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Literature summary for 1.1.1.141 extracted from

  • Ensoe, C.M.; Tai, H.H.
    Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (1994), Biochim. Biophys. Acta, 1208, 151-156.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
K155L inactive enzyme Homo sapiens
K155Q inactive enzyme Homo sapiens
Y151A inactive enzyme Homo sapiens
Y151F inactive enzyme Homo sapiens
Y151S inactive enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0039
-
prostaglandin E2 recombinant enzyme expressed in E. coli Homo sapiens
0.0045
-
prostaglandin A1 recombinant enzyme expressed in E. coli Homo sapiens
0.005
-
prostaglandin E1 recombinant enzyme expressed in E. coli Homo sapiens
0.022
-
NAD+ recombinant enzyme expressed in E. coli Homo sapiens
0.022
-
Prostaglandin A2 recombinant enzyme expressed in E. coli Homo sapiens
0.04
-
prostaglandin F2alpha recombinant enzyme expressed in E. coli Homo sapiens
0.063
-
6-oxo-prostaglandin F1alpha recombinant enzyme expressed in E. coli Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
recombinant enzyme expressed in E. coli, western-blot Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
19.8
-
recombinant enzyme Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, 20% glycerol, 4 weeks, no loss of activity Homo sapiens
4°C, 20% glycerol, 4 weeks, 25% loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin A1 + NAD+
-
Homo sapiens 15-ketoprostaglandin A1 + NADH + H+
-
?
prostaglandin A2 + NAD+
-
Homo sapiens 15-ketoprostaglandin A2 + NADH + H+
-
?
prostaglandin E1 + NAD+
-
Homo sapiens 15-ketoprostaglandin E1 + NADH + H+
-
?

Subunits

Subunits Comment Organism
monomer 1 * 29000, recombinant enzyme, SDS-PAGE Homo sapiens