Literature summary for 1.1.1.145 extracted from

Lorence, M.C.; Naville, D.; Graham-Lorence, S.E.; Mack, S.O.; Murry, B.A.; Trant, J.M.; Mason, J.I.
3beta-Hydroxysteroid dehydrogenase/DELTA 5-4-isomerase expression in rat and characterization of the testis isoform (1991), Mol. Cell. Endocrinol., 80, 21-31.

Search for more literature for 1.1.1.145

Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS-1 monkey kidney tumor cells	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00009	-	dehydroepiandrosterone	-	Rattus norvegicus
0.00013	-	pregnenolone	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dehydroepiandrosterone + NAD+	Rattus norvegicus	-	androst-5-en-3,17-dione + NADH + H+	-	?
pregnenolone + NAD(P)+	Rattus norvegicus	-	pregn-5-en-3,20-dione + NAD(P)H + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dehydroepiandrosterone + NAD+	-	Rattus norvegicus	androst-5-en-3,17-dione + NADH + H+	-	?
pregnenolone + NAD(P)+	-	Rattus norvegicus	pregn-5-en-3,20-dione + NAD(P)H + H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)