Reference on EC 2.7.7.48 - RNA-directed RNA polymerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Blumenthal, T.
Qbeta RNA replicase and protein synthesis elongation factors EF-Tu and EF-Ts
Methods Enzymol.
60
628-638
1979
Qubevirus durum, Qubevirus durum QbetaamB86
Blumenthal, T.
Qbeta replicase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
15
267-279
1982
Qubevirus durum, Qubevirus durum Qbetaam12, Qubevirus durum QbetaamB86
-
Brown, S.; Blumenthal, T.
Function and structure in ribonucleic acid Phage Qbeta ribonucleic acid replicase. Effect of inhibitors of EF-Tu on ribonucleic acid synthesis and renaturation of active enzyme
J. Biol. Chem.
251
2749-2753
1976
Qubevirus durum
Hadidi, A.; Fraenkel-Conrat, H.
Characterization and specificity of soluble RNA polymerase of Brome mosaic virus
Virology
52
363-372
1973
Brome mosaic virus
Ohki, K.; Hori, K.
Replication of viral nucleic acids. II. Inhibition of Q replicase by sulfhydryl-blocking reagents
Biochim. Biophys. Acta
281
233-243
1972
Qubevirus durum
Clark, G.L.; Peden, K.W.C.; Symons, R.H.
Cucumber mosaic virus-induced RNA polymerase: partial purification and properties of the template-free enzyme
Virology
62
434-444
1974
Cucumber mosaic virus
Lazarus, L.H.; Itin, A.
Activity of Foot-and-mouth disease virus RNA-dependent RNA polymerase in vitro: inhibition by polyamines and poly(amino acid)s
Arch. Biochem. Biophys.
156
154-160
1973
Foot-and-mouth disease virus
Traub, A.; Diskin, B.; Rosenberg, H.; Kalmar, E.
Isolation and properties of the replicase of Encephalomyocarditis virus
J. Virol.
18
375-382
1976
Encephalomyocarditis virus
Louis, B.G.; Fitt, P.S.
Purification and properties of the ribonucleic acid-dependent ribonucleic acid polymerase from Halobacterium cutirubrum
Biochem. J.
128
755-762
1972
Halobacterium salinarum
Zabel, P.; Weenen-Swaans, H.; van Kammen, A.
In vitro replication of Cowpea mosaic virus RNA: I. Isolation and properties of the membrane-bound replicase
J. Virol.
14
1049-1055
1974
Cowpea mosaic virus
Chu, P.W.G.; Westaway, E.G.
Characterization of Kunjin virus RNA-dependent RNA polymerase: reinitiation of synthesis in vitro
Virology
157
330-337
1987
Kunjin virus, Kunjin virus MRM61C
Honda, A.; Mukaigawa, J.; Yokoiyama, A.; Kato, A.; Ueda, S.; Nagata, K.; Krystal, M.; Nayak, D.P.; Ishihama, A.
Purification and molecular structure of RNA polymerase from Influenza virus A/PR8
J. Biochem.
107
624-628
1990
Influenza virus A/PR8
Plotch, S.J.; Palant, O.; Gluzman, Y.
Purification and properties of Poliovirus RNA polymerase expressed in Escherichia coli
J. Virol.
63
216-225
1989
Enterovirus C
Quadt, R.; Jaspars, E.M.J.
Characterization of Cucumber mosaic virus RNA-dependent RNA polymerase
FEBS Lett.
279
273-276
1991
Cucumber mosaic virus
Quadt, R.; Jaspars, E.M.J.
Purification and characterization of Brome mosaic virus RNA-dependent RNA polymerase
Virology
178
189-194
1990
Brome mosaic virus
Rouleau, M.; Bancroft, J.B.; Mackie, G.A.
Partial purification and characterization of Foxtail mosaic potexvirus RNA-dependent RNA polymerase
Virology
197
695-703
1993
Foxtail mosaic potexvirus
Schiebel, W.; Haas, B.; Marinkovic, S.; Klanner, A.; Snger, H.L.
RNA-directed RNA polymerase from tomato leaves. I. Purification and physical properties
J. Biol. Chem.
268
11851-11857
1993
Solanum lycopersicum
Schiebel, W.; Haas, B.; Marinkovic, S.; Klanner, A.; Snger, H.L.
RNA-directed RNA polymerase from tomato leaves. II. Catalytic in vitro properties
J. Biol. Chem.
268
11858-11867
1993
Solanum lycopersicum
Brayton, P.R.; Stohlman, S.A.; Lai, M.M.C.
Further characterization of Mouse hepatitis virus RNA-dependent RNA polymerases
Virology
133
197-201
1984
Murine hepatitis virus
Tershak, D.R.
Inhibition of Poliovirus polymerase by guanidine in vitro
J. Virol.
41
313-318
1982
Enterovirus C
Morrow, C.D.; Lubrinski, J.; Hocko, J.; Gibbons, G.F.; Dasgupta, A.
Purification of a soluble template-dependent Rhinovirus RNA polymerase and its dependence on a host cell protein for viral RNA synthesis
J. Virol.
53
266-272
1985
rhinovirus A2
Grun, J.B.; Brinton, M.A.
Characterization of West Nile virus RNA-dependent RNA polymerase and cellular terminal adenylyl and uridylyl transferases in cell-free extracts
J. Virol.
60
1113-1124
1986
West Nile virus
Donofrio, J.C.; Kuchta, J.; Moore, R.; Kaczmarczyk, W.
Properties of a solubilized replicase isolated from corn infected with Maize dwarf mosaic virus
Can. J. Microbiol.
32
637-644
1986
Maize dwarf mosaic virus
-
Stussi-Garaud, C.; Lemius, J.; Fraenkel-Conrat, H.
RNA polymerase from Tobacco necrosis virus-infected and uninfected tobacco. II. Properties of the bound and soluble polymerases and the nature of their products
Virology
81
224-236
1977
unidentified tobacco necrosis virus
Clerx, C.M.; Bol, J.F.
Properties of solubilized RNA-dependent RNA polymerase from Alfalfa mosaic virus-infected and healthy tobacco plants
Virology
91
453-463
1978
Nicotiana tabacum
Gill, D.S.; Kumarasamy, R.; Symons, R.H.
Cucumber mosaic virus-induced RNA replicase: solubilisation and partial purification of the particulate enzyme
Virology
113
1-8
1981
Cucumber mosaic virus
Dorssers, L.; Zabel, P.; van der Meer, J.; van Kammen, A.
Purification of a host-encoded RNA-dependent RNA-polymerase from cowpea mosaic-virus-infected cowpea leaves
Virology
116
236-249
1982
Vigna unguiculata
Kumarasamy, R.; Symons, R.H.
