Information on EC 2.7.4.19 - 5-methyldeoxycytidine-5'-phosphate kinase

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The expected taxonomic range for this enzyme is: Xanthomonas oryzae

EC NUMBER
COMMENTARY hide
2.7.4.19
-
RECOMMENDED NAME
GeneOntology No.
5-methyldeoxycytidine-5'-phosphate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 5-methyldeoxycytidine 5'-phosphate = ADP + 5-methyldeoxycytidine diphosphate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase
The enzyme, from phage XP-12-infected Xanthomonas oryzae, converts m5dCMP into m5dCDP and then into m5dCTP.
CAS REGISTRY NUMBER
COMMENTARY hide
81032-53-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
only in bacteriophage XP-12-infected, not in uninfected strain
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 5-methyldeoxycytidine 5'-phosphate
ADP + 5-methyldeoxycytidine diphosphate
show the reaction diagram
dATP + 5-methyldeoxycytidine 5'-phosphate
dADP + 5-methyldeoxycytidine diphosphate
show the reaction diagram
-
-
-
-
?
dCTP + 5-methyldeoxycytidine 5'-phosphate
dCDP + 5-methyldeoxycytidine diphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
poor donor substrates: dGTP or dTTP, no acceptor substrates: dTMP or dGMP
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-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 5-methyldeoxycytidine 5'-phosphate
ADP + 5-methyldeoxycytidine diphosphate
show the reaction diagram
-
responsible for phosphorylation of modified deoxynucleotide, induced by bacteriophage infection
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
requirement
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4 - 7.6
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-40°C, stable in 10 mM Tris-HCl buffer, pH 7.6, 2 mM 2-mercaptoethanol, 0.1 mM EDTA, 10% v/v glycerol
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE