Reference on EC 2.7.7.7 - DNA-directed DNA polymerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Forterre, P.; Elie, C.; Sioud, M.; Hamal, A.
Studies on DNA polymerases and topoisomerases in archaebacteria
Can. J. Microbiol.
35
228-233
1989
Sulfolobus acidocaldarius, Thermoplasma acidophilum
Wei, X.; Peterson, D.L.
Expression, purification and characterization of an active RNase H domain of the Hepatitis B viral polymerase
J. Biol. Chem.
271
32617-32622
1996
Hepatitis B virus (P03156)
Murakami, E.; Feng, J.Y.; Lee, H.; Hanes, J.; Johnson, K.A.; Anderson, K.S.
Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication
J. Biol. Chem.
278
36403-36409
2003
Homo sapiens
Fisher, P.A.
Enzymologic mechanism of replicative DNA polymerases in higher eukaryotes
Prog. Nucleic Acid Res. Mol. Biol.
47
371-397
1994
Drosophila melanogaster, Homo sapiens
Wang, T.S.F.
Eukaryotic DNA polymerases
Annu. Rev. Biochem.
60
513-552
1991
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Drosophila melanogaster, Homo sapiens, Mammalia, Rattus norvegicus, Xenopus laevis
Kornberg, T.; Kornberg, A.
Bacterial DNA polymerases
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
10
119-144
1974
Bacillus subtilis, Bacteria, Escherichia coli, Micrococcus luteus
-
Lehman, R.
DNA polymerase I of Escherichia coli
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
14
15-37
1981
Escherichia coli
-
McHenry, C.; Kornberg, A.
DNA polymerase III holoenzyme
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
14
39-65
1981
Escherichia coli
-
Lehman, R.
T-phage polymerases
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
14
51-65
1981
Tequatrovirus T4, Tequintavirus T5, Escherichia phage T7
-
Weissbach, A.
Cellular and viral-induced eukaryotic polymerases
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
14
67-86
1981
Bos taurus, Gallus gallus, Herpes simplex virus, Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus, Vaccinia virus
-
Setlow, P.
DNA polymerase I from Escherichia coli
Methods Enzymol.
29
3-12
1974
Escherichia coli
Moses, R.E.
The isolation and properties of DNA polymerase II from Escherichia coli
Methods Enzymol.
29
13-22
1974
Escherichia coli
Kornberg, T.; Gefter, M.L.
Deoxyribonucleic acid polymerase II (Escherichia coli K12)
Methods Enzymol.
29
22-26
1974
Escherichia coli
Gass, K.B.; Cozzarelli, N.R.
Bacillus subtilis DNA polymerases
Methods Enzymol.
29
27-38
1974
Bacillus subtilis
Hamilton, L.D.G.
The purification of the DNA polymerase from Micrococcus luteus
Methods Enzymol.
29
38-45
1974
Micrococcus luteus
Fansler, B.S.; Loeb, L.A.
Sea urchin nuclear DNA polymerase
Methods Enzymol.
29
53-70
1974
Strongylocentrotus purpuratus, Mesocentrotus franciscanus
Bollum, F.J.; Chang, L.M.S.; Tsiapalis, C.M.; Dorson, J.W.
Nucleotide polymerizing enzymes from calf thymus gland
Methods Enzymol.
29
70-81
1974
Bos taurus
Sedwick, W.D.; Wang, T.S.F.; Korn, D.
The DNA polymerases of KB cells
Methods Enzymol.
29
89-102
1974
Homo sapiens
Spampinato, C.P.; Pairoba, C.F.; Colombo, S.L.; Benediktsson, I.; Andreo, C.S.
Properties of DNA polymerase from petunia "Mitchell" chloroplasts. Inhibitory effects of flavonoids
Biosci. Biotechnol. Biochem.
58
822-825
1994
Ruellia sp.
-
Falaschi, A.; Kornberg, A.
Biochemical studies of bacterial sporulation. II. Deoxyribonucleic acid polymerase in spores of Bacillus subtilis
J. Biol. Chem.
241
1478-1482
1966
Bacillus subtilis
Lehman, I.R.; Bessman, M.J.; Simms, E.S.; Kornberg, A.
Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli
J. Biol. Chem.
233
163-170
1958
Escherichia coli
Lehman, I.R.; Karguni, L.S.
DNA polymerase alpha
J. Biol. Chem.
264
4265-4268
1989
Chlorocebus aethiops, Bos taurus, Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mammalia, Mus musculus
Bambara, R.A.; Jessee, C.B.
Properties of DNA polymerases delta and epsilon, and their roles in eukaryotic DNA replication
Biochim. Biophys. Acta
1088
11-24
1991
Bos taurus, Saccharomyces cerevisiae, Oryctolagus cuniculus, Homo sapiens, Mammalia, Mus musculus
Hbscher, U.
DNA polymerase holoenzymes
Trends Biochem. Sci.
9
390-393
1984
Bos taurus, Drosophila melanogaster, Escherichia coli
-
Weissbach, A.
The functional roles of mammalian DNA polymerase
Arch. Biochem. Biophys.
198
386-396
1979
Homo sapiens, Mammalia
Davies II, J.F.; Almassy, R.J.; Hostomska, Z.; Ferre, R.A.; Hostomsky, Z.
2.3 A crystal structure of the catalytic domain of DNA polymerase beta
Cell
76
1123-1133
1994
Rattus norvegicus
Beese, L.S.; Friedman, J.M.; Steitz, T.A.
Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate
Biochemistry
32
14095-14101
1993
Escherichia coli (P00582), Escherichia coli
Shirakihara, Y.; Matsukage, A.; Nishimoto, Y.; Date, T.
Crystallization of 31 kDa C-terminal fragment of rat DNA polymerase beta
J. Mol. Biol.
235
1342-1344
1994
Rattus norvegicus
Pluthero, F.G.
Rapid purification of high-activity Taq DNA polymerase
Nucleic Acids Res.
21
4850-4851
1993
Thermus aquaticus, Thermus aquaticus INValphaF'
Brown, W.C.; Duncan, J.A.; Campbell, J.L.
Purification and characterization of the Saccharomyces cerevisiae DNA polymerase delta overproduced in Escherichia coli
J. Biol. Chem.
268
982-990
1993
Saccharomyces cerevisiae
Yang, C.L.; Chang, L.S.; Zhang, P.; Hao, H.; Zhu, L.; Toomey, N.L.; Lee, M.Y.W.T.
Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta
Nucleic Acids Res.
20
735-745
1992
Homo sapiens (P28340), Homo sapiens
Campos, L.R.; Suarez, M.; Vazquez, A.; de la Fuente, R.; Herrera, L.