Extensive purification of the cucumber mosaic virus-induced RNA replicase
Virology
96
622-632
1979
Cucumber mosaic virus
Bernstein, J.M.; Hruska, J.F.
Characterization of RNA polymerase products of Nebraska calf diarrhea virus and SA11 rotavirus
J. Virol.
37
1071-1074
1981
Bovine rotavirus strain NCDV/G6, Simian rotavirus
Yonesaki, T.; Haruna, I.
In vitro replication of Bacteriophage GA RNA. Subunit structure and catalytic properties of GA replicase
J. Biochem.
89
741-750
1981
Enterobacteria phage GA
Blumenthal, T.
Interaction of Qbeta RNA replicase with guanine nucleotides. Different modes of inhibition and inactivation
Biochim. Biophys. Acta
478
201-208
1977
Qubevirus durum
Lohmann, V.; Roos, A.; Krner, F.; Koch, J.O.; Bartenschlager, R.
Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the Hepatitis C virus
Virology
249
108-118
1998
Hepacivirus C
Guarino, L.A.; Kaesberg, P.
Isolation and characterization of an RNA-dependent RNA polymerase from Black beetle virus-infected Drosophila melanogaster cells
J. Virol.
40
379-386
1981
black beetle virus
Seifried, A.S.; Albrecht, P.; Milstien, J.B.
Characterization of an RNA-dependent RNA polymerase activity associated with Measles virus
J. Virol.
25
781-787
1978
Measles morbillivirus
Ikegami, M.; Fraenkel-Conrat, H.
Characterization of the RNA-dependent RNA polymerase of tobacco leaves
J. Biol. Chem.
254
149-154
1979
Nicotiana tabacum
Park, C.; Kee, Y.; Lee, J.; Oh, J.; Park, J.; Myung, H.
Purification and characterization of recombinant Hepatitis C virus replicase
J. Microbiol. Biotechnol.
9
881-884
1999
Hepacivirus C
-
Ferrari, E.; Wright-Minogue, J.; Fang, J.W.; Baroudy, B.M.; Lau, J.Y.; Hong, Z.
Characterization of soluble Hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli
J. Virol.
73
1649-1654
1999
Hepacivirus C
Zhong, W.; Gutshall, L.L.; Del Vecchio, A.M.
Identification and characterization of an RNA-dependent RNA polymerase activity within the nonstructural protein 5B region of Bovine viral diarrhea virus
J. Virol.
72
9365-9369
1998
Bovine viral diarrhea virus 1
Nguyen, M.; Ramirez, B.C.; Goldbach, R.; Haenni, A.L.
Characterization of the in vitro activity of the RNA-dependent RNA polymerase associated with the ribonucleoproteins of Rice Hoja Blanca tenuivirus
J. Virol.
71
2621-2627
1997
Rice hoja blanca tenuivirus, Rice hoja blanca tenuivirus RHBV
Tomei, L.; Vitale, R.L.; Incitti, I.; Serafini, S.; Altamura, S.; Vitelli, A.; De Francesco, R.
Biochemical characterization of a Hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence
J. Gen. Virol.
81
759-767
2000
Hepacivirus C
Brockway, S.M.; Clay, C.T.; Lu, X.T.; Denison, M.R.
Characterization of the expression, intracellular localization, and replication complex association of the putative Mouse hepatitis virus RNA-dependent RNA polymerase
J. Virol.
77
10515-10527
2003
Murine hepatitis virus
Qin, W.; Yamashita, T.; Shirota, Y.; Lin, Y.; Wei, W.; Murakami, S.
Mutational analysis of the structure and functions of Hepatitis C virus RNA-dependent RNA polymerase
Hepatology
33
728-737
2001
Hepacivirus C
Goodin, M.M.; Schlagnhaufer, B.; Weir, T.; Romaine, C.P.
Characterization of an RNA-dependent RNA polymerase activity associated with La France isometric virus
J. Virol.
71
2264-2269
1997
La France isometric virus
Lohmann, V.; Korner, F.; Herian, U.; Bartenschlager, R.
Biochemical properties of Hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymic activity
J. Virol.
71
8416-8428
1997
Hepacivirus C
Li, Y.I.; Cheng, Y.M.; Huang, Y.L.; Tsai, C.H.; Hsu, Y.H.; Meng, M.
Identification and characterization of the Escherichia coli-expressed RNA-dependent RNA polymerase of Bamboo mosaic virus
J. Virol.
72
10093-10099
1998
bamboo mosaic virus
Hung, M.; Gibbs, C.S.; Tsiang, M.
Biochemical characterization of Rhinovirus RNA-dependent RNA polymerase
Antiviral Res.
56
99-114
2002
rhinovirus A16
Uchil, P.D.; Satchidanandam, V.
Characterization of RNA synthesis, replication mechanism, and in vitro RNA-dependent RNA polymerase activity of Japanese encephalitis virus
Virology
307
358-371
2003
Japanese encephalitis virus
Johnson, R.B.; Sun, X.L.; Hockman, M.A.; Villarreal, E.C.; Wakulchik, M.; Wang, Q.M.
Specificity and mechanism analysis of Hepatitis C virus RNA-dependent RNA polymerase
Arch. Biochem. Biophys.
377
129-134
2000
Hepacivirus C
Xiao, M.; Wang, Y.; Chen, J.; Li, B.
Characterization of RNA-dependent RNA polymerase activity of CSFV NS5B proteins expressed in Escherichia coli
Virus Genes
27
67-74
2003
Classical swine fever virus
Alaoui-Lsmaili, M.H.; Hamel, M.; L'Heureux, L.; Nicolas, O.; Bilimoria, D.; Labonte, P.; Mounir, S.; Rando, R.F.
The Hepatitis C virus NS5B RNA-dependent RNA polymerase activity and susceptibility to inhibitors is modulated by metal cations
J. Hum. Virol.
3
306-316
2000
Hepacivirus C
Nakaishi, T.; Iio, K.; Yamamoto, K.; Urabe, I.; Yomo, T.
Kinetic properties of Qb replicase, an RNA dependent RNA polymerase
J. Biosci. Bioeng.
93
322-327
2002
Qubevirus durum
Behrens, S.E.; Tomei, L.; De Francesco, R.
Identification and properties of the RNA-dependent RNA polymerase of Hepatitis C virus
EMBO J.
15
12-22
1996
Hepacivirus C
Gohara, D.W.; Crotty, S.; Arnold, J.J.; Yoder, J.D.; Andino, R.; Cameron, C.E.
Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B
J. Biol. Chem.
275
25523-25532
2000
Enterovirus C
Shirota, Y.; Luo, H.; Qin, W.; Kaneko, S.; Yamashita, T.; Kobayashi, K.; Murakami, S.
Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity
J. Biol. Chem.
277
11149-11155
2002
Hepacivirus C
Yamashita, T.; Kaneko, S.; Shirota, Y.; Qin, W.; Nomura, T.; Kobayashi, K.; Murakami, S.
RNA-dependent RNA polymerase activity of the soluble recombinant Hepatitis C virus NS5B protein truncated at the C-terminal region
J. Biol. Chem.
273
15479-15486
1998
Hepacivirus C
Wang, M.; Ng, K.K.S.; Cherney, M.M.; Chan, L.; Yannopoulos, C.G.; Bedard, J.; Morin, N.; Nguyen-Ba, N.; Alaoui-Ismaili, M.H.; Bethell, R.C.; James, M.N.G.
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase
J. Biol. Chem.
278
9489-9495
2003
Hepacivirus C (P26663), Hepacivirus C
Carroll, S.S.; Sardana, V.; Yang, Z.; Jacobs, A.R.; Mizenko, C.; Hall, D.; Hill, L.; Zugay-Murphy, J.; Kuo, L.C.
Only a small fraction of purified hepatitis C RNA-dependent RNA polymerase is catalytically competent: implications for viral replication and in vitro assays
Biochemistry
39
8243-8249
2000
Hepacivirus C
Ng, K.K.; Cherney, M.M.; Vazquez, A.L.; Machin, A.; Alonso, J.M.; Parra, F.; James, M.N.
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase
J. Biol. Chem.
277
1381-1387
2002
Rabbit hemorrhagic disease virus
Butcher, S.J.; Makeyev, E.V.; Grimes, J.M.; Stuart, D.I.; Bamford, D.H.
Crystallization and preliminary X-ray crystallographic studies on the Bacteriophage phi6 RNA-dependent RNA polymerase
Acta Crystallogr. Sect. D
56
1473-1475
2000
Cystovirus phi6
Lesburg, C.A.; Cable, M.B.; Ferrari, E.; Hong, Z.; Mannarino, A.F.; Weber, P.C.
Crystal structure of the RNA-dependent RNA polymerase from Hepatitis C virus reveals a fully encircled active site
Nat. Struct. Biol.
6
937-943
1999
Hepacivirus C
Bressanelli, S.; Tomei, L.; Roussel, A.; Incitti, I.; Vitale, R.L.; Mathieu, M.; De Francesco, R.; Rey, F.A.
Crystal structure of the RNA-dependent RNA polymerase of Hepatitis C virus
Proc. Natl. Acad. Sci. USA
96
13034-13039
1999
Hepacivirus C (P26663), Hepacivirus C
Iyer, L.M.; Koonin, E.V.; Aravind, L.
Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases
BMC Struct. Biol.
3
1-23
2003
Arabidopsis thaliana, Arabidopsis thaliana (O82504), Arabidopsis thaliana (Q8H1K9), Arabidopsis thaliana (Q9LKP0), Caenorhabditis elegans, Neurospora crassa, Neurospora crassa (Q9Y7G6), Oryza sativa, Oryza sativa (Q8LHH9), Schizosaccharomyces pombe (O14227), Diaporthe perjuncta (Q8TGV4), Phomopsis sp. (Q8X1C2), Giardia intestinalis (Q95WU3), Dictyostelium discoideum (Q95ZG6), Dictyostelium discoideum (Q95ZG7), Diaporthe ambigua (Q9Q9R1), Solanum lycopersicum (Q9ZR58), Nicotiana tabacum (Q9ZRY7)
Vo, N.V.; Tuler, J.R.; Lai, M.M.C.
Enzymatic characterization of the full-length and C-terminally truncated Hepatitis C virus RNA polymerases: function of the last 21 amino acids of the C terminus in template binding and RNA synthesis
Biochemistry
43
10579-10591
2004
Hepacivirus C
Arnold, J.J.; Cameron, C.E.
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+
Biochemistry
43
5126-5137
2004
Enterovirus C
Arnold, J.J.; Gohara, D.W.; Cameron, C.E.
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+
Biochemistry
43
5138-5148
2004
Enterovirus C
Gohara, D.W.; Arnold, J.J.; Cameron, C.E.
Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection
Biochemistry
43
5149-5158
2004
Enterovirus C
Thompson, A.A.; Peersen, O.B.
Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
EMBO J.
23
3462-3471
2004
Enterovirus C
Nomaguchi, M.; Teramoto, T.; Yu, L.; Markoff, L.; Padmanabhan, R.
Requirements for West Nile virus (-)- and (+)-strand subgenomic RNA synthesis in vitro by the viral RNA-dependent RNA polymerase expressed in Escherichia coli
J. Biol. Chem.
279
12141-12151
2004
West Nile virus
Ferrer-Orta, C.; Arias, A.; Perez-Luque, R.; Escarmis, C.; Domingo, E.; Verdaguer, N.
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA
J. Biol. Chem.
279
47212-47221
2004
Foot-and-mouth disease virus
Ogino, T.; Kobayashi, M.; Iwama, M.; Mizumoto, K.
Sendai virus RNA-dependent RNA polymerase L protein catalyzes cap methylation of virus-specific mRNA
J. Biol. Chem.
280
4429-4435
2005
Murine respirovirus
Laurila, M.R.; Salgado, P.S.; Stuart, D.I.; Grimes, J.M.; Bamford, D.H.
Back-priming mode of phi6 RNA-dependent RNA polymerase
J. Gen. Virol.
86
521-526
2005
Cystovirus phi6 (P11124)
Ranjith-Kumar, C.T.; Sarisky, R.T.; Gutshall, L.; Thomson, M.; Kao, C.C.
De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities
J. Virol.
78
12207-12217
2004
Hepacivirus C
Cai, Z.; Yi, M.; Zhang, C.; Luo, G.
Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase
J. Virol.
79
11607-11617
2005
Hepacivirus C
Appleby, T.C.; Luecke, H.; Shim, J.H.; Wu, J.Z.; Cheney, I.W.; Zhong, W.; Vogeley, L.; Hong, Z.; Yao, N.
Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer
J. Virol.
79
277-288
2005
rhinovirus A16 (Q82122), rhinovirus A16
Nayak, A.; Goodfellow, I.G.; Belsham, G.J.
Factors required for the uridylylation of the foot-and-mouth disease virus 3B1, 3B2, and 3B3 peptides by the RNA-dependent RNA polymerase (3Dpol) in vitro
J. Virol.
79
7698-7706
2005
Foot-and-mouth disease virus
Boerner, J.E.; Lyle, J.M.; Daijogo, S.; Semler, B.L.; Schultz, S.C.; Kirkegaard, K.; Richards, O.C.
Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase
J. Virol.
79
7803-7811
2005
Enterovirus C
Choi, K.H.; Groarke, J.M.; Young, D.C.; Kuhn, R.J.; Smith, J.L.; Pevear, D.C.; Rossmann, M.G.
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation
Proc. Natl. Acad. Sci. USA
101
4425-4430
2004
Bovine viral diarrhea virus 1 (P19711), Bovine viral diarrhea virus 1
Salgado, P.S.; Makeyev, E.V.; Butcher, S.J.; Bamford, D.H.; Stuart, D.I.; Grimes, J.M.
The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase
Structure
12
307-316
2004
Cystovirus phi6 (P11124)
Jabafi, I.; Selisko, B.; Coutard, B.; De Palma, A.M.; Neyts, J.; Egloff, M.P.; Grisel, S.; Dalle, K.; Campanacci, V.; Spinelli, S.; Cambillau, C.; Canard, B.; Gruez, A.
Improved crystallization of the coxsackievirus B3 RNA-dependent RNA polymerase
Acta Crystallogr. Sect. F
63
495-498
2007
Coxsackievirus B3
Yu, F.; Hasebe, F.; Inoue, S.; Mathenge, E.G.; Morita, K.
Identification and characterization of RNA-dependent RNA polymerase activity in recombinant Japanese encephalitis virus NS5 protein
Arch. Virol.
152
1859-1869
2007
Japanese encephalitis virus, Japanese encephalitis virus JaOH0566
Cramer, J.; Jaeger, J.; Restle, T.
Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BDelta21, HC-J4)
Biochemistry
45
3610-3619
2006
Hepacivirus C
Kozlov, M.V.; Polyakov, K.M.; Ivanov, A.V.; Filippova, S.E.; Kuzyakin, A.O.; Tunitskaya, V.L.; Kochetkov, S.N.
Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives
Biokhimiia
71
1021-1026
2006
Hepacivirus C
Gopalsamy, A.; Shi, M.; Ciszewski, G.; Park, K.; Ellingboe, J.W.; Orlowski, M.; Feld, B.; Howe, A.Y.
Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase
Bioorg. Med. Chem. Lett.
16
2532-2534
2006
Hepacivirus C
Rong, F.; Chow, S.; Yan, S.; Larson, G.; Hong, Z.; Wu, J.
Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors
Bioorg. Med. Chem. Lett.
17
1663-1666
2007
Hepacivirus C (P26663), Hepacivirus C
Kim, Y.G.; Yoo, J.S.; Kim, J.H.; Kim, C.M.; Oh, J.W.
Biochemical characterization of a recombinant Japanese encephalitis virus RNA-dependent RNA polymerase
BMC Mol. Biol.
8
59
2007
Japanese encephalitis virus
Koch, U.; Narjes, F.
Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
Curr. Top. Med. Chem.
7
1302-1329
2007
Hepacivirus C, Measles morbillivirus
Zhou, L.; Zhang, J.; Wang, X.; Jiang, H.; Yi, F.; Hu, Y.
Expression and characterization of RNA-dependent RNA polymerase of Dendrolimus punctatus tetravirus
J. Biochem. Mol. Biol.
39
571-577
2006
Dendrolimus punctatus virus
Hosoda, K.; Matsuura, T.; Kita, H.; Ichihashi, N.; Tsukada, K.; Yomo, T.
Kinetic analysis of the entire RNA amplification process by Qbeta replicase
J. Biol. Chem.
282
15516-15527
2007
Qubevirus durum
Rohayem, J.; Jaeger, K.; Robel, I.; Scheffler, U.; Temme, A.; Rudolph, W.
Characterization of norovirus 3Dpol RNA-dependent RNA polymerase activity and initiation of RNA synthesis
J. Gen. Virol.
87
2621-2630
2006
Norovirus Hu/NLV/Dresden174/pUS-NorII/1997/GE
Lee, G.; Piper, D.E.; Wang, Z.; Anzola, J.; Powers, J.; Walker, N.; Li, Y.
Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases
J. Mol. Biol.
357
1051-1057
2006
Hepacivirus C
Fullerton, S.W.; Blaschke, M.; Coutard, B.; Gebhardt, J.; Gorbalenya, A.; Canard, B.; Tucker, P.A.; Rohayem, J.
Structural and functional characterization of sapovirus RNA-dependent RNA polymerase
J. Virol.
81
1858-1871
2007
Sapovirus
Marcotte, L.L.; Wass, A.B.; Gohara, D.W.; Pathak, H.B.; Arnold, J.J.; Filman, D.J.; Cameron, C.E.; Hogle, J.M.
Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase
J. Virol.
81
3583-3596
2007
Enterovirus C
Yap, T.L.; Xu, T.; Chen, Y.L.; Malet, H.; Egloff, M.P.; Canard, B.; Vasudevan, S.G.; Lescar, J.
Crystal structure of the Dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-Angstrom resolution
J. Virol.
81
4753-4765
2007
Dengue virus, Dengue virus (Q6DLV0)
Zhang, C.; Meng, Q.; Gai, J.; Yu, D.
Cloning and functional characterization of an O-acetylserine(thiol)lyase-encoding gene in wild soybean (Glycine soja)
Mol. Biol. Rep.
35
527-534
2008
Gossypium hirsutum
Ellingham, M.; Bunka, D.H.; Rowlands, D.J.; Stonehouse, N.J.
Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus
RNA
12
1970-1979
2006
Foot-and-mouth disease virus
Freistadt, M.S.; Vaccaro, J.A.; Eberle, K.E.
Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase
Virol. J.
4
44
2007
Enterovirus C
Thal, M.A.; Wasik, B.R.; Posto, J.; Hardy, R.W.
Template requirements for recognition and copying by Sindbis virus RNA-dependent RNA polymerase
Virology
358
221-232
2007
Sindbis virus
Yap, T.L.; Chen, Y.L.; Xu, T.; Wen, D.; Vasudevan, S.G.; Lescar, J.
A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution
Acta Crystallogr. Sect. F
F63
78-83
2007
Dengue virus
White, L.K.; Yoon, J.J.; Lee, J.K.; Sun, A.; Du, Y.; Fu, H.; Snyder, J.P.; Plemper, R.K.
Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity
Antimicrob. Agents Chemother.
51
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2007
Measles morbillivirus
Murakami, E.; Niu, C.; Bao, H.; Micolochick Steuer, H.M.; Whitaker, T.; Nachman, T.; Sofia, M.A.; Wang, P.; Otto, M.J.; Furman, P.A.
The mechanism of action of beta-D-2-deoxy-2-fluoro-2-C-methylcytidine involves a second metabolic pathway leading to beta-D-2-deoxy-2-fluoro-2-C-methyluridine 5-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
Antimicrob. Agents Chemother.
