Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Mesocricetus auratus | |
4-Methylpyrazole | isoenzyme AA-ADH, BB-ADH and TT-ADH | Mesocricetus auratus | |
Biochanin A | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | |
daidzein | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | |
genistein | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | |
testosterone | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
all-trans-retinol | isoenzyme TT-ADH | Mesocricetus auratus | |
0.02 | - |
n-Hexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
0.02 | - |
12-hydroxydodecanoate | isoenzyme BB-ADH | Mesocricetus auratus | |
0.03 | - |
n-butanol | isoenzyme BB-ADH | Mesocricetus auratus | |
0.03 | - |
all-trans-retinol | isoenzyme BB-ADH | Mesocricetus auratus | |
0.04 | - |
Cyclohexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
0.04 | - |
n-Hexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
0.05 | - |
12-hydroxydodecanoate | isoenzyme BB-ADH and isoenzyme ADH-TT | Mesocricetus auratus | |
0.05 | - |
all-trans-retinol | isoenzyme AA-ADH | Mesocricetus auratus | |
0.06 | - |
12-hydroxydodecanoate | isoenzyme AA-ADH | Mesocricetus auratus | |
0.07 | - |
n-butanol | isoenzyme AA-ADH | Mesocricetus auratus | |
0.26 | - |
n-Hexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
0.5 | - |
ethanol | isoenzyme AA-ADH | Mesocricetus auratus | |
0.76 | - |
ethanol | isoenzyme BB-ADH | Mesocricetus auratus | |
0.76 | - |
Cyclohexanol | isoenzyme AA-ADH | Mesocricetus auratus | |
2.3 | - |
12-hydroxydodecanoate | isoenzyme TT-ADH | Mesocricetus auratus | |
2.6 | - |
n-butanol | isoenzyme TT-ADH | Mesocricetus auratus | |
28 | - |
ethanol | isoenzyme TT-ADH | Mesocricetus auratus | |
320 | - |
Cyclohexanol | isoenzyme TT-ADH | Mesocricetus auratus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | isoenzyme AA-ADH contains 4.3 zinc atoms per dimeric molecule, isoenzyme BB-ADH contains 3.7 zinc atoms per dimeric molecule, isoenzyme AA-ADH contains 4.1 zinc atoms per dimeric molecule | Mesocricetus auratus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
2 * 40000, SDS-PAGE | Mesocricetus auratus |
80000 | - |
gel filtration | Mesocricetus auratus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
3 major isoenzymes: TT-ADH, AA-ADH and BB-ADH | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | isoenzyme AA-ADH and BB-ADH most abundant in | Mesocricetus auratus | - |
testis | isoenzyme TT-ADH is only found in testis | Mesocricetus auratus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.1 | - |
isoenzyme AA-ADH | Mesocricetus auratus |
2.5 | - |
isoenzyme BB-ADH | Mesocricetus auratus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
12-hydroxydodecanoate + NAD+ | - |
Mesocricetus auratus | 12-oxododecanoic acid + NADH | - |
? | |
3beta-hydroxy-5beta-androstan-17-one + NAD+ | catalyzed by isoenzyme BB-ADH, no activity with isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | 5beta-androstan-3,17-dione + NADH | - |
? | |
all-trans-retinol + NAD+ | - |
Mesocricetus auratus | all-trans-retinal + NADH | - |
? | |
butan-2-ol + NAD+ | - |
Mesocricetus auratus | butan-2-one + NADH | - |
? | |
butanol + NAD+ | - |
Mesocricetus auratus | butyraldehyde + NADH | - |
? | |
cyclohexanol + NAD+ | - |
Mesocricetus auratus | cyclohexanone + NADH | - |
? | |
ethanol + NAD+ | - |
Mesocricetus auratus | acetaldehyde + NADH | - |
? | |
hexanol + NAD+ | - |
Mesocricetus auratus | n-hexanal + NADH | - |
? | |
methylcrotonyl alcohol + NAD+ | - |
Mesocricetus auratus | methylcrotonaldehyde + NADH | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 40000, SDS-PAGE | Mesocricetus auratus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.35 | - |
all-trans retinol | isoenzyme AA-ADH | Mesocricetus auratus | |
1.03 | - |
12-hydroxydodecanoate | isoenzyme TT-ADH | Mesocricetus auratus | |
1.3 | - |
all-trans retinol | isoenzyme TT-ADH | Mesocricetus auratus | |
1.75 | - |
Cyclohexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
1.9 | - |
all-trans retinol | isoenzyme BB-ADH | Mesocricetus auratus | |
2.2 | - |
12-hydroxydodecanoate | isoenzyme BB-ADH | Mesocricetus auratus | |
2.35 | - |
n-Hexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
2.4 | - |
Cyclohexanol | isoenzyme AA-ADH | Mesocricetus auratus | |
2.58 | - |
n-butanol | isoenzymee BB-ADH | Mesocricetus auratus | |
2.63 | - |
methylcrotonyl alcohol | isoenzyme BB-ADH | Mesocricetus auratus | |
2.77 | - |
12-hydroxydodecanoate | isoenzyme AA-ADH | Mesocricetus auratus | |
2.8 | - |
n-Hexanol | isoenzyme AA-ADH | Mesocricetus auratus | |
2.83 | - |
ethanol | isoenzyme AA-ADH | Mesocricetus auratus | |
3 | - |
methylcrotonyl alcohol | isoenzyme AA-ADH | Mesocricetus auratus | |
3.33 | - |
n-butanol | isoenzyme AA-ADH | Mesocricetus auratus | |
3.38 | - |
ethanol | isoenzyme BB-ADH | Mesocricetus auratus | |
4.08 | - |
n-Hexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
7.18 | - |
n-butanol | isoenzyme TT-ADH | Mesocricetus auratus | |
8.5 | - |
Cyclohexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
8.58 | - |
methylcrotonyl alcohol | isoenzyme TT-ADH | Mesocricetus auratus | |
9.58 | - |
ethanol | isoenzyme TT-ADH | Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mesocricetus auratus | |
NADH | - |
Mesocricetus auratus |