Information on EC 2.7.3.7 - opheline kinase

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The expected taxonomic range for this enzyme is: Ophelia neglecta

EC NUMBER
COMMENTARY hide
2.7.3.7
-
RECOMMENDED NAME
GeneOntology No.
opheline kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + guanidinoethyl methyl phosphate = ADP + N'-phosphoguanidinoethyl methylphosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:guanidinoethyl-methyl-phosphate phosphotransferase
Has a little activity on taurocyamine, lombricine and phosphotaurocyamine.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-15-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 2-guanidinoethyl phosphate
ADP + N-phospho-2-guanidinoethyl phosphate
show the reaction diagram
-
-
-
-
?
ATP + lombricine
ADP + phospholombricine
show the reaction diagram
-
-
-
-
?
ATP + opheline
ADP + phosphoopheline
show the reaction diagram
-
i.e. 2-guanidinoethylmethyl phosphate
-
r
ATP + taurocyamine
ADP + phosphotaurocyamine
show the reaction diagram
-
-
-
r
additional information
?
-
-
no phosphorylation of arginine, guanidinoacetate, no reverse reaction with their corresponding phosphagens
-
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Chloroacetophenone
-
-
monoiodoacetate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
13
2-guanidinoethyl phosphate
-
30C
0.85
ADP
-
30C
3
ATP
-
30C
15
lombricine
-
30C
5.8
opheline
-
30C
1.1
phosphoopheline
-
30C
1.8
phosphotaurocyamine
-
30C
50
Taurocyamine
-
30C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
-
reaction with phosphoopheline
8.5
-
phosphorylation of opheline
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 7.5
-
oH 6.0: about 80% of maximal activity, pH 7.5: about 65% of maximal activity, reaction with phosphoopheline
7.5 - 9
-
pH 7.5: about 65% of maximal activity, pH 9.0: about 50% of maximal activity, phosphorylation of opheline
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30 - 35
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE