Reference on EC 2.7.7.50 - mRNA guanylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Myette J.R.; Niles E.G.
Characterization of the vaccinia virus RNA 5-triphosphatase and nucleoside triphosphate phosphohydrolase activities
J. Biol. Chem.
271
11945-11952
1996
Vaccinia virus
Martin, S.A.; Paoletti, E.; Moss, B.
Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions
J. Biol. Chem.
250
9322-9329
1975
Vaccinia virus, Vaccinia virus WR
Martin, S.A.; Moss, B.
Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions
J. Biol. Chem.
250
9330-9335
1975
Vaccinia virus
Ensinger, M.J.; Martin, S.A.; Paoletti, E.; Moss, B.
Modification of the 5-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus
Proc. Natl. Acad. Sci. USA
72
2525-2529
1975
Vaccinia virus
Martin, S.A.; Moss, B.
mRNA guanylyltransferase and mRNA (guanine-7-)-methyltransferase from vaccinia virions. Donor and acceptor substrate specificites
J. Biol. Chem.
251
7313-7321
1976
Vaccinia virus
Monroy, G.; Spencer, E.; Hurwitz, J.
Purification of mRNA guanylyltransferase from vaccinia virions
J. Biol. Chem.
253
4481-4489
1978
Vaccinia virus
Itho, N.; Yamada, H.; Kaziro, Y.; Mizumoto, K.
Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization
J. Biol. Chem.
262
1989-1995
1987
Saccharomyces cerevisiae
Groner, Y.; Aviv, H.
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates
Biochemistry
17
977-982
1978
Homo sapiens
Shibagaki, Y.; Gilboa, E.; Itho, N.; Yamada, H.; Nagata, S.; Mizumoto, K.
mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae
J. Biol. Chem.
267
9521-9528
1992
Saccharomyces cerevisiae
Shuman, S.; Hurwitz, J.
Capping enzyme
The Enzymes, 3rd. Ed. (Boyer, P. D. , ed. )
15
245-265
1982
Homo sapiens, Rattus norvegicus, Vaccinia virus
-
Dunigan, D.D.; Zaitlin, M.
Capping of tobacco mosaic virus RNA. Analysis of viral-coded guanylyltransferase-like activity
J. Biol. Chem.
265
7779-7786
1990
tobacco mosaic virus
Shuman, S.
Catalytic activity of vaccinia mRNA capping enzyme subunits coexpressed in Escherichia coli
J. Biol. Chem.
265
11960-11966
1990
Vaccinia virus
Shuman, S.; Morham, S.G.
Domain structure of vaccinia virus mRNA capping enzyme. Activity of the Mr 95,000 subunit expressed in Escherichia coli
J. Biol. Chem.
265
11967-11972
1990
Vaccinia virus
Itoh, N.; Mizumoto, K.; Kaziro, Y.
Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. I. Purification and subunit structure
J. Biol. Chem.
259
13923-13929
1984
Saccharomyces cerevisiae
Itoh, N.; Mizumoto, K.; Kaziro, Y.
Messenger RNA guanlyltransferase from Saccharomyces cerevisiae. II. Catalytic properties
J. Biol. Chem.
259
13930-13936
1984
Saccharomyces cerevisiae
Wang, D.; Shatkin, A.J.
Synthesis of Gp4N and Gp3N compounds by guanylyltransferase purified from yeast
Nucleic Acids Res.
12
2303-2315
1984
Saccharomyces cerevisiae
Itoh, N.; Mizumoto, K.; Kaziro, Y.
Partial purification and characterization of mRNA guanylyltransferase from Saccharomyces cerevisiae
FEBS Lett.
155
161-166
1983
Saccharomyces cerevisiae
Nishikawa, Y.; Chambon, P.
Purification of mRNA guanylyltransferase from calf thymus
EMBO J.
1
485-492
1982
Bos taurus
Keith, J.M.; Venkatesan, S.; Gershowitz, A.; Moss, B.
Purification and characterization of the messenger ribonucleic acid capping enzyme GTP:RNA guanylyltransferase from wheat germ
Biochemistry
21
327-333
1982
Triticum aestivum
Venkatesan, S.; Gershowitz, A.; Moss, B.
