Cloned (Comment) | Organism |
---|---|
expression inEscherichia coli of N-terminally deleted gene, amino acids 24-292, with an N-terminal His-tag | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y280A | wild-type and mutant enzyme exhibit similar Km values for either cortisone or 11-dehydrocorticosterone. About 10fold increase in IC50-value for glycyrrhetinic acid | Homo sapiens |
Y280F | wild-type and mutant enzyme exhibit similar Km values for either cortisone or 11-dehydrocorticosterone. About 6fold increase in IC50-value for glycyrrhetinic acid | Homo sapiens |
Y280S | wild-type and mutant enzyme exhibit similar Km values for either cortisone or 11-dehydrocorticosterone. 100% increase in IC50-value for glycyrrhetinic acid | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | - |
Homo sapiens | corticosterone + NADP+ | - |
r | |
cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH | - |
r | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |