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors.
Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer.
Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
Re-configuration of sphingolipid metabolism by oncogenic transformation.
Recent advances in the role of sphingosine 1-phosphate in cancer.
Regulation and function of sphingosine kinase 2 in diseases.
Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate.
Regulation of Sphingosine Kinase in Hematological Malignancies and Other Cancers.
Relationship between Sphk1/S1P and microRNAs in human cancers.
Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer.
Renal mesangial cells: moving on sphingosine kinase-1.
Resveratrol Dimers Are Novel Sphingosine Kinase 1 Inhibitors and Affect Sphingosine Kinase 1 Expression and Cancer Cell Growth and Survival.
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.
Role of Sphingosine Kinase in the Expression of Adhesion Molecules on Monocytes Induced by Tumor Necrosis Factor-Alpha (Relevant to Atherosclerosis).
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression.
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Significance of sphingosine kinase 1 expression in feline mammary tumors.
Single-cell sphingosine kinase activity measurements in primary leukemia.
SK1 inhibitor RB005 Induces Apoptosis in Colorectal Cancer Cells through SK1 Inhibition Dependent and Independent Pathway.
Sphingolipid metabolism in cancer signalling and therapy.
Sphingolipids and response to chemotherapy.
Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RAR? expression.
Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers.
Sphingosine 1-phosphate signaling through its receptor S1P
Sphingosine 1-phosphate signalling in cancer.
Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro.
Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site.
Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer.
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.
Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation.
Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.
Sphingosine kinase 1 expression enhances colon tumor growth.
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.
Sphingosine kinase 1 in breast cancer.
Sphingosine kinase 1 in cancer.
Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
Sphingosine kinase 1 is a relevant molecular target in gastric cancer.
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression.
Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancer.
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.
Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer.
Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice.
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.
Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma.
Sphingosine kinase 1 overexpression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma.
Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.
Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules.
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions.
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.
Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.
Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor ?B Activation.
Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.
Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.
Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression.
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.
Sphingosine kinase activity is not required for tumor cell viability.
Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target.
Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells.
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2.
Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography.
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.
Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens.
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.
Sphingosine kinase-1 inhibition sensitizes curcumin-induced growth inhibition and apoptosis in ovarian cancer cells.
Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
Sphingosine kinase-1--a potential therapeutic target in cancer.
Sphingosine kinase-2 Inhibitor ABC294640 Enhances Doxorubicin-Induced Apoptosis of NSCLC Cells via Altering Survivin Expression.
Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1.
Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance.
Sphingosine kinase: a closer look at last.
Sphingosine kinase: A promising cancer therapeutic target.
Sphingosine Kinases as Druggable Targets.
Sphingosine Kinases Signalling in Carcinogenesis.
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.
Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth.
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.
Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma.
Sphingosine-1-phosphate: Driver of NF?B and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer.
Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.
SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/?-catenin signaling pathway.
SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-?B pathway in hepatocellular carcinoma.
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-?B pathways in activated microglia in cerebral ischemia reperfusion.
Sphk1 participates in malignant progression of breast cancer by regulating epithelial-mesenchymal transition and stem cell characteristics.
Sphk1 promotes breast epithelial cell proliferation via NF-?B-p65-mediated cyclin D1 expression.
SphK1 Promotes Cancer Progression through Activating JAK/STAT Pathway and Up-Regulating S1PR1 Expression in Colon Cancer Cells.
SphK1 promotes tumor cell migration and invasion in colorectal cancer.
SphK1-driven autophagy potentiates focal adhesion paxillin-mediated metastasis in colorectal cancer.
SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells.
Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA.
Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.
Structure-activity relationship studies and bioactivity evaluation of 1,2,3-triazole containing analogues as a selective sphingosine kinase-2 inhibitors.
Suppression of breast xenograft growth and progression in nude mice: implications for the use of orally administered sphingolipids as chemopreventive agents against breast cancer.
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.
Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Targeting Ovarian Cancer and Chemoresistance Through Selective Inhibition of Sphingosine Kinase-2 with ABC294640.
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats.
Targeting sphingosine kinase 1 in cancer.
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
Targeting SphK1 as a new strategy against cancer.
Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy.
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells.
The emerging role of FTY720 (Fingolimod) in cancer treatment.
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7.
The expression of sphingosine kinase-1 in head and neck carcinoma.
The Functional Role of Sphingosine Kinase 2.
The impact of sphingosine kinase 1 on the prognosis of hepatocellular carcinoma patients with portal vein tumor thrombus.
The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.
The impact of sphingosine kinase-1 in head and neck cancer.
The Importance of Sphingosine Kinase in Breast Cancer: A Potential for Breast Cancer Management.
The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy.
The role of sphingosine 1-phosphate in inflammation and cancer.