Purification and characterization of mRNA guanylyltransferase from HeLa cell nuclei
J. Biol. Chem.
255
2829-2834
1980
Homo sapiens
Vankatesan, S.; Moss, B.
Donor and acceptor specificities of HeLa cell mRNA guanylyltransferase
J. Biol. Chem.
255
2835-2842
1990
Homo sapiens
Mao, Z.; Joklik, W.K.
Isolation and enzymatic characterization of protein lambda 2, the reovirus guanylyltransferase
Virology
185
377-386
1991
Mammalian orthoreovirus 3, Mammalian orthoreovirus 3 Dearing
Monroy, G.; Spencer, E.; Hurwitz, J.
Characteristics of reactions catalyzed by purified guanylyltransferase from vaccinia virus
J. Biol. Chem.
253
4490-4498
1978
Vaccinia virus
Fresco, L.D.; Buratowski, S.
Active site of the mRNA-capping enzyme guanylyltransferase from Saccharomyces cerevisiae: similarity to the nucleotidyl attachment motif of DNA and RNA ligases
Proc. Natl. Acad. Sci. USA
91
6624-6628
1994
Saccharomyces cerevisiae
Myette, J.R.; Niles, E.g.
Domain structure of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli of a subdomain possessing the RNA 5'-triphosphatase and guanylyltransferase activities and a kinetic comparison to the full-size enzyme
J. Biol. Chem.
271
11936-11944
1996
Vaccinia virus
Yue, Z.; Maldonado, E.; Pillutla, R.; Cho, H.; Reinberg, D.; Shatkin, A.J.
Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II
Proc. Natl. Acad. Sci. USA
94
12898-12903
1997
Homo sapiens (O60942), Homo sapiens, Mus musculus (O55236), Mus musculus
Yamada-Okabe, T.; Mio, T.; Matsui, M.; Kashima, Y.; Arisawa, M.; Yamada-Okabe, H.
Isolation and characterization of the Candida albicans gene for mRNA 5'-triphosphatase: association of mRNA 5'-triphosphatase and mRNA 5'-guanylyltransferase activities is essential for the function of mRNA 5'-capping enzyme in vivo
FEBS Lett.
435
49-54
1998
Saccharomyces cerevisiae
Ho, C.K.; Sriskanda, V.; McCracken, S.; Bentley, D.; Schwer, B.; Shuman, S.
The guanylyltransferase domain of mammalian mRNA capping enzyme binds to the phosphorylated carboxyl-terminal domain of RNA polymerase II
J. Biol. Chem.
273
9577-9585
1998
Mus musculus (O55236), Mus musculus
Hakansson, K.; Wigley, D.B.
Structure of a complex between a cap analog and mRNA guanylyl transferase demonstrates the structural chemistry of RNA capping
Proc. Natl. Acad. Sci. USA
95
1505-1510
1998
Paramecium bursaria Chlorella virus 1
Ho, C.K.; Schwer, B.; Shuman, S.
Genetic, physical, and functional interactions between the triphosphatase and guanylyltransferase components of the yeast mRNA capping apparatus
Mol. Cell. Biol.
18
5189-5198
1998
Saccharomyces cerevisiae
Martinez-Costas, J.; Sutton, G.; Ramadevi, N.; Roy, P.
Guanylyltransferase and RNA 5'-triphosphatase activities of the purified expressed VP4 protein of bluetongue virus
J. Mol. Biol.
280
859-866
1998
bluetongue virus serotype 10
Guarino, L.A.; Jin, J.; Dong, W.
Guanylyltransferase activity of the LEF-4 subunit of baculovirus RNA polymerase
J. Virol.
72
10003-10010
1998
Autographa californica nucleopolyhedrovirus
Luongo, C.L.; Reinisch, K.M.; Harrison, S.C.; Nibert, M.L.
Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein l2
J. Biol. Chem.
275
2804-2810
2000
Mammalian orthoreovirus 3, Mammalian orthoreovirus 3 Dearing
Tiggemann, M.; Jeske, S.; Larsen, M.; Meinhardt, F.