Molecular cloning of the gene, expression in E. coli and purification of the Thermus aquaticus DNA polymerase I
Acta Biotechnol.
12
155-159
1992
Thermus aquaticus, Thermus aquaticus YT1
-
Kuchta, R.D.; Ilsley, D.; Kravig, K.D.; Schubert, S.; Harris, B.
Inhibition of DNA primase and polymerase alpha by arabinofuranosylnucleoside triphosphates and related compounds
Biochemistry
31
4720-4728
1992
Bos taurus
Wright, G.E.; Hbscher, U.; Khan, N.N.; Focher, F.; Verri, A.
Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon
FEBS Lett.
341
128-130
1994
Bos taurus
Simbulan, C.M.G.; Taki, T.; Tamiya-Koizumi, K.; Suzuki, M.; Savoysky, E.; Shoji, M.; Yoshida, S.
Sulfate- and sialic acid-containing glycolipids inhibit DNA polymerase alpha activity
Biochim. Biophys. Acta
1205
68-74
1994
Bos taurus
Khan, N.N.; Reha-Krantz, L.J.; Wright, G.E.
Analysis of inhibitors of bacteriophage T4 DNA polymerase
Nucleic Acids Res.
22
232-237
1994
Tequatrovirus T4
Murakami-Murofushi, K.; Shioda, M.; Kaji, K.; Yoshida, S.; Murofushi, H.
Inhibition of eukaryotic DNA polymerase alpha with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum
J. Biol. Chem.
267
21512-21517
1992
Bos taurus, Escherichia coli, Mammalia
Terry, B.J.; Liu, W.C.; Cianci, C.W.; Proszynski, E.; Fernandes, P.; Bush, K.; Meyers, E.
Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein
J. Antibiot.
45
286-288
1992
Escherichia coli, Herpes simplex virus, Homo sapiens
Taguchi, T.; Matsukage, A.; Ito, H.; Saito, Y.; Kawashima, S.
Inhibition of DNA polymerases by tripeptide derivative protease inhibitors
Biochem. Biophys. Res. Commun.
185
1133-1140
1992
Escherichia coli, Rattus norvegicus
Sen, S.; Mukhopadhyay, S.; Wetzel, J.; Biswas, T.K.
Characterization of the mitochondrial DNA polymerase from Saccharomyces cerevisiae
Acta Biochim. Pol.
41
79-86
1994
Saccharomyces cerevisiae
Shioda, M.; Kano, K.; Kobayashi, M.; Kitagawa, I.; Shoji, M.; Yoshida, S.; Ikegami, S.
Differential inhibition of eukaryotic DNA polymerases by halenaquinol sulfate, a p-hydroquinone sulfate obtained from a marine sponge
FEBS Lett.
350
249-252
1994
Escherichia coli, Mammalia
McDonald, W.F.; Traktman, P.
Overexpression and purification of the vaccinia virus DNA polymerase
Protein Expr. Purif.
5
409-421
1994
Vaccinia virus
Sawaya, M.R.; Pelletier, H.; Kumar, A.; Wilson, S.H.; Kraut, J.
Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism
Science
264
1930-1935
1994
Rattus norvegicus
Matsuda, S.; Takami, K.; Sono, A.; Sakaguchi, K.
A meiotic DNA polymerase from Coprinus cinereus: further purification and characterization
Chromosoma
102
631-636
1993
Coprinopsis cinerea
Aoyama, H.; Juca, M.B.; Castroviejo, M.; Litvak, S.
Inhibition of the wheat germ DNA polymerase A activity by the antiviral drug HPA-23
Plant Mol. Biol.
23
1055-1060
1993
Triticum aestivum
Makioka, A.; Stavros, B.; Ellis, J.T.; Johnson, A.M.
Detection and characterization of DNA polymerase activity in Toxoplasma gondii
Parasitology
107
135-139
1993
Toxoplasma gondii
-
Chavalitshewinkoon, P.; De Vries, E.; Stam, J.G.; Franssen, F.F.J.; Van der Vliet, P.C.; Overdulve, J.P.
Purification and characterization of DNA polymerases from Plasmodium falciparum
Mol. Biochem. Parasitol.
61
243-253
1993
Plasmodium falciparum
Sousa, R.; Chung, Y.J.; Rose, J.P.; Wang, B.C.
Crystal structure of bacteriophage T7 RNA polymerase at 3.3 A resolution [see comments]
Nature
364
593-599
1993
Escherichia phage T7
Lawyer, F.C.; Stoffel, S.; Saiki, R.K.; Chang, S.Y.; Landre, P.A.; Abramson, R.D.; Gelfand, D.H.
High-level expression, purification, and enzymatic characterization of full-length Thermus aquaticus DNA polymerase and a truncated form deficient in 5 to 3 exonuclease activity
PCR Methods Appl.
2
275-287
1993
Thermus aquaticus
Zhu, W.; Ito, J.
Purification and characterization of PRD1 DNA polymerase
Biochim. Biophys. Acta
1219
267-276
1994
Enterobacteria phage PRD1
Burrows, J.A.; Goward, C.R.
Purification and properties of DNA polymerase from Bacillus caldotenax
Biochem. J.
287
971-977
1992
[Bacillus] caldotenax
-
Park, J.H.; Kim, J.S.; Kwon, S.T.; Lee, D.S.
Purification and characterization of Thermus caldophilus GK24 DNA polymerase
Eur. J. Biochem.
214
135-140
1993
Thermus caldophilus, Thermus caldophilus GH24
Niranjanakumari, S.; Gopinathan, K.P.
Isolation and characterization of DNA polymerase epsilon from the silk glands of Bombyx mori
J. Biol. Chem.
268
15557-15564
1993
Bombyx mori
Kosovsky, J.; Subr, Z.; Popovnakova, K.; Zelinka, J.
Production of multiple forms during purification of Streptomyces aureofaciens DNA polymerase: a study using nondenaturing polyacrylamide gradient gel electrophoresis
Biochim. Biophys. Acta
1129
287-293
1992
Kitasatospora aureofaciens
Chen, H.; Ramachandra, M.; Padmanabhan, R.
Biochemical characterization of a temperature-sensitive adenovirus DNA polymerase [published erratum appears in Virology 1995 Feb 20;207(1):342]
Virology
205
364-370
1994
unidentified adenovirus
Torri, A.F.; Englund, P.T.
Purification of a mitochondrial DNA polymerase from Crithidia fasciculata
J. Biol. Chem.
267
4786-4792
1992
Crithidia fasciculata
Nolan, L.L.; Rivera, J.H.; Khan, N.N.
Isolation and partial characterization of a high-molecular-weight DNA polymerase from Leishmania mexicana
Biochim. Biophys. Acta
1120
322-328
1992
Leishmania mexicana
Sellmann, E.; Schrder, K.L.; Knoblich, I.M.; Westermann, P.
Purification and characterization of DNA polymerases from Bacillus species
J. Bacteriol.
174
4350-4355
1992
Geobacillus stearothermophilus, [Bacillus] caldotenax, [Bacillus] caldovelox, Thermus thermophilus
Meiner, K.; Heinhorst, S.; Cannon, G.C.; Brner, T.
Purification and characterization of a gamma-like DNA polymerase from Chenopodium album L
Nucleic Acids Res.
21
4893-4899
1993
Chenopodium album
Aoyagi, N.; Matsuoka, S.; Furunobu, A; Matsukage, A.; Sakaguchi, K.
Drosophila DNA polymerase delta. Purification and characterization
J. Biol. Chem.
169
6045-5050
1994
Drosophila melanogaster
-
Gray, H.; Wong T.W.
Purification and identification of subunit structure of the human mitochondrial DNA polymerase
J. Biol. Chem.
267
5835-5841
1992
Homo sapiens
Peck, V.M.; Germer, E.W.; Cress, A.E.
delta-type DNA polymerase characterized from Drosophila melanogaster embryos
Nucleic Acids Res.
20
5779-5784
1992
Drosophila melanogaster
Wintersberger E.
DNA-dependent DNA pllymerases from eukaryotes
Trends Biochem. Sci.
1977
58-60
1977
Bos taurus, Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
-
Scovassi, A.I.; Plevani, P.; Bertazzoni, U.
Eukaryotic DNA polymerases
Trends Biochem. Sci.
1980
335-337
1980
Bos taurus, Saccharomyces cerevisiae, Dictyostelium discoideum, Euglena gracilis, Homo sapiens, Mammalia, Neurospora crassa, Physarum polycephalum, Tetrahymena pyriformis, Trypanosoma brucei, Ustilago maydis
-
Acel, A.; Udashkin, B.E.; Wainberg, M.A.; Faust, E.A.
Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase
J. Virol.
72
2062-2071
1998
Human immunodeficiency virus 1
Amblar, M.; Lopez, P.
Purification and properties of the 5'-3' exonuclease D190->A mutant of DNA polymerase I from Streptococcus pneumoniae
Eur. J. Biochem.
252
124-132
1998
Streptococcus pneumoniae
Amblar, M.; Sagner, G.; Lopez, P.
Purification and properties of the 5'-3' exonuclease D10A mutant of DNA polymerase I from Streptococcus pneumoniae: a new tool for DNA sequencing
J. Biotechnol.
63
17-27
1998
Streptococcus pneumoniae
Auer, T.; Landre, P.A.; Myers, T.W.
Properties of the 5'->3' exonuclease/ribonuclease H activity of Thermus thermophilus DNA polymerase
Biochemistry
34
4994-5002
1995
Thermus thermophilus
Catalano, C.E.; Kuchta, R.
Inactivation of DNA polymerase alpha-primase by acrolein: loss of activity depends on the DNA substrate
Biochem. Biophys. Res. Commun.
214
971-977
1995
Bos taurus
Goel, A.; Astumian, R.D.; Herschbach, D.
Tuning and switching a DNA polymerase motor with mechanical tension
Proc. Natl. Acad. Sci. USA
100
9699-9704
2003
Escherichia phage T7
Goodman, M.F.; Fygenson, D.K.
DNA polymerase fidelity: from genetics toward a biochemical understanding
Genetics
148
1475-1482
1998
Tequatrovirus T4, Escherichia coli
Khare, V.; Eckert, K.A.
The proofreading 3'->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis
Mutat. Res.
510
45-54
2002
Tequatrovirus T4, Escherichia coli, Herpes simplex virus
Kim, Y.; Hong, Y.B.; Jung, G.
Hepatitis B virus: DNA polymerase activity of deletion mutants
Biochem. Mol. Biol. Int.
47
301-308
1999
Hepatitis B virus
Ma, W.P.; Kaiser, M.W.; Lyamicheva, N.; Schaefer, J.J.; Allawi, H.T.; Takova, T.; Neri, B.P.; Lyamichev, V.I.
RNA template-dependent 5' nuclease activity of Thermus aquaticus and Thermus thermophilus DNA polymerases
J. Biol. Chem.
275
24693-24700
2000
Thermus thermophilus, Thermus aquaticus
Oliveros, M.; Yanez, R.J.; Salas, M.L.; Salas, J.; Vinuela, E.; Blanco, L.
Characterization of an African swine fever virus 20-kDa DNA polymerase involved in DNA repair
J. Biol. Chem.
272
30899-30910
1997
African swine fever virus
Park, H.; Davis, R.; Wang, T.S.F.
Studies of Schizosaccharomyces pombe DNA polymerase alpha at different stages of the cell cycle
Nucleic Acids Res.
23
4337-4344
1995
Schizosaccharomyces pombe
Pavlov, Y.I.; Shcherbakova, P.V.; Kunkel, T.A.
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta
Genetics
159
47-64
2001
Saccharomyces cerevisiae
Pisani, F.M.; De Felice, M.; Manco, G.; Rossi, M.
Domain organization and biochemical features of Sulfolobus solfataricus DNA polymerase
Extremophiles
2
171-177
1998
Saccharolobus solfataricus, Saccharolobus solfataricus MT4
Zhu, F.X.; Biswas, E.; Biswas, S.B.
Purification and characterization of the DNA polymerase alpha associated exonuclease: The RTH1 gene product
Biochemistry
36
5947-5954
1997
Saccharomyces cerevisiae
Saves, I.; Ozanne, V.; Dietrich, J.; Masson, J.M.
Inteins of Thermococcus fumicolans DNA polymerase are endonucleases with distinct enzymatic behaviors
J. Biol. Chem.
275
2335-2341
2000
Thermococcus fumicolans (P74918)
Semizarov, D.G.; Arzumanov, A.A.; Dyatkina, N.B.; Meyer, A.; Vichier-Guerre, S.; Gosselin, G.; Rayner, B.; Imbach, J.L.; Krayevsky, A.A.
Stereoisomers of deoxynucleoside 5'-triphosphates as substrates for template-dependent and -independent DNA polymerases
J. Biol. Chem.
272
9556-9560
1997
Bos taurus, Homo sapiens
Showalter, A.K.; Tsai, M.D.
A DNA polymerase with specificity for five base pairs
J. Am. Chem. Soc.
123
1776-1777
2001
African swine fever virus
Sun, N.J.; Woo, S.H.; Cassady, J.M.; Snapka, R.M.
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia
J. Nat. Prod.
61
362-366
1998
Mammalia, Betapolyomavirus macacae
Takagi, M.; Nishioka, M.; Kakihara, H.; Kitabayashi, M.; Inoue, H.; Kawakami, B.; Oka, M.; Imanaka, T.
Characterization of DNA polymerase from sp. strain KOD1 and its application to PCR
Appl. Environ. Microbiol.
63
4504-4510
1997
Thermococcus kodakarensis (P77933), Thermococcus kodakarensis
Truniger, V.; Lazaro, J.M.; Esteban, F.J.; Blanco, L.; Salas, M.
A positively charged residue of Phi29 DNA polymerase, highly conserved in DNA polymerases from families A and B, is involved in binding the incoming nucleotide
Nucleic Acids Res.
30
1483-1492
2002
Salasvirus phi29
Truniger, V.; Lazaro, J.M.; Salas, M.; Blanco, L.
phi29 DNA polymerase requires the N-terminal domain to bind terminal protein and DNA primer substrates
J. Mol. Biol.
278
741-755
1998
Salasvirus phi29
Tuske, S.; Singh, K.; Kaushik, N.; Modak, M.J.
The J-helix of Escherichia coli DNA polymerase I (Klenow fragment) regulates polymerase and 3'-5'-exonuclease functions
J. Biol. Chem.
275
23759-23768
2000
Escherichia coli (P00582)
Villbrandt, B.; Sagner, G.; Schomburg, D.
Investigations on the thermostability and function of truncated Thermus aquaticus DNA polymerase fragments
Protein Eng.
10
1281-1288
1997
Thermus aquaticus (P19821), Thermus aquaticus
Yakimovich, O.Y.; Alekseev, Y.I.; Maksimenko, A.V.; Voronina, O.L.; Lunin, V.G.
Influence of DNA aptamer structure on the specificity of binding to Taq DNA polymerase
Biochemistry (Moscow)
68
228-235
2003
Thermus aquaticus
Yomo, T.; Hatanaka, T.; Yamamoto, H.; Yamamoto, K.; Shima, Y.; Ko-Mitamura, E.P.; Urabe, I.
Kinetic equation for template-dependent polymerase reactions and its application to Thermus thermophilus DNA polymerase
J. Ferment. Bioeng.
86
379-384
1998
Thermus thermophilus
-
Takeuchi, R.; Oshige, M.; Uchida, M.; Ishikawa, G.; Takata, K.; Shimanouchi, K.; Kanai, Y.; Ruike, T.; Morioka, H.; Sakaguchi, K.
Purification of Drosophila DNA polymerase zeta by REV1 protein-affinity chromatography
Biochem. J.
382
535-543
2004
Drosophila melanogaster
Roettger, M.P.; Fiala, K.A.; Sompalli, S.; Dong, Y.; Suo, Z.
Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu
Biochemistry
43
13827-13838
2004
Homo sapiens
Lebedeva, N.A.; Rechkunova, N.I.; Dezhurov, S.V.; Khodyreva, S.N.; Favre, A.; Blanco, L.; Lavrik, O.I.
Comparison of functional properties of mammalian DNA polymerase l and DNA polymerase b in reactions of DNA synthesis related to DNA repair
Biochim. Biophys. Acta
1751
150-158
2005
Homo sapiens
Pungitore, C.R.; Juri Ayub, M.; Borkowski, E.J.; Tonn, C.E.; Ciuffo, G.M.
Inhibition of Taq DNA polymerase by catalpol
Cell. Mol. Biol.
50
767-772
2004
Thermus aquaticus
Bebenek, K.; Garcia-Diaz, M.; Patishall, S.R.; Kunkel, T.A.
Biochemical properties of Saccharomyces cerevisiae DNA polymerase IV
J. Biol. Chem.
280
20051-20058
2005
Saccharomyces cerevisiae
Luo, N.; Kaguni, L.S.
Mutations in the spacer region of Drosophila mitochondrial DNA polymerase affect DNA binding, processivity, and the balance between Pol and Exo function
J. Biol. Chem.
280
2491-2497
2005
Drosophila melanogaster
Choi, J.J.; Kwon, S.T.
Cloning, expression, and characterization of DNA polymerase from hyperthermophilic bacterium Aquifex pyrophilus
J. Microbiol. Biotechnol.
14
1022-1030
2004
Aquifex pyrophilus
-
Truniger, V.; Lazaro, J.M.; Salas, M.
Two positively charged residues of phi29 DNA polymerase, conserved in protein-primed DNA polymerases, are involved in stabilisation of the incoming nucleotide
J. Mol. Biol.
335
481-494
2004
Salasvirus phi29
Ramadan, K.; Shevelev, I.V.; Maga, G.; Huebscher, U.
De novo DNA synthesis by human DNA polymerase l, DNA polymerase m and terminal deoxyribonucleotidyl transferase
J. Mol. Biol.
339
395-404
2004
Homo sapiens
Fujii, S.; Gasser, V.; Fuchs, R.P.
The biochemical requirements of DNA polymerase V-mediated translesion synthesis revisited
J. Mol. Biol.
341
405-417
2004
Escherichia coli
Choi, J.Y.; Guengerich, F.P.
Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta
J. Mol. Biol.
352
72-90
2005
Homo sapiens
Sutton, M.D.; Duzen, J.M.; Maul, R.W.
Mutant forms of the Escherichia coli beta sliding clamp that distinguish between its roles in replication and DNA polymerase V-dependent translesion DNA synthesis
Mol. Microbiol.
55
1751-1766
2005
Escherichia coli
Biles, B.D.; Connolly, B.A.
Low-fidelity Pyrococcus furiosus DNA polymerase mutants useful in error-prone PCR
Nucleic Acids Res.
32
e176
2004
Pyrococcus furiosus
Doughty, M.B.; Aboudehen, K.; Anderson, G.; Li, K.; Moore, B.II; Poolson, T.
Side-chain conformational restriction in template-competitive inhibitors of E. coli DNA polymerase I Klenow fragment: synthesis, structural characterization and inhibition activity
Nucleosides Nucleotides Nucleic Acids
23
1751-1765
2004
Escherichia coli
Oshige, M.; Takeuchi, R.; Ruike, R.; Kuroda, K.; Sakaguchi, K.
Subunit protein-affinity isolation of Drosophila DNA polymerase epsilon catalytic subunit
Protein Expr. Purif.
35
248-256
2004
Drosophila melanogaster
Schlicke, M.; Brakmann, S.
Expression and purification of histidine-tagged bacteriophage T7 DNA polymerase
Protein Expr. Purif.
39
247-253
2005
Escherichia phage T7
Lebedeva, N.A.; Rechkunova, N.I.; Dezhurov, S.V.; Degtyarev, S.K.; Lavrik, O.I.
Photoreactive dTTP analogues as substrates for thermostable DNA polymerase from Thermus thermophilus B35
Russ. J. Bioorg. Chem.
30
332-336
2004
Thermus thermophilus, Thermus thermophilus B35
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Nishida, H.; Matsumiya, S.; Tsuchiya, D.; Ishino, Y.; Morikawa, K.
Stoichiometric complex formation by proliferating cell nuclear antigen (PCNA) and its interacting protein: purification and crystallization of the DNA polymerase and PCNA monomer mutant complex from Pyrococcus furiosus
Acta Crystallogr. Sect. F
62
253-256
2006
Pyrococcus furiosus
Ray, A.S.; Feng, J.Y.; Murakami, E.; Chu, C.K.; Schinazi, R.F.; Anderson, K.S.
Interaction of 2-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma
Antiviral Chem. Chemother.
18
25-33
2007
Homo sapiens
Liu, X.; Hou, J.; Liu, J.
Chlamydial DNA polymerase I can bypass lesions in vitro
Biochem. Biophys. Res. Commun.
345
1083-1091
2006
Chlamydia pneumoniae, Chlamydia pneumoniae AR39
Ishimaru, C.; Kuriyama, I.; Shimazaki, N.; Koiwai, O.; Sakaguchi, K.; Kato, I.; Yoshida, H.; Mizushina, Y.
Cholesterol hemisuccinate: a selective inhibitor of family X DNA polymerases
Biochem. Biophys. Res. Commun.
354
619-625
2007
Bos taurus, Homo sapiens, Rattus norvegicus
Schoenbrunner, N.J.; Fiss, E.H.; Budker, O.; Stoffel, S.; Sigua, C.L.; Gelfand, D.H.; Myers, T.W.
Chimeric thermostable DNA polymerases with reverse transcriptase and attenuated 3-5 exonuclease activity
Biochemistry
45
12786-12795
2006
Thermotoga maritima, Thermus sp., Thermus sp. Z05
Tsai, Y.C.; Johnson, K.A.
A new paradigm for DNA polymerase specificity
Biochemistry
45
9675-9687
2006
Escherichia phage T7
Kumar, S.; Lamarche, B.J.; Tsai, M.D.
Use of damaged DNA and dNTP substrates by the error-prone DNA polymerase X from African swine fever virus
Biochemistry
46
3814-3825
2007
African swine fever virus (P42489), African swine fever virus
Sucato, C.A.; Upton, T.G.; Kashemirov, B.A.; Batra, V.K.; Martinek, V.; Xiang, Y.; Beard, W.A.; Pedersen, L.C.; Wilson, S.H.; McKenna, C.E.; Florian, J.; Warshel, A.; Goodman, M.F.
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta
Biochemistry
46
461-471
2007
Homo sapiens (P06746)
Bakhtina, M.; Roettger, M.P.; Kumar, S.; Tsai, M.D.
A unified kinetic mechanism applicable to multiple DNA polymerases
Biochemistry
46
5463-5472
2007
African swine fever virus, Escherichia coli, Rattus norvegicus
Kamisuki, S.; Ishimaru, C.; Onoda, K.; Kuriyama, I.; Ida, N.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp
Bioorg. Med. Chem.
15
3109-3114
2007
Homo sapiens
Doncaster, J.R.; Etchells, L.L.; Kershaw, N.M.; Nakamura, R.; Ryan, H.; Takeuchi, R.; Sakaguchi, K.; Sardarian, A.; Whitehead, R.C.
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase
Bioorg. Med. Chem. Lett.
16
2877-2881
2006
Homo sapiens
Sasaki, Y.; Miyoshi, D.; Sugimoto, N.
Effect of molecular crowding on DNA polymerase activity
Biotechnol. J.
1
440-446
2006
Tequatrovirus T4, Thermus aquaticus
Melissis, S.; Labrou, N.E.; Clonis, Y.D.
One-step purification of Taq DNA polymerase using nucleotide-mimetic affinity chromatography
Biotechnol. J.
2
121-132
2007
Thermus aquaticus
Lamers, M.H.; Georgescu, R.E.; Lee, S.G.; ODonnell, M.; Kuriyan, J.
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III
Cell
126
881-892
2006
Escherichia coli
Bailey, S.; Wing, R.A.; Steitz, T.A.
The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases
Cell
126
893-904
2006
Thermus aquaticus (Q9XDH5), Thermus aquaticus
Griep, M.A.; Kotera, C.A.; Nelson, R.M.; Viljoen, H.J.
Kinetics of the DNA polymerase pyrococcus kodakaraensis
Chem. Eng. Sci.
61
3885-3892
2006
Thermococcus kodakarensis
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Yakubovskaya, E.; Lukin, M.; Chen, Z.; Berriman, J.; Wall, J.S.; Kobayashi, R.; Kisker, C.; Bogenhagen, D.F.
The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits
EMBO J.
26
4283-4291
2007
Homo sapiens (Q9UHN1), Homo sapiens
Lee, Y.; Choi, J.J.; Kwon, S.
Cloning, expression, and partial characterization of a family B-type DNA polymerase from the hyperthermophilic crenarchaeon Sulfophobococcus zilligii
Enzyme Microb. Technol.
38
821-830
2006
Sulfophobococcus zilligii (Q29Y55)
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De Felice, M.; Medagli, B.; Esposito, L.; De Falco, M.; Pucci, B.; Rossi, M.; Gruz, P.; Nohmi, T.; Pisani, F.M.
Biochemical evidence of a physical interaction between Sulfolobus solfataricus B-family and Y-family DNA polymerases
Extremophiles
11
277-282
2007
Saccharolobus solfataricus
Hudson, G.; Chinnery, P.F.
Mitochondrial DNA polymerase-gamma and human disease
Hum. Mol. Genet.
15
R244-R252
2006
Homo sapiens
Wang, L.; Yu, X.; Hu, P.; Broyde, S.; Zhang, Y.
A water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV
J. Am. Chem. Soc.
129
4731-4737
2007
Saccharolobus solfataricus
Choi, J.Y.; Guengerich, F.P.
Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota
J. Biol. Chem.
281
12315-12324
2006
Homo sapiens
Liu, S.; Knafels, J.D.; Chang, J.S.; Waszak, G.A.; Baldwin, E.T.; Deibel, M.R.; Thomsen, D.R.; Homa, F.L.; Wells, P.A.; Tory, M.C.; Poorman, R.A.; Gao, H.; Qiu, X.; Seddon, A.P.
