Literature summary for 1.1.1.146 extracted from

Hu, G.; Lin, H.; Lian, Q.; Zhou, S.; Guo, J.; Zhou, H.; Chu, Y.; Ge, R.
Curcumin as a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats (2013), PLoS ONE, 8, e49976.

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Application

Application	Comment	Organism
medicine	curcumin is inhibitory to isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one	derivative of curcumin, IC50 value in intact cells 93 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM	Homo sapiens
(1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one	derivative of curcumin, IC50 value in intact cells 184 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM	Rattus norvegicus
curcumin	inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 2.29 microM	Homo sapiens
curcumin	inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28845	-	-
Rattus norvegicus	P16232	-	-

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Release 2023.1 (January 2023)