Information on EC 2.7.7.27 - glucose-1-phosphate adenylyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.7.7.27
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RECOMMENDED NAME
GeneOntology No.
glucose-1-phosphate adenylyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
glycogen biosynthesis I (from ADP-D-Glucose)
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starch biosynthesis
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glycogen metabolism
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Starch and sucrose metabolism
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Amino sugar and nucleotide sugar metabolism
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Metabolic pathways
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
ATP:alpha-D-glucose-1-phosphate adenylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9027-71-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
Acutodesmus obliquus
green alga
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Manually annotated by BRENDA team
peanut
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
green alga
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Manually annotated by BRENDA team
specific activity of ADP-glucose pyrophosphorylase is 20fold higher in cells grown on glucose than in acetate- or lactate-grown cells
Uniprot
Manually annotated by BRENDA team
carrot
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Escherichia aurescens
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Manually annotated by BRENDA team
strain ER2566
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-
Manually annotated by BRENDA team
glgC
SwissProt
Manually annotated by BRENDA team
strain 618
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Manually annotated by BRENDA team
strain 618
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-
Manually annotated by BRENDA team
SG14
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
lettuce
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
no activity in Arabidopsis thaliana
subunit APS2
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Manually annotated by BRENDA team
no activity in Erwinia carotovora
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Manually annotated by BRENDA team
no activity in Proteus vulgaris or Erwinia carotovora
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Manually annotated by BRENDA team
avocado
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Manually annotated by BRENDA team
Rhodobacter gelatinosa
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Manually annotated by BRENDA team
Rhodobacter globiformis
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Manually annotated by BRENDA team
large subunit isoform AgpL1
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-
Manually annotated by BRENDA team
LS1
SwissProt
Manually annotated by BRENDA team
LS2
SwissProt
Manually annotated by BRENDA team
LS3
SwissProt
Manually annotated by BRENDA team
SS
SwissProt
Manually annotated by BRENDA team
Sorghum sp.
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Manually annotated by BRENDA team
PCC6301
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Manually annotated by BRENDA team
SS1
SwissProt
Manually annotated by BRENDA team
SS2
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
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starch synthesis
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
8-azaATP + alpha-D-glucose 1-phosphate
diphosphate + 8-azaADP-glucose
show the reaction diagram
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the photoaffinity labeling agent is used as a site specific probe of enzyme
reverse reaction is biphasic
r
8-N3-ATP + alpha-D-glucose 1-phosphate
8-N3-ATP-D-glucose + diphosphate
show the reaction diagram
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both the large and small subunit in the heterotetrameric form are labeled at equivalent rates with 8-N3-ATP, an analog which can readily substitute for ATP in catalysis
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r
ATP + alpha-D-glucose 1-phosphate
ADP-D-glucose + diphosphate
show the reaction diagram
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-glucose
show the reaction diagram
ATP + alpha-D-glucose-1-phosphate
ADP-D-glucose + diphosphate
show the reaction diagram
ATP + alpha-D-glucose-1-phosphate
diphosphate + ADP-glucose
show the reaction diagram
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?
ATP + alpha-D-mannose 1-phosphate
diphosphate + ADP-mannose
show the reaction diagram
the catalytic efficiency with glucose 1-phosphate is at least one order of magnitude higher than that with mannose 1-phosphate
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r
diphosphate + ADP
ATP + alpha-D-glucose
show the reaction diagram
diphosphate + ADP-glucose
ATP + alpha-D-glucose 1-phosphate
show the reaction diagram
GTP + alpha-D-glucose 1-phosphate
diphosphate + GDP-glucose
show the reaction diagram
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can somewhat replace ATP
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additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + alpha-D-glucose 1-phosphate
ADP-D-glucose + diphosphate
show the reaction diagram
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-glucose
show the reaction diagram
ATP + alpha-D-glucose-1-phosphate
ADP-D-glucose + diphosphate
show the reaction diagram
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AGP plays a crucial role in the morphogenesis of petal limbs in Xanthi through the synthesis of starch, which is the main carbohydrate source for expansion growth of petal limbs, in sepal tisues, overview
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r
additional information
?
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