Crystal structure of the herpes simplex virus 1 DNA polymerase
J. Biol. Chem.
281
18193-18200
2006
Human alphaherpesvirus 1
Kim, T.W.; Brieba, L.G.; Ellenberger, T.; Kool, E.T.
Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs
J. Biol. Chem.
281
2289-2295
2006
Escherichia phage T7
deLucia, A.M.; Chaudhuri, S.; Potapova, O.; Grindley, N.D.; Joyce, C.M.
The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases
J. Biol. Chem.
281
27286-27291
2006
Sulfolobus acidocaldarius
Tsubota, T.; Tajima, R.; Ode, K.; Kubota, H.; Fukuhara, N.; Kawabata, T.; Maki, S.; Maki, H.
Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae
J. Biol. Chem.
281
32898-32908
2006
Saccharomyces cerevisiae
Duym, W.W.; Fiala, K.A.; Bhatt, N.; Suo, Z.
Kinetic effect of a downstream strand and its 5-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human DNA polymerase lambda
J. Biol. Chem.
281
35649-35655
2006
Homo sapiens
Eoff, R.L.; Angel, K.C.; Egli, M.; Guengerich, F.P.
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and X-ray crystallography of correct and incorrect pairing
J. Biol. Chem.
282
13573-13584
2007
Saccharolobus solfataricus
Frank, E.G.; Woodgate, R.
Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese
J. Biol. Chem.
282
24689-24696
2007
Homo sapiens
Yamanaka, H.; Gatanaga, H.; Kosalaraksa, P.; Matsuoka-Aizawa, S.; Takahashi, T.; Kimura, S.; Oka, S.
Novel mutation of human DNA polymerase gamma associated with mitochondrial toxicity induced by anti-HIV treatment
J. Infect. Dis.
195
1419-1425
2007
Homo sapiens
Kurzynska-Kokorniak, A.; Jamburuthugoda, V.K.; Bibillo, A.; Eickbush, T.H.
DNA-directed DNA polymerase and strand displacement activity of the reverse transcriptase encoded by the R2 retrotransposon
J. Mol. Biol.
23
322-333
2007
Bombyx mori
Choi, J.J.; Nam, K.H.; Min, B.; Kim, S.J.; Soell, D.; Kwon, S.T.
Protein trans-splicing and characterization of a split family B-type DNA polymerase from the hyperthermophilic archaeal parasite Nanoarchaeum equitans
J. Mol. Biol.
356
1093-1106
2006
Nanoarchaeum equitans
Ong, J.L.; Loakes, D.; Jaroslawski, S.; Too, K.; Holliger, P.
Directed evolution of DNA polymerase, RNA polymerase and reverse transcriptase activity in a single polypeptide
J. Mol. Biol.
361
537-550
2006
Thermus aquaticus (P19821)
Loregian, A.; Case, A.; Cancellotti, E.; Valente, C.; Marsden, H.S.; Palu, G.
Cloning, expression, and functional characterization of the equine herpesvirus 1 DNA polymerase and its accessory subunit
J. Virol.
80
6247-6258
2006
Equid alphaherpesvirus 1
Jiang, C.; Hwang, Y.T.; Randell, J.C.; Coen, D.M.; Hwang, C.B.
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication
J. Virol.
81
3495-3502
2007
Herpes simplex virus
Fischhaber, P.L.; McDaniel, L.D.; Friedberg, E.C.
DNA polymerases for translesion DNA synthesis: enzyme purification and mouse models for studying their function
Methods Enzymol.
408
355-378
2006
Mus musculus
Johnson, R.E.; Prakash, L.; Prakash, S.
Yeast and human translesion DNA synthesis polymerases: expression, purification, and biochemical characterization
Methods Enzymol.
408
390-407
2006
Saccharomyces cerevisiae, Homo sapiens
Liu, G.; Chen, X.
DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation
Mol. Cell. Biol.
26
1398-1413
2006
Homo sapiens
Moon, A.F.; Garcia-Diaz, M.; Bebenek, K.; Davis, B.J.; Zhong, X.; Ramsden, D.A.; Kunkel, T.A.; Pedersen, L.C.
Structural insight into the substrate specificity of DNA polymerase mu
Nat. Struct. Mol. Biol.
14
45-53
2007
Mus musculus
Jarosz, D.F.; Godoy, V.G.; Delaney, J.C.; Essigmann, J.M.; Walker, G.C.
A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates
Nature
439
225-228
2006
Escherichia coli
Hogg, M.; Cooper, W.; Reha-Krantz, L.; Wallace, S.S.
Kinetics of error generation in homologous B-family DNA polymerases
Nucleic Acids Res.
34
2528-2535
2006
Tequatrovirus T4 (P04415), Escherichia phage RB69 (P04415), Escherichia phage RB69
Pursell, Z.F.; Isoz, I.; Lundstroem, E.B.; Johansson, E.; Kunkel, T.A.
Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon
Nucleic Acids Res.
35
3076-3086
2007
Saccharomyces cerevisiae
Capp, J.P.; Boudsocq, F.; Besnard, A.G.; Lopez, B.S.; Cazaux, C.; Hoffmann, J.S.; Canitrot, Y.
Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells
Nucleic Acids Res.
35
3551-3560
2007
Homo sapiens
Crespan, E.; Alexandrova, L.; Khandazhinskaya, A.; Jasko, M.; Kukhanova, M.; Villani, G.; Huebscher, U.; Spadari, S.; Maga, G.
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda
Nucleic Acids Res.
35
45-57
2007
Homo sapiens
Fidalgo da Silva, E.; Reha-Krantz, L.J.
DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase
Nucleic Acids Res.
35
5452-5463
2007
Tequatrovirus T4
Takeuchi, R.; Kimura, S.; Saotome, A.; Sakaguchi, K.
Biochemical properties of a plastidial DNA polymerase of rice
Plant Mol. Biol.
64
601-611
2007
Oryza sativa
Castro, C.; Smidansky, E.; Maksimchuk, K.R.; Arnold, J.J.; Korneeva, V.S.; Goette, M.; Konigsberg, W.; Cameron, C.E.
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
Proc. Natl. Acad. Sci. USA
104
4267-4272
2007
Escherichia phage RB69, Human immunodeficiency virus 1
Sun, S.; Geng, L.; Shamoo, Y.
