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Literature summary for 1.1.1.132 extracted from

  • Li, F.; Yu, J.; Yang, H.; Wan, Z.; Bai, D.
    Effects of ambroxol on alginate of mature Pseudomonas aeruginosa biofilms (2008), Curr. Microbiol., 57, 1-7.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ambroxol i.e. 2-amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzylamine, inhibits GMD activity, reduces the production of alginate, the expression of the important genes, and affects the structure of mucoid Pseudomonas aeruginosa biofilms, overview; reduces activity of the key enzyme GMD in alginate biosynthesis in a concentration-dependent manner Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa GMD is the key enzyme in alginate biosynthesis. Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections ?
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?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas aeruginosa P11759
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GMD is the key enzyme in alginate biosynthesis. Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections Pseudomonas aeruginosa ?
-
?

Synonyms

Synonyms Comment Organism
GDP-mannose dehydrogenase
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Pseudomonas aeruginosa
GMD
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Pseudomonas aeruginosa
guanosine diphospho-D-mannose dehydrogenase
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Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Pseudomonas aeruginosa