52
458-464
2008
Hepacivirus C
Shi, S.T.; Herlihy, K.J.; Graham, J.P.; Fuhrman, S.A.; Doan, C.; Parge, H.; Hickey, M.; Gao, J.; Yu, X.; Chau, F.; Gonzalez, J.; Li, H.; Lewis, C.; Patick, A.K.; Duggal, R.
In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
Antimicrob. Agents Chemother.
52
675-683
2008
Hepacivirus C
Zhou, J.F.; Hua, X.G.; Cui, L.; Zhu, J.G.; Miao, D.N.; Zou, Y.; He, X.Z.; Su, W.G.
Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene
Antiviral Res.
74
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2007
Transmissible gastroenteritis virus
Lu, L.; Dekhtyar, T.; Masse, S.; Pithawalla, R.; Krishnan, P.; He, W.; Ng, T.; Koev, G.; Stewart, K.; Larson, D.; Bosse, T.; Wagner, R.; Pilot-Matias, T.; Mo, H.; Molla, A.
Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro
Antiviral Res.
76
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2007
Hepacivirus C (P26663), Hepacivirus C
Wang, Y.K.; Rigat, K.L.; Sun, J.H.; Gao, M.; Roberts, S.B.
RNA template-mediated inhibition of hepatitis C virus RNA-dependent RNA polymerase activity
Arch. Biochem. Biophys.
470
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2008
Hepacivirus C
Burton, G.; Ku, T.W.; Carr, T.J.; Kiesow, T.; Sarisky, R.T.; Lin-Goerke, J.; Hofmann, G.A.; Slater, M.J.; Haigh, D.; Dhanak, D.; Johnson, V.K.; Parry, N.R.; Thommes, P.
Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity
Bioorg. Med. Chem. Lett.
17
1930-1933
2007
Hepacivirus C
Hirashima, S.; Oka, T.; Ikegashira, K.; Noji, S.; Yamanaka, H.; Hara, Y.; Goto, H.; Mizojiri, R.; Niwa, Y.; Noguchi, T.; Ando, I.; Ikeda, S.; Hashimoto, H.
Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety
Bioorg. Med. Chem. Lett.
17
3181-3186
2007
Hepacivirus C
Sun, A.; Chandrakumar, N.; Yoon, J.J.; Plemper, R.K.; Snyder, J.P.
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation
Bioorg. Med. Chem. Lett.
17
5199-5203
2007
Measles morbillivirus, Measles morbillivirus Alaska
Donner, P.L.; Xie, Q.; Pratt, J.K.; Maring, C.J.; Kati, W.; Jiang, W.; Liu, Y.; Koev, G.; Masse, S.; Montgomery, D.; Molla, A.; Kempf, D.J.
Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase
Bioorg. Med. Chem. Lett.
18
2735-2738
2008
Hepacivirus C
Brandl, M.; Wu, X.; Holper, M.; Hong, L.; Jia, Z.; Birudaraj, R.; Reddy, M.; Alfredson, T.; Tran, T.; Larrabee, S.; Hadig, X.; Sarma, K.; Washington, C.; Hill, G.; Smith, D.B.
Physicochemical properties of the nucleoside prodrug R1626 leading to high oral bioavailability
Drug Dev. Ind. Pharm.
34
683-691
2008
Hepacivirus C
Honda, A.; Okamoto, T.; Ishihama, A.
Host factor Ebp1: selective inhibitor of influenza virus transcriptase
Genes Cells
12
133-142
2007
unidentified influenza virus
Nikonov, A.; Juronen, E.; Ustav, M.
Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase
J. Biol. Chem.
283
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2008
Hepacivirus C (O92972), Hepacivirus C
Slater, M.J.; Amphlett, E.M.; Andrews, D.M.; Bravi, G.; Burton, G.; Cheasty, A.G.; Corfield, J.A.; Ellis, M.R.; Fenwick, R.H.; Fernandes, S.; Guidetti, R.; Haigh, D.; Hartley, C.D.; Howes, P.D.; Jackson, D.L.; Jarvest, R.L.; Lovegrove, V.L.; Medhurst, K.J.; Parry, N.R.; Price, H.; Shah, P.; Singh, O.M.; Stocker, R.
Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate
J. Med. Chem.
50
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2007
Hepacivirus C
Sun, A.; Yoon, J.J.; Yin, Y.; Prussia, A.; Yang, Y.; Min, J.; Plemper, R.K.; Snyder, J.P.
Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex
J. Med. Chem.
51
3731-3741
2008
Measles morbillivirus, Measles morbillivirus Alaska
Paeshuyse, J.; Chezal, J.M.; Froeyen, M.; Leyssen, P.; Dutartre, H.; Vrancken, R.; Canard, B.; Letellier, C.; Li, T.; Mittendorfer, H.; Koenen, F.; Kerkhofs, P.; De Clercq, E.; Herdewijn, P.; Puerstinger, G.; Gueiffier, A.; Chavignon, O.; Teulade, J.C.; Neyts, J.
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication
J. Virol.
81
11046-11053
2007
Bovine viral diarrhea virus 1 (P19711), Bovine viral diarrhea virus 1
Strauss, D.M.; Wuttke, D.S.
Characterization of protein-protein interactions critical for poliovirus replication: analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase
J. Virol.
81
6369-6378
2007
Enterovirus C
Arias, A.; Arnold, J.J.; Sierra, M.; Smidansky, E.; Domingo, E.; Cameron, C.E.
Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin
J. Virol.
82
12346-12355
2008
Foot-and-mouth disease virus
Gruez, A.; Selisko, B.; Roberts, M.; Bricogne, G.; Bussetta, C.; Jabafi, I.; Coutard, B.; De Palma, A.M.; Neyts, J.; Canard, B.
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J. Virol.
82
9577-9590
2008
Coxsackievirus B3, Coxsackievirus B3 Nancy
Gao, Q.; Liu, Y.; Wang, M.; Zhang, J.; Gai, Y.; Zhu, C.; Guo, X.
Molecular cloning and characterization of an inducible RNA-dependent RNA polymerase gene, GhRdRP, from cotton (Gossypium hirsutum L.)
Mol. Biol. Rep.
36
47-56
2007
Gossypium hirsutum (B3SND7), Gossypium hirsutum
Kong, L.; Li, S.; Han, X.; Xiang, Z.; Fang, X.; Li, B.; Wang, W.; Zhong, H.; Gao, J.; Ye, L.
Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi
Virus Res.
128
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2007
Hepacivirus C
Yang, S.; Liu, M.; Tien, C.; Chou, S.; Chang, R.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interaction with 3 ends of Japanese encephalitis virus RNA and colocalization with the viral NS5 protein
J. Biomed. Sci.
16
40
2009
Japanese encephalitis virus
Ali, S.; Leveque, V.; Le Pogam, S.; Ma, H.; Philipp, F.; Inocencio, N.; Smith, M.; Alker, A.; Kang, H.; Najera, I.; Klumpp, K.; Symons, J.; Cammack, N.; Jiang, W.R.
Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
Antimicrob. Agents Chemother.
52
4356-4369
2008
Hepacivirus C (B6EAV7), Hepacivirus C
Tomaru, Y.; Takao, Y.; Suzuki, H.; Nagumo, T.; Nagasaki, K.
Isolation and characterization of a single-stranded RNA virus infecting the bloom-forming diatom Chaetoceros socialis
Appl. Environ. Microbiol.
75
2375-2381
2009
Chaetoceros socialis forma radians RNA virus 1 (B9A8E0)
Sabanadzovic, S.; Abou Ghanem-Sabanadzovic, N.
Identification and molecular characterization of a marafivirus in Rubus spp
Arch. Virol.
154
1729-1735
2009
Blackberry virus S
Yu, J.; Kwon, S.J.; Lee, K.M.; Son, M.; Kim, K.H.
Complete nucleotide sequence of double-stranded RNA viruses from Fusarium graminearum strain DK3
Arch. Virol.
154
1855-1858
2009
Fusarium graminearum dsRNA mycovirus-3 (D0TZ30), Fusarium graminearum dsRNA mycovirus 4 (D0TZ31)
Maliogka, V.I.; Dovas, C.I.; Lotos, L.; Efthimiou, K.; Katis, N.I.
Complete genome analysis and immunodetection of a member of a novel virus species belonging to the genus Ampelovirus
Arch. Virol.
154
209-218
2009
Grapevine leafroll-associated virus
Li, L.; Tian, Q.; Du, Z.; Duns, G.J.; Chen, J.
A novel double-stranded RNA virus detected in Primula malacoides is a plant-isolated partitivirus closely related to partitivirus infecting fungal species
Arch. Virol.
154
565-572
2009
Primula malacoides virus China/Mar2007 (A8W7G1)
Bag, S.; Druffel, K.L.; Pappu, H.R.
Structure and genome organization of the large RNA of iris yellow spot virus (genus Tospovirus, family Bunyaviridae)
Arch. Virol.
155
275-279
2009
Iris yellow spot virus (C0KQW8), Iris yellow spot virus
Dhar, A.K.; Lakshman, D.K.; Amundsen, K.; Robles-Sikisaka, R.; Kaizer, K.N.; Roy, S.; Hasson, K.W.; Thomas Allnutt, F.C.
Characterization of a Taura syndrome virus isolate originating from the 2004 Texas epizootic in cultured shrimp
Arch. Virol.
155
315-327
2010
Taura syndrome virus
Zhang, S.; Weng, L.; Geng, L.; Wang, J.; Zhou, J.; Deubel, V.; Buchy, P.; Toyoda, T.
Biochemical and kinetic analysis of the influenza virus RNA polymerase purified from insect cells
Biochem. Biophys. Res. Commun.
391
570-574
2009
influenza A virus
Ellis, D.A.; Blazel, J.K.; Tran, C.V.; Ruebsam, F.; Murphy, D.E.; Li, L.S.; Zhao, J.; Zhou, Y.; McGuire, H.M.; Xiang, A.X.; Webber, S.E.; Zhao, Q.; Han, Q.; Kissinger, C.R.; Lardy, M.; Gobbi, A.; Showalter, R.E.; Shah, A.M.; Tsan, M.; Patel, R.A.; LeBrun, L.A.; Kamran, R.; Bartkowski, D.M.; Nolan, T.G.; Norris, D.A.; S, S.e.
5,5- and 6,6-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
Bioorg. Med. Chem. Lett.
19
6047-6052
2009
Hepacivirus C (P26663), Hepacivirus C
Tonelli, M.; Vazzana, I.; Tasso, B.; Boido, V.; Sparatore, F.; Fermeglia, M.; Paneni, M.S.; Posocco, P.; Pricl, S.; La Colla, P.; Ibba, C.; Secci, B.; Collu, G.; Loddo, R.
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives
Bioorg. Med. Chem.
17
4425-4440
2009
Chlorocebus aethiops, Bos taurus, Cricetulus griseus, Human alphaherpesvirus 1, Homo sapiens, Reovirus sp., Yellow fever virus, Coxsackievirus B2, Respiratory syncytial virus, Bovine viral diarrhea virus 1 (P19711), Bovine viral diarrhea virus 1
Tang, X.; Li, G.; Vasilakis, N.; Zhang, Y.; Shi, Z.; Zhong, Y.; Wang, L.F.; Zhang, S.
Differential stepwise evolution of SARS coronavirus functional proteins in different host species
BMC Evol. Biol.
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52
2009
Severe acute respiratory syndrome-related coronavirus
Paschal, B.M.; McReynolds, L.A.; Noren, C.J.; Nichols, N.M.
RNA polymerases
Curr. Protoc. Mol. Biol.
Chapter 3
Unit3.8
2008
Cystovirus phi6
Fuentes, S.M.; Sun, D.; Schmitt, A.P.; He, B.
Phosphorylation of paramyxovirus phosphoprotein and its role in viral gene expression
Future Microbiol.
5
9-13
2010
Measles morbillivirus, Human respirovirus 3, Mumps orthorubulavirus, Respiratory syncytial virus, Nipah henipavirus, Hendra henipavirus
Gent, J.I.; Schvarzstein, M.; Villeneuve, A.M.; Gu, S.G.; Jantsch, V.; Fire, A.Z.; Baudrimont, A.
A Caenorhabditis elegans RNA-directed RNA polymerase in sperm development and endogenous RNA interference
Genetics
183
1297-1314
2009
Caenorhabditis elegans, Caenorhabditis elegans Bristol N2
Liu, Z.; Robida, J.M.; Chinnaswamy, S.; Yi, G.; Robotham, J.M.; Nelson, H.B.; Irsigler, A.; Kao, C.C.; Tang, H.
Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A
Hepatology
50
25-33
2009
Hepacivirus C (P26663), Hepacivirus C
Esmaeili, F.
Enhancement of RNA interference effect in P19 EC cells by an RNA-dependent RNA polymerase
Iran. Biomed. J.
13
19-25
2009
Caenorhabditis elegans
Kumar, D.; Chaudhury, I.; Kar, P.; Das, R.H.
Site-specific cleavage of HCV genomic RNA and its cloned core and NS5B genes by DNAzyme
J. Gastroenterol. Hepatol.
24
872-878
2009
Hepacivirus C (Q0G9P7), Hepacivirus C
Nygardas, M.; Vuorinen, T.; Aalto, A.P.; Bamford, D.H.; Hukkanen, V.
Inhibition of coxsackievirus B3 and related enteroviruses by antiviral short interfering RNA pools produced using phi6 RNA-dependent RNA polymerase
J. Gen. Virol.
90
2468-2473
2009
Cystovirus phi6
Kanamori, H.; Yuhashi, K.; Ohnishi, S.; Koike, K.; Kodama, T.
RNA dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand
J. Gen. Virol.
91
1207-1212
2010
Hepacivirus C, Hepacivirus C NS5B
Agudo, R.; Arias, A.; Pariente, N.; Perales, C.; Escarmis, C.; Jorge, A.; Marina, A.; Domingo, E.
Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis
J. Mol. Biol.
382
652-666
2008
Foot-and-mouth disease virus
Cannon, N.A.; Donlin, M.J.; Mayes, L.M.; Lyra, A.C.; Di Bisceglie, A.M.; Tavis, J.E.
Evidence for action of ribavirin through the hepatitis C virus RNA polymerase
J. Viral Hepat.
16
595-604
2009
Hepacivirus C (P26663), Hepacivirus C
Kim, S.J.; Kim, J.H.; Sun, J.M.; Kim, M.G.; Oh, J.W.
Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase
J. Viral Hepat.
16
697-704
2009
Hepacivirus C
Hass, M.; Lelke, M.; Busch, C.; Becker-Ziaja, B.; Guenther, S.
Mutational evidence for a structural model of the Lassa virus RNA polymerase domain and identification of two residues, Gly1394 and Asp1395, that are critical for transcription but not replication of the genome
J. Virol.
82
10207-10217
2008
Lassa mammarenavirus
Stapleford, K.A.; Rapaport, D.; Miller, D.J.
Mitochondrion-enriched anionic phospholipids facilitate flock house virus RNA polymerase membrane association
J. Virol.
83
4498-4507
2009
Flock house virus
Kakugawa, S.; Shimojima, M.; Neumann, G.; Goto, H.; Kawaoka, Y.
RuvB-like protein 2 is a suppressor of influenza A virus polymerases
J. Virol.
83
6429-6434
2009
influenza A virus
Ciancanelli, M.J.; Volchkova, V.A.; Shaw, M.L.; Volchkov, V.E.; Basler, C.F.
Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism
J. Virol.
83
7828-7841
2009
Nipah henipavirus
Hyde, J.L.; Sosnovtsev, S.V.; Green, K.Y.; Wobus, C.; Virgin, H.W.; Mackenzie, J.M.
Mouse norovirus replication is associated with virus-induced vesicle clusters originating from membranes derived from the secretory pathway
J. Virol.
83
9709-9719
2009
Murine norovirus 1
Huet, S.; Avilov, S.V.; Ferbitz, L.; Daigle, N.; Cusack, S.; Ellenberg, J.
Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy
J. Virol.
84
1254-1264
2010
influenza A virus
Mansilla, C.; Sanchez, F.; Padgett, H.S.; Pogue, G.P.; Ponz, F.
Chimeras between oilseed rape mosaic virus and tobacco mosaic virus highlight the relevant role of the tobamoviral RdRp as pathogenicity determinant in several hosts
Mol. Plant Pathol.
10
59-68
2009
tobacco mosaic virus, Chinese Rape Mosaic Virus
Obayashi, E.; Yoshida, H.; Kawai, F.; Shibayama, N.; Kawaguchi, A.; Nagata, K.; Tame, J.R.; Park, S.Y.
The structural basis for an essential subunit interaction in influenza virus RNA polymerase
Nature
454
1127-1131
2008
influenza A virus (P03433), influenza A virus
Dias, A.; Bouvier, D.; Crepin, T.; McCarthy, A.A.; Hart, D.J.; Baudin, F.; Cusack, S.; Ruigrok, R.W.
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
Nature
458
914-918
2009
influenza A virus (P31343), influenza A virus Victoria/3/1975 H3N2 (P31343)
Sarin, L.P.; Poranen, M.M.; Lehti, N.M.; Ravantti, J.J.; Koivunen, M.R.; Aalto, A.P.; van Dijk, A.A.; Stuart, D.I.; Grimes, J.M.; Bamford, D.H.
Insights into the pre-initiation events of bacteriophage phi 6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex
Nucleic Acids Res.
37
1182-1192
2009
Cystovirus phi6
Tantikanjana, T.; Rizvi, N.; Nasrallah, M.E.; Nasrallah, J.B.
A dual role for the S-locus receptor kinase in self-incompatibility and pistil development revealed by an Arabidopsis rdr6 mutation
Plant Cell
21
2642-2654
2009
Arabidopsis thaliana (Q9LKP0), Arabidopsis thaliana
Liu, Y.; Gao, Q.; Wu, B.; Ai, T.; Guo, X.
NgRDR1, an RNA-dependent RNA polymerase isolated from Nicotiana glutinosa, was involved in biotic and abiotic stresses
Plant Physiol. Biochem.
47
359-368
2009
Nicotiana glutinosa (C1I213), Nicotiana glutinosa
Guo, X.; Zhang, Z.; Gerstein, M.B.; Zheng, D.
Small RNAs originated from pseudogenes: cis- or trans-acting?
PLoS Comput. Biol.
5
e1000449
2009
Oryza sativa
Hale, C.J.; Erhard, K.F.; Lisch, D.; Hollick, J.B.
Production and processing of siRNA precursor transcripts from the highly repetitive maize genome
PLoS Genet.
5
e1000598
2009
Zea mays
Douet, J.; Tutois, S.; Tourmente, S.
A Pol V-mediated silencing, independent of RNA-directed DNA methylation, applies to 5S rDNA
PLoS Genet.
5
e1000690
2009
Arabidopsis thaliana
Qi, X.; Bao, F.S.; Xie, Z.
Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis
PLoS ONE
4
e4971
2009
Arabidopsis thaliana
Kashiwagi, T.; Leung, B.W.; Deng, T.; Chen, H.; Brownlee, G.G.
The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding
PLoS ONE
4
e5473
2009
influenza A virus
Wu, B.; Pogany, J.; Na, H.; Nicholson, B.L.; Nagy, P.D.; White, K.A.
A discontinuous RNA platform mediates RNA virus replication: building an integrated model for RNA-based regulation of viral processes
PLoS Pathog.
5
e1000323
2009
tomato bushy stunt virus
Lipardi, C.; Paterson, B.M.
Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression
Proc. Natl. Acad. Sci. USA
106
15645-15650
2009
Drosophila melanogaster
Spagnolo, J.F.; Rossignol, E.; Bullitt, E.; Kirkegaard, K.
Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays
RNA
16
382-393
2010
Enterovirus C
Valles, S.M.; Hashimoto, Y.
