Information on EC 2.7.1.B24 - cytidine kinase

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The expected taxonomic range for this enzyme is: Thermococcus kodakarensis

EC NUMBER
COMMENTARY hide
2.7.1.B24
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
cytidine kinase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + cytidine = ADP + CMP
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cytidine 5'-phosphotransferase
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-deoxycytidine + ATP
3'-dCMP + ADP
show the reaction diagram
-
-
-
?
cytidine + ATP
CMP + ADP
show the reaction diagram
-
-
-
?
cytidine + CTP
CMP + CDP
show the reaction diagram
30% activity with CTP compared to ATP
-
-
?
cytidine + GTP
CMP + GDP
show the reaction diagram
70% activity with GTP compared to ATP
-
-
?
cytidine + UTP
CMP + UDP
show the reaction diagram
30% activity with UTP compared to ATP
-
-
?
uridine + ATP
UMP + ADP
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
cytidine + ATP
CMP + ADP
show the reaction diagram
Q5JEK6
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
26% activity compared to Mg2+
KCl
300 mM, 3.6fold increase of activity
Mg2+
most preferred divalent metal ion
Mn2+
68% activity compared to Mg2+
additional information
ca2+, Ni2+, Zn2+, cu2+ show less than 20% avtivation
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytidine
substrate inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.11
3'-deoxycytidine
pH and temperature not specified in the publication
5.72
ATP
pH and temperature not specified in the publication
1.71
cytidine
pH and temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
226
3'-deoxycytidine
Thermococcus kodakarensis
Q5JEK6
pH and temperature not specified in the publication
222
ATP
Thermococcus kodakarensis
Q5JEK6
pH and temperature not specified in the publication
280
cytidine
Thermococcus kodakarensis
Q5JEK6
pH and temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
55
3'-deoxycytidine
Thermococcus kodakarensis
Q5JEK6
pH and temperature not specified in the publication
61869
38.8
ATP
Thermococcus kodakarensis
Q5JEK6
pH and temperature not specified in the publication
4
164
cytidine
Thermococcus kodakarensis
Q5JEK6
pH and temperature not specified in the publication
372
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
29.3
cytidine
pH and temperature not specified in the publication
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE