Reference on EC 2.7.4.24 - diphosphoinositol-pentakisphosphate 1-kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Voglmaier, S.M.; Bembenek, M.E.; Kaplin, A.I.; Dorman, G.; Olszewski, J.D.; Prestwich, G.D.; Snyder, S.H.
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor
Proc. Natl. Acad. Sci. USA
93
4305-4310
1996
Rattus norvegicus
Huang, C.F.; Voglmaier, S.M.; Bembenek, M.E.; Saiardi, A.; Snyder, S.H.
Identification and purification of diphosphoinositol pentakisphosphate kinase, which synthesizes the inositol pyrophosphate bis(diphospho)inositol tetrakisphosphate
Biochemistry
37
14998-15004
1998
Rattus norvegicus
Shears, S.B.; Ali, N.; Craxton, A.; Bembenek, M.E.
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo
J. Biol. Chem.
270
10489-10497
1995
Rattus norvegicus
Safrany, S.T.
Protocols for regulation and study of diphosphoinositol polyphosphates
Mol. Pharmacol.
66
1585-1591
2004
Mesocricetus auratus
Fridy, P.C.; Otto, J.C.; Dollins, D.E.; York, J.D.
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases
J. Biol. Chem.
282
30754-30762
2007
Homo sapiens (O43314), Homo sapiens (Q6PFW1), Homo sapiens
Choi, J.H.; Williams, J.; Cho, J.; Falck, J.R.; Shears, S.B.
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress
J. Biol. Chem.
282
30763-30775
2007
Rattus norvegicus (P0C644), Homo sapiens (Q6PFW1), Homo sapiens
Lin, H.; Fridy, P.C.; Ribeiro, A.A.; Choi, J.H.; Barma, D.K.; Vogel, G.; Falck, J.R.; Shears, S.B.; York, J.D.; Mayr, G.W.
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases
J. Biol. Chem.
284
1863-1872
2009
Saccharomyces cerevisiae, Homo sapiens
Weaver, J.D.; Wang, H.; Shears, S.B.
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
Biosci. Rep.
33
e00022
2013
Homo sapiens (O43314), Homo sapiens
Riley, A.M.; Wang, H.; Weaver, J.D.; Shears, S.B.; Potter, B.V.
First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase
Chem. Commun. (Camb. )
48
11292-11294
2012
Homo sapiens (O43314)
Wang, H.; Godage, H.Y.; Riley, A.M.; Weaver, J.D.; Shears, S.B.; Potter, B.V.
Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery
Chem. Biol.
21
689-699
2014
Homo sapiens (O43314)
Nair, V.; Gu, C.; Janoshazi, A.; Jessen, H.; Wang, H.; Shears, S.
Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
Biosci. Rep.
38
BSR20171549
2018
Homo sapiens (Q6PFW1)
Gu, C.; Nguyen, H.N.; Hofer, A.; Jessen, H.J.; Dai, X.; Wang, H.; Shears, S.B.
The significance of the bifunctional kinase/phosphatase activities of diphosphoinositol pentakisphosphate kinases (PPIP5Ks) for coupling inositol pyrophosphate cell signaling to cellular phosphate homeostasis
J. Biol. Chem.
292
4544-4555
2017
Homo sapiens (O43314), Homo sapiens (Q6PFW1)
Yousaf, R.; Gu, C.; Ahmed, Z.M.; Khan, S.N.; Friedman, T.B.; Riazuddin, S.; Shears, S.B.; Riazuddin, S.
Mutations in diphosphoinositol-pentakisphosphate kinase PPIP5K2 are associated with hearing loss in human and mouse
PLoS Genet.
14
e1007297
2018
Homo sapiens (O43314), Homo sapiens, Mus musculus (Q6ZQB6), Mus musculus
Baughman, B.M.; Wang, H.; An, Y.; Kireev, D.; Stashko, M.A.; Jessen, H.J.; Pearce, K.H.; Frye, S.V.; Shears, S.B.
A High-throughput screening-compatible strategy for the identification of inositol pyrophosphate kinase inhibitors
PLoS ONE
11
e0164378
2016
Homo sapiens (O43314)
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