Crystallization (Comment) | Organism |
---|---|
isozyme alphaalpha in complex with inhibitor N-cyclopentyl-N-cyclobutylformamide, isozyme beta(1)beta(1) in complex with inhibitors N-benzylformamide and N-heptylformamide, and isozyme gamma(2)gamma(2) in complex with inhibitor N-1-methylheptylformamide, X-ray diffraction structure determination and analysis at 1.45-2.5 A resolution, structure modeling | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A93F | isozyme alphaalpha, altered active site structure and inhibitor binding | Homo sapiens |
S48T | isozyme gamma(2)gamma(2), altered active site structure and inhibitor binding | Homo sapiens |
V141L | isozyme gamma(2)gamma(2), altered active site structure and inhibitor binding | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-1-methylheptylformamide | inhibits isozyme gamma(2)gamma(2) | Homo sapiens | |
N-benzylformamide | inhibits isozyme beta(1)beta(1) | Homo sapiens | |
N-cyclopentyl-N-cyclobutylformamide | inhibits isozyme alphaalpha, complex structure | Homo sapiens | |
N-heptylformamide | inhibits isozyme beta(1)beta(1) | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | catalytic zinc | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
class I enzyme, several isozymes | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a primary alcohol + NAD+ = an aldehyde + NADH + H+ | Ser48 is involved in catalysis, isozyme gamma(2)gamma(2) | Homo sapiens |