Structure and enzymatic properties of a chimeric bacteriophage RB69 DNA polymerase and single-stranded DNA binding protein with increased processivity
Proteins
65
231-238
2006
Escherichia phage RB69
Bailey, M.F.; Van der Schans, E.J.; Millar, D.P.
Dimerization of the Klenow fragment of Escherichia coli DNA polymerase I is linked to its mode of DNA binding
Biochemistry
46
8085-8099
2007
Escherichia coli
Tegova, R.; Tover, A.; Tarassova, K.; Tark, M.; Kivisaar, M.
Involvement of error-prone DNA polymerase IV in stationary-phase mutagenesis in Pseudomonas putida
J. Bacteriol.
186
2735-2744
2004
Pseudomonas putida
Sanders, L.H.; Rockel, A.; Lu, H.; Wozniak, D.J.; Sutton, M.D.
Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis
J. Bacteriol.
188
8573-8585
2006
Pseudomonas aeruginosa
Jarvis, T.C.; Beaudry, A.A.; Bullard, J.M.; Janjic, N.; McHenry, C.S.
Reconstitution of a minimal DNA replicase from Pseudomonas aeruginosa and stimulation by non-cognate auxiliary factors
J. Biol. Chem.
280
7890-7900
2005
Pseudomonas aeruginosa
Mazzucco, C.E.; Hamatake, R.K.; Colonno, R.J.; Tenney, D.J.
Entecavir for treatment of hepatitis B virus displays no in vitro mitochondrial toxicity or DNA polymerase gamma inhibition
Antimicrob. Agents Chemother.
52
598-605
2008
Drosophila melanogaster
Souza, T.M.; De Souza, M.C.; Ferreira, V.F.; Canuto, C.V.; Marques, I.P.; Fontes, C.F.; Frugulhetti, I.C.
Inhibition of HSV-1 replication and HSV DNA polymerase by the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid and its aglycone
Antiviral Res.
77
20-27
2008
Human alphaherpesvirus 1
Sergerie, Y.; Boivin, G.
Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes
Antiviral Res.
77
77-80
2008
Human alphaherpesvirus 1
Roy, S.; Choudhury, S.R.; Sengupta, D.N.
Analysis of processivity of mungbean dideoxynucleotide-sensitive DNA polymerase and detection of the activity and expression of the enzyme in the meristematic and meiotic tissues and following DNA damaging agent
Arch. Biochem. Biophys.
475
55-65
2008
Vigna radiata
Xu, P.; Oum, L.; Geacintov, N.E.; Broyde, S.
Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism
Biochemistry
47
2701-2709
2008
Saccharolobus solfataricus (Q97W02), Saccharolobus solfataricus
Wang, Y.; Musser, S.K.; Saleh, S.; Marnett, L.J.; Egli, M.; Stone, M.P.
Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV
Biochemistry
47
7322-7334
2008
Saccharolobus solfataricus (Q97W02), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97W02), Saccharolobus solfataricus P2
DeCarlo, L.; Gowda, A.S.; Suo, Z.; Spratt, T.E.
Formation of purine-purine mispairs by Sulfolobus solfataricus DNA polymerase IV
Biochemistry
47
8157-8164
2008
Saccharolobus solfataricus
Naganuma, M.; Nishida, M.; Kuramochi, K.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae
Bioorg. Med. Chem.
16
2939-2944
2008
Bos taurus, Brassica oleracea, Escherichia coli, Homo sapiens, Rattus norvegicus, Tequatrovirus T4, Thermus aquaticus
Angileri, F.F.; Aguennouz, M.; Conti, A.; La Torre, D.; Cardali, S.; Crupi, R.; Tomasello, C.; Germano, A.; Vita, G.; Tomasello, F.
Nuclear factor-kappaB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas
Cancer
112
2258-2266
2008
Thermus aquaticus
Sasaki, R.; Suzuki, Y.; Yonezawa, Y.; Ota, Y.; Okamoto, Y.; Demizu, Y.; Huang, P.; Yoshida, H.; Sugimura, K.; Mizushina, Y.
DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells
Cancer Sci.
99
1040-1048
2008
Bos taurus, Homo sapiens, Rattus norvegicus
Cramer, J.; Rangam, G.; Marx, A.; Restle, T.
Varied active-site constraints in the Klenow fragment of E. coli DNA polymerase I and the lesion-bypass Dbh DNA polymerase
ChemBioChem
9
1243-1250
2008
Escherichia coli
Nishida, M.; Hada, T.; Kuramochi, K.; Yoshida, H.; Yonezawa, Y.; Kuriyama, I.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
Diallyl sulfides: Selective inhibitors of family X DNA polymerases from garlic (Allium sativum L.)
Food Chem.
108
551-560
2008
Tequatrovirus T4, Bos taurus, Brassica oleracea, Drosophila melanogaster, Escherichia coli, Homo sapiens, Rattus norvegicus, Thermus aquaticus, Oncorhynchus masou
Takahashi, S.; Yonezawa, Y.; Kubota, A.; Ogawa, N.; Maeda, K.; Koshino, H.; Nakata, T.; Yoshida, H.; Mizushina, Y.
Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth
Int. J. Oncol.
32
451-458
2008
Tequatrovirus T4, Bos taurus, Brassica oleracea, Drosophila melanogaster, Escherichia coli, Homo sapiens, Rattus norvegicus, Thermus aquaticus, Oncorhynchus masou
Wang, Y.; Schlick, T.
Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization
J. Am. Chem. Soc.
130
13240-13250
2008
Saccharolobus solfataricus
Kukreti, P.; Singh, K.; Ketkar, A.; Modak, M.J.
Identification of a new motif required for the 3-5 exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): the RRRY motif is necessary for the binding of single-stranded DNA substrate and the template strand of the mismatched duplex
J. Biol. Chem.
283
17979-17990
2008
Escherichia coli (P00582), Escherichia coli
Richartz, A.; Hoeltje, M.; Brandt, B.; Schaefer-Korting, M.; Hoeltje, H.D.
Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding
J. Enzyme Inhib. Med. Chem.
23
94-100
2008
Homo sapiens
Kurzynska-Kokorniak, A.; Jamburuthugoda, V.K.; Bibillo, A.; Eickbush, T.H.
DNA-directed DNA polymerase and strand displacement activity of the reverse transcriptase encoded by the R2 retrotransposon
J. Mol. Biol.
374
322-333
2007
Bombyx mori
Yasui, M.; Suenaga, E.; Koyama, N.; Masutani, C.; Hanaoka, F.; Gruz, P.; Shibutani, S.; Nohmi, T.; Hayashi, M.; Honma, M.
