Literature summary for 1.1.1.1 extracted from

Gibbons, B.J.; Hurley, T.D.
Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors (2004), Biochemistry, 43, 12555-12562.

Search for more literature for 1.1.1.1

Crystallization (Commentary)

Crystallization (Comment)	Organism
isozyme alphaalpha in complex with inhibitor N-cyclopentyl-N-cyclobutylformamide, isozyme beta(1)beta(1) in complex with inhibitors N-benzylformamide and N-heptylformamide, and isozyme gamma(2)gamma(2) in complex with inhibitor N-1-methylheptylformamide, X-ray diffraction structure determination and analysis at 1.45-2.5 A resolution, structure modeling	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A93F	isozyme alphaalpha, altered active site structure and inhibitor binding	Homo sapiens
S48T	isozyme gamma(2)gamma(2), altered active site structure and inhibitor binding	Homo sapiens
V141L	isozyme gamma(2)gamma(2), altered active site structure and inhibitor binding	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
N-1-methylheptylformamide	inhibits isozyme gamma(2)gamma(2)	Homo sapiens
N-benzylformamide	inhibits isozyme beta(1)beta(1)	Homo sapiens
N-cyclopentyl-N-cyclobutylformamide	inhibits isozyme alphaalpha, complex structure	Homo sapiens
N-heptylformamide	inhibits isozyme beta(1)beta(1)	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	catalytic zinc	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	class I enzyme, several isozymes	-

Reaction

Reaction	Comment	Organism	Reaction ID
a primary alcohol + NAD+ = an aldehyde + NADH + H+	Ser48 is involved in catalysis, isozyme gamma(2)gamma(2)	Homo sapiens	a

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Release 2023.1 (January 2023)