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Literature summary for 1.1.1.108 extracted from

  • Mori, N.; Mitsuzumi, H.; Kitamoto, Y.
    Purification and properties of carnitine dehydrogenase from Pseudomonas sp. YS-240 (1994), J. Ferment. Bioeng., 78, 337-340.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Rhizobium sp. YS-240
Ag+
-
Rhizobium sp. YS-240
Ca2+ 60-70% inhibition Rhizobium sp. YS-240
Co2+ 60-70% inhibition Rhizobium sp. YS-240
Cu+ 60-70% inhibition Rhizobium sp. YS-240
Cu2+
-
Rhizobium sp. YS-240
Hg+ strong inhibition Rhizobium sp. YS-240
Hg2+
-
Rhizobium sp. YS-240
o-phenanthroline 38% inhibition Rhizobium sp. YS-240
p-chloromercuribenzoate
-
Rhizobium sp. YS-240
Zn2+ 60-70% inhibition Rhizobium sp. YS-240

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
NADH
-
Rhizobium sp. YS-240
0.1
-
NAD+
-
Rhizobium sp. YS-240
0.54
-
3-dehydrocarnitine
-
Rhizobium sp. YS-240
1.2
-
L-carnitine
-
Rhizobium sp. YS-240

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
2 * 50000, SDS-PAGE Rhizobium sp. YS-240
110000
-
gel filtration Rhizobium sp. YS-240

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ Rhizobium sp. YS-240
-
3-dehydrocarnitine + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Rhizobium sp. YS-240
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Toyopearl, ammonium sulfate, hydroxylapatite, Sephacryl S-200, hydroxylapatite Rhizobium sp. YS-240

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
23.3
-
-
Rhizobium sp. YS-240

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+
-
Rhizobium sp. YS-240 3-dehydrocarnitine + NADH + H+
-
r
carnitine + NAD+
-
Rhizobium sp. YS-240 3-dehydrocarnitine + NADH + H+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 50000, SDS-PAGE Rhizobium sp. YS-240

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Rhizobium sp. YS-240

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
35
-
30 min in 100 mM potassium phosphate, pH 7.5, enzyme is rapidly inactivated above 40°C Rhizobium sp. YS-240

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 8 reduction of 3-dehydrocarnitine Rhizobium sp. YS-240
9.5
-
oxidation of L-carnitine Rhizobium sp. YS-240

pH Stability

pH Stability pH Stability Maximum Comment Organism
7 8
-
Rhizobium sp. YS-240

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rhizobium sp. YS-240