Information on EC 2.7.1.92 - 5-dehydro-2-deoxygluconokinase

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The expected taxonomic range for this enzyme is: Enterobacter aerogenes

EC NUMBER
COMMENTARY hide
2.7.1.92
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RECOMMENDED NAME
GeneOntology No.
5-dehydro-2-deoxygluconokinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
myo-inositol degradation I
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Inositol phosphate metabolism
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Metabolic pathways
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
62213-35-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
C1, constitutive strain
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Manually annotated by BRENDA team
C1, constitutive strain
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 2-deoxy-5-keto-D-gluconic acid
ADP + 2-deoxy-5-keto-D-gluconic acid 6-phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 2-deoxy-5-keto-D-gluconic acid
ADP + 2-deoxy-5-keto-D-gluconic acid 6-phosphate
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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MgCl2 is included in assay mixture on the assumption that it is required
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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enzyme is induced by growth on myo-inositol
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.097
2-deoxy-5-keto-D-gluconic acid
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 8.5
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broad, Tris-chloride buffer
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
225000
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sucrose density gradient centrifugation
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
purified enzyme is unstable to repeated freezing and thawing in 20 mM potassium phosphate buffer, pH 7, 5 mM EDTA, 10 mM 2-mercaptoethanol
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C, 20 mM potassium phosphate buffer, pH 7, 5 mM EDTA, 10 mM 2-mercaptoethanol, 1 month or more, stable
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4°C, enzyme of DEAE-Sephadex fractions, 20 mM potassium phosphate buffer, pH 7, 5 mM EDTA, 10 mM 2-mercaptoethanol, 0.2 M KCl, 5 months, stable
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial, 20fold, not seperated from 2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase
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