Application | Comment | Organism |
---|---|---|
medicine | expression in nontumorigenic IEC-18 cells, with and without K-RasV12 and analysis of the ability of cells to form tumors in nu/nu mice. Transformed cells show increased 15-hydroxyprostaglandin dehydrogenase activity with decreased prostaglandin E2 and prostaglandin I2 levels, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and proliferation rates. Xenografts of cells expressing both the enzyme and K-RasV12 exhibit delayed tumor formation with negligible cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and significantly decreased prostaglandin E2 levels. Tumors have decreased staining of the proliferative marker, Ki-67, and a significant increase in apoptosis in the central region of the tumor | Rattus norvegicus |
medicine | PGDH expression suppresses K-RasV12-mediated tumorigenesis in intestinal epithelial cells | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression in IEC-18 cell | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression in nontumorigenic IEC-18 cells, with and without K-RasV12 and analysis of the ability of cells to form tumors in nu/nu mice. Transformed cells show increased 15-hydroxyprostaglandin dehydrogenase activity with decreased prostaglandin E2 and prostaglandin I2 levels, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and proliferation rates. Xenografts of cells expressing both the enzyme and K-RasV12 exhibit delayed tumor formation with negligible cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and significantly decreased prostaglandin E2 levels. Tumors have decreased staining of the proliferative marker, Ki-67, and a significant increase in apoptosis in the central region of the tumor | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-[[4-(ethoxycarbonyl)phenyl]azo]2-hydroxy-benzene acetic acid | CAY-10397 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | O08699 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
IEC-18 cell | - |
Rattus norvegicus | - |
intestinal epithelium | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostaglandin E2 + NAD+ | - |
Rattus norvegicus | 15-ketoprostaglandin E2 + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-PGDH | - |
Rattus norvegicus |
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Rattus norvegicus |