The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?
The role of sphingosine kinase and sphingosine-1-phosphate in the regulation of endothelial cell biology.
The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas.
The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.
The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy.
The therapeutic value of SC66 in human renal cell carcinoma cells.
The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target.
Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.
TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.
Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.
Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression.
Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes.
Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde.
Tumour necrosis factor alpha (TNF-{alpha}) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-{alpha} to activate nuclear factor {kappa}B and reduced sphingosine kinase-1 activity.
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.
Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma.
Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer.
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins.
Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity.
When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
[Regulation of sphingosine kinase 1 in the TNF-?-induced expression of MUC5AC in airway epithelial cells.]
[Relationship between sphingosine kinase 1 expression and tumor invasion, metastasis and prognosis in gastric cancer].
[Sphingosine kinase 1 and tumor].
[TNF-? regulates the proliferation of human breast cancer cells via regulation of ceramide content].
Neoplasms, Squamous Cell
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Nervous System Diseases
Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival.
Neuralgia
Effects of extracorporeal shock waves on neuralgia in diabetic rats.
Neuroblastoma
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide.
Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma.
Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.
Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation.
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Sphingosine Kinase 1/S1P Pathway Involvement in the GDNF-Induced GAP43 Transcription.
Neurodegenerative Diseases
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Novelty of Sphingolipids in the Central Nervous System Physiology and Disease: Focusing on the Sphingolipid Hypothesis of Neuroinflammation and Neurodegeneration.
Regulation and function of sphingosine kinase 2 in diseases.
Sphingosine kinase 1 could enhance stem cell therapy efficiency for neurodegenerative diseases through induction of HIF-1.
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.
Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease.
Neuroinflammatory Diseases
A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation.
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy.
Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-?B pathways in activated microglia in cerebral ischemia reperfusion.
Neutropenia
A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo.
Niemann-Pick Disease, Type C
Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation.
Non-alcoholic Fatty Liver Disease
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
Generation of sphingosine-1-phosphate by sphingosine kinase 1 protects nonalcoholic fatty liver from ischemia/reperfusion injury through alleviating reactive oxygen species production in hepatocytes.
Telmisartan and/or chlorogenic acid attenuates fructose-induced non-alcoholic fatty liver disease in rats: Implications of cross-talk between angiotensin, the sphingosine kinase/sphingoine-1-phosphate pathway, and TLR4 receptors.
Obesity
Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease.
K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.
Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor ? in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity.
Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance.
Sphk2-/- mice are protected from obesity and insulin resistance.
Optic Atrophy, Autosomal Dominant
Mitochondrial A-kinase anchoring proteins in cardiac ventricular myocytes.
Osteoarthritis
Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Experimental Osteoarthritis in Rats Is Attenuated by ABC294640, a Selective Inhibitor of Sphingosine Kinase-2.
miRNA-103 promotes chondrocyte apoptosis by down-regulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis.
Osteosarcoma
Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro.
Furowanin A Exhibits Antiproliferative and Pro-Apoptotic Activities by Targeting Sphingosine Kinase 1 in Osteosarcoma.
Long Noncoding RNA MALAT1 Interacts with miR-124-3p to Modulate Osteosarcoma Progression by Targeting SphK1.
MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1.
MicroRNA-506-3p initiates mesenchymal-to-epithelial transition and suppresses autophagy in osteosarcoma cells by directly targeting SPHK1.
Sphingosine kinase 1 contributes to doxorubicin resistance and glycolysis in osteosarcoma.
SphK2 over-expression promotes osteosarcoma cell growth.
The therapeutic value of the SphK1-targeting microRNA-3677 in human osteosarcoma cells.
Ovarian Neoplasms
CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1.
Exosomal transfer of miR-124 inhibits normal fibroblasts to cancer-associated fibroblasts transition by targeting sphingosine kinase 1 in ovarian cancer.
Follicle-stimulating hormone promotes the proliferation of epithelial ovarian cancer cells by activating sphingosine kinase.
MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1.
Sphingolipids as multifaceted mediators in ovarian cancer.
Sphingosine kinase 1 is required for TGF-? mediated fibroblastto- myofibroblast differentiation in ovarian cancer.
Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis.
Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo.
Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.
Sphingosine kinase-1 inhibition sensitizes curcumin-induced growth inhibition and apoptosis in ovarian cancer cells.
Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
Targeting Ovarian Cancer and Chemoresistance Through Selective Inhibition of Sphingosine Kinase-2 with ABC294640.
The anti-ovarian cancer activity by WYE-132, a mTORC1/2 dual inhibitor.
Pancreatic Neoplasms
Different Roles of Sphingosine Kinase 1 and 2 in Pancreatic Cancer Progression.
Digestive Disease Week 2010. Turning Science into Medicine--part 2.
Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-?B signaling.
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer.
KAI1 inhibits HGF-induced invasion of pancreatic cancer by sphingosine kinase activity.
Long Intergenic Nonprotein Coding RNA 173 Inhibits Tumor Growth and Promotes Apoptosis by Repressing Sphingosine Kinase 1 Protein Expression in Pancreatic Cancer.
Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
Pancreatitis
The role of sphingosine kinase 1 in patients with severe acute pancreatitis.
Parkinson Disease
Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase.
Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease.
Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP(+)-treated MN9D cells in vitro.
Periapical Periodontitis
SPHK1-S1PR1-RANKL Axis Regulates the Interactions Between Macrophages and BMSCs in Inflammatory Bone Loss.
Peritoneal Neoplasms
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.
Peritonitis
A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo.
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Refining siRNA in vivo transfection: silencing SPHK1 reveals its key role in C5a-induced inflammation in vivo.
Pheochromocytoma
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors.
Enzymatic measurement of sphingosine 1-phosphate.
Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation.
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12.
Pneumonia
Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung.
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.
Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness.
S1P Generation by Sphingosine Kinase-2 in Recruited Macrophages Resolves Lung Inflammation by Blocking STING Signaling in Alveolar Macrophages.
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Pneumonia, Pneumococcal
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.
Polycystic Kidney Diseases
Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.
Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression.
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.
Pregnancy, Ectopic
Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy.
Premature Birth
Inhibition of sphingosine kinase prevents lipopolysaccharide-induced preterm birth and suppresses proinflammatory responses in a murine model.
Sphingosine kinase: a novel putative target for the prevention of infection-triggered preterm birth.
Prostatic Neoplasms
Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase.
Anti-cancer effect of pristimerin by inhibition of HIF-1? involves the SPHK-1 pathway in hypoxic prostate cancer cells.
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.
Coumestrol suppresses hypoxia inducible factor 1? by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells.
Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.
Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1? and sphingosine kinase 1.
Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival.
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel.
Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1? inactivation in hypoxic PC-3 prostate cancer cells.
Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens.
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.
Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.
Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.
Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.
Proteinuria
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies.
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Pseudolymphoma
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions.
Psoriasis
A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
Pulmonary Arterial Hypertension
Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Mechanistic regulation of SPHK1 expression and translocation by EMAP II in pulmonary smooth muscle cells.
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-?B activation.
Targeting sphingosine kinase 1 for the treatment of pulmonary arterial hypertension.
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Ceramide and sphingosine-1 phosphate in COPD lungs.
Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720.
Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease.
Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis.
Pulmonary Edema
Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema.
Pulmonary Fibrosis
Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy.
Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.
Sphingolipids in pulmonary fibrosis.
Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis.
The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Renal Insufficiency, Chronic
Sphingosine kinase-1: a potential mediator of renal fibrosis.
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
Reperfusion Injury
A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.
Digestive Disease Week 2010. Turning Science into Medicine--part 2.
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway.
Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways.
Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury.
Sphingosine kinase 1 promotes cerebral ischemia-reperfusion injury through inducing ER stress and activating the NF-?B signaling pathway.
Sphingosine kinase 1 protects against renal ischemia-reperfusion injury in mice by sphingosine-1-phosphate(1) receptor activation.
Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-?.
The Role of Sphingomyelin Metabolism in the Protection of Rat Brain Microvascular Endothelial Cells by Mild Hypothermia.
Respiratory Distress Syndrome
Expression of sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 in malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model.
Respiratory Syncytial Virus Infections
Sphingosine kinase 1 in viral infections.
Retinal Degeneration
Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration.
Retinal Neovascularization
Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.
Rheumatic Diseases
Sphingosine kinase and sphingosine-1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis?
Sandhoff Disease
Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
Sepsis
Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice.
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis.
Inhibition of Sphingosine Kinase 1 Attenuates Sepsis-induced Microvascular Leakage via Inhibiting Macrophage NLRP3 Inflammasome Activation in Mice.
n-3 Polyunsaturated Fatty Acids Improve Inflammation via Inhibiting Sphingosine Kinase 1 in a Rat Model of Parenteral Nutrition and CLP-Induced Sepsis.
Preclinical evidence of sphingosine kinase 1 inhibition in alleviation of intestinal epithelial injury in polymicrobial sepsis.
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.
Stopping sepsis by targeting sphingosine kinase 1.
Shock, Septic
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis.
Stopping sepsis by targeting sphingosine kinase 1.
Skin Diseases
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
Small Cell Lung Carcinoma
[Role of SPHK1 regulates multi-drug resistance of small cell lung cancer ?and its clinical significance].
sphingosine kinase deficiency
Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.
Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPAR?.
Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model.
Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signalling in macrophages.
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness.
Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins.
Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-?.
Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts.
Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition.
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.
Spinal Cord Injuries
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
A role of sphingosine kinase 1 in head and neck carcinogenesis.
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma.
Enhancement of SPHK1 in vitro by carbon ion irradiation in oral squamous cell carcinoma.
Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma.
Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer.
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.
Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.
Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
The expression of sphingosine kinase-1 in head and neck carcinoma.
The impact of sphingosine kinase-1 in head and neck cancer.
Starvation
Endothelin-1 inhibits apoptosis through a sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells.
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation.
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
Stomach Neoplasms
A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells.
Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts.
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer.
Functional Genetic Variants in SPHK1 Affect Susceptibility to Gastric Cancer in a Chinese Population.
Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.
METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2.
miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1.
Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.
Sphingosine kinase 1 is a relevant molecular target in gastric cancer.
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients.
SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling.
Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.
[Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro].
[Relationship between sphingosine kinase 1 expression and tumor invasion, metastasis and prognosis in gastric cancer].
Stroke
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway.
Junctional protein regulation by sphingosine kinase 2 contributes to blood-brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance.
Regulation and function of sphingosine kinase 2 in diseases.
Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.
Sphingosine kinase 2 as the promising target for stroke research.
The Functional Role of Sphingosine Kinase 2.
Subarachnoid Hemorrhage
Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice.
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
Synovitis
Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses.
Sphingosine kinase and sphingosine-1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis?
Teratocarcinoma
A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.
Thrombocytopenia
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes.
Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).
Thrombosis
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Regulation and function of sphingosine kinase 2 in diseases.
Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation.
The impact of sphingosine kinase 1 on the prognosis of hepatocellular carcinoma patients with portal vein tumor thrombus.
Thyroid Cancer, Papillary
Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer.
Long noncoding RNA LINC00520 accelerates progression of papillary thyroid carcinoma by serving as a competing endogenous RNA of microRNA-577 to increase Sphk2 expression.
MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2.
MiR-577 inhibits papillary thyroid carcinoma cell proliferation, migration and invasion by targeting SphK2.
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.
Thyroid Neoplasms
Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer.
MiR-128 suppresses the growth of thyroid carcinoma by negatively regulating SPHK1.
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
Sphingosine kinase 1 is overexpressed and promotes proliferation in human thyroid cancer.
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2.
SPHK1 promotes metastasis of thyroid carcinoma through activation of the S1P/S1PR3/Notch signaling pathway.
Triple Negative Breast Neoplasms
Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triple-negative breast cancer cells to EGF receptor blockade.
Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway.
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate.
Sphingosine kinase 1 activation by estrogen receptor ?36 contributes to tamoxifen resistance in breast cancer.
Sphingosine kinase 1 in breast cancer.
Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.
SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Trypanosomiasis, African
Sphingosine Kinase Regulates Microtubule Dynamics and Organelle Positioning Necessary for Proper G1/S Cell Cycle Transition in Trypanosoma brucei.
Tuberculosis
Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase.
Macrophage's proinflammatory response to a mycobacterial infection is dependent on sphingosine kinase-mediated activation of phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and phosphatidylinositol 3-kinase.
Mechanisms of mycobacterial persistence in tuberculosis.
Sphingolipids Are Dual Specific Drug Targets for the Management of Pulmonary Infections: Perspective.
Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis.
Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy.
Tuberculosis, Lymph Node
Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy.
Ureteral Obstruction
Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.
Knockout of Sphingosine Kinase 1 Attenuates Renal Fibrosis in Unilateral Ureteral Obstruction Model.
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.
Urethral Obstruction
Tumor necrosis factor superfamily 14 is critical for the development of renal fibrosis.
Urinary Bladder Neoplasms
Down-regulation of Sphk2 suppresses bladder cancer progression.
Increased SPHK1 expression is associated with poor prognosis in bladder cancer.
miR-613 inhibits bladder cancer proliferation and migration through targeting SphK1.
MiRNA-125b inhibits proliferation and migration by targeting SphK1 in bladder cancer.
Uterine Cervical Neoplasms
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
Vascular System Injuries
Differential regulation of sphingosine kinases 1 and 2 in lung injury.
Virus Diseases
In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.
Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses.
Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.
Sphingosine kinase 1 in viral infections.
Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence.
Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus.
Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.
Whooping Cough
Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms.
Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms.
Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals.
Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase.
Hemolysis induced by Bacillus cereus sphingomyelinase.
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.
Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation.
The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.
The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.
Wilms Tumor
A novel sphingosine kinase 1 inhibitor (SKI-5C) induces cell death of Wilms' tumor cells
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.