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Literature summary for 1.1.1.141 extracted from

  • Iijima, Y.; Ueno, T.; Sasagawa, K.; Yamazaki, M.
    Inhibition of 15-hydroxyprostaglandin dehydrogenase by papaverine (1978), Biochem. Biophys. Res. Commun., 80, 484-489.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation by cAMP Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by Ca2+ Canis lupus familiaris
papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Canis lupus familiaris
papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Cavia porcellus
papaverine
-
Gallus gallus
papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Rattus norvegicus
papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate pH 7.4, 37°C Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Cavia porcellus
-
-
soluble
-
Sus scrofa
-
-
soluble
-
Canis lupus familiaris
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Cavia porcellus first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Rattus norvegicus first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Sus scrofa first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Canis lupus familiaris first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially from heart Cavia porcellus
native enzyme partially from kidney Rattus norvegicus
native soluble enzyme partially from heart ventricular tissue by ultracentrifugation, ammonium sulfate fractionation, gel filtration, and anion exchange chromatography Canis lupus familiaris
native soluble enzyme partially from lung Sus scrofa
native soluble enzyme partially from lung by ultracentrifugation, ammonium sulfate fractionation and anion exchange chromatography Cavia porcellus
partial Gallus gallus
partial Cavia porcellus
partial Rattus norvegicus
partial Sus scrofa
partial Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Gallus gallus
-
heart
-
Cavia porcellus
-
heart
-
Rattus norvegicus
-
heart
-
Sus scrofa
-
heart
-
Canis lupus familiaris
-
kidney
-
Gallus gallus
-
kidney
-
Cavia porcellus
-
kidney
-
Rattus norvegicus
-
kidney
-
Sus scrofa
-
kidney
-
Canis lupus familiaris
-
lung
-
Cavia porcellus
-
lung
-
Rattus norvegicus
-
lung
-
Sus scrofa
-
lung
-
Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Cavia porcellus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Rattus norvegicus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Canis lupus familiaris (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Cavia porcellus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Rattus norvegicus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Canis lupus familiaris (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
15-hydroxyprostaglandin dehydrogenase
-
Cavia porcellus
15-hydroxyprostaglandin dehydrogenase
-
Rattus norvegicus
15-hydroxyprostaglandin dehydrogenase
-
Sus scrofa
15-hydroxyprostaglandin dehydrogenase
-
Canis lupus familiaris
15-OH-PGDH
-
Cavia porcellus
15-OH-PGDH
-
Rattus norvegicus
15-OH-PGDH
-
Sus scrofa
15-OH-PGDH
-
Canis lupus familiaris
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
Cavia porcellus
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
Rattus norvegicus
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
Sus scrofa
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
Canis lupus familiaris

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Cavia porcellus
37
-
assay at Rattus norvegicus
37
-
assay at Sus scrofa
37
-
assay at Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Cavia porcellus
7.4
-
assay at Rattus norvegicus
7.4
-
assay at Sus scrofa
8.7
-
assay at Canis lupus familiaris

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Cavia porcellus
NAD+
-
Rattus norvegicus
NAD+
-
Sus scrofa
NAD+
-
Canis lupus familiaris

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.026
-
papaverine
-
Cavia porcellus
0.026
-
papaverine pH 7.4, 37°C Cavia porcellus
0.068
-
papaverine enzyme from kidney Canis lupus familiaris
0.068
-
papaverine kidney enzyme, pH 7.4, 37°C Canis lupus familiaris
0.07
-
papaverine enzyme from heart Canis lupus familiaris
0.07
-
papaverine heart enzyme, pH 7.4, 37°C Canis lupus familiaris
0.098
-
papaverine
-
Gallus gallus
0.098
-
papaverine pH 7.4, 37°C Cavia porcellus
0.12
-
papaverine
-
Sus scrofa
0.12
-
papaverine pH 7.4, 37°C Sus scrofa
0.4
-
papaverine
-
Rattus norvegicus
0.4
-
papaverine kidney enzyme, pH 7.4, 37°C Rattus norvegicus