Kluyveromyces lactis cytoplasmic plasmid pGKL2: heterologous expression of Orf3p and proof of guanylyltransferase and mRNA-triphosphatase activities
Yeast
18
815-825
2001
Kluyveromyces lactis
Hsiao, J.; Martinez-Costas, J.; Benavente, J.; Vakharia, V.N.
Cloning, Expression, and Characterization of Avian Reovirus Guanylyltransferase
Virology
296
288-299
2002
Avian orthoreovirus, Avian orthoreovirus 1733
Bougie, I.; Parent, A.; Bisaillon, M.
Thermodynamics of ligand binding by the yeast mRNA-capping enzyme reveals different modes of binding
Biochem. J.
384
411-420
2004
Saccharomyces cerevisiae
Bougie, I.; Bisaillon, M.
The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme
J. Biol. Chem.
279
22124-22130
2004
Vaccinia virus
Hausmann, S.; Altura, M.A.; Witmer, M.; Singer, S.M.; Elmendorf, H.G.; Shuman, S.
Yeast-like mRNA capping apparatus in Giardia lamblia
J. Biol. Chem.
280
12077-12086
2005
Cyanidioschyzon merolae, Cyanidioschyzon merolae CMA035C, Giardia intestinalis
Jaafar, F.M.; Attoui, H.; Mertens, P.P.C.; de Micco, P.; de Lamballerie, X.
Identification and functional analysis of VP3, the guanylyltransferase of Banna virus (genus Seadornavirus, family Reoviridae)
J. Gen. Virol.
86
1141-1146
2005
Banna virus (Q9INI4), Banna virus
Huang, Y.L.; Han, Y.T.; Chang, Y.T.; Hsu, Y.H.; Meng, M.
Critical residues for GTP methylation and formation of the covalent m7GMP-enzyme intermediate in the capping enzyme domain of bamboo mosaic virus
J. Virol.
78
1271-1280
2004
bamboo mosaic virus
Takagi, Y.; Sindkar, S.; Ekonomidis, D.; Hall, M.P.; Ho, C.K.
Trypanosoma brucei encodes a bifunctional capping enzyme essential for cap 4 formation on the spliced leader RNA
J. Biol. Chem.
282
15995-16005
2007
Trypanosoma brucei
Souliere, M.F.; Perreault, J.P.; Bisaillon, M.
Kinetic and thermodynamic characterization of the RNA guanylyltransferase reaction
Biochemistry
47
3863-3874
2008
Paramecium bursaria Chlorella virus 1
Benarroch, D.; Smith, P.; Shuman, S.
Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain
Structure
16
501-512
2008
Acanthamoeba polyphaga Mimivirus (Q5UQX1)
Swift, R.V.; Ong, C.D.; Amaro, R.E.
Magnesium-induced nucleophile activation in the guanylyltransferase mRNA capping enzyme
Biochemistry
51
10236-10243
2012
Paramecium bursaria Chlorella virus 1 (Q84424)
Lin, H.Y.; Yu, C.Y.; Hsu, Y.H.; Meng, M.
Functional analysis of the conserved histidine residue of Bamboo mosaic virus capping enzyme in the activity for the formation of the covalent enzyme-m7GMP intermediate
FEBS Lett.
586
2326-2331
2012
bamboo mosaic virus
Stahla-Beek, H.J.; April, D.G.; Saeedi, B.J.; Hannah, A.M.; Keenan, S.M.; Geiss, B.J.
Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme
J. Virol.
86
8730-8739
2012
Yellow fever virus (P03314), Yellow fever virus, Dengue virus (P29990), Dengue virus, Dengue virus 16681 (P29990)
Picard-Jean, F.; Bougie, I.; Shuto, S.; Bisaillon, M.
The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme
PLoS ONE
8
e54621
2013
Homo sapiens (O60942), Homo sapiens
Chu, C.; Das, K.; Tyminski, J.R.; Bauman, J.D.; Guan, R.; Qiu, W.; Montelione, G.T.; Arnold, E.; Shatkin, A.J.
Structure of the guanylyltransferase domain of human mRNA capping enzyme
Proc. Natl. Acad. Sci. USA
108
10104-10108
2011
Homo sapiens (O60942), Homo sapiens
Hu, R.; Lin, M.; Hsu, Y.; Meng, M.
