Information on EC 2.7.4.11 - (deoxy)adenylate kinase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
2.7.4.11
-
RECOMMENDED NAME
GeneOntology No.
(deoxy)adenylate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + dAMP = ADP + dADP
show the reaction diagram
AMP can also act as acceptor
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
purine deoxyribonucleosides salvage
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-
purine metabolism
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Purine metabolism
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Metabolic pathways
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:(d)AMP phosphotransferase
AMP can also act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-19-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain 201 infected with bacteriophage T4amBL292, a maturation defective phage mutant, host-coded activity which is a component of T4 dNTP-synthesizing enzyme complex
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-
Manually annotated by BRENDA team
strain 201 infected with bacteriophage T4amBL292, a maturation defective phage mutant, host-coded activity which is a component of T4 dNTP-synthesizing enzyme complex
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + AMP
ADP + ADP
show the reaction diagram
-
-
-
?
ATP + dAMP
ADP + dADP
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + dAMP
ADP + dADP
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
requirement, half as effective as Mg2+ or Mn2+
Fe2+
-
requirement, half as effective as Mg2+ or Mn2+
Fe3+
-
activation, only about 15% as effective as Mg2+ or Mn2+
Mg2+
-
requirement, as good as Mn2+
Mn2+
-
requirement, as good as Mg2+
additional information
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no activation by Ca2+, Zn2+ or KCl
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
-
substrate inhibition
EDTA
-
-
additional information
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no inhibition by p-hydroxymercuribenzoate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
AMP
-
cosubstrate ATP
0.1
ATP
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-
1
dAMP
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cosubstrate ATP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 9
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broad, Tris-HCl preferred to 3,3-dimethylglutarate buffer
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80
-
94%, 97%, 98% or 100% loss of activity within 2, 5, 20 or 30 min, respectively
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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