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Literature summary for 1.1.1.146 extracted from
- Specificity of human 11beta-hydroxysteroid dehydrogenase (1981), J. Steroid Biochem., 14, 807-809.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11alpha-hydroxy-pregn-4-ene-3,20-dione + ? | Homo sapiens | 2fold higher activity than for cortisol | pregn-4-ene-3,11,20-trione + ? | - |
? |  |
| 11alpha-hydroxy-pregn-4-ene-3,20-dione + ? | Homo sapiens | i.e. 11alpha-hydroxy progesterone | pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + ? | Homo sapiens | i.e. cortisol | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta,17beta-dihydroxyandrost-4-ene-3-one + ? | Homo sapiens | same activity as for cortisol | 17beta-hydroxyandrost-4-ene-3,11-dione + ? | - |
? | |
| 11beta,17beta-dihydroxyandrost-4-ene-3-one + ? | Homo sapiens | i.e. 11beta-hydroxy-testosterone | 17beta-hydroxyandrost-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20alpha-dihydroxypregn-4-ene-3-one + ? | Homo sapiens | 4fold activity than for cortisol | 20alpha-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20alpha-dihydroxypregn-4-ene-3-one + ? | Homo sapiens | i.e. 11beta-hydroxy,20-dihydroprogesterone | 20alpha-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20beta-dihydroxypregn-4-ene-3-one + ? | Homo sapiens | 46% of the activity compared to cortisol | 20beta-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20beta-dihydroxypregn-4-ene-3-one + ? | Homo sapiens | i.e. 11beta,20beta-dihydroxoprogesterone | 20beta-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,21-dihydroxypregn-4-en-3,20-dione + ? | Homo sapiens | i.e. corticosterone | 11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ? | - |
? | |
| 11beta,21-dihydroxypregn-4-en-3,20-dione + ? | Homo sapiens | 3fold activity than for cortisol | 11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ? | - |
? | |
| 11beta-hydroxy-pregn-4-ene-3,20-dione + ? | Homo sapiens | highest activity | pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta-hydroxy-pregn-4-ene-3,20-dione + ? | Homo sapiens | i.e. 11beta-hydroxy progesterone | pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta-hydroxyandrost-4-ene-3,17-dione + ? | Homo sapiens | i.e. 11beta-hydroxy-androstenedione | androst-4-ene-3,11,17-trione + ? | - |
? | |
| 11beta-hydroxyandrost-4-ene-3,17-dione + ? | Homo sapiens | 38% of the activity compared to cortisol | androst-4-ene-3,11,17-trione + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11alpha-hydroxy-pregn-4-ene-3,20-dione + ? | 2fold higher activity than for cortisol | Homo sapiens | pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11alpha-hydroxy-pregn-4-ene-3,20-dione + ? | i.e. 11alpha-hydroxy progesterone | Homo sapiens | pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + ? | i.e. cortisol | Homo sapiens | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta,17beta-dihydroxyandrost-4-ene-3-one + ? | same activity as for cortisol | Homo sapiens | 17beta-hydroxyandrost-4-ene-3,11-dione + ? | - |
? | |
| 11beta,17beta-dihydroxyandrost-4-ene-3-one + ? | i.e. 11beta-hydroxy-testosterone | Homo sapiens | 17beta-hydroxyandrost-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20alpha-dihydroxypregn-4-ene-3-one + ? | 4fold activity than for cortisol | Homo sapiens | 20alpha-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20alpha-dihydroxypregn-4-ene-3-one + ? | i.e. 11beta-hydroxy,20-dihydroprogesterone | Homo sapiens | 20alpha-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20beta-dihydroxypregn-4-ene-3-one + ? | 46% of the activity compared to cortisol | Homo sapiens | 20beta-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20beta-dihydroxypregn-4-ene-3-one + ? | i.e. 11beta,20beta-dihydroxyprogesterone | Homo sapiens | 20beta-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,20beta-dihydroxypregn-4-ene-3-one + ? | i.e. 11beta,20beta-dihydroxoprogesterone | Homo sapiens | 20beta-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 11beta,21-dihydroxypregn-4-en-3,20-dione + ? | i.e. corticosterone | Homo sapiens | 11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ? | - |
? | |
| 11beta,21-dihydroxypregn-4-en-3,20-dione + ? | 3fold activity than for cortisol | Homo sapiens | 11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ? | - |
? | |
| 11beta-hydroxy-pregn-4-ene-3,20-dione + ? | highest activity | Homo sapiens | pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta-hydroxy-pregn-4-ene-3,20-dione + ? | i.e. 11beta-hydroxy progesterone | Homo sapiens | pregn-4-ene-3,11,20-trione + ? | - |
? | |
| 11beta-hydroxyandrost-4-ene-3,17-dione + ? | i.e. 11beta-hydroxy-androstenedione | Homo sapiens | androst-4-ene-3,11,17-trione + ? | - |
? | |
| 11beta-hydroxyandrost-4-ene-3,17-dione + ? | 38% of the activity compared to cortisol | Homo sapiens | androst-4-ene-3,11,17-trione + ? | - |
? | |
| 20alpha-hydroxypregn-4-ene-3-one + ? | 4fold activity than for cortisol | Homo sapiens | 20alpha-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
| 20alpha-hydroxypregn-4-ene-3-one + ? | i.e. 11beta-hydroxy,20-dihydroprogesterone | Homo sapiens | 20alpha-hydroxypregn-4-ene-3,11-dione + ? | - |
? | |
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