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Literature summary for 1.1.1.1 extracted from

  • Martras, S.; Alvarez, R.; Martinez, S.E.; Torres, D.; Gallego, O.; Duester, G.; Farres, J.; de Lera, A.R.; Pares, X.
    The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina (2004), Eur. J. Biochem., 271, 1660-1670.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozymes in Escherichia coli strain BL21 Mus musculus
expression of isozymes in Escherichia coli strain BL21 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km for isozymes ADH1, and ADH4 for all retinoid substrates in forward and reverse reaction Mus musculus
additional information
-
additional information Km for isozymes ADH1B1, ADH1B2, and ADH4 for all retinoid substrates in forward and reverse reaction Homo sapiens
0.006
-
Hexanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus
0.011
-
9-cis-retinol isozyme ADH1B1, pH 7.5, 25°C Homo sapiens
0.018
-
11-cis-retinol isozyme ADH1B2, pH 7.5, 25°C Homo sapiens
0.023
-
9-cis-retinol isozyme ADH1B2, pH 7.5, 25°C Homo sapiens
0.03
-
all-trans-retinol isozyme ADH1B1, pH 7.5, 25°C Homo sapiens
0.033
-
all-trans-retinol isozyme ADH1B2, pH 7.5, 25°C Homo sapiens
0.035
-
11-cis-retinol isozyme ADH1B1, pH 7.5, 25°C Homo sapiens
0.085
-
Hexanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
0.48
-
ethanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
0.63
-
Hexanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus
0.83
-
ethanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
1.9
-
Hexanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
255
-
ethanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus
1625
-
ethanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ 1 catalytic and 1 structural zinc ion per subunit Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes ADH1B1, ADH1B2, and ADH4
-
Mus musculus
-
isozymes ADH1 and ADH4
-

Purification (Commentary)

Purification (Comment) Organism
recombinant isozymes from Escherichia coli strain BL21 Mus musculus
recombinant isozymes from Escherichia coli strain BL21 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
retina isozyme ADH4 Mus musculus
-
retina isozyme ADH4 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-cis-retinol + NAD+
-
Mus musculus 11-cis-retinal + NADH
-
?
11-cis-retinol + NAD+
-
Homo sapiens 11-cis-retinal + NADH
-
?
13-cis-retinol + NAD+ no activity with isozyme ADH1 Mus musculus 13-cis-retinal + NADH
-
?
13-cis-retinol + NAD+ no activity with isozyme ADH1 Homo sapiens 13-cis-retinal + NADH
-
?
7-cis-retinol + NAD+
-
Mus musculus 7-cis-retinal + NADH
-
?
7-cis-retinol + NAD+
-
Homo sapiens 7-cis-retinal + NADH
-
?
9-cis-retinol + NAD+
-
Mus musculus 9-cis-retinal + NADH
-
?
9-cis-retinol + NAD+
-
Homo sapiens 9-cis-retinal + NADH
-
?
all-trans-retinol + NAD+
-
Mus musculus all-trans-retinal + NADH
-
?
all-trans-retinol + NAD+
-
Homo sapiens all-trans-retinal + NADH
-
?
ethanol + NAD+
-
Mus musculus acetaldehyde + NADH
-
?
ethanol + NAD+
-
Homo sapiens acetaldehyde + NADH
-
?
hexanol + NAD+
-
Mus musculus hexaldehyde + NADH
-
?
hexanol + NAD+
-
Homo sapiens hexanal + NADH
-
?

Synonyms

Synonyms Comment Organism
ADH
-
Mus musculus
ADH
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mus musculus
25
-
assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information kcat for isozymes ADH1, and ADH4 for all retinoid substrates in forward and reverse reaction Mus musculus
additional information
-
additional information kcat for isozymes ADH1B1, ADH1B2, and ADH4 for all retinoid substrates in forward and reverse reaction Homo sapiens
0.45
-
Hexanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
1.92
-
ethanol recombinant isozyme ADH1, pH 7.5, 25°C Mus musculus
3.83
-
Hexanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
4.42
-
ethanol recombinant isozyme ADH1, pH 10.5, 25°C Mus musculus
30.8
-
Hexanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus
41.3
-
ethanol recombinant isozyme ADH4, pH 7.5, 25°C Mus musculus
86.5
-
Hexanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus
215
-
ethanol recombinant isozyme ADH4, pH 10.5, 25°C Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
isozyme ADH1B2, assay at Homo sapiens
10.5
-
assay at Mus musculus
10.5
-
isozyme ADH1B1, ADH4, assay at Homo sapiens