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Literature summary for 1.1.1.146 extracted from

  • Klusonova, P.; Kucka, M.; Ergang, P.; Miksik, I.; Bryndova, J.; Pacha, J.
    Cloning of chicken 11beta-hydroxysteroid dehydrogenase type 1 and its tissue distribution (2008), J. Steroid Biochem. Mol. Biol., 111, 217-224.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Gallus gallus
-
type 1 enzyme
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein sequence contains one N-linked glycosylation site Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
brain weak expression Gallus gallus
-
brain low level of expression, low acitivity Gallus gallus
-
gonad weak expression Gallus gallus
-
gonad low level of expression Gallus gallus
-
heart weak expression Gallus gallus
-
heart low level of expression, low activity Gallus gallus
-
intestine high expression Gallus gallus
-
intestine high level of expression and activity Gallus gallus
-
kidney high expression Gallus gallus
-
kidney high level of expression and activity Gallus gallus
-
liver high expression Gallus gallus
-
liver high level of expression and activity Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
corticosterone + NADP+
-
Gallus gallus 11-dehydrocorticosterone + NADPH
-
r
cortisol + NADP+
-
Gallus gallus cortisone + NADPH
-
r

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 1
-
Gallus gallus
11HSD1
-
Gallus gallus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Gallus gallus