Miscoding properties of 2-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases
J. Mol. Biol.
377
1015-1023
2008
Homo sapiens
Furukawa, T.; Nishida, M.; Hada, T.; Kuramochi, K.; Sugawara, F.; Kobayashi, S.; Iijima, H.; Shimada, H.; Yoshida, H.; Mizushina, Y.
Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic DNA polymerase I activity and cell growth of Escherichia coli
J. Oleo Sci.
56
43-47
2007
Escherichia coli
Fiala, K.A.; Sherrer, S.M.; Brown, J.A.; Suo, Z.
Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase
Nucleic Acids Res.
36
1990-2001
2008
Saccharolobus solfataricus
Brown, J.A.; Newmister, S.A.; Fiala, K.A.; Suo, Z.
Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase
Nucleic Acids Res.
36
3867-3878
2008
Saccharolobus solfataricus
Broyde, S.; Wang, L.; Rechkoblit, O.; Geacintov, N.E.; Patel, D.J.
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases
Trends Biochem. Sci.
33
209-219
2008
Saccharolobus solfataricus (Q97W02), Saccharolobus solfataricus
Bailey, C.M.; Kasiviswanathan, R.; Copeland, W.C.; Anderson, K.S.
R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity
Antimicrob. Agents Chemother.
53
2610-2612
2009
Homo sapiens
Frederick, A.M.; Davis, M.L.; Rice, K.P.
Inhibition of human DNA polymerase beta activity by the anticancer prodrug cloretazine
Biochem. Biophys. Res. Commun.
378
419-423
2009
Homo sapiens
Kanao, R.; Hanaoka, F.; Masutani, C.
A novel interaction between human DNA polymerase eta and MutLalpha
Biochem. Biophys. Res. Commun.
389
40-45
2009
Homo sapiens
Huang, Q.M.; Akashi, T.; Masuda, Y.; Kamiya, K.; Takahashi, T.; Suzuki, M.
Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells
Biochem. Biophys. Res. Commun.
391
542-546
2010
Homo sapiens
Kumar, S.; Bakhtina, M.; Tsai, M.D.
Altered order of substrate binding by DNA polymerase X from African swine fever virus
Biochemistry
47
7875-7887
2008
African swine fever virus
Zhang, H.; Beckman, J.; Wang, J.; Konigsberg, W.
RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity
Biochemistry
48
6940-6950
2009
Escherichia phage RB69
Donny-Clark, K.; Shapiro, R.; Broyde, S.
Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing?
Biochemistry
48
7-18
2009
Homo sapiens (Q9UNA4), Homo sapiens
Makarova, A.V.; Tarantul, V.Z.; Gening, L.V.
Evolution of DNA polymerase iota structure and function in eukaryotes
Biochemistry
73
346-352
2008
Canis lupus familiaris, Gallus gallus, Coturnix coturnix, Oryctolagus cuniculus, Misgurnus fossilis, Mus musculus, Rana temporaria, Rattus norvegicus, Triturus cristatus, Testudines agrionemys, Philothamnus punctatus
Nishida, M.; Ida, N.; Horio, M.; Takeuchi, T.; Kamisuki, S.; Murata, H.; Kuramochi, K.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp
Bioorg. Med. Chem.
16
5115-5122
2008
Homo sapiens
Berdis, A.
Mechanisms of DNA polymerases
Chem. Rev.
109
2862-2879
2009
Geobacillus stearothermophilus, Bacillus subtilis, Tequatrovirus T4, Escherichia phage T7, Escherichia coli, Homo sapiens, Escherichia phage RB69, Thermus aquaticus (P19821)
Martomo, S.A.; Saribasak, H.; Yokoi, M.; Hanaoka, F.; Gearhart, P.J.
Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes
DNA Repair
7
1603-1608
2008
Mus musculus
Hidaka, K.; Yamada, M.; Kamiya, H.; Masutani, C.; Harashima, H.; Hanaoka, F.; Nohmi, T.
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Homo sapiens (Q07864 AND Q9NR33 AND P56282 AND Q9NRF9), Homo sapiens
Milton, M.E.; Choe, J.Y.; Honzatko, R.B.; Nelson, S.W.
Crystal structure of the apicoplast DNA polymerase from Plasmodium falciparum the first look at a plastidic A-family DNA polymerase
J. Mol. Biol.
428
3920-3934
2016
Plasmodium falciparum (Q8ILY1)
Ucisik, M.N.; Hammes-Schiffer, S.
Effects of active site mutations on specificity of nucleobase binding in human DNA polymerase eta
J. Phys. Chem. B
121
3667-3675
2017
Homo sapiens (Q9Y253)
Yamashita, M.; Xu, J.; Morokuma, D.; Hirata, K.; Hino, M.; Mon, H.; Takahashi, M.; Hamdan, S.; Sakashita, K.; Iiyama, K.; Banno, Y.; Kusakabe, T.; Lee, J.
Characterization of recombinant Thermococcus kodakaraensis (KOD) DNA polymerases produced using silkworm-baculovirus expression vector system
Mol. Biotechnol.
59
221-233
2017
Thermococcus kodakarensis (P77933), Thermococcus kodakarensis, Thermococcus kodakarensis ATCC BAA-9180 (P77933)
Stern, H.R.; Sefcikova, J.; Chaparro, V.E.; Beuning, P.J.
Mammalian DNA polymerase kappa activity and specificity
Molecules
24
2805
2019
Homo sapiens (Q9UBT6)
Walsh, M.T.; Huang, X.
Measurement of incorporation kinetics of non-fluorescent native nucleotides by DNA polymerases using fluorescence microscopy
Nucleic Acids Res.
45
e175
2017
Escherichia coli
Ghosh, S.; Goldgur, Y.; Shuman, S.
Mycobacterial DNA polymerase I activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme
Nucleic Acids Res.
48
3165-3180
2020
Mycolicibacterium smegmatis (A0QYZ2), Mycolicibacterium smegmatis ATCC 700084 (A0QYZ2)
Burke, C.R.; Luptak, A.
DNA synthesis from diphosphate substrates by DNA polymerases
Proc. Natl. Acad. Sci. USA
115
980-985
2018
Thermus aquaticus (P19821), Thermococcus litoralis (P30317), Geobacillus stearothermophilus (P52026), Pyrococcus furiosus (P61875), Bacillus subtilis (P94544), Bacillus subtilis 168 (P94544)
Zheng, W.; Wang, Q.; Bi, Q.
Construction, expression, and characterization of recombinant Pfu DNA polymerase in Escherichia coli
Protein J.
35
145-153
2016
Pyrococcus furiosus (P61875), Pyrococcus furiosus, Pyrococcus furiosus ATCC 43587 (P61875)
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