Literature summary for 1.1.1.141 extracted from

Lee, S.C.; Levine, L.
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types (1975), J. Biol. Chem., 250, 548-552.

Inhibitors

Inhibitors	Comment	Organism
3,3',5-triiodothyronine	-	Gallus gallus
indomethacin	-	Canis lupus familiaris
indomethacin	-	Gallus gallus
indomethacin	-	Homo sapiens
indomethacin	-	Platyrrhini
indomethacin	-	Sus scrofa
additional information	not inhibited by L-thyronine and NADH	Gallus gallus
additional information	-	Homo sapiens
additional information	not inhibited by thyroid hormones and NADPH	Platyrrhini
NADH	-	Gallus gallus
NADH	-	Homo sapiens
NADH	-	Sus scrofa
NADPH	-	Gallus gallus
NADPH	-	Homo sapiens
NADPH	-	Sus scrofa
Tetraiodothyroacetic acid	-	Gallus gallus
thyroxine	-	Canis lupus familiaris
thyroxine	-	Gallus gallus
thyroxine	-	Homo sapiens
thyroxine	-	Platyrrhini
thyroxine	-	Sus scrofa

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.014	-	prostaglandin E2	-	Gallus gallus
0.025	-	prostaglandin F2alpha	-	Gallus gallus

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-
Gallus gallus	-	-	-
Homo sapiens	-	-	-
Platyrrhini	-	-	-
Sus scrofa	-	-	-

Purification (Comment)	Organism
partial	Gallus gallus
partial	Platyrrhini

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
brain	-	Platyrrhini	-
erythrocyte	-	Platyrrhini	-
heart	-	Gallus gallus	-
heart	-	Canis lupus familiaris	-
heart	-	Platyrrhini	-
kidney	-	Gallus gallus	-
kidney	-	Homo sapiens	-
kidney	-	Sus scrofa	-
kidney	-	Canis lupus familiaris	-
kidney	-	Platyrrhini	-
liver	-	Platyrrhini	-
lung	-	Homo sapiens	-
lung	-	Sus scrofa	-
lung	-	Platyrrhini	-
spleen	-	Gallus gallus	-
spleen	-	Homo sapiens	-
spleen	-	Sus scrofa	-
spleen	-	Canis lupus familiaris	-
spleen	-	Platyrrhini	-

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.025	-	enzyme from heart, substrate prostaglandin E2	Gallus gallus
0.136	-	enzyme from brain, substrate prostaglandin E2	Platyrrhini

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+	-	Homo sapiens	11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH	-	?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+	-	Sus scrofa	11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH	-	?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+	-	Canis lupus familiaris	11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH	-	?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+	NAD+ is much more effective than NADP+	Gallus gallus	11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH	-	?
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+	NADP+ is more effective than NAD+	Platyrrhini	11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH	-	?
prostaglandin E2 + NAD+	-	Gallus gallus	15-oxoprostaglandin E2 + NADH + H+	-	r
prostaglandin F2alpha + NAD+	-	Homo sapiens	15-ketoprostaglandin F2alpha + NADH + H+	-	?
prostaglandin F2alpha + NAD+	-	Sus scrofa	15-ketoprostaglandin F2alpha + NADH + H+	-	?
prostaglandin F2alpha + NAD+	-	Canis lupus familiaris	15-ketoprostaglandin F2alpha + NADH + H+	-	?
prostaglandin F2alpha + NAD+	NAD+ is much more effective than NADP+	Gallus gallus	15-ketoprostaglandin F2alpha + NADH + H+	-	?
prostaglandin F2alpha + NAD+	NADP+ is more effective than NAD+	Platyrrhini	15-ketoprostaglandin F2alpha + NADH + H+	-	?

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	8.5	-	Gallus gallus
7.2	8.5	-	Platyrrhini

Cofactor	Comment	Organism
NAD+	-	Homo sapiens
NAD+	-	Sus scrofa
NAD+	-	Canis lupus familiaris
NAD+	much more effective than NADP+	Gallus gallus
NAD+	NADP+ is more effective	Platyrrhini
NADP+	more efficient than NAD+	Platyrrhini