Mutational effects of the consensus aromatic residues in the mRNA capping domain of Bamboo mosaic virus on GTP methylation and virus accumulation
Virology
411
15-24
2011
bamboo mosaic virus
Doamekpor, S.K.; Sanchez, A.M.; Schwer, B.; Shuman, S.; Lima, C.D.
How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes
Genes Dev.
28
1323-1336
2014
Schizosaccharomyces pombe (P40997), Schizosaccharomyces pombe, Schizosaccharomyces pombe ATCC 24843 (P40997)
Bullard-Feibelman, K.M.; Fuller, B.P.; Geiss, B.J.
A sensitive and robust high-throughput screening assay for inhibitors of the Chikungunya virus nsP1 capping enzyme
PLoS ONE
11
e0158923
2016
Chikungunya virus (Q1H8W7), Chikungunya virus
Issur, M.; Bougie, I.; Despins, S.; Bisaillon, M.
Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism
PLoS ONE
8
e75310
2013
Paramecium bursaria Chlorella virus 1 (Q84424)
Takizawa, N.; Fujiwara, T.; Yamasaki, M.; Saito, A.; Fukao, A.; Nomoto, A.; Mizumoto, K.
The essential role for the RNA triphosphatase Cet1p in nuclear import of the mRNA capping enzyme Cet1p-Ceg1p complex of Saccharomyces cerevisiae
PLoS ONE
8
e78000
2013
Saccharomyces cerevisiae (Q01159), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q01159)
Bharati, A.P.; Singh, N.; Kumar, V.; Kashif, M.; Singh, A.K.; Singh, P.; Singh, S.K.; Siddiqi, M.I.; Tripathi, T.; Akhtar, M.S.
The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II
Sci. Rep.
6
31294
2016
Saccharomyces cerevisiae (Q01159), Saccharomyces cerevisiae
Kyrieleis, O.J.; Chang, J.; de la Pena, M.; Shuman, S.; Cusack, S.
Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus
Structure
22
452-465
2014
Vaccinia virus (P04298), Vaccinia virus, Vaccinia virus Western Reserve (P04298)
Tate, J.; Boldt, R.L.; McFadden, B.D.; DCosta, S.M.; Lewandowski, N.M.; Shatzer, A.N.; Gollnick, P.; Condit, R.C.
Biochemical analysis of the multifunctional vaccinia mRNA capping enzyme encoded by a temperature sensitive virus mutant
Virology
487
27-40
2016
Vaccinia virus (P04298), Vaccinia virus, Vaccinia virus IHDW (P04298)
Sen, R.; Kaja, A.; Ferdoush, J.; Lahudkar, S.; Barman, P.; Bhaumik, S.R.
An mRNA capping enzyme targets FACT to the active gene to enhance the engagement of RNA polymerase II into transcriptional elongation
Mol. Cell. Biol.
37
e00029-17
2017
Saccharomyces cerevisiae, Saccharomyces cerevisiae YSB709
Hoefer, K.; Li, S.; Abele, F.; Frindert, J.; Schlotthauer, J.; Grawenhoff, J.; Du, J.; Patel, D.; Jaeschke, A.
Structure and function of the bacterial decapping enzyme NudC
Nat. Chem. Biol.
12
730-734
2016
Escherichia coli
-
Ramanathan, A.; Robb, G.; Chan, S.
mRNA capping Biological functions and applications
Nucleic Acids Res.
44
7511-7526
2016
Mus musculus
Mullen, N.J.; Price, D.H.
Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function
PLoS ONE
12
e0186423
2017
Homo sapiens
Fujiwara, R.; Damodaren, N.; Wilusz, J.; Murakami, K.
The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation
Proc. Natl. Acad. Sci. USA
116
22573-22582
2019
Saccharomyces cerevisiae
Chen, P.; Zhou, Z.; Yao, X.; Pang, S.; Liu, M.; Jiang, W.; Jiang, J.; Zhang, Q.
Capping enzyme mRNA-cap/RNGTT regulates hedgehog pathway activity by antagonizing protein kinase A
Sci. Rep.
7
2891
2017
Drosophila melanogaster
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