Isolation and characterization of Solenopsis invicta virus 3, a new positive-strand RNA virus infecting the red imported fire ant, Solenopsis invicta
Virology
388
354-361
2009
Solenopsis invicta virus 3 (C1JCT1), Solenopsis invicta virus 3
Gursinsky, T.; Schulz, B.; Behrens, S.E.
Replication of Tomato bushy stunt virus RNA in a plant in vitro system
Virology
390
250-260
2009
tomato bushy stunt virus
Cai, G.; Myers, K.; Hillman, B.I.; Fry, W.E.
A novel virus of the late blight pathogen, Phytophthora infestans, with two RNA segments and a supergroup 1 RNA-dependent RNA polymerase
Virology
392
52-61
2009
Phytophthora infestans RNA virus 1
Valles, S.M.; Allen, C.; Varone, L.; Briano, J.
Complete genome sequence of an Argentinean isolate of Solenopsis invicta virus 3
Virus Genes
40
293-297
2009
Solenopsis invicta virus 3 (D2JRZ3), Solenopsis invicta virus 3
McGavin, W.J.; Macfarlane, S.A.
Rubus chlorotic mottle virus, a new sobemovirus infecting raspberry and bramble
Virus Res.
139
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2009
Sowbane mosaic virus (B5DC58), Sowbane mosaic virus
Villordo, S.M.; Gamarnik, A.V.
Genome cyclization as strategy for flavivirus RNA replication
Virus Res.
139
230-239
2009
Dengue virus, Japanese encephalitis virus, Yellow fever virus, Saint Louis encephalitis virus, West Nile virus (P06935), Japanese encephalitis virus JEV, Saint Louis encephalitis virus SLEV, Dengue virus DENV, West Nile virus WNV (P06935)
Aoki, N.; Moriyama, H.; Kodama, M.; Arie, T.; Teraoka, T.; Fukuhara, T.
A novel mycovirus associated with four double-stranded RNAs affects host fungal growth in Alternaria alternata
Virus Res.
140
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2009
Alternaria alternata virus 1
Ahn, D.G.; Choi, J.K.; Taylor, D.R.; Oh, J.W.
Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
Arch. Virol.
157
2095-2104
2012
Severe acute respiratory syndrome-related coronavirus (P0C6X7), Severe acute respiratory syndrome-related coronavirus
Shatskaya, G.S.; Drutsa, V.L.; Koroleva, O.N.; Osterman, I.A.; Dmitrieva, T.M.
Investigation of activity of recombinant mengovirus RNA-dependent RNA polymerase and its mutants
Biochemistry (Moscow)
78
96-101
2013
Mengo virus
Carta, A.; Briguglio, I.; Piras, S.; Corona, P.; Boatto, G.; Nieddu, M.; Giunchedi, P.; Marongiu, M.E.; Giliberti, G.; Iuliano, F.; Blois, S.; Ibba, C.; Busonera, B.; La Colla, P.
Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors
Bioorg. Med. Chem.
19
7070-7084
2011
Bovine viral diarrhea virus 1, Hepacivirus C
Lin, M.; Ye, S.; Xiong, Y.; Cai, D.; Zhang, J.; Hu, Y.
Expression and characterization of RNA-dependent RNA polymerase of Ectropis obliqua virus
BMB Rep.
43
284-290
2010
Ectropis obliqua picorna-like virus
Duan, G.; Saint, R.B.; Helliwell, C.A.; Behm, C.A.; Wang, M.B.; Waterhouse, P.M.; Gordon, K.H.
C. elegans RNA-dependent RNA polymerases rrf-1 and ego-1 silence Drosophila transgenes by differing mechanisms
Cell. Mol. Life Sci.
70
1469-1481
2013
Caenorhabditis elegans (G5EBQ3), Caenorhabditis elegans (G5ECM1), Caenorhabditis elegans
Jin, Z.; Leveque, V.; Ma, H.; Johnson, K.A.; Klumpp, K.
Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex
J. Biol. Chem.
287
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2012
Hepacivirus C (AJ242654), Hepacivirus C
Mastrangelo, E.; Pezzullo, M.; Tarantino, D.; Petazzi, R.; Germani, F.; Kramer, D.; Robel, I.; Rohayem, J.; Bolognesi, M.; Milani, M.
Structure-based inhibition of norovirus RNA-dependent RNA polymerases
J. Mol. Biol.
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norovirus, Murine norovirus
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Arabidopsis thaliana (Q9SG02), Arabidopsis thaliana
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Arabidopsis thaliana (Q9LQV2), Arabidopsis thaliana (Q9SG02), Arabidopsis thaliana
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West Nile virus (Q8JU43), West Nile virus, West Nile virus 3356 (Q8JU43)
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Japanese encephalitis virus, West Nile virus, Yellow fever virus, Dengue virus type 3, Tick-borne encephalitis virus (Q01299), Zika virus (Q32ZE1)
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Zika virus
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Hepacivirus C (O92972), Hepacivirus C
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Bovine viral diarrhea virus 1
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Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
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Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
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Oryza sativa RNA-dependent RNA polymerase 6 contributes to double-strand break formation in meiosis
Plant Cell
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Oryza sativa
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RNA-dependent RNA polymerases of both virulent and benign rabbit Caliciviruses induce striking rearrangement of Golgi membranes
PLoS ONE
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Rabbit hemorrhagic disease virus, Rabbit calicivirus
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Norovirus RNA-dependent RNA polymerase A computational study of metal-binding preferences
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Norwalk virus
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Enterovirus A71 (E5RPG2), Enterovirus A71
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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Science
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2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Gao, Y.; Yan, L.; Huang, Y.; Liu, F.; Zhao, Y.; Cao, L.; Wang, T.; Sun, Q.; Ming, Z.; Zhang, L.; Ge, J.; Zheng, L.; Zhang, Y.; Wang, H.; Zhu, Y.; Zhu, C.; Hu, T.; Hua, T.; Zhang, B.; Yang, X.; Li, J.; Yang, H.; Liu, Z.; Xu, W.; Guddat, L.W.; Wang, Q.; Lou, Z.; Rao, Z.
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Science
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Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Liu, J.; Li, X.D.; Xu, S.
Single amino acid substitutions in the coat protein and RNA-dependent RNA polymerase alleviated the virulence of Cucumber green mottle mosaic virus and conferred cross protection against severe infection
Virus Genes
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2020
Cucumber green mottle mosaic virus
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Sesbania mosaic virus (Q9EB07), Sesbania mosaic virus
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Flavivirus RNA-dependent RNA polymerase interacts with genome UTRs and viral proteins to facilitate flavivirus RNA replication
Viruses
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929
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Japanese encephalitis virus, West Nile virus, Yellow fever virus, Dengue virus type 2, Dengue virus type 4, dengue virus type I, Zika virus, Dengue virus type 3
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