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Literature summary for 1.1.1.145 extracted from

  • Armstrong, D.G.
    Properties of 5-ene-3beta-hydroxysteroid dehydrogenase in granulosa tissue from the domestic fowl (Gallus domesticus) (1982), J. Steroid Biochem., 17, 225-230.
    View publication on PubMed
Search for more literature for 1.1.1.145

Inhibitors

Inhibitors Comment Organism Structure
20alpha-hydroxy-4-pregnen-3-one
-
 Gallus gallus
20beta-hydroxy-4-pregnen-3-one
-
 Gallus gallus
androstenedione
-
 Gallus gallus
estradiol-17beta
-
 Gallus gallus
progesterone
-
 Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Gallus gallus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + NAD(P)+ Gallus gallus
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell preovulatory follicular Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Gallus gallus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
pregnenolone + NAD(P)+
-
 Gallus gallus pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
 50 min, in microsomes 40-55% loss of activity, solubilized 80% loss of activity Gallus gallus
60
-
 microsomal fraction, inactivation Gallus gallus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Gallus gallus